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이은미,박종희,경기열,전일순,조혜정,지웅길 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-
The aim of this study was to improve the moisturizing and water retaining effects of a gel containing poloxamer 407, glycerin, sod hyaluronate, sorbo(sorbitol 70%). Topical preparations were formulated as a gel containing different concentration poloxamer 407, glycerin, sod. hyaluronate, sorbo(sorbito1 70%), lipid(ceramide. sphingosine ratio 1:l). We tested a various combination of different additives for the moisturizing effect The water holding capacity of the mixture was measured using a moisture analyzer. In vivo test was carried out on human skin using Skicon-200 and water retaining effect was increased by addition of lipid. Water evaporation test was performed by various concentration of additives and water evaporation characteristics of the preparations were determined using the moisture analyzer. Moisturizing and water retaining effects was increased by adequate combination of various additives with topical gel formulations.
김철재,이지해,이은혜,문혜진,주나미 숙명여자대학교 건강·생활과학연구소 2006 生活科學硏究誌 Vol.- No.22
In order to develop the functional muffin prepared with different levels of sprouted brown rice flour (SBRF), the mixing conditions of SBRF, butter and water were optimized by response surface methodology(RSM), using central composite design with 3 variables and 5 levels. The result of three-dimensional plot was showed that decrease of SBRF content increased the volume, maximum length, crumb grain, moistness and overall quality of muffin. The overall quality of the functional muffin was maximized under the preparing condition of 31.49 g SBRF(15% of flour used), 85.36 g butter, and 123.86 g water. Moreover, the optimum conditions for preparing muffin were as follow : 29.95 g, 81,24 g, 120.45 g for volume ; 23.67 g, 88.18 g, 118.24 g for maximum length ; 38.44 g, 63.38 g, 117.26 g for flavor ; 29.86 g, 93.04 g, 126.42 g for taste ; and 55.43 g, 94.40 g, 133.61 g for moistness. The range of optimum preparing conditions for the functional muffin in consideration of the physical and sensory characteristics were shown to the 30~40 g as SBRF, 80~90 g as butter, and 120~130 g as water.
A case of Churg-Strauss syndrome presenting as a acneiform eruption at trunk
( Mi Hye Lee ),( Woo Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Mi Woo Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Churs-Strauss syndrome (CSS) is a rare syndrome characterized by asthma, blood and tissue eosinophilia, and in its full-blown form, eosinophilic systemic vasculitis, along with necrotizing granulomas centered around necrotic eosinophils. A 42-year-old man with CSS who had been treated with steroid for several years presented with 1-month history of multiple asymptomatic erythematous papules on his chest and both hands. Physical examination showed acneiform eruptions on his upper chest and whitish papules on his thumb. Although their clinical finding appears to be acne vulgaris or steroid induced folliculitis, histologic findings for both sites show palisaded granulomatous dermatitis with collagen degeneration and neutrophilic infiltration, consistent with Churg-strauss syndrome. Although not included in the diagnostic criteria, cutaneous manifestations are frequently observed in CSS. As the skin is the most easily accesible site for histologic examinations, greater awareness of the cutaneous features would help in earlier diagnosis.
Development of Squamous cell carcinoma superimposed on nevus sebaceus in a 10-year-old girl
( Mi Hye Lee ),( Woo Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Mi Woo Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Nevus sebaceous (NS) is a congenital hamartoma of primary epithelial germ cells. It is known that various types of cutaneous neoplasm are associated with NS such as trichobastoma, syringocystadenoma papilliferum, or basal cell carcinoma. We here report a case of facial squamous cell carcinoma (SCC), keratoacanthoma (KA) type, arising in a young child. A 10-year-old Korean girl presented a rapidly growing verrucous papule on her right cheek. Localized erythematous lesions had been present on her cheek since birth. Although the patient was prepubertal girl and the lesion appeared to be a warty benign lesions, Histopathologic examination revealed proliferation of atypical keratinocyte. A diagnosis of SCC, KA type developing in a lesion of nevus sebaceous was made. In literature, malignant transformation is reported to be rare in nevus sebaceous (less than 1%) and usually occurs in adulthood. Although the Incidence of KA type of SCC on NS is low, It tends to occur in younger patients and on the face, rather than scalp. Therefore, considering its potential of malignant transformation and cosmetic problems, more early prophylactic excision of facial NS should be discussed.
