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Kyung-Lak Son,Dooyoung Jung,Kwang-Min Lee,Chan-Woo Yeom,Gyu Han Oh,Tae-Yong Kim,Seock-Ah Im,Kyung-Hun Lee,David Spiegel,Bong-Jin Hahm 대한의학회 2022 Journal of Korean medical science Vol.37 No.5
Background: The purpose of this longitudinal prospective cohort study was to investigate the role of chronotype in the incidence of chemotherapy-induced peripheral neuropathy (CIPN) among women with breast cancer. Methods: We recruited women with breast cancer awaiting adjuvant chemotherapy, including four cycles of docetaxel. Participants reported peripheral neuropathy symptoms of numbness/ tingling at the baseline, and at 4weeks after completion of chemotherapy. Candidate psychiatric factors associated with CIPN were assessed at the baseline, using the Composite Scale of Morningness, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale. To examine the association between chronotype and CIPN, we built logistic regression models, adjusting for demographic, clinical, and other psychiatric variables. Results: Among 48 participants, 29 participants developed CIPN. The morning chronotype was inversely associated with CIPN (odds ratio, 0.06; confidence interval, 0.01–0.74; P = 0.028) after adjusting for age, BMI, education, type of operation, alcohol use, smoking, sleep quality, depression, and anxiety. Conclusion: Our results suggest that the morning chronotype is a protective factor against the development of CIPN in patients with breast cancer who were treated with docetaxel.
Allegretto Component 를 이용한 슬관절 부분 치환술
김병순,배대경,소재근,손용락 대한슬관절학회 1994 대한슬관절학회지 Vol.6 No.2
There is some controversy regarding long term suvivorship of unicompartmental knee arthroplasty compared to total knee arthroplasty. In unicompartmental knee arthroplasty, wear and loosening may shorten the survivorship due to stress lacalized to the small area of components. For that reason exact central tracking of femoral component relative to the tibial component is important for preventing wear and loosening of the components. Twenty seven unicompartmental knee arthroplasties using Aregretto components were performed in nineteen patients between June 1992 and July 1993 at the Department of Orthopaedic Surgery, Kyung Hee University, The purpose of this paper is to analyze the preliminary clinical results and to evaluate the tracking of camponents radiologically. The average age at the time of operation was 59.1 years and follow-up period was from one to two years. Functional assessments including rating by Hospital for Special Surgery knee score were conducted. Radiologically we measured the distance from center of the tibial component to center of the femoral component on anteroposterior roentgenogram. 1. The preoperative diagnosis was osteoarthritis in 16 patients, osteonecrosis in two patients and rheumatoid arthritis in one patient. Twenty six knees had undergone medial compartment arthreplasty and one knee had undergone latera1 compartment arthroplasty. 2. The average preoperative range of motion was 127.0 degress and the average postoperative range of motion was 136.1 degrees. 3. The average preoperative knee rating score was 61.1 points and postoperaively average score improved to 89.0 points. 4. The center of femoral component was displaced medially from the center of tibia1 component in 16 knees, laterally in seven knees and was not displaced in four knees. The average displacement of central tracking was 2.3mm (range, 0-6mm). 5. Regarding central tracking, there was no significant difference of clinical results depending on the amount of displacement in our cases.
Choi Jung-In,Jung Sanghyup,Oh Gyu Han,Son Kyung-Lak,Kwang-Min Lee,Jung Dooyoung,Kim Tae-Yong,Im Seock-Ah,Lee Kyung-Hun,Min-Sup Shin,Hahm Bong-Jin,염찬우 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.11
Objective Pre-treatment anxiety (PA) before chemotherapy increases complaints of chemotherapy-related symptoms (CRS). The results on the association have been inconsistent, and the effect of temperament remains unclear. We aimed to determine whether PA is a risk factor for CRS and the effect of differing temperaments on CRS.Methods This prospective study comprised 176 breast cancer patients awaiting adjuvant chemotherapy post-surgery. We assessed CRS, PA, and temperament using the MD Anderson Symptom Inventory (MDASI), the Hospital Anxiety and Depression Scale, and the short form of the Temperament and Character Inventory-Revised, respectively. The MDASI was re-administered three weeks after the first chemo-cycle.Results PA showed weak positive correlation with several CRS after the first cycle; no CRS was significantly associated with PA when pre-treatment depressive symptoms and baseline CRS were adjusted in multiple regression analysis. Moderation model analysis indicated that the PA effect on several CRS, including pain, insomnia, anorexia, dry mouth, and vomiting, was moderated by harm avoidance (HA) but not by other temperament dimensions. In particular, PA was positively associated with CRS in patients with low HA.Conclusion The results in patients with low HA indicate that more attention to PA in patients with confident and optimistic temperaments is necessary.
