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Functional role of TFG in collagen synthesis in human dermal fibroblast
( So Jung Kong ),( Jeong Min Ha ),( Sue Jeong Kim ),( Yun Hee Chang ),( Young Ah Shin ),( Hae Eul Lee ),( Myung Im ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ),( Young Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: TFG encodes a protein which is a conserved regulator of protein secretion and controls the export of materials from the endoplasmic reticulum. There is no paper about functional role of TFG in skin except TFG works as a tumor suppressor gene in metastatic melanoma. Objectives: We investigated the use of genome-wide association study (GWAS) to explore molecular basis of skin phenotype of wrinkle and the effect of TFG on collagen and matrix metalloproteinase expression in human dermal fibroblasts. Methods: A GWAS was conducted to investigate the genetic factors influencing wrinkle formation in Korean females along with molecular studies of genes in human dermal fibroblasts for functional study in vitro.Results: GWAS identified 24 SNPs that were highly associated with skin wrinkle. Among the genes, we investigated the effect of TFG gene in human dermal fibroblasts. When TFG was overexpressed, COL1A1 and COL1A2 protein level were increased and UVB decreased the expression of COL1A1, COL1A2 and TFG. Conclusion: The results suggest that TFG is a positive regulator on collagen expression in dermal fibroblasts. And our results suggest that genetic variants in the intronic region of TFG could be determinants in the wrinkle formation of Korean females.
Loss and efficiency comparisons of single‑phase full‑bridge inverters according to switch structures
So-Jeong Kong,Young-Joo Kim,Jin-Su Kim,Jae-Hyuck Choi,Jun-Young Lee 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.2
The purpose of this study is to analyze the performances of the single-phase full-bridge inverter according to different switch structures and to propose a cost-effective structure that depends on the operating area of the inverter. The five switch structures considered are: (1) insulated-gate bipolar transistor (IGBT) type, (2) resonance type based on IGBTs, (3) SiC FET type, (4) Si FET type, and 5) hybrid type, using both Si FET and IGBTs. According to each switch structure, the consistency of the analytical formula is verified by theoretical loss analyses, prototype experiments, and comparative analyses. Additionally, by comparing the prices and efficiencies of each structure, a suitable structure can be selected depending on the operating area. For the performance comparisons, 3 kW inverters with direct current (DC) input voltages of 400 V and 700 V and an output voltage of 220 Vac/60 Hz are implemented and tested at switching frequencies of 20 kHz and 40 kHz.
Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene Expression Through FXRα Suppression
Seong Mi So,Jang Jeong Ah,Jeong Ye Rim,Kim Ye Bin,Kyaw Yi Yi,Kong Hee Jeong,Lee Jung-Hyun,Cheong JaeHun 한국미생물학회 2023 The journal of microbiology Vol.61 No.7
Fibroblast growth factor 11 (FGF11) is a member of the intracellular FGF family, which shows different signal transmission compared with other FGF superfamily members. The molecular function of FGF11 is not clearly understood. In this study, we identified the inhibitory effect of FGF11 on hepatitis B virus (HBV) gene expression through transcriptional suppression. FGF11 decreased the mRNA and protein expression of HBV genes in liver cells. While the nuclear receptor FXRα1 increased HBV promoter transactivation, FGF11 decreased the FXRα-mediated gene induction of the HBV promoter by the FXRα agonist. Reduced endogenous levels of FXRα by siRNA and the dominant negative mutant protein (aa 1–187 without ligand binding domain) of FXRα expression indicated that HBV gene suppression by FGF11 is dependent on FXRα inhibition. In addition, FGF11 interacts with FXRα protein and reduces FXRα protein stability. These results indicate that FGF11 inhibits HBV replicative expression through the liver cell-specific transcription factor, FXRα, and suppresses HBV promoter activity. Our findings may contribute to the establishment of better regimens for the treatment of chronic HBV infections by including FGF11 to alter the bile acid mediated FXR pathway.