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RISS 인기검색어
- 검색키워드
- 저자 : Soon-Jai Park (검색결과 258 건)
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박재순,이근후 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.4
The author studied the somatic discomforts of 120 depressed women who were in-patients and out-patients in department of neuropsychiatry, Soon Chun Hyang Medical College and Paik Hospital of In Je Medical College from Sept. 1, 1979 to Dec. 31, 1980. The result were as follows; 1. The most frequent age distribution was the fourth decade. 2. somatic discomforts reported by at least 50% of all patients were 13 of 69 items and these were "anorexia", (70%), "shallow and easily disrupted sleep", (69%), "initial insomnia"(64%), "indigestion and stomach aches"(63%), "heavy headedness" (58%), "periods of weakness/extreme fatigue" (57%) and "heart pounding " (56%) etc. 3. The classes of discomforts with high pretreatment severity were "sleep disturbances", "stomach troubles", "fatigue", "dry mouth", and "climacteric symptoms" in that order and all of these classes showed statistically significant improvement after a treatment period of 3 weeks (p<0.01). Each items of discomforts with high pretreatment severity were "shallow and easily disrupted sleep", "anorexia", "initial insomnia", "giddiness or dizziness", "heavy headedness" and "indigestion and stomach aches". 4. Eight classes of discomforts such as "autonomic", "intestinal", "gastric", "sleep", "dry mouth", "climacteric", "constipation", "muscular symptoms" showed "significantly" higher severity in the depressed group at admission than in the non-patient control group (p<0.05). Comparing the somatic discomforts by different age brackets, patients in the third decade were predominated by gastrointestinal symptoms, these in the fourth decade were characterized by muscular discomforts, those in the fifth decade by drymouth and those in the sixth decade by climacteric symptoms and constipation. Sleep disturbances were conspicuous discomforts among depressed women of all ages.
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朴在純,車喆煥 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3
The garlic which is consumed as a daily spice in Korea contains abundant amounts of thiol compounds such as SH and S-S radicals. These compounds have been though to be involved in the detoxification mechanism of heavy metal poison by the formation of thiochelate compounds when reacting with heavy metals in living body. As part of an examination of this hypothesis, the effect of garlic on the detoxification mechanism of alkyl mercury poisoning in rats was studied. The experimental rats were fed 6ppm of phenyl mercury in potable water in addition to 3 different concentrations of garlic in pellets (1.70%, 3.35%, and 6.70%) which was compared with the control(no mercury and garlic) and the "garlic only" fed group (no mercury). After rearing for 12 weeks with the above prescription, alkaline phosphatase activities in the blood and the accumulation of total mercury in the tissues of target of the brain, liver and kidney were measured. To derive objective clues, additionally, histopathological changes in the tissues of the above organs were observed histologically. As the result, it was found that components of garlic have some roles in detoxificating phenyl mercury poisoning such as decreasing alkaline phosphatase activity, increasing concentration of mercury in target organs, and inducing pathological damages to the organs.
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제주도 연안 해수의 화학적 및 미생물학적 수질 현황에 관한 연구
김재하,박길순,강영주 제주대학교 해양연구소 1981 해양자원연구소연구보고 Vol.5 No.-
A survey of seawater pollution was carried out monthly during October 1979 through May 1980 for three major harbors in Jeju island ; Jeju, Seogwipo and Seogsanpo. Eight different sites were selected for each harbor to determine a chemical and microbiological pollution level together with a pigment content. Among three harbors, Jeju was most polluted chemically and microbiologically with significantly high level of pollution at the inner harbor which were well above the maximum permitted level. The inner harbor of Seogwipo also was in excess of permitted level under the influence of Cheonjicheon, but the other sites were rather clean. Seongsanpo is not polluted at the present time. It was shown that the pigment contents in seawater were higly variable from month to month. The highest pigment content in Jeju with the similar low values in Seogwipo and Seongsanpo were obtained oqter port. This indicates that the sites with inflowing fresh water or sewage were and carotenoid. throughout the investigating period. The differences in the pigment contents among the sampling sites showed that the inner harbor was much higher than outer prot. This indicates that the sites with inflowing fresh water or sewage were generally high in pigment content. In pigment sorts, there always appeared higher amount of chlorophyll c than chlorophyll a,b and carotenoid.
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안기원,박정선,서순팔,문재동,조진형 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1
In order to evaluate the genotoxic hazard among workers potentially exposed to low level petrochemical substances, the analyses of micronuclei(MN) and sister chromatid exchanges(SCEs) in lymphocytes were performed in 46 male workers(as exposed group) and 46 nonexposed subjects(as control group). Mean frequencies of MN and SCEs(respectively, 12.9/1000 cells and 6.5/cell) in exposed group were very significantly higher than those(10.2/1000 cells and 5.4/cell) in control group. And there were also significant differences in mean frequencies of MN and SCEs adjusted for age, employment duration, smoking, and drinking between two groups. Median frequencies of MN and SCEs in exposed group were very significantly higher than those in control group. Frequencies of SCEs were higher in smokers than in non-smoker. Frequencies of MN in smokers, however, were similiar to those of non-smoker. Interaction between exposure and smoking on MN and SCEs induction was not observed. The results suggest that there is genotoxic hazard in high risk group like workers handling carcinogens in petrochemical plants and the analyses of MN and SCEs are useful biomarkers for the exposure to hazard substances even at the level below the exposure limit.
