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An Inhibitory Effects of Silsosangami on the Atherosclerosis in Hypercholesterolemic Rabbits
Shin, Sang Seub,Choi, Dall Yeong,Kim, Cherl Ho,Park, Soo Young,Kim, Chang Hwan,Kim, Jun Kee,Park, Sun Dong,Moon, Jin Young,Kim, Beub Jin,Park, Won Hwan 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
The traditinal korean therapeutic system has been used for the treatment of various disease, including the clinical treatment of hypercholesterolemia, diabetes and obesity. Hypercholesterolemia is considered to be a major cause of the lesions associated with atherosclerosis, and a number of hypercholesterolemic drugs are used to improve the plasma lipid level of patients. Silsosangami(SSG) has been reported to have a hypolipidemic effect in patients with hypercholesterolemia and in cholesterol-induced experimental models. The present paper reports the effect of extracts obtained from SSG on heperlipemia and normal rabbits. The inhibitory effects of the traditional herbal medicine SSG on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model , Kurosawa and Kusanagi-hypercholesterolemic(KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein(LDL) oxidation were measured in a control group and a SSG group. In the control group, the area of atheromatous plaques of the aorta progressed between 4 weeks (30.43%) and 8 weeks (47.48%). This progressin of atherosclerotic lesions did not happen in the SSG-treated group between 4 weeks (22.65%) and 8 weeks (23.23%). Antioxidative effects on LDL were seen in the SSG in weeks 12 and 14. SSG improved the hypercholestrolemia in the KHC rabbits. These results suggest that SSG has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits.
( Sung Hwan Choi ),( Seung Han Shin ),( Ee-kyung Kim ),( Han-suk Kim ) 대한주산의학회 2019 Perinatology Vol.30 No.1
Objective: The objective of this study was to describe respiratory and neurodevelopmental outcomes in infants with severe bronchopulmonary dysplasia (BPD) who needed invasive ventilation until 36 weeks’ postmenstrual age (PMA). Methods: A retrospective observational single-center study was conducted in our hospital. Eighty preterm infants born between January 2007 and December 2016 with less than 28 weeks’ gestational age and classified as having severe BPD were included in the study. Patients with invasive ventilation at 36 weeks’ PMA (invasive group) were compared with those with noninvasive ventilation (noninvasive group) in terms of perinatal characteristics and postnatal outcomes. Results: Antenatal characteristics and basic patient characteristics were comparable between the two groups. Incidence of pulmonary hemorrhage (13.6 vs. 1.7%, P=0.061) and clinical sepsis (66.7 vs. 31.0%, P=0.004) was more in the invasive group. Invasive group had longer hospital stay (133.50± 104.52 vs. 114.00±24.71 days, P=0.031), higher rates of readmission due to respiratory problems before 12 months of corrected age (57.1 vs. 32.1%, P=0.045), higher rates of having a tracheostomy (22.7 vs. 1.7%, P=0.005), and higher rates of infants with respiratory support at a corrected age of 6 months (22.7 vs. 3.5%, P=0.016). Neurodevelopmental outcomes including Bayley Scales of Infant Development-III, cerebral palsy, hearing aid, blindness, and composite outcome of them revealed no differences between the two groups. Conclusion: Invasive ventilation until postmenstrual age of 36 weeks does not predict poorer neurodevelopmental outcomes in infants with severe BPD. However, the invasive group was more prone to develop respiratory problems after discharge.
Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.).
Shin, Hye-Young,Kim, Sang-Hyun,Kang, Sin-Myoung,Chang, Ik-Jun,Kim, Sang-Yong,Jeon, Hoon,Leem, Kang-Hyun,Park, Won-Hwan,Lim, Jong-Pil,Shin, Tae-Yong Marcel Dekker 2009 Immunopharmacology and immunotoxicology Vol.31 No.2
<P>Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-alpha, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-kappaB activation in HMC-1 cells, which was inhibited by MW (1 mg/ml). MW inhibited secretion of TNF-alpha, IL-6, and IL-8 possibly by inhibiting NF-kappaB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.</P>
Analysis of online questions about dental hygienist: Case report in Naver Intelligent Network
( Sang-hwan Oh ),( Na-ri Shin ),( Soo-jeong Hwang ) 조선대학교 구강생물학연구소 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.1
Current trends note that individuals utilize the information provided through online knowledge search services, to solve their curiosity for news and world events, as well as to read information written by others and acquire new knowledge on a variety of subjects. The purpose of this study was to analyze the questions about dental hygienists, in an effort to know which information they would want to gain through a web-based question and answer service. The questions were available through the service from October 2002 to March 2017, and it was through the web-based question-answer service in Naver that is called knowledge iN which was searched, using the key words of chigwawiseangsa and chiwiseangsa in the Korean language. As a result, there were a total of 1693 questions about the profession of the dental hygienist occupation which were extracted and analyzed. In particular, it was noted that the high school students asked about the occupation of dental hygienists the most. The middle and high school students required the information about the required entrance examination and employment in this growing field of study, and it was noted that the university students and dental hygienists wanted to know more information regarding statistics of available employment of dental hygienists (such the job options that would be available as upon graduation from their certificate program, etc.). The information orders that the questioners wanted answered were determined and identified as follows: employment (39.3%), entrance examination (18.8%), working conditions (11.5%), tasks (11.3%), and curriculum (9.4%). When the information captured from the questions from the participants and questioners were assorted in detail, the detail information orders that the questioners wanted were as follows: information on applicable places of study, such as the available university (13.0%), annual salary (11.5%), prospects (10.3%). overseas employment (9.3%), and public dental hygienists (8.7%).
