황색포도알균에 의한 급성 화농성 천골장골관절염 1예

문수연,신준범,김경엽,김석연,문수영,문송미,이미숙 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

저자들은 특별한 위험 인자 없이 심한 허리 및 왼쪽 둔부 통증으로 내원하여 황색포도알균에 의한 균혈증이 진단된 젊은 여성에서 드문 감염질환인 화농성 천골장골관절염과 엉덩근 및 엉덩허리근 농양이 발생된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Pyogenic sacroiliits is a rare disease and the diagnosis is difficult because of unawareness of the disease and nonspecific symptoms and signs mimicking septic hip, iliopsoas muscle abscess and herniation of intervertebral disk. There are some predisposing factors related to the disease like trauma, pregnancy, intravenous drug abuse and infection of other systems such as skin, genitourinary system and heart. Staphylococcus aureus is the most common causative bacteria. Here we describe a case of 27-year-old woman presented with acute onset of back and left buttock pain. Bone scintigraphy revealed increased uptake at left sacroiliac joint and computed tomography of the pelvis showed left sacroiliitis with left iliacus and iliopsoas abscess. There was no history of usual predisposing conditions. S. aureus was grown from blood cultures and the patient improved with 2 weeks of intravenous cefazolin followed by 4 weeks of oral clindamycin treatment.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

-본문참고-

Roll-Mill을 이용한 재생 발포스티렌과 고무 Blend의 기계적 물성

윤형구,박문수,허양일 全南大學校 觸媒硏究所 1998 觸媒硏究 論文集 Vol.20 No.-

In order to recyling expended polystyrene (EPS) wastes, volume-reduced EPS and rubber (NR, SBR) blends were prepared by melting-blending in a injection molder and investigated its mechanical properties such as impact strength and tensile strength. The volume-reduction process of EPS carried out by hot-pressed at 150℃ for 10 min using a roll-mill (called RPS) and compared with a hot-wind contacting method (TPS). Impact strength of RPS/rubber blend a increase of 2-5 times as compared with TPS/rubber blends. When the contents of rubber in RPS/SBR blends were around 15 wt%, maximum tensile modulus was obtained.

포도알균 균혈증 환자에서 사망 예측 위험인자

문수연,이미숙,손준성,이희주,이상오 대한감염학회 2008 감염과 화학요법 Vol.40 No.3

Background : Staphylococcus aureus is a common cause of severe infection and frequently results in death or disability. We investigated potential risk factors influencing clinical outcome in S. aureus bacteremia (SAB). Materials and Methods : Our study is based on retrospective chart review for episodes of SAB from 168 patients, identified between January 2003 and December 2005. Twenty patients were excluded: 2 patients with infective endocarditis and 18 patients with metastatic lesions. Demographic, underlying diseases, sources of SAB, antimicrobial therapy, laboratory, and microbiologic characteristics were identified. Outcome was classified as death or survival 12 weeks after onset of SAB. Results : A total of 97 patients had survived and 51 patients died 12 weeks after the onset of SAB. Death group was older (66.4±13.6 vs. 59.4±14.9 years, P=0.007) and had higher Acute Physiology and Chronic Health Evaluation II system score (17.5±6.3 vs. 13.5±5.1, P<0.001) and the acute physiology score (11.1±5.5 vs. 8.0±4.3, P<0.001). Patients with nosocomial SAB (36 (70.6%) vs. 49 (50.5%), P=0.03] and ineradicable primary source of SAB (46 (90.2%) vs. 66 (68.0%), P=0.005] were more vulnerable to death. Multivariate analysis shows that hospital acquisition [adjusted odds ratio (OR)=2.93), ineradicable primary source (adjusted OR=5.74) and high APACHE II score (adjusted 0R=1.22) lead to higher mortality rate from SAB. Conclusion : Our study shows hospital acquisition, ineradicable primary source, and high APACHE II score are the risk factors related to death from SAB. On the other hand, methicillin resistance or initially ineffective antimicrobial therapy is not much correlated with mortality rate from SAB. 목적 : 황색포도알균은 중증 감염의 흔한 원인이며, 사망하거나 합병증이 발생하는 경우가 종종 있다. 본 연구를 통해 황색포도알균 균혈증 환자에서 임상적 결과에 영향을 미칠 수 있는 위험인자를 확인해 보고자 한다. 재료 및 방법 : 본 연구는 2003년 1월부터 2005년 12월까지 3년간 168 명의 환자에서 발생한 황색포도알균 균혈증에 대해 후향적 의무기록 조사를 바탕으로 이루어졌다. 성별, 나이, 기저 질환, 황색포도알균 균혈증의 원발 병소, 항생제 사용력과 미생물학적 특징에 대한 자료를 모았으며, 균혈증 발생 당시 질환의 중증도는 acute physiology score (APS)와 APACHE II 점수(acute physiology and conic health evaluation II system, APACHE II score)를 이용하여 측정하였다. 결과는 균혈증 발생 12 주 후 사망과 생존으로 나누어 분석하였다. 결과 : 황색포도알균 균혈증 발생 12 주 후 97명의 환자가 생존하였으며, 51명이 사망하였다. 사망 환자 군이 나이가 더 많았으며(66.4±13.6 vs. 59.5±14.9세, P=0.007), APACHE II 점수(17.5±6.3 vs. 13.5±5.1, P<0.001)와 APS (11.1±5.5 vs. 8.0±4.3, P<0.001)가 높았다. 병원 내 감염에 의한 황색포도알균 균혈증 환자[36 (70.62%) vs. 49 (50.5%), P=0.030]와 제거 불가능한 원발 병소를 지닌 경우[46 (90.2%) vs. 66 (68.0%), P=0.005] 사망위험성 이 높았다. 다 변량 분석에 의하면 병원 내 감염[adjusted odds ratio (OR)=2.93]과 제거 불가능한 원발 병소(adjusted OR=5.74), 높은 APACHE II 점수(adjusted 0R=1.22)에 의해 황색포도알균에 의한 사망률이 증가하였다 결론 : 본 연구에서 병원 내 감염과 제거 불가능한 원발 병소, 높은 APACHEH 점수가 황색포도알균 균혈증에 의한 사망과 관련된 위험인자이다. 반면, 메티실린 내성과 초기 부적절한 항생제 사용은 황색포도알균 균혈증의 사망률과 연관성이 없었다.

