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Kang, Suki,Maeng, Heysun,Kim, Baek Gil,Qing, Gao Ming,Choi, Yoon Pyo,Kim, Hak Yong,Kim, Pan Soo,Kim, Yangsun,Kim, Young Hwan,Choi, Young Deuk,Cho, Nam Hoon American Chemical Society 2012 JOURNAL OF PROTEOME RESEARCH Vol.11 No.9
<P>Modifications in the tumor microenvironment (TME) play a major role in the establishment, progression, and metastasis of cancer. Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a powerful technique that enables the simultaneous identification and localization of biological compounds within tissues. To detect markers of early TME remodeling in invasive breast cancer, we used MALDI-MSI to compare the molecular profiles of tissues from the breast cancer interface zone, tumor zone, and normal-tissue zone. Using direct-tissue MALDI tandem mass spectrometry (MS/MS), we identified immunoglobulin heavy constant alpha 2 (IGHA2) as a new, zone-specific protein in the breast TME. The zone-specific expression of IGHA2 was verified by immunoblotting and immunohistochemical analysis. IGHA2 expression was consistently positive in tumor cells that were metastatic to regional nodes, with intense expression along the cytoplasmic borders. As a factor related to an increased percentage of nodes with tumor metastasis, IGHA2 expression was upregulated 3.745-fold in cases with an increased number of cancerous nodes (<I>p</I> = 0.0468). Our results provide the first evidence of IGHA2 as a marker of the early process of TME remodeling in invasive breast cancer. Furthermore, IGHA2 may be a novel marker for regional metastases in the lymph nodes of patients with breast cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2012/jprobs.2012.11.issue-9/pr3003672/production/images/medium/pr-2012-003672_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr3003672'>ACS Electronic Supporting Info</A></P>
A Low Power SOC Architecture for the V2.0+EDR Bluetooth Using a Unified Verification Platform
KIM, Jeonghun,KIM, Suki,BAEK, Kwang-Hyun The Institute of Electronics, Information and Comm 2010 IEICE transactions on information and systems Vol.93 No.9
<P>This paper presents a low-power System on Chip (SOC) architecture for the v2.0+EDR (Enhanced Data Rate) Bluetooth and its applications. Our design includes a link controller, modem, RF transceiver, Sub-Band Codec (SBC), Expanded Instruction Set Computer (ESIC) processor, and peripherals. To decrease power consumption of the proposed SOC, we reduce data transfer using a dual-port memory, including a power management unit, and a clock gated approach. We also address some of issues and benefits of reusable and unified environment on a centralized data structure and SOC verification platform. This includes flexibility in meeting the final requirements using technology-independent tools wherever possible in various processes and for projects. The other aims of this work are to minimize design efforts by avoiding the same work done twice by different people and to reuse the similar environment and platform for different projects. This chip occupies a die size of 30mm<SUP>2</SUP> in 0.18µm CMOS, and the worst-case current of the total chip is 54mA.</P>
A 10-bit, 40Msamples/s Foldidng & Interpolating A/D Converter with Wide Range Error Correction
Kim, Tae-hyoung,Sung, Jun-jey,Kim, Soo-hwan,Lim, Shin-il,Kim, Suki 연세대학교 아식설계공동연구소 2000 Journal of the Research Institute of ASIC Design Vol.7 No.1
This paper describes an 10-bit, 40Msamples/s CMOS folding and interpolating analog-to-digital converter(F&I ADC). A new cascading-folding architecture is proposed to reduce the number of comparators and power consumption, and to increase input signal bandwidth. In order to reduce the nonlinear switch errors related to the sample-and-holder, a charge-pump circuit is used. Furthermore, by using a Wide range error correction scheme, the relaxed design of comparators is possible. The coarse comparators with offsets as large as ±7.8mV are tolerable due to this wide range error correction scheme. The ADC was designed using a 0.25 ㎛ 1-poly 5-metal CMOS process. It consumes 62mW at 40Msamples/s. The INL/DNL is less than ±0.5LSB/±0.4LSB by MATLAB pre-simulation
Kim, Se‐,Heon,Koo, Bon‐,Seok,Kang, Suki,Park, Kyeongmee,Kim, Haeryoung,Lee, Kyung Ryul,Lee, Moo Joo,Kim, Jong Man,Choi, Eun Chang,Cho, Nam Hoon Wiley Subscription Services, Inc., A Wiley Company 2007 International journal of cancer: Journal internati Vol.120 No.7
