Dendrosomal Curcumin Suppresses Metastatic Breast Cancer in Mice by Changing M1/M2 Macrophage Balance in the Tumor Microenvironment

Shiri, Sadaf,Alizadeh, Ali Mohammad,Baradaran, Behzad,Farhanghi, Baharak,Shanehbandi, Dariush,Khodayari, Saeed,Khodayari, Hamid,Tavassoli, Abbas Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as well as 40 and 80 mg/kg groups of DNC to investigate the involvement of macrophages in the antitumor effects of curcumin in a typical animal model of metastatic breast cancer. At the end of intervention, the tumor volume and weight were significantly reduced in DNC groups compared to control (P<0.05). Histopathological data showed the presence of macrophages in tumor and spleen tissues. Real-time PCR results showed that DNC increased the expression of STAT4 and IL-12 genes in tumor and spleen tissues in comparison with control (P<0.05), referring to the high levels of M1 macrophages. Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage. The results confirm the role of macrophages in the protective effects of dendrosomal curcumin against metastatic breast cancer in mice.

Optimal Design of Low-Speed Secondary-Sheet Single-Sided Linear Induction Motor

Shiri, Abbas,Shoulaie, Abbas The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3

Among different linear motors, single-sided linear induction motors have been widely used in industry due to their simplicity and low construction cost. However, these types of motors suffer from low efficiency and power factor. In this paper, an effective procedure is proposed to design single-sided linear induction motors. The designed motor is simulated in MATLAB software in order to investigate the effect of design parameters on the performance of the machine. Regarding the obtained results, the Genetic Algorithm is employed to optimize the design considering product of efficiency and power factor as objective function. The results show significant improvement of the performance. Finally, experimental results and 2D finite element method is used to validate the model parameters and the optimization results.

The caspase-3 inhibitor (peptide Z-DEVD-FMK) affects the survival and function of platelets in platelet concentrate during storage

Reza Shiri,Fatemeh Yari,Minoo Ahmadinejad,Shahram Vaeli,Mohammad Reza Tabatabaei 대한혈액학회 2014 Blood Research Vol.49 No.1

Background Although apoptosis occurs in nucleated cells, studies show that this event also occurs in some anucleated cells such as platelets. During storage of platelets, the viability of platelets decreased, storage lesions were observed, and cells underwent apoptosis. We investigated the effects of caspase-3 inhibitor on the survival and function of platelets after different periods of storage. Methods Platelet concentrates were obtained from the Iranian Blood Transfusion Organization in plastic blood bags. Caspase-3 inhibitor (Z-DEVD-FMK) was added to the bags. These bags along with control bags to which no inhibitor was added were stored in a shaking incubator at 22℃ for 7 days. The effects of Z-DEVD-FMK on the functionality of platelets were analyzed by assessing their ability to bind to von Willebrand factor (vWF) and to aggregate in the presence of arachidonic acid and ristocetin. Cell survival was surveyed by MTT assay. Background Although apoptosis occurs in nucleated cells, studies show that this event also occurs in some anucleated cells such as platelets. During storage of platelets, the viability of platelets decreased, storage lesions were observed, and cells underwent apoptosis. We investigated the effects of caspase-3 inhibitor on the survival and function of platelets after different periods of storage. Methods Platelet concentrates were obtained from the Iranian Blood Transfusion Organization in plastic blood bags. Caspase-3 inhibitor (Z-DEVD-FMK) was added to the bags. These bags along with control bags to which no inhibitor was added were stored in a shaking incubator at 22℃ for 7 days. The effects of Z-DEVD-FMK on the functionality of platelets were analyzed by assessing their ability to bind to von Willebrand factor (vWF) and to aggregate in the presence of arachidonic acid and ristocetin. Cell survival was surveyed by MTT assay. Results At day 4 of storage, ristocetin-induced platelet aggregation was significantly higher in the inhibitor-treated (test) than in control samples; the difference was not significant at day 7. There was no significant difference in arachidonic acid-induced platelet aggregation between test and control samples. However, at day 7 of storage, the binding of platelets to vWF was significantly higher in test than in control samples. The MTT assay revealed significantly higher viability in test than in control samples at both days of study. Conclusion Treatment of platelets with caspase-3 inhibitor could increase their functionality and survival.

Analysis of thin composite structures using an efficient hex-shell finite element

Seddik Shiri,Hakim Naceur 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.12

In this paper a general methodology for the modeling of material composite multilayered shell structures is proposed using a Hex-shell finite element modeling. The first part of the paper is devoted to the general FE formulation of the present composite 8-node Hex-shell element called SCH8, based only on displacement degrees of freedom. A particular attention is given to alleviate shear, trapezoidal and thickness locking, without resorting to the classical plane-stress assumption. The anisotropic material behavior of layered shells is modeled using a fully three dimensional elastic orthotropic material law in each layer, including the thickness stress component. Applications to laminate thick shell structures are studied to validate the methodology, and good results have been obtained in comparison with ABAQUS© commercial code.

The caspase-3 inhibitor (peptide Z-DEVD-FMK) affects the survival and function of platelets in platelet concentrate during storage

Reza Shiri,Fatemeh Yari,Minoo Ahmadinejad,Shahram Vaeli,Mohammad Reza Tabatabaei 대한혈액학회 2014 Blood Research Vol.49 No.1

Background Although apoptosis occurs in nucleated cells, studies show that this event also occurs in some anucleated cells such as platelets. During storage of platelets, the viability of platelets decreased, storage lesions were observed, and cells underwent apoptosis. We investigated the effects of caspase-3 inhibitor on the survival and function of platelets after different periods of storage. Methods Platelet concentrates were obtained from the Iranian Blood Transfusion Organization in plastic blood bags. Caspase-3 inhibitor (Z-DEVD-FMK) was added to the bags. These bags along with control bags to which no inhibitor was added were stored in a shaking incubator at 22℃ for 7 days. The effects of Z-DEVD-FMK on the functionality of platelets were analyzed by assessing their ability to bind to von Willebrand factor (vWF) and to aggregate in the presence of arachidonic acid and ristocetin. Cell survival was surveyed by MTT assay. Background Although apoptosis occurs in nucleated cells, studies show that this event also occurs in some anucleated cells such as platelets. During storage of platelets, the viability of platelets decreased, storage lesions were observed, and cells underwent apoptosis. We investigated the effects of caspase-3 inhibitor on the survival and function of platelets after different periods of storage. Methods Platelet concentrates were obtained from the Iranian Blood Transfusion Organization in plastic blood bags. Caspase-3 inhibitor (Z-DEVD-FMK) was added to the bags. These bags along with control bags to which no inhibitor was added were stored in a shaking incubator at 22℃ for 7 days. The effects of Z-DEVD-FMK on the functionality of platelets were analyzed by assessing their ability to bind to von Willebrand factor (vWF) and to aggregate in the presence of arachidonic acid and ristocetin. Cell survival was surveyed by MTT assay. Results At day 4 of storage, ristocetin-induced platelet aggregation was significantly higher in the inhibitor-treated (test) than in control samples; the difference was not significant at day 7. There was no significant difference in arachidonic acid-induced platelet aggregation between test and control samples. However, at day 7 of storage, the binding of platelets to vWF was significantly higher in test than in control samples. The MTT assay revealed significantly higher viability in test than in control samples at both days of study. Conclusion Treatment of platelets with caspase-3 inhibitor could increase their functionality and survival.

Optimal Design of Low-Speed Secondary-Sheet Single-Sided Linear Induction Motor

Abbas Shiri,Abbas Shoulaie 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.3

Among different linear motors, single-sided linear induction motors have been widely used in industry due to their simplicity and low construction cost. However, these types of motors suffer from low efficiency and power factor. In this paper, an effective procedure is proposed to design single-sided linear induction motors. The designed motor is simulated in MATLAB software in order to investigate the effect of design parameters on the performance of the machine. Regarding the obtained results, the Genetic Algorithm is employed to optimize the design considering product of efficiency and power factor as objective function. The results show significant improvement of the performance. Finally, experimental results and 2D finite element method is used to validate the model parameters and the optimization results.

Internet Financial Reporting: Case of Iran

Mahmoud Mousavi Shiri,Mahdi Salehi,Nahid Bigmoradi 한국유통과학회 2013 유통과학연구 Vol.11 No.3

Purpose – The purpose of this paper is has been to identify the information disclosed by Internet website companies listed in Tehran Stock Exchange. Research design, data, methodology – The list was prepared includes 84 attributes for financial information in two parts and 36 non-financial information attributes and with 48 attributes of listed companies in Tehran Stock Exchange. Results – The results show that Internet reporting in Iran has improved compared to previous research. However, the level of financial disclosure and accounting firms with the most important research in this area is weak and these companies are more willing to disclose non-financial information to disclose their financial information. In Iran has been little research on Internet financial reporting. Conclusions - Although this study has been to the best possible information is available on the website of each company covered and fully evaluated but May have some unwanted data hidden from view has been fulfilled and is missing. The attribute relating to support of other languages​​, in this study, only the presence or absence of links (other languages​​) and information disclosed is limited to languages ​​have not been studied other than Persian.

Metaheuristic algorithms for a sustainable saffron supply chain network considering government policies and product quality under uncertainty

Sogandi Fatemeh,Shiri Mahdyeh 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.5

Iranian saffron products hold a unique place in the global market as the most highly valued agricultural and medicinal commodities. The various uses of saffron make it clear that there is a need for special attention to the supply chain network. Unfortunately, the absence of an integrated supply chain network within the saffron industry has resulted in significant challenges related to supply management and demand fulfillment. Addressing real-world uncertainties is paramount when developing models for optimization problems. Therefore, this research proposes a multi-objective optimization model for designing a saffron supply chain network under uncertainty. The model objectives are to decrease the total cost of the supply chain, increase job opportunities and economic development in regions, and improve the quality of products. The proposed mathematical model is solved using the interactive fuzzy method to deal with multiple functions. Furthermore, possibilistic chance constrained programming is employed to effectively manage uncertain variables such as demand, cost, and social parameters within the model. To demonstrate the applicability and validity of the proposed model and solution method, a real case study was conducted in Khorasan Razavi province, Iran. Additionally, because of the complexity of the proposed model in large-scale networks, non-dominated sorting genetic algorithm-II and multi-objective simulated annealing algorithms are proposed. Different parameters are analyzed to determine their impact on the results so that decision-makers can choose values more accurately. The sensitivity analysis and statistical tests performed on the results support the performance of the proposed model. Overall, the results demonstrate that the exact method and metaheuristic algorithms are capable of solving the problem in different dimensions. The computational results derived from this model offer invaluable managerial insights, empowering decision-makers to align their strategies and preferences more effectively.

Effect of Ethanol on the Protolytic Properties of the Vitamins B Group

Ghasemi, J.,Shiri, F. Korean Chemical Society 2007 대한화학회지 Vol.51 No.1

다중파장 분광광도법 적정을 사용하여 25 oC에서 0.1M NaNO3를 함유한 에탄올-물 이성분 혼합 용매 중에서 네 가지 수용성 비타민인 엽산(비타민 B9 또는 B10), 티아민(비타민 B1), 리보플라빈(비타민 B2) 및 피리독살(비타민 B6)의 양성자이전상수를 조사하였다. 인자분석모형으로 pH-흡광도 데이터를 적절한 질량균형방정식에 곡선맞추기 (curve fitting)하여 양성자이전 평형상수, 스펙트럼, 농도 도표와 성분 수를 계산하였다. DATAN 프로그램으로 산도상수를, SPECFIT 프로그램으로 표준편차와 부분상관계수를 계산하였다. Gran 도시에 바탕을 둔 4-파라미터 식, pH = α + SpcH + JH+[H+] + JOH-Kw/[H+]에 의거한 유리전극 보정과정을 사용하여 pH값을 농도 척도(pcH)로 읽었으며, 용매가 양성자이전상수에 미치는 영향을 고찰하였다. A multiwavelength spectrophotometric titration method was applied to study protolytic constants of four water-soluble vitamins, folic acid(vitamin B9 or B0), thiamine(vitamin B1), riboflavin(vitamin B2) and pyridoxal (vitamin B6) in binary ethanol-water mixtures at 25oC and an ionic strength of 0.1M NaNO3. The protolytic equilibrium constants, spectral profiles, concentration diagrams and also the number of components has been calculated from the curve fitting of the pH-absorbance data with appropriate mass balance equations by an established factor analysis model. DATAN program was used for determination of acidity constant and SPECFIT program was used for calculation of standard deviations and partial correlation coefficients. A glass electrode calibration procedure based on the four parameter equation pH=α+SpcH+JH+[H+]+ JOH-Kw/[H+] based on the Gran,s plots was used to obtain pH-readings in the concentration scale (pcH). The effect of the solvent on the protolytic constants was discussed.

Fe(HSO₄)₃ as an Efficient Catalyst for Diazotization and Diazo Coupling Reactions

Rahimizadeh, Mohammad,Eshghi, Hossein,Shiri, Ali,Ghadamyari, Zohreh,Matin, Maryam M.,Oroojalian, Fatemeh,Pordeli, Parvaneh Korean Chemical Society 2012 대한화학회지 Vol.56 No.6

Diazo coupling reactions of aromatic amines with 2-naphthol in a green, efficient and easy procedure is described. Ferric hydrogensulfate catalyses this reaction in water at room temperature and short reaction time with high yields. The antibacterial activities of the synthesized compounds against four pathogenic bacteria are also investigated.