간아세포종 환아의 임상적 특성과 예후

김민영,김대연,안효섭,김종재,김인원,정성은,이성철,박귀원,김우기,Kim, Min-Young,Kim, Dae-Yeon,Ahn, Hyo-Seep,Kim, Chong-Jai,Kim, In-One,Jung, Sung-Eun,Lee, Seong-Cheol,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 1997 소아외과 Vol.3 No.2

Hepatoblastoma is a rare pediatric malignancy which frequently presents at an advanced un resectable stage. With the neoadjuvant chemotherapy, improved resectability and survival have been reported. Twenty children with biopsy proven hepatoblastoma were treated during the period between January 1987 and June 1995. Median age at diagnosis was 13 months(2 months to 7 year and 10 months), and 13 were male. Histologic profile was 13 epithelial(5 fetal, 4 mixed, 1 embryonal, 3 undetermined), and 5 mixed mesenchymal and epithelial and 2 of undetermined type. Chemotherapy effectively reduced the tumor volume($p$=0.008), and was able to convert 7 out of 9 initially unresectable cases(78%) to resectable ones. Twelve radical and 2 palliative operations were done with or without adjuvant chemotherapy. The Median follow up period was 33 months and the median survival was 26 months. The group with curative resection had a 61.1% 5 year survival rate, but none of palliative resection group survived more than 13 months($p$=0.0001). In univariate analysis for prognostic factors revealed, large tumor size at diagnosis and abscence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Histological pure fetal type did not mean a better prognosis. Even with a recent neoadjuvant chemotherapy, the strategy should be focused on the radical resection as early as possible.

국내산 식물의 항균활성 검색

최원균,김용성,조규성,성창근 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.4

한국에서 자생하는 125종의 식물에서 추출한 141가지 메탄올 추출물들에서 식품부패미생물인 Bacillus subtillis, Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes 그리고 Pseudomonas aeruginosa에 대한 항균 활성도를 조사하였다. Bacillus subtillis에 대해 가장 강한 항균력을 보인 것은 오미자였으며 staphylococcus aureus 에 대해서 대황이, Pseudomonas aeruginosa에 대해서는 산사가 가장 강한 항균력을 나타냈다. 금은화는 Bacillus subtilis를, 산사는 Stophylococcus aureus를, 모과와 황금은 Pseudomonas aeruginosa를, 모감주나무꽃, 밤나무꽃, 장미꽃과 파꽃은 Enterobacter aerogenes를, 오미자는 Escherichia coli를 제외한 나머지 4가지 균주에 모두 항균력이 있었다 141 methanol extracts from 125 plant species which populate in Korea were screened for antimicrobial activity against various food-borne pathogens and food spoilage microorganisms. Those plants were selected from 3 different plant groups : traditional herbs, edible plants and flowers. The methanol extracts were tested by using the disk diffusion assay against five bacteria : Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli. From the evaluation of the inhibition zone diameter of microbial growth, the most significant antimicrobial activity against bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli was observed from the extract of Schizandra chinensis (Turcz) Baill., Rheum officinale Baill., Schizandra chinesis (Turcz) Baill., Koelreuteria paniculata Lax and Crataegus pinnatifida Bunge, respectively. The extract from many plants - Koelreuteria paniculata Lax, Chaenomeles sinensis Koehne, Scutellaria bacicalensis Georgi, Castanea crenata Sieb. et Zucc., Rosa centifolia L;, Allium fistulosum L. var. giganteum Makino, Crataegus pinnatifida Bunge, Schizandra chinensis (Turcz) Baill., Lonicera japonica - showed antimicrobial activity all four tested bacteria.