Saim Jung,Joon Sung Shin,Sun Hyung Lee,Sungwon Lee,Jaehyun Kim,Kyung-Lak Son,Bong-Jin Hahm,Chan-Woo Yeom 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.2
Objective This study aimed to develop and validate the Korean version of the Somatic Symptom Disorder-B Criteria Scale (SSD-12) in outpatients at a psychiatric clinic and assess its diagnostic accuracy.Methods A total of 207 patients completed SSD-12. For the diagnostic accuracy of SSD-12, the somatic symptom disorder (SSD) section of the structured clinical interview for DSM-5 disorders-research version (SCID-5-RV) was used. The SSD-12 construct and concurrent validity were assessed by examining the correlations with Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), PHQ-15, 5-level EQ-5D version (EQ-5D-5L), and World Health Organization Quality of Life Brief Version (WHOQOL-BREF).Results The SSD-12 had excellent internal consistency (Cronbach α=0.90). Confirmatory factor analysis revealed good fit indices for a general factor model (comparative fit index [CFI]=0.92, Tucker-Lewis index [TLI]=0.88, root mean square error of approximation [RMSEA]=0.10; 95% confidence interval [CI], 0.08–0.11) and a three-factor model (CFI=0.94, TLI=0.91, RMSEA=0.08; 95% CI, 0.07–0.10). The total SSD-12 score was significantly correlated with anxiety (GAD-7: r=0.53, p<0.001), depression (PHQ-9: r=0.52, p<0.001), physical symptom burden (PHQ-15: r=0.36, p<0.001), and quality of life (EQ-5D-5L: r=-0.40, p<0.001; WHOQOL-BREF: r=-0.51, p<0.001). SSD-12 demonstrated good accuracy (area under the curve=0.75, standard error=0.04; 95% CI, 0.68–0.82) with an optimal cut-off of 29.Conclusion The Korean SSD-12 demonstrates reliability and validity for diagnosing SSD in clinical setting.
Choi Yoon Jin,이용찬,Kim Jung Mogg,Kim Jin Il,Moon Jeong Seop,Lim Yun Jeong,백광호,Son Byoung Kwan,Lee Hang Lak,Kim Kyoung Oh,Kim Nayoung,Ko Kwang Hyun,Jung Hye-Kyung,Shim Ki-Nam,Chun Hoon Jai,Kim Byung-Woo 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.4
Background/Aims: We examined the efficacy and safety of tegoprazan as a part of first-line triple therapy for Helicobacter pylori eradication. Methods: A randomized, double-blind, controlled, multicenter study was performed to evaluate whether tegoprazan (50 mg)-based triple therapy (TPZ) was noninferior to lansoprazole (30 mg)- based triple therapy (LPZ) (with amoxicillin 1 g and clarithromycin 500 mg; all administered twice daily for 7 days) for treating H. pylori. The primary endpoint was the H. pylori eradication rate. Subgroup analyses were performed according to the cytochrome P450 (CYP) 2C19 genotype, the minimum inhibitory concentration (MIC) of amoxicillin and clarithromycin, and underlying gastric diseases. Results: In total, 350 H. pylori-positive patients were randomly allocated to the TPZ or LPZ group. The H. pylori eradication rates in the TPZ and LPZ groups were 62.86% (110/175) and 60.57% (106/175) in an intention-to-treat analysis and 69.33% (104/150) and 67.33% (101/150) in a per-protocol analysis (non-inferiority test, p=0.009 and p=0.013), respectively. Subgroup analyses according to MICs or CYP2C19 did not show remarkable differences in eradication rate. Both first-line triple therapies were well-tolerated with no notable differences. Conclusions: TPZ is as effective as proton pump inhibitor-based triple therapy and is as safe as first-line H. pylori eradication therapy but does not overcome the clarithromycin resistance of H. pylori in Korea (ClinicalTrials.gov identifier NCT03317223).
Protective Effects of Chlorella vulgaris on Liver Toxicity in Cadmium-Administered Rats
Jae-Young Shim,Hye-seoung Shin,Jae-Gab Han,Hyeung-Suk Park,Byung-Lak Lim,Kyung-Won Chung,Ae-Son Om 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
The biochemical mechanisms of Chlorella vulgaris protection against cadmium (Cd)-induced liver toxicity were investigated in male Sprague-Dawley rats (5 weeks of age, weighing 90–110 g). Forty rats were randomly divided into one control and three groups treated with 10 ppm Cd: one Cd without Chlorella (Cd-0C), one Cd with 5% Chlorella (Cd-5C), and one Cd with 10% Chlorella (Cd-10C) groups. The rats had free access to water and diet for 8 weeks. Body weight gain and relative liver weight were significantly lower in the Cd-0C group than in Cd-5C and Cd-10C groups. Rats in the Cd-0C group had significantly higher hepatic concentrations of Cd and metallothioneins (MTs) than in the Cd-5C or Cd-10C group. The hepatic MT I/II mRNA was expressed in all experimental rats. MT II was more expressed in the Cd-5C and Cd-10C groups than in the Cd-0C group. Morphologically, a higher level of congestion and vacuolation was observed in the livers of the Cd-0C group compared to those of the Cd-5C and Cd-10C groups. Therefore, this study suggests that C. vulgaris has a protective effect against Cd-induced liver damage by reducing Cd accumulation and stimulating the expression of MT II in liver. However, the details of the mechanism of C. vulgaris on liver toxicity remains to be clarified by further studies.