발기부전 검사에서 천연색 복합초음파촬영술과 야간음경발기검사의 일치도

송윤섭,구자현,김민의,이혜경,김두상,박영호,이남규 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

We intended to know that the result of color duplex ultrasonography corresponded to that nocturnal penile tumescence rigidity in the diagnosis of erctile dysfunction. We performed both color duplex ultrasonography and nocturnal penile tumescence rigidity in 15 erectile dysfunction men. Colr duplex ultrasonography was done with a 7 MHz. color Doppler unit after intracorporeal pharmacological injection and measured maximal arterail diameter, peak systolic velocity, end-diastolic velocity and the results were compared with rigidity and tumescence in nocturnal penile tumescence rigidity using RigiScan. The positive predictive value, negative predictive value, sensitivity, specificity, overall accuracy of color duplex ultrasonography was reasonable when the result of color duplex ultrasonography was compared with the that of nocturnal penile tumescence rigidity. According to this results, color duplex ultrasonography could not only predict but also correspond to nocturnal penile tumescence. Therefore, we suggest that color duplex ultrasonography can relpace nocturnal penile tumescence rigidity if psychogenic and neurogenic erectile dysfunction are distinguished by history and neurologic examination.

흰쥐 해마에서 Glycine이 세로토닌 유리에 미치는 영향

송윤섭 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Purpose: Hippocampus contains interneurons where glycine is located, but the connectivity of these has not been well studied. Glycine may influence the serotonergic nervous system through the interneurons. Serotonergic nerve fibers pass through nearly all areas of the hippocampus. We investigate the effects of glycine on serotonin release from rat hippocampal slices for the better understanding of the complex effects of glycine at the hippocampus. Materials and Methods: The hippocampus was obtained from the male rat brain and sliced. The slices were incubated in a buffer containing 0.1mM [^(3)H]5-hydroxytryptamine(5-HT) for uptake. The release of 5-HT into the buffer during each 10 min period was measured and the radioactivities in each buffer and the tissue were counted using liquid scintillation counter and the results were expressed as a percentage of the total activity. After 50 min from the initiation, glycine were administered at 6th and 7th 10 min period respectively. The changes of 5-HT release were expressed as percent values compared to the 5th 10 min period. Results: A steady release of 5-HT was observed up to 100 min after the rapid release during the first 40 min. The 5-HT release during 10 and 20 min of glycine(10_(-6)M) treatment showed no significant change than those of control group. Conclusions: The release of 5-HT was not changed by glycine. This results suggest that glycine does not influence on the serotonergic nervous system that is responsible for the inhibition of the penile erection as well as induction of the penile erection.

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

왜소음경증과 남성 성기능에 관한 연구

송윤섭,김민의,이남규,박영호,전윤수,김응구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Micropenis is defined as a normally formed penis with a size greater than 2 standard deviations below the mean. Twenty three patients with micropenis were managed at Soonchunhyang University Hospital from January 1988 to December 1995 We interviewed and examined them with micropenis to investigate the cause of micropenis, concomitant diseases, the efficacy of treatment and their sexual activity in postpubertal men. The patients were divided into 2 groups: 16 prepubertal and 7 postpubertal men. 9 patients had cryptorchidism, 3 of them were bilateral and 5 patients had hypospadias. Etiology was determined by hormonal assay including HCG stimulation test ; 8 as hypogonadotrophic hypogonadism, 4 as primary testicular dysfunction and 5 as idiopathic. However etiology was undetermined in 6 patients. All patients had endocrine therapy using HCG or depot testosterone. All except 4 cases responded satisfactorily. All postpubertal patients(group 2) were below the 10th percentile. Puberty was delayed in 3 patients in the older group. All patients were heterosexual and they have had erections and orgasms. Five patients have had ejaculations, 3 of them were sexually active and they have experienced vaginal penetration, Nevertheless, their sexual partners have had complaints and the patients themselves have felt ashamed and dissatisfied. Fortunately, they were mentally healthy. None of these patients were married or had a child.

만성전립선염 환자에 있어서 항정자항체의 존재와 정자의 운동성 감소

송윤섭,김민의,박영호 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Chronic prostatitis may be related to the decrease of semen quality affecting fertility due to the existence of antisperm antibody. So we evaluated the characteristics of antisperm antibody in the control group and patients with chronic prostatitis. Statistical significance was noted in average path velocity(VAP), straight line velocity(VSL), curvilinear velocity(VCL), beat frequency(BCF), elongation of sperm motility parameters between the control group and patients with chronic prostatitis. Detection of antisperm antobody with direct and indirect immunobead test were 0%(0/11), 9.1%(1/11) in the control group and 6.3%(1/16), 37.5%(6/16) in the patients with chronic prostatitis. Titers of antisperm antibodies according to isotype (% binding, control group/ patients with chronic prostatitis) were 0/0.63±2.5(IgG), 0/0(IgA), 0.13±0.5/0(IgM) with direct immunobead test and 0.18±0.60/1.19±1.80(IgG), 0/0.06±0.25(IgG), 0/1.25±2.32(IgM) with indirect immunobead test. Statistical significance was noted in VAP, VCL, BCF between chronic prostatitis patients with and without antisperm antibody. The correlation between IgG and VAP, IgG and VCL existed. In conclusion, decreased sperm motility and the antispermantibody were found in chronic prostatitis. The antisperm antibody showed sharp contrast between the control group and the patients by indirect immunobead test, rather than by direct immunobead test. The existence of antisperm antibody correlated with sperm motility in chronic prostatitis.

