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Yong Sun,Jing Ping Zhang,Fei Guo,Lian Zhang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.9
Hydrochar was produced from hydrothermal treatment of corn straw black liquor. Response surface methodology (RSM) and the central composite design (CCD) were employed for determination of optimal char with maximum Pb2+ removal capacity. The operational parameters such as hydrothermal temperature (oC), duration (min) and solid liquid ratio (LSR) were chosen as independent variables in CCD. The statistical analysis indicates that the effects of hydrothermal temperature, duration, LSR and combined effect of hydrothermal temperature and duration are all significant for the Pb2+ removal capacity. The optimal condition for achieving the maximum Pb2+ adsorption capacity is obtained as the following: hydrothermal temperature (205 oC), duration (28min), LSR (12) with Pb2+ removal capacity reaching 47mg/g. The BET specific surface area of char prepared at optimal conditions could reach 85m2/g.
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A Concise Design for Irradiating U-10Zr Metallic Fuel at Very Low Burnup
Haibing Guo,Wei Zhou,Yong Sun,Dazhi Qian,Jimin Ma,Jun Leng,Heyong Huo,Shaohua Wang 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.4
In order to investigate the swelling behavior and fuelecladding interaction mechanism ofUe10Zr alloy metallic fuel at very low burnup, an irradiation experiment was conciselydesigned and conducted on the China Mianyang Research Reactor. Two types of irradiationsamples were designed for studying free swelling without restraint and the fuelecladdinginteraction mechanism. A new bonding material, namely, pure aluminum powder, wasused to fill the gap between the fuel slug and sample shell for reducing thermal resistanceand allowing the expansion of the fuel slug. In this paper, the concise irradiation rig designis introduced, and the neutronic and thermalehydraulic analyses, which were carried outmainly using MCNP (Monte Carlo N-Particle) and FLUENT codes, are presented. Out-of-piletests were conducted prior to irradiation to verify the manufacturing quality and hydraulicperformance of the rig. Nondestructive postirradiation examinations using cold neutronradiography technology were conducted to check fuel cladding integrity and swellingbehavior. The results of the preliminary examinations confirmed the safety and effectivenessof the design.
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Zhou, Yong,Guo, Peng,Sun, Lili,Liu, Linlin,Xu, Xiaowei,Li, Wenxian,Li, Xiaowei,Lee, Kwang-Ryeol,Wang, Aiying Elsevier Sequoia 2019 Surface & coatings technology Vol.361 No.-
<P><B>Abstract</B></P> <P>Diamond-like carbon (DLC) films with weak carbide metal Al and carbide metal Ti co-doping (Al/Ti-DLC) were prepared by a hybrid ion beam deposition system. The atomic ratios of doped Al to Ti were tailored via designing the special Al/Ti combined sputtering target. The composition, microstructure, roughness, residual stress, hardness, toughness, and tribological behaviors of the deposited films were systematically evaluated to explore the dependence of structural properties on Al/Ti ratios. Results indicated that the high-throughput preparation of DLC films with different Al/Ti atomic ratios was achieved by tailoring the sputtering target and process parameters without the difference in both the film thickness and total Al/Ti content. With the Al/Ti ratios in the films decreased from 8.8 to 3.0, the residual stress, hardness, and toughness of Al/Ti-DLC films increased obviously, originating from the increased fraction of titanium carbide and the reduced Al content. However, the coefficient of friction and wear rate with decreasing the Al/Ti ratio were obviously improved, which was related with the transformation of underlying friction mechanism from the sliding interface graphitization to dangling bond-passivation. The present results not only suggest a high-throughput method to fabricate co-doped DLC films, but also promote the scientific understanding and engineering application of DLC films with high performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ti/Al co-doped diamond-like carbon films were fabricated by a hybrid ion beam method. </LI> <LI> Different Al/Ti ratios were successfully achieved at one time using designed target. </LI> <LI> Al/Ti ratios had no effect on the chemical state of co-doped Ti and Al atoms. </LI> <LI> The mechanical and tribological properties were strongly dependent on Ti/Al ratios. </LI> <LI> Different friction mechanisms were observed with Al/Ti ratios ranged from 8.8 to 3.0. </LI> </UL> </P>
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Sliding Mode Control with Adaptive Fuzzy Immune Feedback Reaching Law
Chenchen Sun,Guo-fang Gong,Hua-yong Yang 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.2
In this paper, a novel adaptive fuzzy immune feedback reaching law (AFIFRL) based sliding mode control (SMC) strategy is proposed for uncertain nonlinear systems with time-varying disturbances. First, a nonlinear immune feedback reaching law (IFRL) inspired by biological immune feedback regulation mechanism is designed to alleviate chattering effect without losing the robustness against disturbances. Second, an improved IFRL is developed in a thin boundary layer to enhance tracking performance. Then, the applied fuzzy controller adjusts the boundary layer online to further improve control performance despite large system uncertainties and disturbances. Furthermore, an adaptive law is employed to estimate the unknown bound of uncertainties, which can effectively attenuate chattering and minimize control effort. The stability analysis is derived by Lyapunov stability theorem. Finally, numerical simulations are conducted to evidence the effectiveness and superiority of the proposed AFIFRL based SMC scheme.
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Clinical Study on Carboplatin for Treating Pediatric Patients with Wilms Tumors
Zhang, Yong,Sun, Ling-Li,Li, Tao,Sun, Hui,Mao, Guo-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
This analysis was conducted to evaluate the efficacy and safety of carboplatin based chemotherapy in treating pediatric patients with Wilms tumors. Methods: Clinical studies evaluating the efficacy and safety of carboplatin based regimens on response and safety for pediatric patients with Wilms tumors were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In carboplatin based regimens, 4 clinical studies which including 127 patients with advanced Wilms tumors were considered eligible for inclusion. With this carboplatin based chemotherapy, 2 clinical studies included carboplatin, ifosfamide and etoposide. Systemic analysis suggested that, in all patients, the pooled PR was 64.5% (82/127) in carboplatin based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with carboplatin based treatment. Conclusion: This systemic analysis suggests that carboplatine based regimens are associated with a reasonable response rate and accepted toxicities for treating pediatric patients with Wilms tumors.
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Gender-dependent hepatic alterations in H-<i>ras</i>12V transgenic mice
Wang, Ai-Guo,Moon, Hyung-Bae,Lee, Mi-Ran,Hwang, Chae Young,Kwon, Ki-Sun,Yu, Seong-Lan,Kim, Yong-Sung,Kim, Mirang,Kim, Jin-Man,Kim, Sang-Keun,Lee, Tae-Hoon,Moon, Eun-Yi,Lee, Dong-Seok,Yu, Dae-Yeul Elsevier 2005 Journal of hepatology Vol.43 No.5
<P><B>Background/Aims</B></P><P>Although it has been proposed that Ras and related signal pathways play important roles in hepatocarcinogenesis, appropriate in vivo models are lacking.</P><P><B>Methods</B></P><P>Two hepatocellular carcinoma lines were established using pronuclear microinjection techniques to create an insertion of the H-<I>ras</I>12V transgene under the control of the albumin enhancer/promoter. The resulting phenotypes and related molecular events were then examined.</P><P><B>Results</B></P><P>Male (but not female) transgenic mice older than 2 months showed hepatic alterations with a high degree of reproducibility, as compared to the wild-type mice. The liver/body-weight ratios were lower for the females than for the males. The transgene-carrying line 28 was investigated extensively with respect to molecular differences between the genders. Male hepatocytes showed higher Ras activity and higher reactive oxygen species (ROS) levels than female hepatocytes. The female hepatocytes showed higher expression levels of p53 and p21<SUP>Waf1/Cip1</SUP>, enhanced cytochrome <I>c</I> release, which correlated with cell cycle arrest, and higher levels of hypodiploid cell formation, as compared to the male hepatocytes.</P><P><B>Conclusions</B></P><P>The gender-related differences in molecular responses to activated Ras may have implications for the prevalence of hepatic alterations in males. Our transgenic mice represent a potentially valuable animal model for future investigations.</P>
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Xi-Peng Sun,Li-Li Wan,Quan-Jun Yang,Yan Huo,Yong-Long Han,Cheng Guo 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.7
