저용량 Droperodol 의 지속적 정맥내 주사가 방사선 치료로 유발된 구토에 대한 효과 : As a Substitution for Granisetron for the Treatment of Gastrointestinal Symptoms from Palliative Radiation Therapy

문성록,박수경,정영표,김태요,최유선 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Background: Radiation therapy in palliative cancer management leads mainly to nausea, vomiting, dyspepsia and anorexia. Several agents have been used to treat above symptoms and sings. We assessed the usefulness of continuous intravenous infusion of low-dose droperidol, compared to granisetron for the control of gastrointestinal symptoms due to radiation therapy. Method: We devided 30 patients who developed gastrointestinal symptoms after undergoing palliative radiation therapy due to metastatic bone pain in two groups. In group G(n=15), the patients were injected granisetron(3㎎) and then injected it, 3㎎ per day. In group D(n=15), the patients were injected low-dose droperidol(0.25㎎) and then infused continuously at low-dose(1㎎/day) by the disposable continuous infusion pump. Result: There were no significant differences in the patient's satisfaction, improvement of appetite and incidences of side effects between two groups. Conclusion: The continuous intravenous infusion of low-dose droperidol can substitute for serotonin-receptor antagonist for the treatment of gastrointestinal symptoms during radiation therapy for cancer patients.

심신의학(心身醫學)

이명수,장혜숙,류훈,문성록 한국정신과학학회 2002 韓國精神科學學會誌 Vol.6 No.2

The oriental idea that health begins in mind is currently being applied in the clinical field by mind-body medicine. In the past decade. we have seen an increase 10 the popularity of mind-body medicine as an alternative or complement to traditional health care interventions. This paper explores the scientific idea of mind-body medicine and how particular mind-body intervention focusing on stress reduction and relaxation can be useful methods to Improving health state. On the basis of the psycho- neuroendocrine-immune triangular circuit, the mind-body pathway has been Investigated. Among many mind-body intervention, Qi-training and Qi-therapy are described, research on their effectiveness is reviewed, conclusions are drawn, and the applicability to clinical practice is discussed. Given existing empirical support for the effectiveness of these interventions, the authors provide Korean scientists With an overview of the psychoneuroimmunological effects of Qi-training and Qi-training, and possibility of their medical benefits.

기(氣) 시술(施術)이 노인의 심리상태와 통증에 미치는 효과

장혜숙,이명수,장정원,문성록 한국정신과학학회 2002 韓國精神科學學會誌 Vol.6 No.2

Recently, we reported that Qi-therapy (QT) may be beneficial in reducing negative psychological symptoms, increasing melatonin levels, neutrophil and NK cell cytotoxicity in young subjects. however there is little scientific evidence of their efficacy on the elder subjects, Therefore, this study was designed to investigate the effects of QT on anxiety, depression, fatigue, pam and blood pressure In the elder subjects Ninety-four elderly subjects were randomly assigned to either QT (n=47) or mimic therapy (n=47) groups, Both groups received a ten minute intervention period using the same procedures. With respect to pre-QT, the QT group exhibited a greater reduction in anxiety, depression, fatigue, and pain level compared to the placebo group, From these results, It is suggested that the practical application of QT may exert a positive psychological and physiological effect m spite of the lack of a long-term intervention period However, further research is necessary In order to fully understand the long-term Impact of QI-therapy on psychological health Recently, we reported that Qi-therapy (QT) may be beneficial in reducing negative psychological symptoms, increasing melatonin levels, neutrophil and NK cell cytotoxicity in young subjects. however there is little scientific evidence of their effIcacy on the elder subjects, Therefore, this study was designed to investigate the effects of QT on anxiety, depression, fatigue, pam and blood pressure In the elder subjects Ninety-four elderly subjects were randomly assigned to either QT (n=47) or mimic therapy (n=47) groups, Both groups received a ten minute intervention period using the same procedures. With respect to pre-QT, the QT group exhibited a greater reduction in anxiety, depression, fatigue, and pam level compared to the placebo group, From these results, It is suggested that the practical application of QT may exert a positive psychological and physiological effect m spite of the lack of a long-term intervention period However, further research is necessary In order to fully understand the long-term Impact of QI-therapy on psychological health

특수기능성섬유가 성장기 운동선수의 수면 중 성장호르몬 분비에 미치는 영향

이명수,이진희,고경찬,문성록 한국의류산업학회 2003 한국의류산업학회지 Vol.5 No.1

The purpose of this study was to investigate the effect of multi-functional fabric on EEG and growth hormone (GH) during sleep and quality of sleep with the 9 young female athletes. The subjects participated in separated experimental procedure; sleeping in multi-functional fabric wear (experimental group) and cotton wear (control group) for 450min. During the night (22:00-05:30), we recorded the changes of nocturnal polysomnographic sleep recording and GH were measured every 60min. The results show that there are significant differences in percentage of stage 1, 2 and slow wave sleep (SWS) between two groups(S1, p<.05;S2, SWS, p<.01). The SWS percentage of experimental group is 1.89 times higher than control group. The changes of GH secretion varied depending on two experimental procedures. The peak of GH secretion in experimental group is more than controls by 2.4time (p<.001). The quality of sleep in experimetal group is significantly higher than control (p<.01). These results suggest muti-functional fabric wear is effective in inducing the deep sleep and increasing GH and quality of sleep.

기(氣)수련이 노인과 청년의 호중구 기능에 미치는 영향

박미숙,이명수,문성록,김용규 圓光大學校 附設 體力科學硏究所 2003 體力科學硏究 Vol.26 No.1

The main objective of this study is to examine the effect of Qi-training on the immune system, especially neutrophil bactericidal function. Nine healthy young male subjects and 9 elderly were studied for the effects of one bout of Qi-training on superoxide (O_(2)) production and adhesion capacity of neutrophils at times immediately after (Post Ⅰ) and 2hours after the Qi-training (Post Ⅱ). The Qi-training enhanced the O_(2) production, reaction velocity and neutrophil adhesion capacity and there were significant differences at Post Ⅰ compared to before Qi-training (Pre) in both group. Therefore, Qi-training increase the resistance of trained individuals against common infection and inflammation.

특수기능성섬유가 심박변화도와 심리변수에 미치는 효과

이명수,김혜경,김혜정,박기원,문성록 한국의류산업학회 2003 한국의류산업학회지 Vol.5 No.3

The study investigated the effect of multi-functional fabric on the autonomic nervous function and psychological variables of 20 students. The experimental group exhibited lower values in anxiety, depression, fatigue and stress level and higher emotional level. This study reveals that multi-functional fabrics reduced the low frequency/high frequency power ratio of heart rate variability. These results support the multi-functional fabrics increases cardiac parasympathetic tone. In addition, experimental group were found to have lower heart rate compared with controls. This augmented heart rate in experiment provides support for stablizing autonomic nervous system. In conclusion, multi-functional fabrics may stabilize the autonomic nervous system and psychological symptoms.

기(氣)수련이 스트레스 반응에 미치는 영향

박미숙,이명수,정영자,김혜정,문성록,김용규 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.3

본 연구는 스트레스 반응을 측정하는 스트레스 반응 척도 설문지(Symptoms of Stress: SOS)를 이용한 횡단적 연구로서 심신수련의 하나인 기수련이 스트레스 반응에 미치는 효과를 살펴보았다. 72명의 건강한 정상인과 180명의 기수련자를 대상으로 하여 조사하였으며, 기수련자들은 수련기간에 따라 초급군(1-4개월; 64명), 중급군(5-12개월; 50명), 고급군(1년 이상; 66명)로 나누었다. 실험결과 1년 이상 수련한 기수련자들이 말초혈관 증상군, 심폐 증상군, 중추신경계 증상군, 위장계증상군, 습관적 행동 형태군, 우울 증상군, 불안증상군등의 스트레스 반응 하위척도에서 대조군에 비해 통계적으로 유의하게 감소하였다. 전체 스트레스 값은 대조군에 비해 기수련자 집단이 아주 낮았으며 수련기간이 길수록 감소하였다. 이러한 결과는 기수련이 스트레스 중재와 스트레스 증상을 줄이는데 효과가 있음을 나타낸다. We examined the effects of Qi-training, one of Korean traditional psychosomatic training, on stress coping ability by cross-sectional investigation with inventory of symptoms of stress (SOS). Four types of groups- normal healthy (n-74), three groups of Qi-trainees (group primary level: subjects with Qi-training for 1-4months, n=64; middle level: 5-12 months, n=50; high level: more than 12 months, n=66) participated in this study, Qi-trainees with over 1 year training had significantly lower scores in all SOS subscales compared to controls. Total stress scores of Qi-trainee groups were substantially lower than controls and further reduction with larger training periods. These results suggest Qi-training is effective in stress management and decreasing symptoms of stress

Irradiation of the Intrathoracic Esophagus : prone versus supine treatment positions

