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Experimental investigation of a linear-chain structure in the nucleus <sup>14</sup>C
Yamaguchi, H.,Kahl, D.,Hayakawa, S.,Sakaguchi, Y.,Abe, K.,Nakao, T.,Suhara, T.,Iwasa, N.,Kim, A.,Kim, D.H.,Cha, S.M.,Kwag, M.S.,Lee, J.H.,Lee, E.J.,Chae, K.Y.,Wakabayashi, Y.,Imai, N.,Kitamura, N.,Lee North-Holland Pub. Co 2017 Physics letters. Section B Vol.766 No.-
It is a well-known fact that a cluster of nucleons can be formed in the interior of an atomic nucleus, and such clusters may occupy molecular-like orbitals, showing characteristics similar to normal molecules consisting of atoms. Chemical molecules having a linear alignment are commonly seen in nature, such as carbon dioxide. A similar linear alignment of the nuclear clusters, referred to as linear-chain cluster state (LCCS), has been studied since the 1950s, however, up to now there is no clear experimental evidence demonstrating the existence of such a state. Recently, it was proposed that an excess of neutrons may offer just such a stabilizing mechanism, revitalizing interest in the nuclear LCCS, specifically with predictions for their emergence in neutron-rich carbon isotopes. Here we present the experimental observation of α-cluster states in the radioactive <SUP>14</SUP>C nucleus. Using the Be10+α resonant scattering method with a radioactive beam, we observed a series of levels which completely agree with theoretically predicted levels having an explicit linear-chain cluster configuration. We regard this as the first strong indication of the linear-chain clustered nucleus.
Study on α-cluster levels in non-4n nuclei using low-energy RI beams
Yamaguchi, H,Kahl, D,Hayakawa, S,Sakaguchi, Y,Abe, K,Nakao, T,Suhara, T,Iwasa, N,Kim, A,Kim, D H,Cha, S M,Kwag, M S,Lee, J H,Lee, E J,Chae, K Y,Wakabayashi, Y,Imai, N,Kitamura, N,Lee, P,Moon, J Y,Lee, IOP Publishing 2017 Journal of physics. Conference series Vol.863 No.-
A Primary Role for Nucleus Accumbens and Related Limbic Network in Vocal Tics
McCairn, Kevin W.,Nagai, Y.,Hori, Y.,Ninomiya, T.,Kikuchi, E.,Lee, J.Y.,Suhara, T.,Iriki, A.,Minamimoto, T.,Takada, M.,Isoda, M.,Matsumoto, M. Cell Press 2016 Neuron Vol.89 No.2
<P>Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain PET imaging identified prominent, bilateral limbic cortico-subcortical activation. Local field potentials (LFPs) developed abnormal spikes in the NAc and the anterior cingulate cortex (ACC). Vocalization could occur without obvious LFP spikes, however, when phase-phase coupling of alpha oscillations were accentuated between the NAc, ACC, and the primary motor cortex. These findings contrasted with myoclonic motor tics induced by disinhibition of the dorsolateral putamen, where PET activity was confined to the ipsilateral sensorimotor system and LFP spikes always preceded motor tics. We propose that vocal tics emerge as a consequence of dysrhythmic alpha coupling between critical nodes in the limbic and motor networks.</P>
Central Nervous System Drug Evaluation Using Positron Emission Tomography
Mizuho Sekine,Jun Maeda,Hitoshi Shimada,Tsuyoshi Nogami,Ryosuke Arakawa,Harumasa Takano,Makoto Higuchi,Hiroshi Ito,Yoshiro Okubo,Tetsuya Suhara 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.1
In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of action. In addition, the frequency of administration has been estimated from drug kinetics in blood. However, there is a problem regarding an objective index of drug effects in the living body. Furthermore, the possibility that the concentration of drug in blood does not necessarily reflect the drug kinetics in target organs has been pointed out. Positron emission tomography (PET) techniques have made progress for more than 20 years,and made it possible to measure the distribution and kinetics of small molecule components in living brain. In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET.