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Myongsoon Sung,Jonghyun Lee,Sung Soo Kim,Kyung Hwan Byu 순천향대학교 순천향의학연구소 2020 Journal of Soonchunhyang Medical Science Vol.26 No.2
There was an episode of complete recovery of congenital muscular torticollis presenting an ipsilateral neck mass due to the right sternocleidomastoid muscle (SCM) with other symptoms such as contralateral rotation of the head and restricted motion following initial physiotherapy for 6 months in a male infant. Physical examination and neck ultrasonography in the neonate clinic at 6 months revealed that his neck mass had disappeared, so therapy was discontinued. After 12 months of the episode, there was a re- occurrence of congenital muscular torticollis with the only symptom of ipsilateral neck mass and subsequently recovered without restricted motion. After 26 months of the reoccurrence, with no treatment except for 2 months of the second physiotherapy which was proven to be ineffective, spontaneous resolution of the right neck mass was demonstrated on serial ultrasound. Recovery of relapse SCM hypertrophy is extremely rare; therefore, we report the case. We suggest that the case may help clinicians diagnose and treating patients with the recovery of relapse SCM hypertrophy without complications.
Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review
Myongsoon Sung 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.8
Vitamin D exhibits anti-inflammatory properties throughmultiple mechanisms. Vitamin D deficiency is associated withincreased inflammation, exacerbations, and overall worseoutcomes in pediatric asthma and is observed in asthmaticchildren with obesity. In addition, given the increase in theprevalence of asthma over the last few decades, there has beenenormous interest in vitamin D supplementation as a potentialtherapeutic option. However, recent studies have suggested nostrong association between vitamin D levels or supplementationand childhood asthma. Recent studies have reported thatobesity and vitamin D deficiency are associated with increasedasthma symptoms. Thus, this review summarizes the findingsof clinical trials regarding the role of vitamin D in pediatricasthma and analyzes the study trends of vitamin D over the past2 decades.
Associations Between Phthalate, Eosinophil, and Aeroallergen Sensitization in Schoolchildren
Yi Jeongsik,Shin Ho-Sang,Han Man Yong,Choi Hee Jin,Lee Mi Seon,Sung Myongsoon 대한의학회 2023 Journal of Korean medical science Vol.38 No.45
Background: Phthalates and bisphenol A (BPA) are endocrine-disrupting chemicals and may cause immunological disorders in children. Therefore, according to the region, we investigated urinary phthalates and BPA levels and the relationship between urinary phthalate, aeroallergen sensitization, and eosinophil count during the coronavirus disease 2019 pandemic. Methods: In total, 203 schoolchildren (134 residential and 69 industrial) aged 7–10 years were enrolled between July 2021 and July 2022. The BPA, metabolites of four high-molecularweight phthalates (Σ4HMWP) and three low-molecular-weight phthalates (Σ3LMWP), were measured in the urine samples. Total eosinophil count and transepidermal water loss (TEWL) were also measured along with the skin prick test. Results: The two groups had no differences in terms of BPA. The industrial group had significantly more plastic container usage, and there was a difference in the Σ3LMWP (P < 0.001) between the two groups but no difference in the Σ4HMWP (P = 0.234). The quartiles of urinary Σ4HMWP and Σ3LMWP (P < were not associated with the total eosinophil count, vitamin D level, or TEWL. After adjusting for cofactors, the quartiles of urinary Σ4HMWP and Σ3LMWP were significantly associated with total eosinophil count (P < 0.001) but not with aeroallergen sensitization or vitamin D. Conclusion: Exposure to phthalates was significantly associated with eosinophil count but not with aeroallergen sensitization or vitamin D. Therefore, reducing the use of plastic containers may effectively prevent exposure to phthalates and reduce Th2 cell-mediated inflammation in children.
김민지 ( Minji Kim ),김현희 ( Hyun Hee Kim ),김효빈 ( Hyo-bin Kim ),나영호 ( Yeong-ho Rha ),박양 ( Yang Park ),성명순 ( Myongsoon Sung ),신윤호 ( Youn Ho Shin ),염혜영 ( Hye Yung Yum ),이경석 ( Kyung Suk Lee ),이용주 ( Yong Ju Le 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4
Allergic rhinitis (AR) is one of the most common allergic diseases characterized by stuffy nose, rhinorrhea, sneezing, and itching. Re-searchers have indicated an increase in the prevalence of AR and younger-age onset during the last few decades. The increasing burden of AR has caused many researchers to investigate time trends of the prevalence of AR and to identify its risk factors. The most commonly used epidemiological studies are cross-sectional ones such as the International Study of Asthma and Allergies in Childhood study and big data from National Health Insurance Service or National Health and Nutrition Examination Survey. How-ever, these studies have many limitations including recall bias, selection bias, and deficit of objective evaluation. Furthermore, cross- sectional studies cannot reflect new risk factors associated with the development of AR. New epidemiological studies will be needed to cover genetic factors, environmental changes, microbiomes, and lifestyles that are known to be risk factors for AR. Fur-ther studies will be needed to determine the prevalence, natural history, and risk factors of AR in order to advance our understand-ing of the pathophysiology, prevention, and management of comorbidities of AR. (Allergy Asthma Respir Dis 2021;9:203-207)
전윤홍 ( Yoon Hong Chun ),김민지 ( Minji Kim ),김효빈 ( Hyo-bin Kim ),나영호 ( Yeong-ho Rha ),박양 ( Yang Park ),박용민 ( Yong Mean Park ),성명순 ( Myongsoon Sung ),신윤호 ( Youn Ho Shin ),염혜영 ( Hye Yung Yum ),이경석 ( Kyung S 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.2
Among allergic diseases of the Korean pediatric population, allergic rhinitis shows the most rapidly increasing prevalence. Its economic burden is substantial in many Asian countries including South Korea. This investigation of its risk factors aims to reduce the socioeconomic burden by blocking exposure of susceptible individuals to identified causes. However, the risk factors of allergic rhinitis varied considerably depending on the seasons, geographical locations, and populations involved. This review article primarily deals with studies on the risk factors for allergic rhinitis in Korean children that were published during the last 10 years and additionally investigates associated large scale international studies. Our investigation identified several single-nucleotide polymorphisms, inhalant allergens, pollution, tobacco smoke, chemicals, and family affluence as risk factors for allergic rhinitis. In contrast, breastfeeding, older sibling, and microbial diversity were protective factors against allergic rhinitis. This suggests that various genetic and environmental factors might affect the manifestation and presentation of allergic rhinitis complexly. These findings are beneficial as they can provide insights into modifiable risk factors that may hinder the development of allergic rhinitis. (Allergy Asthma Respir Dis 2022;10:73-79)
KAAACI Guidelines for Allergen Immunotherapy
Lee Hwa Young,이상민,강성윤,Kim Kyunghoon,Kim Ju Hee,Ryu Gwanghui,Min Jin-Young,Park Kyung Hee,Park So-Young,Sung Myongsoon,Lee Youngsoo,Yang Eun Ae,Jee Hye Mi,Ha Eun Kyo,Shin Yoo Seob,Chung Eun Hee,Choi Su 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6
Allergen immunotherapy (AIT) is a causative treatment for various allergic diseases such as allergic rhinitis, allergic asthma, and bee venom allergy that induces tolerance to offending allergens. The need for uniform practice guidelines in AIT is continuously growing because of the increasing discovery of potential candidates for AIT and evolving interest in new therapeutic approaches. This guideline is an updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT published in 2010. This updated guideline proposes an expert opinion by allergy, pediatrics, and otorhinolaryngology specialists with an extensive literature review. The guideline deals with basic knowledge and methodological aspects of AIT, including mechanisms, clinical efficacy, patient selection, allergens extract selection, schedule and doses, management of adverse reactions, efficacy measurements, and special consideration in pediatrics. The guidelines for sublingual immunotherapy will be covered in detail in a separate article.
The KAAACI Guidelines for Sublingual Immunotherapy
Min Jin-Young,Jee Hye Mi,Lee Hwa Young,강성윤,Kim Kyunghoon,Kim Ju Hee,Park Kyung Hee,Park So-Young,Sung Myongsoon,Lee Youngsoo,Yang Eun-Ae,Ryu Gwanghui,Ha Eun Kyo,이상민,Lee Yong Won,Chung Eun Hee,Choi Sun 대한천식알레르기학회 2024 Allergy, Asthma & Immunology Research Vol.16 No.1
Allergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of SLIT is increasing among patients with allergies. After 30 years of SLIT use, numerous pieces of evidence supporting its efficacy, safety, and mechanism allows SLIT to be considered as an alternative option to subcutaneous immunotherapy. Based on the progressive development of SLIT, the current guideline from the Korean Academy of Asthma, Allergy, and Clinical Immunology aims to provide an expert opinion by allergy, pediatrics, and otorhinolaryngology specialists with an extensive literature review. This guideline addresses the use of SLIT, including 1) mechanisms of action, 2) appropriate patient selection for SLIT, 3) the currently available SLIT products in Korea, and 4) updated information on its efficacy and safety. This guideline will facilitate a better understanding of practical considerations for SLIT.