18MeV 선형가속기의 ARC Therapy에 관한 고찰

신세원,김명세,김성규 영남대학교 의과대학 1988 Yeungnam University Journal of Medicine Vol.5 No.2

회전조사시 회전각도에 따른 계산치와 측정치를 비교, 검토하여 다음과 같은 결과를 얻었다. 90°회전시에는 계산치와 측정치와는 4.5%의 차이를 나타내었고, 120°회전시에는 4.4%, 180°회전시에는 3.9%, 240°회전시에는 2.9%, 360°회전시에는 2.1%의 차이를 나타내어 회전각도가 클수록 계산치와 측정치와의 차이는 적은 것으로 나타났다. 또한 회전각도에 따라 최고선량지점이 상부로 이동하는 정도는 90°에서 240°까지 회전할 때 tumor depth가 4.5㎝일 경우에는 1.67㎝에서 1.10㎝정도 상부로 이동하였으며, tumor depth가 8㎝일 경우에는 2.45㎝에서 1.40㎝정도 상부로 이동하는 것으로 나타났다. In recent years there has been a growing interest in all forms of rotational therapy and many different types of therapy machines designed for this kind of treatment have become available. To the medical radiation physicist, the dosimetry of rotation therapy has presented a number of interesting problems, and much useful work has been published on the basic data of dose distribution and dosage calculation. The setting dose for ARC therapy were obtained by computer calculation and measurement with cylindrical phantom. Authors compared computer calculation with measured value. And in ARC therapy, the region of maximum dose is shifted from the tumor center. The extent of shift was analyzed by isodose distribution for ARC therapy techniques.

HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice

Kim, Young-Eun,Lee, Minji,Gu, Hyejung,Kim, Jeongwoo,Jeong, Seongju,Yeo, Sujin,Lee, You Jeong,Im, Sin-Hyeog,Sung, Young-Chul,Kim, Hak Jae,Weissman, Irving L.,Ahn, G-One The Company of Biologists Ltd 2018 Disease models & mechanisms Vol.11 No.7

<P><B>ABSTRACT</B></P><P>Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypoxia-inducible factor (HIF), a transcription factor activated under hypoxic conditions in myeloid cells, in the progression of IBD. To do this, we utilized myeloid-specific knockout (KO) mice targeting HIF pathways, created by a Cre-loxP system with human MRP8 (hMRP8), an intracellular calcium-binding protein, as the myeloid promoter. By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (<I>Vhl</I>) KO mice, in which HIF-1α and HIF-2α are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice. These parameters were restored to, if not better than, the WT levels when we examined hMRP8 <I>Hif-1a</I> KO mice upon 5% DSS feeding. hMRP8 <I>Hif-2a</I> KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice. Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 <I>Hif-1a</I> KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1α in myeloid cells is dispensable for tumorigenesis. Collectively, our results suggest that HIF-1α activation in myeloid cells critically regulates IBD progression.</P>

고 선량률 강내 치료기를 이용한 식도암 치험 1례

김경애,김성규,신세원,김명세 영남대학교 의과대학 1988 Yeungnam University Journal of Medicine Vol.5 No.1

식도암 환자에서 외부 방사선 치료와 고 선량률 강내 치료를 병용하여 자각 증상의 호전은 물론 식도 촬영상에서도 좋은 반응을 보인 환자에서 장기간이 경과후에 발생한 식도 출혈과 식도 기관루를 경험하였기에 문헌 고찰도 함께 하였다. Esophageal cancers are highly malignant neoplasms. Prognosis of esophageal cancer treated by external irradiation alone is rather poor because of local recurrence and distant metastasis. Recently intracavitary irradiation has been used as a boost therapy after external irradation to optain better local control. One case of esophageal cancer has been treated by high dose rate remote-controlled afterloading unit as boost therapy after external irradiation. The result was excellent in short term follow up esophagogram but esophageal bleeding and esophagotracheal fistula were noted in further follow up examination after inappropriate posttreatment management including insufficient chemotherapy due to poor general condition. We reviewed possible causes of esophageal bleeding and esophagotracheal fistula after external irradiation and high dose rate ICR.

