The Association of Ponticulus Posticus & Elongated Styloid Process with Headaches

Shivani Sharma,Rakesh Nagaraju,Shweta Sharma 대한안면통증∙구강내과학회 2018 Journal of Oral Medicine and Pain Vol.43 No.3

Purpose: The present study was designed to investigate the association of ponticulus posticus(PP) and elongated styloid process (ESP) with headaches. Methods: Analysis of head and neck cone beam computed tomography samples from the archivesof the Department of Oral Radiology was done for the presence of partial or completePP and ESP length, type, thickness, mediolateral angulation, anterioposterior angulation (horizontal& vertical), lateral or medial curvature. This was followed by personal & telephonicquestionnaires to the subjects for the evaluation of the presence of headaches & other associatedsymptoms. Results: Among 134 subjects, 62 subjects (46.3%) presented with headache and 72 subjects(53.7%) did not have any headache. On further analysing the total 62 subjects with headache,it was found out that 31 subjects (50.0%) of them had ESP and PP both, 16 subjects (25.8%)had only ESP, and 15 subjects (24.2%) had only PP. A strong association was present betweenheadache and presence of PP & ESP individually and together. Conclusions: All health care professionals dealing with the head and neck pain disordersshould also consider the presence of ESP & PP during diagnosis and treatment.

The Association of Ponticulus Posticus & Elongated Styloid Process with Headaches

Sharma, Shivani,Nagaraju, Rakesh,Sharma, Shweta Korean Academy of Orofacial Pain and Oral Medicine 2018 Journal of Oral Medicine and Pain Vol.43 No.3

Purpose: The present study was designed to investigate the association of ponticulus posticus (PP) and elongated styloid process (ESP) with headaches. Methods: Analysis of head and neck cone beam computed tomography samples from the archives of the Department of Oral Radiology was done for the presence of partial or complete PP and ESP length, type, thickness, mediolateral angulation, anterioposterior angulation (horizontal & vertical), lateral or medial curvature. This was followed by personal & telephonic questionnaires to the subjects for the evaluation of the presence of headaches & other associated symptoms. Results: Among 134 subjects, 62 subjects (46.3%) presented with headache and 72 subjects (53.7%) did not have any headache. On further analysing the total 62 subjects with headache, it was found out that 31 subjects (50.0%) of them had ESP and PP both, 16 subjects (25.8%) had only ESP, and 15 subjects (24.2%) had only PP. A strong association was present between headache and presence of PP & ESP individually and together. Conclusions: All health care professionals dealing with the head and neck pain disorders should also consider the presence of ESP & PP during diagnosis and treatment.

FPGA Based Energy Efficient Universal Asynchronous Receiver Transmitter Design Using Thermal Scaling

Rashmi Sharma,Shivani Sharma,Paresh Khaneja,Navya Bhasin,Vanshaj Taxali 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.6

This paper throws light on the behavior of the UART in response to the variations in the junction temperature. Analysis has been done to find the most ideal temperature range for the operation of the UART. After all the calculations, deduction comes to a point that lowering the temperature values increases the efficiency of the UART significantly since the losses due to the leakage power are reduced to a minimum value when the temperature is decreased. Significant reduction in the percentage of leakage power is seen as the temperature is lowered. Implementation has been done on the FPGA generations Virtex-6, Virtex-5, Virtex-4 using XILINX simulator and Verilog Hardware Description Language. Different reduction percentages have been observed within a range of 8% to 37.4% for the leakage power and 16.8% to 69.3%for the ambient temperature as the results are obtained for frequency values of 1GHz and 1MHz. Thus various power loss parameters have been studied to get the best energy efficient UART.

Radiative and seesaw threshold corrections to the _{S 3} symmetric neutrino mass matrix

Gupta, Shivani,Kim, C.S.,Sharma, Pankaj North-Holland Pub. Co 2015 Physics letters. Section B Vol.740 No.-

<P><B>Abstract</B></P> <P>We systematically analyze the radiative corrections to the <SUB> S 3 </SUB> symmetric neutrino mass matrix at high energy scale, say the GUT scale, in the charged lepton basis. There are significant corrections to the neutrino parameters both in the Standard Model (SM) and Minimal Supersymmetric Standard Model (MSSM) with large tan ⁡ β , when the renormalization group evolution (RGE) and seesaw threshold effects are taken into consideration. We find that in the SM all three mixing angles and atmospheric mass squared difference are simultaneously obtained in their current 3<I>σ</I> ranges at the electroweak scale. However, the solar mass squared difference is found to be larger than its allowed 3<I>σ</I> range at the low scale in this case. There are significant contributions to neutrino masses and mixing angles in the MSSM with large tan ⁡ β from the RGEs even in the absence of seesaw threshold corrections. However, we find that the mass squared differences and the mixing angles are simultaneously obtained in their current 3<I>σ</I> ranges at low energy when the seesaw threshold effects are also taken into account in the MSSM with large tan ⁡ β .</P>

Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines by SiO₂/P₂O₅-SeO₂ under Mild and Heterogeneous Conditions

Paul, Satya,Sharma, Shivani,Gupta, Monika,Choudhary, Deepak,Gupta, Rajive Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.2

Diverse characters of Brennan’s paw incision model regarding certain parameters in the rat

Rahul Kumar Sharma,Shivani Gupta,Mayank Gautam,Saroj Kaler Jhajhria,Subrata Basu Ray 대한통증학회 2019 The Korean Journal of Pain Vol.32 No.3

Background: Brennan’s rodent paw incision model has been extensively used for understanding mechanisms underlying postoperative pain in humans. However, alterations of physiological parameters like blood pressure and heart rate, or even feeding and drinking patterns after the incision have not been documented as yet. Moreover, though eicosanoids like prostaglandins and leukotrienes contribute to inflammation, tissue levels of these inflammatory mediators have never been studied. This work further investigates the antinociceptive effect of protein C after intra-wound administration.Methods: Separate groups of Sprague–Dawley rats were used for quantitation of cyclooxygenase (COX) activity and leukotriene B4 level by enzyme-linked immunosorbent assay, as well as estimation of cardiovascular parameters and feeding and drinking behavior after paw incision. In the next part, rats were subjected to in-cision and 10 g of protein C was locally administered by a micropipette. Both evoked and non-evoked pain parameters were then estimated.Results: COX, particularly COX-2 activity and leukotriene B4 levels increased after incision. Hemodynamic parameters were normal. Feeding and drinking were affected on days 1 and 3, and on day 1, respectively. Protein C attenuated non-evoked pain behavior alone up to day 2. Conclusions: Based upon current observations, Brennan’s rodent paw incision model appears to exhibit a prolonged period of nociception similar to that after surgery, with minimal interference of physiological parameters. Protein C, which is likely converted to activated protein C in the wound, attenuated the guarding score, which probably represents pain at rest after surgery in humans.

Dosimetric comparison of IMRT versus 3DCRT for post-mastectomy chest wall irradiation

Rastogi, Kartick,Sharma, Shantanu,Gupta, Shivani,Agarwal, Nikesh,Bhaskar, Sandeep,Jain, Sandeep The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. Materials and Methods: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-$D_{near-max}$ ($D_2$), $D_{near-min}$ ($D_{98}$), $D_{mean}$, $V_{95}$, and $V_{107}$-homogeneity index (HI), and conformity index (CI) were compared. The mean doses of lung and heart, percentage volume of ipsilateral lung receiving 5 Gy ($V_5$), 20 Gy ($V_{20}$), and 55 Gy ($V_{55}$) and that of heart receiving 5 Gy ($V_5$), 25 Gy ($V_{25}$), and 45 Gy ($V_{45}$) were extracted from dose-volume histograms and compared. Results: PTV parameters were comparable between the two groups. CI was significantly improved with IMRT (1.127 vs. 1.254, p < 0.001) but HI was similar (0.094 vs. 0.096, p = 0.83) compared to 3DCRT. IMRT in comparison to 3DCRT significantly reduced the high-dose volumes of lung ($V_{20}$, 22.09% vs. 30.16%; $V_{55}$, 5.16% vs. 10.27%; p < 0.001) and heart ($V_{25}$, 4.59% vs. 9.19%; $V_{45}$, 1.85% vs. 7.09%; p < 0.001); mean dose of lung and heart (11.39 vs. 14.22 Gy and 4.57 vs. 8.96 Gy, respectively; p < 0.001) but not the low-dose volume ($V_5$ lung, 61.48% vs. 51.05%; $V_5$ heart, 31.02% vs. 23.27%; p < 0.001). Conclusions: For left sided breast cancer, IMRT significantly improves the conformity of plan and reduce the mean dose and high-dose volumes of ipsilateral lung and heart compared to 3DCRT, but 3DCRT is superior in terms of low-dose volume.

Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines by SiO2/P2O5-SeO2 under Mild and Heterogeneous Conditions

Satya Paul*,Shivani Sharma,Monika Gupta,Deepak Choudhary,Rajive Gupta 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.2

Nanoemulsions loaded Carbopol® 934 based gel for intranasal delivery of neuroprotective Centella asiatica extract: in–vitro and ex–vivo permeation study

Maneesh Jaiswal,Arun Kumar,Shivani Sharma 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.1

The objective of the present study was to develop a formulation for sustained release of phytotherapeutics through nasal membrane for brain targeting (anti- Alzheimer) in order to overcome their low residence time and poor nasal permeability issues. A dual approach containing nanoemulsions within gel (NE-gels) was used to achieve the objectives utilizing biocompatible biomaterials. Nanoemulsions were characterized for particle size and zeta potential. NE-gels loaded with Centella asiatica (CA) extract were developed using Carbopol® 934 and were characterized for rheological properties (spreadability, viscosity), drug release and prolong anti-oxidant profile. In vitro nasal permeation and free radical scavenging activity were performed to investigate their expected sustained pharmacological responses. With increasing Carbopol ® content, viscosity of NE-gels was found to increase up to 6237.3 ± 1.1 cp which adversely influenced the spreadability (3.06 ± 0.98) of the NE-gels. Enhancement in sustained release of the CA extract across the nasal membrane (four fold; up to 48 h) as well as retention time in nasal cavity (four fold; i.e. 48 h) were observed with NEgels in comparison to CA solution (i.e. 12 h). In vitro nasal permeation study showed 10 folds enhancement of percentage drug permeation across the nasal mucosa in comparison to extract solution while three folds increase in free radical scavenging activity was observed by NE-gel (i.e.48 h) in comparison to nanoemulsion (i.e. 24 h), respectively. Extensive in vitro investigation established these nanocarriers as suitable nanoformulations for brain targeting of water insoluble phytochemicals.

Dosimetric comparison of IMRT versus 3DCRT for post-mastectomy chest wall irradiation

Kartick Rastogi,Shantanu Sharma,Shivani Gupta,Nikesh Agarwal,MBBS,Sandeep Bhaskar,Sandeep Jain 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. Materials and Methods: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-D near-max (D 2 ), D near-min (D 98 ), D mean , V 95 , and V 107 -homogeneity index (HI), and conformity index (CI) were compared. The mean doses of lung and heart, percentage volume of ipsilateral lung receiving 5 Gy (V 5 ), 20 Gy (V 20 ), and 55 Gy (V 55 ) and that of heart receiving 5 Gy (V 5 ), 25 Gy (V 25 ), and 45 Gy (V 45 ) were extracted from dose-volume histograms and compared. Results: PTV parameters were comparable between the two groups. CI was significantly improved with IMRT (1.127 vs. 1.254, p < 0.001) but HI was similar (0.094 vs. 0.096, p = 0.83) compared to 3DCRT. IMRT in comparison to 3DCRT significantly reduced the high-dose volumes of lung (V 20 , 22.09% vs. 30.16%; V 55 , 5.16% vs. 10.27%; p < 0.001) and heart (V 25 , 4.59% vs. 9.19%; V 45 , 1.85% vs. 7.09%; p < 0.001); mean dose of lung and heart (11.39 vs. 14.22 Gy and 4.57 vs. 8.96 Gy, respectively; p < 0.001) but not the low-dose volume (V 5 lung, 61.48% vs. 51.05%; V 5 heart, 31.02% vs. 23.27%; p < 0.001). Conclusions: For left sided breast cancer, IMRT significantly improves the conformity of plan and reduce the mean dose and high-dose volumes of ipsilateral lung and heart compared to 3DCRT, but 3DCRT is superior in terms of low-dose volume.