Shin, Chang Hwan,Huh, Jung Oh,Baek, Sun Jong,Kim, Sang Kyu,Lee, Min Hyung,Do, Youngkyu WILEY-VCH Verlag 2010 European journal of inorganic chemistry Vol.2010 No.23
<P>Novel iridium(III)/iridium(III) and iridium(III)/platinum(II) dinuclear complexes, [{Ir(ppyFF)<SUB>2</SUB>}<SUB>2</SUB>(μ<SUB>2</SUB>-L)] (4) and [{Ir(ppyFF)<SUB>2</SUB>}(μ<SUB>2</SUB>-L){Pt(ppy)}] (5) [ppyFF = 2-(2,4-difluorophenyl)pyridine, ppy = 2-phenylpyridine, L = 1,3-bis(3-phenyl-3-oxopropanoyl)benzene], linked by an L bridging ligand were prepared, and their photophysical properties were investigated in solution and in the solid state. The photophysical properties of mononuclear iridium(III) and platinum(II) complexes, [Ir(ppyFF)<SUB>2</SUB>(dbm)] (1) and [Pt(ppy)(dbm)] (2) bearing a dibenzoylmethane (dbm) ligand were also compared. Whereas the UV/Vis absorption spectra of 4 and 5 show independent light absorption at each metal-centered moiety, the photoluminescence spectra of 4 and 5 display almost identical features, but very weak emissions in solution at both room temperature and 77 K. The weak emission in solution is found to mainly originate from a <SUP>3</SUP>LX state of the L bridging ligand, which reflects the occurrence of efficient energy convergence from the triplet states of the Pt(ppy) and Ir(ppyFF) moieties to the <SUP>3</SUP>LX state of L. By contrast, intense orange-red emission, that is, aggregation-induced emission, is produced in the solid state of 4 and 5. Inspection of the crystal-packing structures of 5 reveals that strong intermolecular π–π interactions between the adjacent pyridine rings of ppyFF ligands in the Ir-centered moieties are responsible for the emissive metal-to-ligand–ligand charge-transfer [<SUP>3</SUP>M(LL)CT] state of the solid-state dinuclear systems. The electrochemical properties of 4 and 5 further indicate that the first two reductions occur at the dbm moieties of the L bridging ligand linked to each metal center, which is consistent with the fact that the lowest-energy excited state of the L bridging ligand dominates the excited-state properties of 4 and 5 in solution.</P> <B>Graphic Abstract</B> <P>Dinuclear complexes [{Ir(ppyFF)<SUB>2</SUB>}<SUB>2</SUB>(μ<SUB>2</SUB>-L)] (4) and [{Ir(ppyFF)<SUB>2</SUB>}(μ<SUB>2</SUB>-L){Pt(ppy)}] (5) [ppyFF = 2-(2,4-difluorophenyl)pyridine, ppy = 2-phenylpyridine, L = 1,3-bis(3-phenyl-3-oxopropanoyl)benzene] linked by bridging ligand L have been prepared. Although 4 and 5 exhibit weak emission in solution, an intense orange-red emission (i.e., aggregation-induced phosphorescence) is produced in the solid state. <img src='wiley_img_2010/14341948-2010-2010-23-EJIC201000275-fig000.gif' alt='wiley_img_2010/14341948-2010-2010-23-EJIC201000275-fig000'> </P>
Induction of Oxidative Stress in the Epididymis of Rats After Subchronic Exposure to Epichlorohydrin
Shin, In-Sik,Lim, Jeong-Hyeon,Kim, Sung-Hwan,Kim, Kang-Hyeon,Park, Na-Hyeong,Bae, Chun-Sik,Kang, Seong-Soo,Moon, Changjong,Kim, Sung-Ho,Jun, Woojin,Kim, Jong-Choon Springer-Verlag 2010 Bulletin of environmental contamination and toxico Vol.84 No.6
Sang Baek Ryu,Eun Kyung Bae,Jinhyung Kim,Yong Sup Hwang,Changkyun Im,Jin Woo Chang,Hyung-Cheul Shin,Kyung Hwan Kim 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson s disease (PD). Despite successful application of DBS, its mechanism of therapeutic effect is not clearly understood. Because PD results from the degeneration of dopamine neurons that affect the basal ganglia (BG) network, investigation of neuronal responses of BG neurons during STN DBS can provide informative insights for the understanding of the mechanism of therapeutic effect. However, it is difficult to observe neuronal activity during DBS because of large stimulation artifacts. Here, we report the observation of neuronal activities of the globus pallidus (GP) in normal and PD model rats during electrical stimulation of the STN. A custom artifact removal technique was devised to enable monitoring of neural activity during stimulation. We investigated how GP neurons responded to STN stimulation at various stimulation frequencies (10, 50, 90 and 130 Hz). It was observed that activities of GP neurons were modulated by stimulation frequency of the STN and significantly inhibited by high frequency stimulation above 50 Hz. These findings suggest that GP neuronal activity is effectively modulated by STN stimulation and strongly dependent on the frequency of stimulation.