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딜라트렌 정(카르베딜롤 25 mg)에 대한 카베롤 정의 생물학적 동등성
조혜영,이문석,박순철,임동구,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Carvedilol is an antihypertensive and antianginal compound that combines nonselective beta-adrenoceptor blocking and vasodilation properties and is devoid of intrinsic sympathomimetic activity. The purpose of the present study was to evaluate the bioequivalence of two carvedilol tablets, Dilatrend^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Carvelol^TM (Dae Won Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The carvedilol release from the two carvedilol tablets in vitro was tested using KP ⅦI Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB80 into water). Eighteen normal male volunteers, 24.22±1.86 years in age and 64.81±4.56㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 25㎎ of carvedilol was orally administered, blood was taken at predetermined time intervals and the concentrations of carvedilol in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two carvedilol tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed AUC_t, and C_max. The results showed that the differences in AUC_t, C_max and T_max between two tablets based on the Dilatrend^TM were 2.23%, -2.00% and 0.00%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 13.55% and 17.61% for AUC_t and C_max respectively). The powers (1-β) at α=0.05, Δ=0.2 for AUC_t and C_max were 98.08% and 88.81%, respectively. The 90% confidence intervals were within ±20% (e.g., -5.69~10.16 and -12.30~8.30 for AUC_t and C_max, respectively). There were no sequence effect between two tablets in logarithmically transformed AUC_t and C_max. The 90% confidence intervals using logarithmically transformed were within the acceptance range of log(0.8) to log(l.25) (e.g., 0.95~1.11 and 0.89~1.09 for AUC_t and C_max, respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that Carvelol^TM tablet is bioequivalent to Dilatrend^TM tablet.
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딜라트렌정(카르베딜롤 25mg)에 대한 카베롤 정의 생물학적 동등성
조혜영,이문석,박순철,임동구,문재동,이용복 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.4
Carvedilol is an antihypertensive and antianginal compound that combines nonselective beta-adrenoceptor blocking and vasodilation properties and is devoid of intrinsic sympathomimetic activity. The purpose of the present study was to evaluate the bioequivalence of two carvedilol tablets, Dilatrend^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Carvelol^TM (Dae Won Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The carvedilol release from the two carvedilol tablets in vitro was tested using KP VII Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB80 into water). Eighteen normal male volunteers, 24.22±1.86 years in age and 64.81±4.56 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 25 mg of carvedilol was orally administered, blood was taken at predetermined time intervals and the concentrations of carvedilol in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two carvedilol tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed AUC_t and C_max The results showed that the differences in AUC_t C_max and T_max between two tablets based on the Dilatrend^TM were 2.23%, -2.00% and 0.00%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=8 were less than 20% (e.g., 13.55% and 17.61% for AUC_t and C_max respectively). The powers (1-β) at α=0.05, Δ=0.2 for AUC_t and C_max were 98.08% and 88.81%, respectively. The 90% confidence intervals were within 20% (e.g., -5.69∼10.16 and -12.30∼8.30 for AUC_t and C_max, respectively). There were no sequence effect between two tablets in logarithmically transformed AUC_t and C_max, The 90% confidence intervals using logarithmically transformed were within the acceptance range of log(0.8) to log(1.25) (e.g., 0.95∼1.11 and 0.89∼1.09 for AUC_t and C_max respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that Carvelol^TM tablet is bioequivalent to Dilatrend^TM tablet.
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안영진,이승호,강신정,황방연,박웅양,안병태,노재섭,이경순 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-
A chemical examination of the phenolic compounds in the leaves of Sapium japonicum (Euphorbiaceae) has led to the isolation of eleven phenolic compounds. containing five hydrolysable tannins and six flavonoids. On the basis of chemical and spectroscopic evidences, the structures of these compounds were confirmed to be galic acid(1), 5-O-caffeoyl quinic acid(2), 1-O-galloyl-3, 6-(R)-HHDP-β-n-glucose(coriiagin)(3), 1-O-galloyl-2.4-(R)-DHHDP-βn-glucose (furosin)(4), 1-O-galloyl-2.4-(R)-DHHDP-3.6-(R)-HHDP-β-m-glucose(geraniin)(5), astragalin(6), trifolin(7), afzelin(8), quercetin(9), isoquercitrin(10) and rutin(11). Among them geraniin was the main component.
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