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이은숙 ; 한만덕 ; 나수정 ; 장종화 김천대학교 2016 김천대학교 논문집 Vol.19 No.-
This study was performed to analyze
다량의 수양성 설사후 발생한 아급성 허혈성 대장염 1예
이승현,김남수,김정권,이승옥,김광훈,최정기,이수택,김대건,안덕수 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2
Ischemic colitis represents most common form of gastrointestinal ischemia, usually developed in elderly or debilitated patient with a variety of underlying medical problems. The presumed etiologies are numerous. It usually presents as an acute abdominal illness with bloody diarrhea. Subacute ischemic colitis in healthy adults develops spontaneously in the absence of major vasculature occlusion, and the original insult precipitating the ischemic event usually cannot be established. Diagnosis is based on the clinical symptom, barium study, colonoscopic and histopathologic findings. Therapy and outcome are dependent on the severity of disease. It usually requires only medical management and is asso-ciated a good prognosis. We report a case of subacute ischemic colitis in healthy adults developed after severe watery diarrhea with literatures.
Deuk Ki Lee,Jeong Shik Cho,Taejong Yu,Yong Su Lee,Jae Wan Choe,Sang Soo Lee 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.11
A kinetic model for the catalytic wet air oxidation of aqueous ammonia over Ru/TiO2 catalyst was developed considering the consecutive reaction steps as follows: (i) formation of active oxygen sites O* by the dissociative adsorption of aqueous O2 on the catalyst, (ii) oxidation of aqueous NH3 by the reaction with three O* sites to produce HNO2, (iii) aqueous phase dissociation of HNO2 into H+ and NO2 −, (iv) formation of NH4 + by the association of NH3 with the HNO2-dissociated H+, (v) formation of N2 by the aqueous phase reaction between NO2 − and NH4 +, (vi) formation of NO3 by the reaction of NO2 − with an O* site. For each reaction step, a rate equation was derived and its kinetic parameters were optimized by experimental data fitting. Activation energies for the reactions (ii), (v), and (vi) were 123.1, 76.7, and 54.5 kJ/mol, respectively, suggesting that the oxidation reaction of aqueous NH3 to HNO2 was a ratedetermining step. From the simulation using the kinetic parameters determined, the initial pH adjustment of the ammonia solution proved to be critical for determining the oxidation product selectivity between desirable N2 and undesirable NO3 − as well as the degree of oxidation conversion of ammonia.
Expression of Multiple Monoclonal Antibodies Produced in a Single Plant
Deuk-Su Kim,Jeong-Hwan Lee,Kyung-Jin Lee,Young-Kug Choo,Kyung-A Hwang,Kisung Ko 한국당과학회 2013 한국당과학회 학술대회 Vol.2013 No.1
Plant expression system for mass production of highly valuable recombinant therapeutic proteins has several advantages over other existing expression systems with economical and safety issues. Immunotherapy of multiple monoclonal antibodies, which can recognize multiple targeting including specific proteins and their glycans highly expressed on the surface of cancer cells, can be an efficient treatment compared to a single targeting immunotherapy using a single antibody. In this study, we have established plant production system to express two different targeting monoclonal antibodies in a single transgenic plant through crossing fertilization between two different transgenic plants expressing anti-colorectal cancer mAb CO17-1A (mAb CO) and anti-breast cancer mAbBR55 (mAb BR), respectively. The F1 seedlings were obtained cross fertilization between the two transgenic parental plants. The presence, transcription, and protein expression of heavy chain (HC) and light chain (LC) genes of both mAbs in the seedlings were investigated by PCR and immunoblot analyses, respectively. The seedlings with presence and transcription of HC and LC genes of both mAbs were selected, and the selected seedlings were confirmed to have relatively stronger density of HC and LC protein bands compared to the transgenic plant expressing only each mAb. N-glycan structure analysis will be conducted to confirm the glycan structure of multiple monoclonal antibodies mAbP CO x BR. These results indicate that the F1 seedling plant with carrying both mAb genes was established. Taken together, plant crossing fertilization can be applied to generate an efficient production system expressing multiple monoclonal antibodies for immunotherapy in a single plant.
연구보문 : 환경화학 ; GC-ECD/MS를 이용한 농산물 중 Captan, Folpet, Captafol 및 Chlorothalonil의 잔류분석법
이수진 ( Su Jin Lee ),황영선 ( Young Sun Hwang ),김영학 ( Young Hak Kim ),권찬혁 ( Chan Hyeok Kwon ),도정아 ( Jung A Do ),임무혁 ( Moo Hyeog Im ),이영득 ( Young Deuk Lee ),정명근 ( Myoung Gun Choung ) 한국환경농학회 2010 한국환경농학회지 Vol.29 No.2
A gas chromatographic (GC) method was developed to determine residues of captan, folpet, captafol, and chlorothalonil, known as broad-spectrum protective fungicides for the official purpose. All the fungicide residues were extracted with acetone containing 3% phosphoric acid from representative samples of five agricultural products which comprised rice, soybean, apple, pepper, and cabbage. The extract was diluted with saline, and dichloromethane partition was followed to recover the fungicides from the aqueous phase. Florisil column chromatography was additionally employed for final cleanup of the extracts. The analytes were then determined by gas chromatography using a DB-1 capillary column with electron capture detection. Reproducibility in quantitation was largely enhanced by minimization of adsorption or thermal degradation of analytes during GLC analysis. Mean recoveries generated from each crop sample fortified at two levels in triplicate ranged from 89.0~113.7%. Relative standard deviations (RSD) were all less than 10%, irrespective sample types and fortification levels. As no interference was found in any samples, limit of quantitation (LOQ) was estimated to be 0.008 mg/kg for the analytes except showing higher sensitivity of 0.002 mg/kg for chlorothalonil. GC/Mass spectrometric method using selected-ion monitoring technique was also provided to confirm the suspected residues. The proposed method was reproducible and sensitive enough to determine the residues of captan, folpet, captafol, and chlorothalonil in agricultural commodities for routine analysis.