Moon, Sun Rock,Kim, Hye Jung,Won, Jong Jin 圓光大學校 韓醫學硏究所 1992 圓光醫科學 Vol.8 No.1-2

식도암의 방사선치료시 원발병소에 60 Gy이상의 방사선량을 조사하면서 근접한 척수의 조사선량을 46 Gy 이하로 제한하는 것은 식도와 척수의 해부학적 근접성때문에 많은 문제점을 가지고 있다. 치료계획시 환자가 복와위를 취하게하면 식도는 척수로부터 다소 멀어져 치료계획시 잇점이 있는 것으로 알려져 있다. 저자들은 총 10명의 환자들을 대상으로 앙와위와 복와위로 동시에 방사선치료계획을 시행하여 두방법의 장단점을 비교하였다. 각각의 자세에서 조영제를 삼키면서 전후방 및 측방으로 단순촬영을 시행하여 조영제가 차있는 식도의 내강 중심으로부터 척수까지의 거리를 기관분기점(Carina) 및 6 ㎝ 상방, 6 ㎝ 하방과 12 ㎝ 하방의 횡단면에서 계측하였다. 각각의 위치에서의 평균식도전위는 1.6(+0.9) ㎝, 1.3(+0.8) ㎝, 1.7(+1.0) ㎝ 및 1.9(+1.1) ㎝이었고 계측된 총 40위치에서의 전위범위는 0에서 4.3 ㎝ 이었으며 평균전위는 1.6 ㎝ 이었다. 복와위에 의한 치료시 병소부위와 장상주변장기의 선량분포를 비교하기 위해 전예에서 복와위와 앙와위의 삼차원적 산량분포를 6문조사법과 8문조사법을 이용하여 예측하였으며 선량분포의 예측은 전산화 치료계획장치를 이용하였다. 6문조사법이나 8문조사법 모두에서 북와위시 앙와위에 비해 동일한 종양조사선량을 유지하면서 주변장기인 척수의 조사선량을 효과적으로 감소시킬 수 있었다. The treatment of esophageal cancer is made difficult by the close proximity of the esophagus to the spinal cord and the requirement to treat the esophageal target volume to doses greater than or equal to 60 Gy while limiting the spinal cord dose to less than or equal to 46 Gy. By placing the patient in the prone position, the esophagus can be displaced away from the spinal cord. We explored the results of this commonly used technique on 10 patients who have undergone simulation in both supine and prone positions. Both AP and lateral orthogonal radiographs were obtained in both positions. The distance between contrast material in the esophagus and spinal cord was noted in at least four transverse planes through the thoracic esophagus on each of the 10 patients. The four transverse planes were located at 3 cm above the carina, at the carina, 3 cm below the carina and 6 cm below the carina. The mean displacement (±1 SD) of the esophagus away from the spinal cord when the patient was in the prone position compared to supine at each of these levels was 1.3 (±0.8)㎝, 1.6 (±0.9) ㎝, 1.7 (±1.0) ㎝, and 1.9 (±1.1) ㎝. The range of displacement for all 40 displacement determinations was 0 to 4.3 ㎝ with a mean of 1.6 ㎝. To evaluate further the consequences of prone positioning on treatment planning and doses received to target volumes and critical structures, we performed 3-dimensional treatment planning with a patient in both prone and supine position. The requirements were to achieve a tumor volume dose of 60 Gy while keeping the spinal cord dose below 46 Gy. Two types of conventional treatment plans were examined in prone and supine positions. A 6-field plan consisted of delivery of 40 Gy through a large 3-field beam arrangement followed by delivery of 20 Gy through a similar 3-field cone down. An 8-field plan involved the delivery of 30 Gy through AP/PA beams followed by a 3-field beam arrangement to 40 Gy and a subsequent 3-field cone-down for the final 20 Gy. Regarding the primary consideration of coverage of target volume with avoidance of spinal cord, prone positioning was superior to supine positioning whether 6- or 8-field arrangements were used.

Postoperative Radiotherapy for Squamous Cell Carcinomas of the Oral Cavity

Moon, Sun Rock,Garden, Adam S,Ang, K. Kian 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Purpose: The purpose of this study was to determine the impact of anatomic subsite on the results of treatment with oral cavity cancers. Methods: Between 1970 and 1994, 284 patients with squamous cell carcinoma of the oral tongue (162 patients) and floor of mouth (122 patients) were treated with surgery followed by postoperative radiotherapy. All had an indication(s) for radiotherapy including advanced primary disease, close or positive margin, and multiple positive neck nodes and/or extracapsular extension. Results: The 5-year actuarial local control rate was 77.1% for oral tongue vs. 67.5% for floor of mouth(p = 0.03). The 5-year actuarial neck control rate was 76.0% for oral tongue vs. 82.3% for floor of mouth(p = 0.06). The 5-year actuarial disease-free survival rate was 54% for oral tongue vs. 48% for floor of mouth(p = 0.34). The 5-year actuarial overall survival was 40.9% for oral tongue vs. 33.6% for floor of mouth(p = 0.3). Conclusions: This study showed significant differences in local control between floor of mouth and oral tongue cancers in response to surgery and postoperative radiotherapy. Future strategies should be directed at the improvement of local control for floor of mouth and better systemic therapy for those with advanced N-stage.

마이크로 채널 내 액체 시료의 실시간 열분석 기법 개발

최선락(Sun Rock Choi),홍종간(Jonggan Hong),김동식(Dongsik Kim) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

This work introduces a novel method for real-time measurement of the thermal conductivity and heat capacity of nanoliter-scale liquid samples. The device uses a micromachined thermal sensor composed of a microchannel and a thin-film probe. The method, based on the 3w technique, employs a multiparameter-fitting scheme to determine the thermal properties with numerical computation of heat transfer. The results demonstrate that the sensor can measure the thermal conductivity and heat capacity of 12 nl samples simultaneously. Furthermore, real-time thermal characterization of fluid samples flowing in a microchannel has been demonstrated, manifesting strong potential of the proposed technique as an in-situ probe in various microfluidic applications.