Q 열에 의한 감염성 심내막염 2예

문수연,최영실,박미연,이정아,정미경,정혜숙,정두련,송재훈,백경란 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Q fever is a zoonosis caused by Coxiella burnetii, Presenting as acute and chronic illness and it has been reported worldwide. Acute Q fever is usually asymptomatic or mild and self-limiting, but infective endocarditis is one of the most serious complications of chronic Q fever and can be fatal. Known risk factors for Q fever endocarditis are valvular heart disease, immunocompromised hosts, and pregnancy. There have been some reports on Q fever in Korea but there exists no report on Q fever endocarditis. We have experienced 2 cases of Q fever with underlying valvular heart disease; both Patients came to the hospital for evaluation of prolonged fever. Although Q fever and Q fever endocarditis are rare in Korea, Q fever endocarditis should be considered in the differential diagnosis of patient with infective endocarditis when causative microorganism cannot be identified.

만성 B형 간염환자에서 인터페론 치료 후 간 조직검사 소견의 변화와 Tumor Necrosis Factor의 임상적 의의

김홍수,윤동진,김은주,정일권,박상흠,이문호,김선주 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background: Interferon has been widely used in the treatment of chronic hepatitis B, but its effectiveness is debatable. The clinical indices as the loss of HBeAg, HBV DNA, and improvement of liver function are applicated to identify the effectiveness of interferon therapy, but the mechanism of hepatohistological change is not well known. We investigated the changes of histologic finding and plasma tumor necrosis factor(TNF) in the patients with chronic hepatitis B after treatment with interferon-alpha. Methods: 11 patients with chronic hepatitis B who had treated by interferon-alpha were enrolled for this study. Liver biopsy was done before and after treatment of interferon and plasma TNF was evaluated at the same time. A semiquantitative study using a histologic scoring system was applied on pre and post liver biopsy specimens and the changes of HBeAg and HBV DNA were also evaluated. Results: Among subjects, the response group, recurrence group, and non-response group based on serologic response with clearance of HbeAg were6, 3, and 2 patients, respectively. The changes of serum ALT level and HBV DNA titer on pre and post therapy decreased significantly in the response group. The change of mean plasma TNF level in the response group decreased insignificantly to 19.4 from 19.9. The histological improvements of grading and staging were shown 4 patients in the response group. Conclusions: Serologic response with clearance of HBeAg was associated with histolofical improvement. The loss of HBsAg in the serum was significant indicator of reduction in the amount of HBV core antigen and HBV surface antigen in the hepatocytes. Plasma TNF level was not associated with response of interferon-alpha therapy and histologic activity.

熱傳達 및 熱損失을 考慮한 冷凍사이클의 解析

金壽淵,文晟基,鄭仁基 嶺南大學校 工業技術硏究所 1986 연구보고 Vol.14 No.2

For the refrigeration system using the reversed Carnot cycle, maximum conditions of effectiveness and available energy output are studied with taking account of the heat transfer between heat sources and the cycle, and of the heat loss due to heat leakage into the cold heat source. The extremum of the effectiveness exists for the variables T₁and T??. Therefore, the desirable results in engineering applications that available energy output is not zero under maximum condition of the effectiveness are obtained. In addition, the extremum of the available energy output does not exists for the variable T₁a but for the variable T??. As the heat loss increases, the availible energy output and the effectiveness decrease, the regions of T₁and T?? where the refrigeration system is possible to operate become smaller.