( Hye Sook Min ),( Jung Eun Kim ),( Mi Hwa Lee ),( Hye Kyoung Song ),( Mi Jin Lee ),( Ji Eun Lee ),( Hyun Wook Kim ),( Jin Joo Cha ),( Young Youl Hyun ),( Jee Young Han ),( Dae Ryong Cha ),( Young Sun 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.1
Background: Obesity-related metabolic disorders are closely associated with inflammation induced by innate immunity. Toll-like receptors (TLRs) play a pivotal role in the innate immune system by activating proinflammatory signaling pathways. GIT27 (4,5-dihydro-3-phenyl-5-isoxasole acetic acid) is an active immunomodulatory agent that primarily targets macrophages and inhibits secretion of tumor necrosis factor α [as well as interleukin (IL)-1β, IL-10, and interferon γ]. However, the effect of TLR antagonist on kidney diseases has rarely been reported. We investigated whether the TLR antagonist GIT27 has beneficial effects on the progression of kidney disease in obese mice on a high-fat diet (HFD). Methods: Six-week-old male C57BL/6 mice were divided into three groups: mice fed with normal chow diet (N=4); mice fed with a HFD (60% of total calories from fat, 5.5% from soybean oil, and 54.5% from lard, N=4); and GIT27-treated mice fed with a HFD (N=7). Results: Glucose intolerance, oxidative stress, and lipid abnormalities in HFD mice were improved by GIT27 treatment. In addition, GIT27 treatment decreased the urinary excretion of albumin and protein in obesity-related kidney disease, urinary oxidative stress markers, and inflammatory cytokine levels. This treatment inhibited the expression of proinflammatory cytokines in the kidneys and adipose tissue, and improved extracellular matrix expansion and tubulointerstitial fibrosis in obesity-related kidney disease. Conclusion: TLR inhibition by administering GIT27 improved metabolic parameters. GIT27 ameliorates abnormalities of lipid metabolism and may have renoprotective effects on obesity-related kidney disease through its anti-inflammatory properties.
6 cases of multicolored tattoos treated with a Picosecond 755-nm Alexandrite Laser
( Mi Hye Lee ),( Tai Kyung Noh ),( Kwang Ho Choi ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Kee Chan Moon ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
The laser treatment and related energy devices targetingtattoo pigment particles has advanced much over the last few decades. To achieve selective photothermolysis fordestruction of the target and protection of surrounding normal tissues, sufficient energy to damage the target chromophore needs to be delivered with a pulse duration that is less than the thermal relaxation time of the target. A thermal relaxation time of tattoo ink particles is shorter than that of melanosome, around 10ns, suggesting that energy delivery in the picosecond range (10 -12 seconds) should be effective to selective photothermolysis. We here report 6 cases of patients with tattoos, including 5 patients of blue to black colored tattoos (2 females and 3 males, age of 23-45 years) on their upper extremities and trunk and 1 patient with black and red colored tattoo on her upper arm (56-year-old woman). They received 1 to 6 treatments with a 755-nm, 750 picosecond laser with a spot size of 2 to 3 mm, 1 to 2 passes and fluence of 2.68 to 5.25 J/cm2. All patients reported tattoo clearance of greater than 75% with no side effect. To our knowledge, this is the first case of successful treatment for red-colored tattoo using picosecond, 755-nm alexandrite laser(Picosure). Our study suggest this novel, picosecond 755-nm alexandrite laser is effective and safe for multicolored tattoos in Korean patients.
( Mi Hye Lee ),( Young Jae Kim ),( Woo Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Epithelioid sarcoma, a slowly growing soft-tissue tumor often misunderstood as a benign neoplasm. But it usually progresses with aggressive course with high rate of local recurrence and metastasis. Histologically defined proximal-type epithelioid sarcoma is generally found in the pelvic and perineal regions and genital tracts of young to middle-aged adults. A 33-year-old man presented with a 2-year history of a palpable painful mass on his scrotum and was diagnosed as proximal-type epithelioid sarcoma by skin biopsy and immunohistochemistry. Through oneyear follow up, Fusion Whole Body PET showed metastatic and local recurrent features. The results are clinically matched with multiple skin nodules. Herein we reported a rare case of proximal type epithelioid sarcoma presenting with multiple nodules on scrotum and lower abdomen, and emphasize again the importance of early differential diagnostic approaches to proximal type epithelioid sarcoma as a dermatologist.