Capsaicin이 성숙한 흰쥐의 통각반응과 open-field 행동에 미치는 영향

박순권,김현택,나흥식,홍승길 한국심리학회 한국심리학회지 생물 및 생리 Vol.7 No.1

성숙한 흰쥐에게 전신계로 투여한 capsaicin(150㎎/㎏)이 개방장(open-field)행동과 통각반응의 역치 및 반응잠재기에 미치는 효과를 알아보았다. 첫째, open-field행동에는 capsaicin의 효과가 관찰되지 않았는데 이것은 capsaicin이 흰쥐의 정서반응성과 운동기능에는 영향을 미치지 않음을 의미하는 것이다. 둘째, capsaicin 투여에 의해 열자극에 대한 앞발 및 뒷발핥기의 역치는 변화되지 않았으나, 뛰어오르기의 역치는 증가되었다. 또한 역치 이상의 열자극에 대한 뒷발핥기 반응의 잠재기도 capsaicin 투여에 의해 증가되었다. 이 결과는 비교적 약한 열자극에 대한 적응반응에는 capsaicin이 영향을 미치지 않으나 강한 열자극에 대한 대처반응에는 영향을 미치는 것으로 해석된다. We investigated the effects of capsaicin(s.c. 150㎎/㎏) on the open-field behaviors and the thresholds and latency of nociceptive responses in adult rats. Results are as follows. 1) Capsaicin did not affect open-field behaviors. It hints that capsaicin did not alter the emotionality and motor function of rats. 2) Whereas the threshold of jumping was elevated, those of fore and hind paw licking were not in animals treated with capsaicin. Capsaicin also enhanced hind paw licking latency to thermal stimulus over thershold in hot plate test. These results suggest that capsaicin affects the coping reaction to strong thermal stimulus, but not adaptive reaction to mild stimulus, in adult rats.

Capsaicin 사전 투여에 의한 흰쥐의 공격성 감소 및 자율적 체온조절의 결손

박순권,홍승길,나흥식,김현택 한국심리학회 한국심리학회지 생물 및 생리 Vol.7 No.1

capsaicin 사전 처치가 흰쥐의 공격성과 체온조절에 미치는 영향을 알아보았다. 생후 6주경에 capsaicin을 피하주사하였고, 완전히 성숙한 후에 공격성 및 체온조절 기능을 검사하였다. 실험 1의 공격성 검사 결과 capsaicin 처치동물들의 공격성은 통제동물보다 낮았는데, 이것은 선행 연구의 결과와 상반된다. 체온조절 기능을 알아본 실험 2에서는 capsaicin 처치동물들이 37℃ 및 40℃ 조건에서 과체온과 빠른 체온증가를 보여주었다. 이것은 출생 직후 또는 성숙한 후에 약물을 투여한 선행연구들과 일치되는 결과이다. 따라서 capsaicin이 체온조절에 미치는 영향은 투여 시기와 무관한 것 같다. 논의에서는 본 연구의 두 가지 결과를 시상하부와 관련시켜 해석하였다. The present study was designed to examine effects of capsaicin administration on aggressive behaviors and autonomic thermoregulation in rats. In six-week-old rat, capsaicin was injected subcutaneously on 4 consecutive days in increasing doses(20㎎/㎏, 30㎎/㎏, 30㎎/㎏, 50㎎/㎏) to total of 150㎎/㎏ of the drug. The controls were treated in the same way with vehicle alone. Two experments began six or eight weeks after the treatment. In experiment 1, isolation-induced agressive behaviors, scored a 10-min session in the dyadic situation, were significantly decreased by capsaicin pretreatment. This result was not in accord with the previous findings. In experiment 2, body temperature of the capsaicin-treated rats increased more than the control's at two amibient temperatures studied(37℃ and 40℃). Our result concerning thermoregulation supports the preceding studies that applied to the capsaicin-treated animals as neonate or adult. Thus, it is likely that the effect of capsaicin treatment on thermoregulation has nothing to do with the age of capsaicin injection. The capsaicin effects from this study were compared with hypothalamic lesion effects in the discussion part.

만성 신부전 환자에서 과도한 수분섭취로 유발된 심한 저나트륨혈증 1예

문기원,권순길,김혜영 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

만성 신부전에서는 사구체 여과율이 감소함에 따라 농축능은 손상되지만 희석능은 오랜 기간 유지되기 때문에 심한 저나트륨혈증은 잘 발생하지 않는 것으로 알려져 있다. 저자들은 잘못된 민간 의료지식으로 인하여 만성 신부전 환자에서 과도한 수분섭취로 유발된 심한 저나트륨혈증을 합병증 없이 치료한 증례를 경험한 바 있어 보고하는 바이다. Hyponatremia is one of the most common electrolytes imbalances in clinical medicine. However, it may be fatal if not corrected appropriately. In pre-dialytic chronic renal failure patients, severe hyponatremia is rare, because the dilutional capacity of the nephron is well preserved despite of diminished glomerular filtration rate. We report a case of severe hyponatremia induced by excessive water intake in a 33-year-old woman with chronic renal failure, treated successfully with diuretics and 3% saline. She had drunken 2-3 liters of free water daily for 7 days, and nausea, vomiting and dyspnea were developed 2 days later. At admission, serum sodium concentration was 103 mEq/L and serum creatinine was 4.7 mg/dL. Salt and free water intake were restricted and furosemide was administered intravenously, but serum sodium concentration rose only by 2 mEq/L. Then, 3% saline was added and serum sodium concentration rose to 118 mEq/L after 48 hours. On 7th hospital days, serum sodium concentration was 132 mEq/L, the patient discharged without any complication at all.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

Is Cholecystectomy Necessary After ERCP for Bile Duct Stones in Patients with Gallbladder in situ ?