교합-압박 골수정으로 치료한 대태골 간부 골절의 불유합

박윤수,문영완,성기선 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 내고정술 후 발생한 대퇴골 간부 불유합에서 골절 부에 압박을 가할 수 있는 교합-압박 골수정(IC Nail??, Osteo, Switzerland)을 사용한 동적 압박 골 유합술의 임상적 결과를 보고하고자 하였다. 대상 및 방법: 20명, 21례의 대퇴골 간부 불유합율 교합-압박 골수정 고정술로 치료하였다. 평균 나이는 44 (18~69)세였으며, 골절 후 기준 수술까지 8에서 45 (중앙값 19)개월이 경과하였고, 추시 기간은 6에서 49 (평균 29)개월이었다. 천지료로 폐쇄적 골수정 삽입술이 10례, 개방적 골수정 삽입술이 10례, 금속판 삽입술이 1례였고 17례에서 골이식 및 동역화 (dynamization) 등 한 번 이상의 부가적 시술이 시행되었고, 과혈관성 불유합이 17례, 부혈관성이 3례였으며, 감염성은 1례였다. 시술은 골수강 확공 후 골수정 고정을 하였고, 근위부에 동적 교합 나사못을 삽입한 후 압박 나사를 이용하여 골절 부위를 압박하였고, 골이식은 하지 않았다. 결 과: 1례를 제외한 20례에서 임상적, 방사선학적 유합이 이루어졌다. 방사선학적 유합은 기준 수술 후 4에서 15 (평균 7.4)개월에 이루어졌다. 개방적 골수정 삽입술 후 1회의 골수정 치환술과 2회의 골이식을 받은 36세 남자에서 술 후 12개월까지 유합을 얻지 못했다. 결 론: 확공 후 교합-압박 골수정 삽입술은 초기 치료 방법에 상관 없이 대퇴 간부 불유합의 치료에 효과적인 방법이라 생각된다. 그런, 이전의 골수정 치환술이 실패한 무혈관성 불유합에서는 부가적인 시술이 고려되어야 할 것으로 사료된다. Purpose: To evaluate the effectiveness of a specially designed Interlocking-Compression Nail(IC Nail??, Osteo, Switzerland) which allows compression force across the nonunion site for the treatment of femoral shaft nonunions. Materials and Methods: Between Nov. 1998 and June 2002, twenty one nonunions of femoral shaft fractures in twenty patients were treated with reamed IC nails of larger diameters without bone grafting in 9 men and 11 women, 8 to 45 months after initial operations. Seventeen cases were hypervascular nonunions, 3 avascular, and 1 infected. For initial operation, 10 closed nailing, 10 open nailing and 1 plate fixation were performed. One or more additional procedures had been done in 17 cases prior to IC nailing. Results: The nonunion gap was considerably narrowed from 7.4㎜ to 3.1㎜ with IC nailing and bony unions were achieved in all but one case. The time for radiographic union was 4 to 15 months posteoperatively with an average of 7.4. Conclusion: Reamed IC Nail?? with a larger diameter is an effective procedure for femoral shaft fracture nonunion regardless of initial treatment modalities and even in 3 avascular nonunions, 2 have shown radiographic union without bone grafting. Additional procedures are to be considered in failed surgery of avascular nonunions.

CPPU유도 참다래 단위결과 과실의 특성

조윤섭,조혜성,박문영,박재옥,박태동,김월수 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study was designed to find out an alternative to artificial pollination in kiwifruit production. The parthenocarpic kiwifruits induced by (N-2-chloro-4-pyridyl)-N-phenyl urea (CPPU) treatment tended to be less attractive due to deep furrowing and excessive outgrowth of stigma in mature fruits. Especially, on flower buds after CPPU spray, severe fruit-drop was induced. It was considered enough to spray CPPU at more than 4ppm to attain sufficient fruit set but needed to spray CPPU at more than 16ppm to attain marketable fruit size. When CPPU at 16ppm was sprayed to the same flower once, twice or three time, the fruits received CPPU treatment more time was larger but less attractive. Application of CPPU mare than at 16ppm seemed to be necessary to produce fruits heavier than 80 gr. Enlargement of the fruits received CPPU treatment mainly occurred cross wisely and vertical development was not affected and thickening of outer pericarp primarily contributed to the fruit enlargement. Difference in flesh color or contents of vitamin C and sugars between control fruits and CPPU-treated fruits was not noticed. In conclusion, CPPU treatment to induce parthenocarpic kiwifruits could be commercially applicable, only the method for improving fruit appearance is worked out.

算術平均에 의한 바닥衝擊音 遮音性能 評價에 관한 硏究

장길수,남기봉,문연준 東新大學校 1999 論文集 Vol.11 No.-

It is known that arithmetic mean values of impact sound have an unexpectedly high correlation with the loudness of the sound. This measure is simple and much more easily obtained than the measures specified in tile existing standards. This finding was obtained by psycho-acoustic experiments, however, not by field experiments. This paper aims to specify the relationship between this measure and existing measure, L value by JIS A 1419, and to review the proper range of frequencies to be considered by using 63 data of actual impact sounds for domestic floors. As a result, arithmetic mean values of sound levels showed good correlation with L values. And mean values in octave bands from 125 to 2㎑ were proper for light weight impact sound and those from 125 to 2kH were proper for heavy weight impact sound. In addition it was found that L values(by JIS A 1419) estimated from same floor could be underestimated compared to arithmetic values.