과민성방광의 비수술적 치료 : 방광의 저장용적을 증가시키는 치료법 Therapy to Increase Bladder Storage Capacity

송윤섭,문기혁,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Overactive bladder including frequency, nocturia, urgency ate common and Its cause is decreased bladder storage capacity. Non-pharmacologic therapy to facilitate bladder storage capacity are behavioral, bladder overdistention or electrical stimulation. For behavioral therapy, patient education about lower urinary tract function, information about lifestyle changes or dietary modification, bladder training which includes instituting intervals of timed voiding and gradually increasing these intervals, pelvic floor physiotherapy with or without biofeedback are necessary. For physically or mentally challenged individuals, schedulled toileting or prompted voiding is necessary, too. Bladder overdistention, electrical stimulation or neuromodulation are also used for the treatment of overactive bladder.

Genestone 190 체외충격파쇄석기를 이용한 요로결석 치료의 초기 경험

김민의,송윤섭,박영호,구자현 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Shock wave lithotripsy monotherapy was performed in 180 patients with urinary calculi using Genestone 190 lithotriptor between January 1996 and April 1998. Age range of the patients was 17 to 71 years (mean of 44.7 years)and male to female ratio was 2.3:1. There were 54 cases(30%) with renal calculi and 126 cases (70%) with ureteral calculi. NO regional or general anesthesia was required, but parenteral analgesics were required in some patients. The spark voltage was from 16 to 22Kv and average numbers were 2.04 sessions and the mean number of shock per session was 2230±350. The success rates of urinary calculi below 5㎜, 6-10㎜, 11-15㎜, 16-20㎜ and over 21㎜ were 95%, 94%, 91%,75% and 50%, respectively. The success rates of renal, midureter and lower ureter calculi were 85%, 98% and 73%, respectively. There were no significant complications. We think that SWL monotherapy using Genestone 190 lithotriptor is effective and safe procedure for calculi of kidney and upper ureter and calculi below 15㎜.

여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

촉매 코팅방법에 따른 기능성 여과포의 NO 제거 반응 특성

강민필,송윤섭,이효송,김상도,박영옥,황택성,이영우 한국화학공학회 2002 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.40 No.6

NO_x와 먼지 동시 제거용 기능성 여과포 개발의 일환으로 V_2O_5/TiO_2계열의 상용촉매를 사용하여 P-84, Nomex, PTFE 여과포에 코팅하였다. 사용된 코팅 방법은 Sol-gel법, Spray법 그리고 Dip코팅 방법이었으며 코팅방법이 여과포의 NO_x 제거반응에 미치는 영향을 조사하였다. NO_x 제거반응실험은 여과포의 작동온도에 맞는 100-250℃의 반응온도범위에서, 공간속도 5,000hr^-1, 산소농도 6%, NH_3/NO 몰비는 1.0의 조건하에서 수행되었다. 본 연구에서 시도된 세 가지 코팅 방법 중 촉매량의 조절 및 균일한 코팅이 용이한 Sol-gel법에 의해 제조된 기능성여과포가 가장 좋은 NO_x 전환율을 나타냈다. A series of fabric filters including P-84, Nomex and PTFE were coated with a commercial V_2O_5/TiO_2 catalyst as an effort to develop a functional fabric filter of simultaneous removal of dust and NO_x. The coating methods employed are solgel coating method, spray coating method and dip coating method, and the effects of coating method on NO_x removal performance of functional fabric filter were investigated. Experimental conditions are as follows: the temperatures of 100-250℃ which are the normal operating temperature range of fabric filters, the space velocity of 5,000hr^-1, the oxygen concentration of 6%, and the NH_3/NO ratio of 1.0. Results showed that the sol-gel coating method gave the best NO_x removal performance mainly due to its ability in controlling the amount of catalyst and uniform coating.

항정자항체 평가에 있어서 정장액 interleukin-6 측정의 유용성

김민의,박영호,송윤섭 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Breakdown of the blood-testis barrier by infection, trauma, or operation allows sensitization of spermatozoal antigens. Sperm antibodies may be a relative cause of infertility in infertile males. Multiple assay techniques have been developed to detect antisperm antibody. Older tests have been supplanted by the newer immunoglobulin specific assays. Immunobead test was used widely. Interleukin(IL)-6 is necessary for formation of antibody. So, this study was performed to investigate the value of interleukin-6 in the detection of immunologic cause of infertility. The antisperm antibody titers and interleukin-6 was measured in 10 healthy males and 30 patients with chronic prostatitis using immunobead methods and enzyme immunoassay kit. Titers of direct and indirect IgG, IgA and IgM antisperm antibody(% binding) was 0/0.7±0.7, 0/0, 0/0.1±0.1 and 0/1.1±0.5, 0/0.1±0.06, 0/1.1±0.6 in control group and patients with chronic prostatitis. Titers of direct and indirect IgG, IgA and IgM antisperm antibody was 1.8±1.7,0, 0.3±0.3 and 0.3±0.9, 0, 2.8±1.1 in patients with chronic prostatitis whom the antisperm antibody was found in. There was significant difference in indirect IgG and IgM between control group and patients with chronic prostatitis whom the antisperm antibody was found in. The value of seminal IL-6(pg/ml) was 3.2±0.9 and 9.6±2.3 in control group and patients with chronic prostatitis. There was significant difference. The value of seminal IL-6 was 7.0±2.7 and 13.4±5.1 in patients without chronic prostatitis and patients with chronic prostatitis. There was no significant difference. It is suggested that the examination of seminal IL-6 alone can be useful to evaluate the immunologic state of seminal tract but can not take the place of Immunobead test that detect the antisperm antibody formation.