성인 환자에서 구치부 압하를 통한 개방교합의 치료와 유지

문철현,이주신,이현선,최진휴 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.6

성장이 종료된 치성 또는 골격성 개방교합 환자를 치료하는 것은 매우 어려운 일이다. 전치부 개방교합 환자는 증가된 전안면고경, 상악 구치부의 과도한 수직성장, 큰 하악각 등의 특징을 지닌다. 이러한 증례에서 구치의 압하를 통한 개방교합의 해소는 좋은 치료전략이다. 본 연구는 교정용 미니임플란트를 이용하여 개방교합을 치료하고 성공적인 유지를 얻은 두 명의 환자에 대한 보고이다. 적절한 진단이 시행되고 교정용 미니임플란트 등의 장치를 이용한 치료기법을 적용하면 수술치료 없이 교정치료만으로 개방교합의 치료가 가능하며, 하악구치부에 posterior bite block을 추가한 가철식 유지장치 및 SFR이 개교환자를 위한 유지장치 또는 보조유지장치로 유용하게 사용될 수 있다는 결론을 얻었다. Successful treatment of the non-growing patient with an open bite of either dental skeletal pattern often presents a difficult challenge. The morphologic pattern in anterior open bite is characterized by longer vertical dimensions, an increase in development of the maxillary posterior dento-alveolar structure and a steep mandibular plane. In such cases, molar intrusion would be a good remedy for treatment. This article reports the successful treatment and retention of two anterior open-bite cases. We used orthodontic mini-implants for treatment and a circumferential retainer with posterior bite block or skeletal fixed retainer for retention. The diagnostic criteria and mechanics for appropriate treatment are discussed. Our results suggest that open bite can be reduced successfully with intrusion of molars using orthodontic mini-implants (OMI) without orthognathic surgery, and that circumferential retainer with posterior bite block and skeletal fixed retainer are effective for retention.

Eethyl benezylidencyanoacetate 유도체에 대한 thiophenol 첨가 반응의 속도론적 연구

맹주양,黃善岩,金文執,崔元植,朴茂淳 順天鄕大學 1991 순천향대학논문집 Vol.14 No.1

Bisthmus 제재와 항생제의 복합 투여가 Helicobactor pylori 박멸과 재발에 미치는 영향

김선주,황성규,박상흠,이문호 순천향대학교 1994 논문집 Vol.17 No.4

위점막내에 존재하는 Helicobacter pylori는 소화성 궤양의 발생과 재발에 중요한 인자로 인식되고 있으며, bisthmus, metronidazole, amoxicillin을 포함하는 3제 병합요법을 시행하면 H. pylori균의 박멸에 유효하고 소화성 궤양 재발 빈도를 낮출 수 있다고 한다. 그러나 3제 병합요법은 부작용 발생율이 높아 치료 실패의 주원인이 되고 있다. 이에 저자등은 H. pylori 양성인 소화성 궤양환자에서 H₂ 길항제 투여와 함께 3제 병합요법을 시행하였고, 또한 비교적 약제 부작용이 많은 metronidazole을 제외한 이제 병합 요법을 시행하여 H₂ 길항제 단독 투여한 대조군과 6개월간 추적하여 균의 박멸및 재발 여부를 비교 관찰하였다. 대조군은 Nizatidine을 8주간 투여하였으며 치료 1군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용), amoxicilline(500mg 하루 4회 복용) 투여하였다. 치료 2군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용)과 amoxicilline(500mg 하루 4회복용) metronidazole (250mg thrice a day)을 투여하였다. 치료 8주후 치료 1군은 53%에서, 치료 2군은 100%에서 균이 음전되었으나 대조군은 1예도 음전되지 않았다. 치료 2군의 13%에서 약물에 의한 부작용이 관찰되었다. 치료 6개월 추적 검사시 대조군은 모두 H. pylori 감염이 지속되었으며 치료 1군에서는 63%에서 재발하였으며, 치료 2군에서는 15%에서 재발하였다. 대조군에서는 소화성 궤양(위궤양 1명, 십이지장 궤양 4명)이 5명에서 재발하였으나 치료군에서는 재발이 없었다. H. pylori박멸된 환자에서의 항 H.pylori 항체(IgG)가는 치료 6개월에 치료전의 40%로 감소한 반면, 대조군의 항체가는 변화가 없었다. 이상의 결과로 H₂ 길항제(nizatidine)을 metronidazole 750mg/day, TDB 480mg/day, amoxicillin 2.0gm/day를 2주간 투여하면 약제에 의한 합병증이 비교적 적고, Helicobacter pylori 박멸과 재발 방지에 효과적이며 혈청 H. pylori 항체(IgG)의 추적 검사는 항 H. pylori 치료후 균박멸의 추적검사에 유용함을 알 수 있었다. It has recently been recognized that Helicobacter pylori is a important factor in the development and the recurrence of peptic ulcer diseases. Several studies has been shown that the eradication of Helicobacter pylori is associated with considerable reduction in the the rate of recurrence of peptic ulcer. Triple therapy including bisthmus, amoxicillin, metronidazole is known to be useful in the eradication of Helicobacter pylori, but relatively frequent side effects are a major problem. This study was performed to evaluate the clinical course and the efficacy of triple therapy with H₂ blocker and bisthmus plus amoxicillin therpy with H₂ blocker in the eradication and the recurrence of Helicobacter pylori at 8 weeks and 6 months of treatment. Forty five patients with peptic ulcer disease with a positive urease test of the gastric mucosa were enrolled and assigned to receive H₂ blocker (nizatidine 150mg twice a day) for 8 weeks(control group), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day for 2 weeks, nizatidine for 8 weeks (treatment group Ⅰ), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day, metronidazole 250mg thrice a day for 2 weeks, nizatidine for 8 weeks(treatment group Ⅱ). H. pylori was eradicated in 53% of treatment group Ⅰ, 100% of treatment group Ⅱ, none of control group after 8 weeks of treatment. Helicobacter pylori infection is recurred in 63% of of treatment group Ⅰ and 15% of treatment group Ⅱ. Side effects were recorded in 3 patients(2 patients on treatment group Ⅱ, 1 patient on treatment group Ⅰ), but it were minor side effects. No patients on treatment groups recurred peptic ulcer disease, while 5 patients on control group. Anti-H. pylori antibody IgG remained constant in bacteria positive control group, but in patients in whom H. pylori had been eradicated serum antibody titers fell significantly at 6 months of treatment. In conclusion, triple therapy including a low dose metronidazole with nizatidine is effective on the eradication of Helicobacter pylori infection and reduced the rate of side effects. Bisthmus and amoxicillin with nizatidine is not effective on the eradication and the recurrence of Helicobactor pylori infection. Serologic tests for H. pylori are reliable means of monitoring success of eradication of H. pylori.

전슬관절 동통환자의 등속성 근력 평가에 관한 연구

柳碩柱,李聖喆,朴泰永,柳文集,金明昊,鄭宣根 단국대학교 1995 論文集 Vol.29 No.-

We studied 25 cases of patients with anterior knee joint pain without any other knee problems with a isokinetic evaluation technique using Cybex. The results are 1. The peak torques for the knee extensor muscles were decreased statistically 2. The peak torques for the knee flexor muscles were decreased relatively also but not statistically 3. TAE(Torque Acceleration Energy) values for knee extensor & flexors were all decreased from disuse atrophy 4. The torque curve for extensors showed decreased power around 30 degrees of knee flexion

Interleukin-1β에 의한 사람 정상 코점막 상피세포의 분비기능 및 형태 변화

김경수,윤주헌,최진우,이정권,문형진,박준호,전희선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.11

혈액에서 분리된 세균의 항생제감수성 : Vitek System을 이용한 최소억제농도측정 Minimal Inhibitory Concentration Determined by Vitek System

김의종,김선주,신보문,박명희,조한익,김상인 대한화학요법학회 1988 대한화학요법학회지 Vol.6 No.1

Minimal inhibitory concentrations of total 148 strains isolated from blood culture at Seoul National University Hospital were determined by Vitek System. 90% MIC of gram-negative bacteria against amikacin was 2-16㎍/㎖, and those against beta-lactams was > 16㎍/㎖ in general, Except Salmonella spp,. 90% MIC against chloramphenicol and tetracycline was >8㎍/㎖. Range of 90% MIC against vancomycin was ≤.5-4㎍/㎖ in case of garm-positive bacteria, except Enterococcus spp. which showed 90% MIC as >16㎍/㎖. Against ampicillin, 90% MIC of Staphylococcus spp. was >16㎍/㎖, but those of Streptococcus spp. was ≤.25-2㎍/㎖. Streptococcus viridans group showed 90%MIC against penicillin as ≤.03㎍/㎖. Susceptibility of gram-negative bacteria was generally 98% against amikacin, and those of gram-positive bacteria was 80% against vancomycin. 34% of Staphylococcus spp. was resistant of oxacillin. These results may be useful for the primary selection and the dosage determination of antibiotics in the treatment of patients with bacteremia.

Columella 缺損例의 成形外科的 治療 : 1例報告

임풍,조문제,빈주원,함기선 大韓成形外科學會 1976 Archives of Plastic Surgery Vol.3 No.1

Columella defect is a noticable deformity which is seen following its loss secondary to injures, diseases, or surgical excisions. The reconstruction of the defect can be achieved by one of the following four methods as advocated by Converse in 1964, i.e. 1) the cervical tubes, 2) the forehead flaps, 3) the nasolabial flaps, and 4) the composite grafts. There is tendency for most surgeons to prefer the nasolabial flap method because of the lesser extend of resulting scar and deformities. Authors obtained a good result in correcting a columella defect from a chronic inflammatory disease in 27 years old woman. Vomerian and nasal tip flaps were employed to make a new columella and the resulting inner raw surface was covered with buccal mucous membrane of the upper lip. The pedicle of the mucosal flap was detached on 10th postoperative day.

Eethyl benezylidencyanoacetate 유도체에 대한 thiophenol 첨가 반응의 속도론적 연구

朴茂淳,金文執,崔元植,黃善岩,孟柱煬 순천향대학교 1991 논문집 Vol.14 No.1

Reaction of benzaldehyde derivatives with ethylacetate afforded ethylbenzylidenecyanoacetate. Especially, the crystal structure of ethyl p-methoxybenzylidenecyanoacetate were demonstrated by X-ray diffrection method. The crystal structure is only exist in E-form. The kinetic studies on the mechanism of nucleophilic addition of thiophenol to ethyl benzylidenecyanoacetate have been investigated by UV-spectrophotomery and the rate equation which can be applied over wide pH range was obtained. From the rate equation, effect of generalbase and substituent, the fellowing reaction proposed. Below pH 3.0, thiophenol added to the double bond, while above pH9.0 thiophenoxide ion added to the double bond. In the range of pH from 3.0 to 9.0, these reaction occurred competitively.

한국인 만성 긴장형두통 환자에서 바이오피드백을 활용한 자율적 이완훈련의 효과

강은호,안주연,구문선,박주언,유범희 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : We aimed to evaluate the efficacy of biofeedback-assisted autogenic training for chronic tension-type headache, and to determine the relationship among the changes in electromyography (EMG) activity, headache activity, and mood states according to the psychophysiological treatment. Methods : Chronic tension-type headache patients aged from 20 to 40 years (n=35) were randomized to the treatment group receiving biofeedback-assisted autogenic training (8 sessions) or the monitoring-only control group. EMG activities, headache index, and various psychological variables were examined. Results : We found greater treatment response rate (≥50% reduction in headache index) in patients with biofeedback-assisted autogenic training than in the monitoring group (61% vs. 18% ; χ²=6.882, df=1, p=0.01). There were no significant changes in the mean values of the pretreatment EMG activities across the sessions m either group (all p’s>0.1). Mood states including anxiety and depression improved over time in the both groups, with the improvements being more prominent in the treatment group. Moreover, the reduction in depression level predicted treatment outcome in terms of headache index (95% confidence interval : 0.272-0.966, p=0.039). Conclusion : These results show that biofeedback-assisted autogenic training is effective for the treatment of chronic tension-type headache in a Korean population. Changes in mood states may be closely associated with the clinical outcome in the treatment of chronic tension-type headache using biofeedback-assisted autogenic training.

만성 B형 간염환자에서 인터페론 치료 후 간 조직검사 소견의 변화와 Tumor Necrosis Factor의 임상적 의의

김홍수,윤동진,김은주,정일권,박상흠,이문호,김선주 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background: Interferon has been widely used in the treatment of chronic hepatitis B, but its effectiveness is debatable. The clinical indices as the loss of HBeAg, HBV DNA, and improvement of liver function are applicated to identify the effectiveness of interferon therapy, but the mechanism of hepatohistological change is not well known. We investigated the changes of histologic finding and plasma tumor necrosis factor(TNF) in the patients with chronic hepatitis B after treatment with interferon-alpha. Methods: 11 patients with chronic hepatitis B who had treated by interferon-alpha were enrolled for this study. Liver biopsy was done before and after treatment of interferon and plasma TNF was evaluated at the same time. A semiquantitative study using a histologic scoring system was applied on pre and post liver biopsy specimens and the changes of HBeAg and HBV DNA were also evaluated. Results: Among subjects, the response group, recurrence group, and non-response group based on serologic response with clearance of HbeAg were6, 3, and 2 patients, respectively. The changes of serum ALT level and HBV DNA titer on pre and post therapy decreased significantly in the response group. The change of mean plasma TNF level in the response group decreased insignificantly to 19.4 from 19.9. The histological improvements of grading and staging were shown 4 patients in the response group. Conclusions: Serologic response with clearance of HBeAg was associated with histolofical improvement. The loss of HBsAg in the serum was significant indicator of reduction in the amount of HBV core antigen and HBV surface antigen in the hepatocytes. Plasma TNF level was not associated with response of interferon-alpha therapy and histologic activity.