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Key Factors of Change Readiness for the Success of Management Innovation in Manufacturing Industry
Seo Shinwon,Park Sunguk,Go Mihyun,Kim Namgyu,Lim Sunguk 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.10
Today, there are many important factors which enterprises should consider to innovate. When there is an organizational change, the employees’ understanding of the change and individual readiness that measures the state of readiness are also important factors. Studies have been conducted focusing on the roles of leaders to make a change but for true innovation, all employees should prepare for changes. This study examined 9 domains focusing on the K Company to find out key factors in change readiness. In addition to key factors, this study suggested a plan for employees’ effective change management activities by analyzing a perception gap in different positions by factors.
Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata
( Jimyung Seo ),( Yeongjoo Oh ),( Shinwon Hwang ),( Zhenlong Zheng ),( Hemin Lee ),( Do Young Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Intramuscular triamcinolone acetonide (IM TAC) is an important therapeutic option in the treatment of various steroid-responsive dermatologic diseases. However, due to concerns regarding side effects of systemic steroids, this form of corticosteroid might be undervalued and underused. We introduce the efficacy of IM TAC for the treatment of refractory alopecia areata (AA). We retrospectively analyzed seven Korean patients (M = 5; F = 2) who were refractory to diphenylcyclopropenone (DPCP) therapy and underwent IM TAC as a second-line therapy. IM TAC dose of 40mg was injected in the gluteus maximus muscle every 4 weeks for a maximum of 6 months. Four patients showed significant hair growth (≥75% hair regrowth). Tolerance was excellent for male patients with AA, but the two female patients experienced dysmenorrhea and osteoporosis respectively. In conclusion, as a rescue therapy, IM TAC may be valuable for use in male patients with recalcitrant AA.
Eccrine adenocarcinoma treated by Mohs micrographic surgery
( Jimyung Seo ),( Minseok Lee ),( Shinwon Hwang ),( Jun Young Kim ),( Jihee Kim ),( Kyoung Ae Nam ),( Kee Yang Chung ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Primary eccrine adenocarcinoma is a rare malignant cutaneous adnexal tumor most commonly arising in the head and neck. Eccrine adenocarcinoma does not have diagnostic clinical features, and histologic recognition becomes important to consolidate the diagnosis of this tumor. Due to the small number of reported cases in the literature, optimal treatment modality has yet to be established. Earlier, surgical resection with wide local excision was performed for most of the cases. Mohs micrographic surgery (MMS), which becomes popular for treating infiltrative skin cancers, can be suggested as another treatment option for this rare malignant tumor of the skin. We have experienced five patients (M = 4; F = 1) with primary eccrine adenocarcinoma of the skin. Four patients had facial lesions and one had the tumor on the interdigital finger web space. Mean patient age was 50.4 ± 14.6 years (range, 29-70 years). Whole-body positron emission tomography revealed no other visceral neoplasm. Sentinel lymph node biopsy or lymph node dissection was performed if clinically indicated. All five patients were treated by MMS using frozen sections. Local recurrence occurred in one patient who were referred to our clinic and underwent MMS after initial recurrence. The remaining four patients showed no recurrence and metastases of the tumor during the follow-up period.
( Yuri Ahn ),( Jimyung Seo ),( