비글개에서 신원방우황청심원의 급성 및 아급성독성시험

성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

The Maintenance of Organizational Healthiness through Regular Organizational Culture Diagnosis

Ju, Hyo-Jin(주효진),Jang, Bong-Jin(장봉진),Myung, Sung-Jun(명성준),Ju, Dong-Beom(주동범) 한국정부학회 2017 한국행정논집 Vol.29 No.4

본 연구에서는 산림청을 대상으로 2006년부터 2012년까지 2년을 주기로 정기적으로 조직문화에 어떠한 변화가 일어났는지를 조직문화진단을 통해 실증적으로 분석하였다. 진단을 통해 조직의 건강성을 지속적으로 유지하면서 조직발전이 이루어지기 위해 필요한 전략들을 조직문화에 대한 변화관리전략을 중심으로 모색하였다. 분석결과를 살펴보면 1차 진단에서는 현재 수준의 조직문화 유형에서 시장지향문화가 가장 강한 것으로 나타났고, 상대적으로 혁신지향문화가 가장 약한 문화유형으로 인식하고 있는 것으로 나타났다. 그리고 2차 진단, 3차 진단, 4차 진단 모두 시장지향문화가 가장 강한 것으로 나타났고, 혁신지향문화가 가장 약한 문화유형으로 인식하고 있는 것으로 나타났다. 직급별로 살펴보면 상위직 직원들의 조직문화에 대한 진단을 비교분석해 보면, 상위직의 경우 노무현 정부의 현재수준에서는 관계지향문화를 이명박 정부 때에는 시장지향문화를 가장 강한 조직문화유형으로 인식하고 있었고, 2010년의 3차 진단을 제외하고는 혁신지향문화를 가장 약한 조직문화유형으로 인식하고 있는 것으로 분석되었다. 또한 미래의 바람직한 조직문화유형에 대해서는 관계지향문화가 현재수준과 같이 가장 강한 조직문화유형이 되기를 희망하고 있었고, 가장 약한 조직문화유형은 위계지향문화가 되기를 원하고 있는 것으로 분석되었다. 직의 경우 현재수준에서는 시장지향문화를 가장 강한 조직문화유형으로 인식하고 있었고, 혁신지향문화를 가장 약한 조직문화유형으로 인식하고 있는 것으로 분석되었다. 또한 미래의 바람직한 조직문화유형에 대해서는 관계지향문화가 가장 강한 조직문화유형이 되기를 희망하고 있었고, 가장 약한 조직문화유형은 시장지향문화가 되기를 원하고 있는 것으로 분석되었다. 조직문화에 대한 진단과 분석을 통해 나타난 결과를 바탕으로 하여 조직문화 관리방안을 제시해 보면 다음과 같다. 첫째, 일관성 있는 조직문화의 강도는 조직에 안정감을 가져다준다는 측면과 문화적 동일성으로 인해 정책 및 사업전반에 대한 명확한 의사전달과 의사결정에서의 합의 또는 공감대 형성이 용이하다는 장점이 산림청에서는 아주 긍정적으로 작용하고 있다는 것을 시사해 주고 있다. 둘째, 바람직한 미래문화와 현재문화 사이에 존재하는 차이(gap)의 강도에 대해 확인할 수 있었으며, 이에 대한 처방이 필요하다는 것을 알 수 있다. 셋째, 조직문화를 통해 조직이 발전하고자 하는 방향에 대해서 직원들 모두의 공감대를 형성하는 작업들도 병행될 필요가 있다는 것을 조직의 기관장이 인식하는 것이 필요하다. 마지막으로 조직의 지속적인 발전과정을 확인하기 위해서는 현재시점에서의 조직문화에 대한 연구보다는 여러 해에 걸친 시계열적 관점에서의 조직문화에 대한 연구가 더욱 활성화될 필요가 있다. This study conducts organizational diagnosis and analyzes changes in organizational culture of the head office of Korea Forest Service in the span of 2-year, from 2006 to 2012. Through the diagnosis this study looks for strategies for maintaining the organizational healthiness of KFS, which are centered on managing organizational culture sustainably. Comparative analysis of the first, second, third, and fourth diagnosis results on organizational culture of the public officials of KFS shows that market culture was strongest at the current level of the first diagnosis. On the other hand, adhocracy culture was the least perceived type. In the second, third, and fourth diagnoses, market culture is the strongest and adhocracy culture was the least perceived culture. high-ranked officials perceived clan culture as the strongest culture at the current level during the Roh Moo-Hyun Government and market culture during the Lee Myung-Bak Government. Except the third diagnosis in 2010, they perceived adhocracy culture as the weakest. Comparative analysis on lower position officials’ diagnosis on organizational culture shows that they perceived market culture as the strongest culture at the current level and adhocracy culture was weakest culture. As for future desirable culture, they hoped for clan culture to be the strongest culture and market culture to be the weakest culture. The measures to manage organizational culture based on the results of regular diagnosis and analysis on organizational culture with two years in cycle from 2006 to 2012 targeting the public officials of KFS are presented as follows: First, The consistent organizational cultural strength has an aspect bringing stability to the organization and merits that clear communication on policy and overall business becomes easier, and agreement or sympathy formation in decision making becomes easier, due to cultural homogeneity. Those merits are implied to work positively in KFS. Second, strength of gap between desirable future culture and current culture could be confirmed, and thus it was understood that measures to cope with such a phenomenon are needed. Third, organization’s head to recognize the need for simultaneously shaping sympathy of all the public officials regarding a direction for organizations to develop through organizational culture. Lastly, this study employs time-series analysis to study the change of organizational culture and confirms the continuous effort for organizational development.

간호대학생의 임상실습에 대한 인식유형 : Q방법론적 접근

김명애,김효은,남승희 성인간호학회 2001 성인간호학회지 Vol.13 No.2

The purpose of this study is to explore perception types and to understand the nature education by using the Q methodology A Q sample was developed through a review of the literature and descriptions about nursing students' experience in clinical practice. Thirty-six statements made up the finalized Q sample. The P sample consisted of 33 third grade nursing students in K university. Q statements were written on separate cards and were given to the 33 subjects to sort according to degree of agreement or disagreement. The Q-sorts by each subject were coded and analysed with the Quanl PC program. A a result, three major perception types, namely, 'alienation of ideal and reality'<type 1>, 'active participation'<type 2>, and 'perception of identifying the nature of the three types. this limitation of ability'<type 3> were identified. By identifying the nature of the three types, this study suggests efficient strategies for developing clinical educational programs according to the perception types of nursing students Clinical education would thereby be more valuable.

석탄회 펠렛의 미연탄소 연소 현상 분석

崔尙丁,李孝眞,吳明淑 弘益大學校 科學技術硏究所 2001 科學技術硏究論文集 Vol.12 No.-

As the number of coal fired power plants in the domestic power industry continues to increases, the amount of fly ash produced is also increasing, making the reutilization of fly ash a vital issue. Various methods to reutilize the fly ash from coal power plants have been investigated, and one of such areas with the potential to grow is the usage as light weight sintered construction materials. Sintered fly ash aggregates are produced in two steps; the first is the pellet formation step, during which the fly ash particles containing unburnt carbons were made into a pellet using caking components, and the second the pellet sintering by the combustion heat of the carbons. During the sintering process, the combustion rate of the carbon affects the characteristics of sintered pellets. The combustion of carbon occurs via adsorption of O₂ on the active sites, and desorption of CO/CO₂. The parameters which affect the rate of adsorption, desorption, and transfer of O₂ and CO/CO₂ include the O₂ partial pressure and flow rate, the pellet size, the porosity, the pore tortuosity, the pore size distribution, the carbon content and distribution. This study investigated the combustion of carbon during the production of sintered fly ash through modeling. A simple combustion model using Langmuir isotherm is used to calculate the pellet temperature. The oxygen diffusion through the pores is ignored. At the temperatures of sintering, the desoption process is a rate limiting process, making the overall rate sensitive to the desoption kinetic parameters. In addition, it was found that the carbon content and the heat capacity of the pellet affected both the rate of the reaction and the final pellet temperature, while the area of active sites only affect the reaction rate. The future work will include the combustion modeling with external and internal diffusion of O₂, and the model confirmation through experimentation.

돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학

윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.

부산 경남지방에 발생한 쭈쭈가무시병 64예의 임상적 고찰

이상훈,전명호,신병철,박기찬,김영효,배성,전광수,김종성 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

골수염에 대한 Fucidin의 임상경험

문명상,이인주,정구효 최신의학사 1985 最新醫學 Vol.28 No.12

비글개에서 신우황청심원의 급성 및 아급성독성시험

권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.

비글개에서 l-muscone의 급성독성 및 아급성독성시험 연구

유아선,권오경,성하정,곽형일,방명주,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of l-muscone, a major active ingredient of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dosage of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of l-muscone, 0.2㎎/㎏/day(low dosage group), 2 ㎎/㎏/day(middle dosage group), or 20 ㎎/㎏day(high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korean Food and Drug Administration(1996.4.16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ on oral route for both male and females. In animals administered with l-muscone, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, eye examination, hematology, serum chemistry, organ weight and other findings. No histolopathological lesions were observed in both control and treatment groups. Above data strongly suggest that l-muscone in beagle dogs is considered to be safe.