The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. The present study investigated the effects of scutellarin against DOX-induced cardiotoxicity in rats using pharmacodynamic and pharmacokinetic approaches. DOX (20 mg/kg) was injected intraperitoneally (i.p.) as a single dose, and scutellarin (5 mg/kg/day) was injected intravenously (i.v.) for 3 days. Rats treated with DOX showed acute cardiotoxicity as indicated by the elevated serum lactate dehydrogenase (LDH) activity (4057.8 ± 107.2 vs. 2032.7 ± 70.95), tissue malondialdehyde (MDA) level (2.083 ± 0.10 vs. 1.103 ± 0.09), cardiac troponin T (cTnT) concentration (0.1695 ± 0.0114 ng/mL), the decreased left ventricular ejection fraction (LVEF) (47.75 ± 15.79 vs. 78.72 ± 7.25) and left ventricular fractional shortening (LVFS) (20.66 ± 8.06 vs. 43.7 ± 6.76) compared with those of the control group. Cotreatment with scutellarin significantly decreased the LDH activity (2595.9 ± 72.73), MDA level (1.380 ± 0.06), cTnT concentration (0.0222 ± 0.0041 ng/ m L), increased LVEF (76.70 ± 3.91) and LVFS (40.28 ± 3.68). Histopathological studies showed disruption of cardiac tissues in the DOX groups. Cotreatment with scutellarin reduced the damage to cardiac tissues. In the pharmacokinetic and tissue distribution study, scutellarin reduced the heart tissue exposure to DOX but did not change the AUC of plasma. These results suggest that scutellarin can protect against DOX-induced acute cardiotoxicity through its antioxidant activity and alterations of heart concentrations.
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Tian Ding,Yong-Guo Jin,S. M. E. Rahman,Jai-Moung Kim,Kang-Hyun Choi,Gye-Sun Choi,오덕환 한국식품위생안전성학회 2009 한국식품위생안전성학회지 Vol.24 No.3
This study was conducted to develop a model for describing the effect of storage temperature (4, 10, 15, 20, 25, 30 and 35oC) on the growth of Escherichia coli O157 : H7 in ready-to-eat (RTE) lettuce treated with or without (control) alkaline electrolyzed water (AIEW). The growth curves were well fitted with the Gompertz equation, which was used to determine the specific growth rate (SGR) and lag time (LT) of E. coli O157 : H7 (R2 = 0.994). Results showed that the obtained SGR and LT were dependent on the storage temperature. The growth rate increased with increasing temperature from 4 to 35oC. The square root models were used to evaluate the effect of storage temperature on the growth of E. coli O157 : H7 in lettuce samples treated without or with AIEW. The coefficient of determination (R2), adjusted determination coefficient (R2 Adj), and mean square error (MSE) were employed to validate the established models. It showed that R2 and R2 Adj were close to 1 (> 0.93), and MSE calculated from models of untreated and treated lettuce were 0.031 and 0.025, respectively. The results demonstrated that the overall predictions of the growth of E. coli O157 : H7 agreed with the observed data. This study was conducted to develop a model for describing the effect of storage temperature (4, 10, 15, 20, 25, 30 and 35oC) on the growth of Escherichia coli O157 : H7 in ready-to-eat (RTE) lettuce treated with or without (control) alkaline electrolyzed water (AIEW). The growth curves were well fitted with the Gompertz equation, which was used to determine the specific growth rate (SGR) and lag time (LT) of E. coli O157 : H7 (R2 = 0.994). Results showed that the obtained SGR and LT were dependent on the storage temperature. The growth rate increased with increasing temperature from 4 to 35oC. The square root models were used to evaluate the effect of storage temperature on the growth of E. coli O157 : H7 in lettuce samples treated without or with AIEW. The coefficient of determination (R2), adjusted determination coefficient (R2 Adj), and mean square error (MSE) were employed to validate the established models. It showed that R2 and R2 Adj were close to 1 (> 0.93), and MSE calculated from models of untreated and treated lettuce were 0.031 and 0.025, respectively. The results demonstrated that the overall predictions of the growth of E. coli O157 : H7 agreed with the observed data.
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