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한국인의 혈중 Lipoprotein ( a ) 농도와 Apolipoprotein ( a ) 유전적 표현형 분포특성
서홍석(Hong Seog Seo),오동주(Dong Joo Oh),이상칠(Sang Chil Lee),임도선(Do Sun Lim),박창규(Chang Kyu Park),김영훈(Young Hoon Kim),심완주(Wan Joo Shim),노영무(Young Moo Ro),김순덕(Soon Duk Kim),유재명(Jae Myung Yu) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
N/A Lipoprotein(a)[Lp(a)] is a cholestryl ester-rich lipoprotein composed of two components' an LDL -like particle to which is attached a single large glycoprotein, apolipoprotein(a)[apo(a)]. Elevated concentrations of Lp(a) have been established as a geneticalqly controlled risk factor for atherosclerotic vascular disease. Variable alleles at the apo(a) gene locus determine, to a large extent, the Lp(a) concentration in the general population. To determine and compare the mean and distribution of Lp(a) concentration, apo(a) phenotypes and allele frequencies of Lp(a) in Korean people and other several esthnic groups, we investigated the Lp(a) plasma concentration, apo(a) phenotypes and other lipid profiles in 481 Korean People, who were consisted of 280 cases with non-atherosclerotic vascular disease and 201rases with atherosclerotic vascular disease. Mean concentrations of Lp(a) in Korean people were 27.3±28.6mg/dl in cases with non-atherosclerotic vascular disease an 29.9±31.2mg/dl in cases with atherocslerotic vascular disease. No differences was found in Lp(a) doncentration between the two groups. Lp(a) concentration of Korean people was simular to those of Indian, but far higher than those of Caucacian, Chinese or Japanese. Proportion of those below 5mg/dl of Lp(a) concentration was 26.6%, and those below 30mg/ dl was 68.0%. Frequency distribution patterns of Lp(a) concentrations in Korean population were similar to those of Chinese, Japanese and Malysian, but different from those of Caucacian, Indian of African. In apo(a) phenotype of Korean, the mode of single band was S3(44.3%), and the mode of double bank was S3S4(8.2%), which were similar to those of Chinese, Malysian and Indian. Order of allele frequencies of Lp(a) of Korean was Lps4, null(Lp0), Lps3, Lps2, and Lps1. Similar frequency was seen in those of Chinese, and other Asians execpt Japanese, but not in those of Caucacian and black people. Lp(a) concentration was not correlated with any other lipid profiles. Homology of study samples with Korean population was confirmed by Hardy-Weinberg equilibrium test. These results show that Korean people has higher concentration of Lp(a) in Asian, and has characteristics of apo(a) phenotype and Lp(a) allele frequences.