(Soon Kil Kwon),(Byung Seok Lee),(Nam Jae Kim),(Heon Young Lee),(Hee Bok Chae),(Sei Jin Youn),(Seon Mee Park) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.4

N/A Background: The requirement for subsequent cholecystectomy in patients with gallbladder in situ after endoscopic removal of stones from the common bile duct (CBD) is controversial. The aims of this study were to assess the requirement for subsequent cholecystectomy for gallbladder-related symptoms, and to identify the patients who develop symptoms after the endoscopic removal of CBD stones. Methods: Of 241 patients with gallbladder in situ following endoscopic removal of stones from the CBD, 146 patients (78 men and 68 women; mean age 69±13 years, range 20-93) with a follow-up time of more than three months without elective cholecystectomy were enrolled in the study. Fifty-nine patients had gallbladder stones (single stones in 27 and multiple stones in 32) and 87 patients had gallbladder in situ without stones. The time from entry to the occurrences of death or cholecystectomy was evaluated retrospectively. Cox regression analysis was used to evaluate the risk factors associated with these events. Results: The mean duration of follow-up was 24.1±18.0 months (range 3-70 months). During follow-up, seven patients (4.8%) underwent cholecystectomy, on average 18.4 months after CBD stone removal, as the result of acute cholecystitis in four cases, biliary pain in two cases and acute pancreatitis in one case. Laparoscopic cholecystectomy was performed in four patients and open cholecystectomy in three patients. Post-operative morbidity occurred in two patients, with improvement after conservative management. Nine patients (6.2%) died as the result of unrelated biliary disease. Age, sex, presence of gallbladder stones, multiplicity of gallbladder stones and underlying disease did not correlate with subsequent cholecystectomy by Cox regression analysis. Conclusion: Elective cholecystectomy is not warranted in patients with bile duct stones when the common duct can be cleared of stones by endoscopic sphincterotomy. We could not find any clinical predictors of further symptoms or complications arising from the retained gallbladder.

Urine synaptopodin excretion is an important marker of glomerular disease progression

( Soon Kil Kwon ),( Seung Jung Kim ),( Hye-young Kim ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.5

Background/Aims: Podocytes play an important role in maintaining the glo­merular filtration barrier and in formation of the slit diaphragm. Podocyte loss is associated with chronic kidney disease progression, but it is not clear whether urinary podocyte proteins in urine reflect the clinical extent of glomerular dam­age. We investigated the correlation between the amounts of urinary podocyte proteins and renal function and albuminuria. Methods: The study enrolled 33 patients with diabetic kidney disease or glomer­ular disease and measured urinary podocytes proteins using Western blotting. Urinary podocyte proteins were measured according to the density of the bands on Western blotting. We measured serum creatinine and the spot urine albu­min/creatinine ratio as markers of renal damage, and compared the correlation of urinary podocyte protein in the glomerular disease patients. Results: The mean patient age was 49.3 ± 16.5 years, the mean serum creatinine level was 2.30 ± 1.76 mg/dL, and the mean albumin/creatinine ratio was 4.85 ± 3.52. Among the podocyte proteins, urine synaptopodin showed strong correlation with serum creatinine by multivariate regression analysis (p < 0.001) and showed linear correlation (r = 0.429, p < 0.01). Urine podocyte proteins were increased in patients with diabetes, and synaptopodin showed the greatest significant differ­ence (7.68 ± 5.61 vs. 2.56 ± 3.11, p < 0.001), but this might be associated with renal impairment. The urine albumin excretion did not differ between the diabetics and non-diabetics (p = 0.73). Conclusions: Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion.

155미리 곡사포 저호 모듈 장약용 추진제

권순길(Soon-Kil Kwon),정진영(Jin-Young Jung),최재현(Jae-Hyun Choi),이원민(Won-Min Lee) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.5

155mm 곡사포 저호 장약용 추진제로 복기조성을 선정하여 단공원통형 그레인으로 형상 설계하였다. 설계 된 추진제를 155mm 곡사포 저호 모듈 장약에 적용하여 발사 시험한 결과는 저온(-54℃)에서 고온(63℃)까지 부의 차압은 허용치를 만족하였으며 발사 후 약실내에 미연소 잔유물이 없었다. The propellant of bottom charge module for 155mm howitzer was designed as a single-holed cylindrical grain with double-based composition. When the propellant was applied to the bottom charge for 155mm howitzer, the gun fired results showed that the negative differential pressure was satisfied to the range of limitation and there was no residue in the chamber after firing from low(-54℃) to high(63℃) temperature.

안지오텐신 2에 의한 사구체 상피세포 α-Actinin의 변화

권순길 ( Soon Kil Kwon ),하태선 ( Tae Sun Ha ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5

하대정맥과 양쪽 신정맥의 혈전으로 발견된 루프스 신염 1예

권순길 ( Soon Kil Kwon ),김혜영 ( Hye Young Kim ),류동희 ( Dong Hee Rhyu ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1

Poster Session 2 : Production and characterization of human methionine sulfoxide reductase A (hMsrA) monoclonal antibodies

( Hee Soon Choi ),( Sun Hwa Lee ),( Dae Won Kim ),( Soo Hyun Choi ),( So Young Kim ),( Hyeok Yil Kwon ),( Hyung Joo Kwon ),( Jung Hoon Kang ),( Oh Shin Kwon ),( Jin Seu Park ),( Kil Soo Lee ),( Won Si 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-