<P><B>Abstract</B></P><P>The prevalence of human papillomavirus (HPV) infection is high in the oropharyngeal mucosal regions, of which the tonsil is the most commonly affected. There may be a link between HPV and the pathogenesis of tonsillar cancer (TC), because of common anatomical characteristics between cervical and tonsillar cancer. We aimed to clarify whether HPV directly affects the oncogenesis and biologic behavior of TC by making a comparison between infection prevalence, physical status and viral loading numbers, and clinicopathologic prognostic factors. To compare HPV‐related molecules between TC and tonsillitis (CFT), p16, survivin, HIF‐1α, skp‐1, cyclin A, cyclin B1, c‐myc and EGFR were investigated. We observed a significant difference in HPV prevalence between 52 TCs and 69 CFTs (73.1% <I>vs.</I> 11.6%), and most of the HPVs were type 16 (87.2%) and nonepisomal (94.1%). Most TCs associated with HPV arose from the tonsillar crypts, and tended to be inverted and poorly differentiated. Compared with HPV‐negative TC, HPV‐positive TC showed a strong association with p16 overexpression (<I>p</I> < 0.0001), and an inverse association with EGFR amplification (<I>p</I> = 0.0478). HPV‐16 integration status was strongly associated with c‐myc amplification (<I>p</I> = 0.034) and HIF‐1α overexpression (<I>p</I> = 0.022). HPV‐16 integration could be directly related to tonsillar carcinogenesis initially in tonsillar crypts, followed by cell cycle aberration such as p16 overexpression related to the G1‐S phase. © 2006 Wiley‐Liss, Inc.</P>
Kim, Ji Eun,Kim, Baek Gil,Jang, Yeonsue,Kang, Suki,Lee, Joo Hyun,Cho, Nam Hoon Elsevier 2020 Cancer letters Vol.469 No.-
<P><B>Abstract</B></P> <P>Stroma-derived exosomal microRNA (exomiR) contributes to tumor progression, however, which remains poorly understood. In our study, we analyzed exomiRs from the cancer-associated fibroblast (CAF) and normal fibroblast (NF) isolated from an invasive ductal carcinoma (IDC) patient and found that the level of microRNA (miR)-4516 was approximately 5-fold lower in CAF-derived exosomes than NF-derived ones. In gene annotation analysis, miR-4516 target genes were mainly associated with the regulation of proliferation. miR-4516 overexpression or mimic treatment suppressed the proliferation of breast cancer cells, especially triple negative breast cancer (TNBC) cells. Among miR-4516 targets, FOSL1 was overexpressed in TNBC cells compared to non-TNBC cells and promoted tumor proliferation. The expression of miR-4516 and FOSL1 was reversely correlated in breast cancer patient tissues. Particularly, TNBC patients with high FOSL1 expression showed a significant poorer survival than those with low FOSL1 expression. Our results show that the loss of miR-4516 from CAF-derived exosomes is associated with FOSL1-dependent TNBC progression and suggest that miR-4516 can be used as an anti-cancer drug for TNBC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The loss of miR-4516 was associated with FOSL1-dependent TNBC progression. </LI> <LI> The level of miR-4516 was lower in CAF-derived exosomes than NF-derived ones. </LI> <LI> MiR-4516 suppressed the proliferation of TNBC cells by targeting FOSL1. </LI> </UL> </P>
6-bit 1.6-GS/s 85-mW Flash Analog to Digital Converter Using Symmetric Three-Input Comparator
KIM, Yun-Jeong,LEE, Jong-Ho,KOO, Ja-Hyun,BAEK, Kwang-Hyun,KIM, Suki The Institute of Electronics, Information and Comm 2008 IEICE transactions on electronics Vol. No.
<P>In this paper, we describe a 6-bit 1.6-GS/s flash analog to digital converter (ADC). To reduce the power consumption and active area, we propose a new interpolation architecture using a symmetric three-input comparator. This ADC achieves 5.56 effective bits for input frequencies up to 220MHz at 1.6GS/s, and almost five effective bits for 660MHz input at 1.6GS/s. Peak INL and DNL are less than 0.5LSB and 0.45LSB, respectively. This ADC consumes 85mW from 1.8V at 1.6GS/s and occupies an active area of 0.27mm<SUP>2</SUP>. It is fabricated in 0.18-μm CMOS.</P>
The v2.0+EDR Bluetooth SOC architecture for multimedia
Kim, Jeonghun,Choi, Youngwhan,Jeong, Jungwon,Lee, Suhho,Kim, Suki IEEE 2006 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.52 No.2
This paper presents a Bluetooth system on chip (SOC) architecture for multimedia applications. The SOC includes all necessary baseband-parts, RF-parts, a sub-band codec (SBC) and an application processor to achieve a Bluetooth specification v2.0+EDR (enhanced data rate). Dual bus architecture is selected to improve data transmission efficiency between a baseband and a system bus. The receiver uses an optimized low-IF (1.5 MHz) architecture which is trade-off between power and performance on CMOS technology. The transmitter uses a direct up conversion architecture. This chip occupies a die size of 28 mm<SUP>2</SUP> in a 0.18 μm CMOS. This chip and a flash memory are put into multi chip package (MCP). The maximum current consumption of the total chip is 65 mA at the TX mode. The internal supply voltages of RF- and digital-parts are 1.8 V. First measurement results meet most of the Bluetooth specification v2.Q+EDR and show the suitability of the presented single-chip concept.