국소진행 위암의 술중조사 2례

김경애,김성규,신세원,김명세,김홍진,권굉보,김홍대 영남대학교 의과대학 1988 Yeungnam University Journal of Medicine Vol.5 No.1

수술중 방사선 치료는 우리 나라와 같이 위암환자가 많은 경우에 그 이용 범위가 넓고 특히 국소적으로 진행된 경우에 효과가 있으므로 앞으로 그 이용 가치가 높다고 하겠다. 저자들은 국소적으로 진행된 두 명의 위암환자에서 일반외과, 마취과, 치료방사선과가 합동으로 수술중 방사선 치료를 시행 하였기에 문헌 고찰과 함께 보고하는 바이다. Stomach cancer is the most popular tumor in Korea but the prognosis following extensive surgery and chemotherapy has not improved for many years. Conventional external radiotherapy also has some limitation, namely, a cancerocidal does can not be delivered to tumors because of low radiation tolerance of adjacent critical sensitive organs. In order to overcome these limitations of curative surgery and external radiotherapy, intraoperative radiotherapy was proposed in many centers and the results were excellent. We treated two cases of locally advanced gastric cancers with IORT by using NEC 18 MeV Linear Accelerator after standard subtotal resection of the stomach. After treatment, the patients are in good conditions so far, but in order to evaluate the effectiveness of IORT, a study will be performed on the survival rates between patients treated by IORT and those treated by surgery alone.

The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study

( One Zoong Kim ),( Dong Soo Han ),( Chan Hyuk Park ),( Chang Soo Eun ),( You Sun Kim ),( Young-ho Kim ),( Jae Hee Cheon ),( Byong Duk Ye ),( Joo Sung Kim ) 대한간학회 2018 Gut and Liver Vol.12 No.1

Background/Aims: We aimed to evaluate the clinical characteristics and prognosis of Crohn’s disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. Methods: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement. Results: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677). Conclusions: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes. (Gut Liver 2018;12:67-72)

The Effect of Therapy Oriented CT in Radiation Therapy Planning

Sung Kyu Kim(김성규),Sei One Shin(신세원),Myung Se Kim(김명세) 대한방사선종양학회 1987 Radiation Oncology Journal Vol.5 No.2

전산화 단층촬영(CT)은 진단 분야 뿐 아니라 방사선 치료 계획 및 치료효과의 추적 등 치료분야에 까지 광범위하게 사용되고 있다. 그러나 환자의 체위가 치료시와는 다름으로 얻어진 영상이 치료시의 영상과는 차이가 있으며, 삼차원적인 치료면적의 계산이 곤란할 뿐 아니라 조영제를 사용함으로 생길 수 있는 선량계산의 오라 및 정확한 조사야가 표현되지 많음으로 병소 및 중요 정상장기의 선량 측정이 정확하지 못한점 등의 단점이 없다. 저자들은 1986년 5월 1일부터 1987린 4월 30일까지 영남대학병원 치료방사선과에서 치료받은 총 365명의 환자 중 일반 CT의 단점을 보완한 치료용 CT와 종래의 simulation을 병행한 106명의 치료계획을 비교 분석하여 다음과 같은 결과를 얻었다. 치료용 CT후 두경부 암 환자의 47%, 흉부암 환자의 79%, 복부암 환자의 63%에서 치료계획의 변경이 있어 치료용 CT가 두경부암, 흉부암, 복부암에서 거의 철수적임을 시사하였다. 그러나 직장암, 자궁경부암에서는 추가치료의 조사야의 측정 및 선량계산 이외의 전예에서 치료계획의 변경이 없었다. 선량분포의 비교측정에서는 윤곽만을 사용한 종래의 선량계산이 CT를 사용한 경우에 비해서 두경부암에서는 평균 20%, 흉부암, 복부암에서는 약 10%의 차이를 보여 전례에서 CT보다 과측정 되었음을 보여 종래의 윤곽만을 사용한 치료계획시의 저선량 조사에 대한 보정이 필요함을 시사하였다. The success of radioation therapy depends on exact treatment of the tumor with significant high dose for maximizing local control and excluding the normal tissues for minimizing unwanted complications. To achieve these goals, correct estimation of target volume in three dimension, exact dose distribution in tumor and normal critical structures and correction of tissue inhomogeneity are required. The effect of therapy oriented CT (plannng CT) were compared with conventional simulation method in necessity of planning change, set dose, and proper distribution of tumor dose. Of 365 new patients examined, planning CT was performed in 104 patients (28%). Treatment planning was changed in 47% of head and neck tumor, 79%> of intrathoracic tumor and 63% of abdmonial tumor. in breast cancer and musculoskeletal tumors, planning CT was recommended for selection of adequate energy and calculation of exact dose to critical structures such as kidney or spinal cord. The average difference of tumor doses between CT planning and conventional simulation was 10% in intrathoracic and intra-abdominal tumors but 20% in head and neck tumors which suggested that tumor dose may be overestimated in conventional simulation Although some limitations and disadvantages including the cost and irradiation during CT are still criticizing, our study showed that CT Planning is very helpful in radiotherapy Planning.

Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images

Sung, Wonmo,Jeong, Yoon,Kim, Hyejin,Jeong, Hoibin,Grassberger, Clemens,Jung, Seongmoon,Ahn, G-One,Kim, Il Han,Schuemann, Jan,Lee, Kangwon,Ye, Sung-Joon BioOne (Radiation Research Society) 2018 Radiation research Vol.190 No.5

정부출연연구기관의 서비스 품질, 고객만족 및 성과의 구조적 관계분석: 경제·인문사회연구회 산하 6개 정부출연연구기관을 중심으로

김성원(Sung-One Kim),이은희(Eunhee Yi),박수경(Soo-Kyung Park) 경인행정학회 2020 한국정책연구 Vol.20 No.4

본 연구는 국무조정실에서 주관하여 경제·인문사회연구회 소관 정부출연연구기관에서 매년 외부 고객을 대상으로 수행하는 고객만족도 설문조사 결과를 바탕으로, 서비스 품질이 고객만족을 통하여 기관 성과에 어떤 영향을 미치는지 분석하여 해당 요인들간의 관계를 실증적으로 검증하는 것을 목적으로 한다. 이를 위하여, 소관 출연연 26개 중에 고객만족도 조사를 실시하고, 해당 자료 내역을 공개한 6개 출연연의 2018년도 조사 자료를 활용하였다. 연구를 위한 조사 방법은 10점 척도를 사용한 개발 및 구조화된 설문지에 의해 수행된 설문조사였으며, 분석 대상 표본은 총 1,575명이었다. 설문자료의 분석방법으로는 구조방정식 모형을 활용한 확인적 요인분석 및 경로분석 실시를 통해 각 변수 간 인과관계를 검증하였다. 분석도구로는 SPSS 18.0과 AMOS 21.0을 활용하였다. 분석결과 서비스 과정품질, 결과품질 그리고 사회적품질은 고객만족에 유의미한 영향을 주었으며, 미시적 성과와 거시적 성과에는 사회적품질만 영향을 준 것으로 나타났다. 고객만족은 미시적 성과와 거시적 성과에 영향을 준 것으로 나타났다. 마지막으로 결과품질, 과정품질, 사회적품질이 성과요인에 영향을 미칠 때 모든 경로에서 전반적 만족요인은 간접효과를 보였다. To assess customer satisfaction of its external customers, customer service survey is organized by the Government Policy Coordination Office and conducted annually by twenty-six government-funded research institutions affiliated with the National Economic, Humanities and Social Sciences Research Council(NRC). This paper seeks to analyze how service quality affects performance of an institution through customer satisfaction, and empirically verify the relationship between these factors. 2018 data on survey results of six institutions were used, as these were the only ones to disclose results out of the twenty-six institutions. Research method consists of developing a structured questionnaire with a10-point scale and conducted on a sample of 1,575 people. To verify causal relationship between each factor, Structural E Model(SEM) was used to conduct Confirmatory Factor Analysis(CFA) and Path Analysis with SPSS 18.0 and AMOS 21.0. used as analysis tools. Results show service process quality, result quality and social quality have significant impact on customer satisfaction. However, only social quality directly impacts micro and macro performance with customer satisfaction affecting both micro and macro performance. In conclusion, when result quality, process quality, and social quality influence performance factors, overall satisfaction factor serves to indirectly affect all paths.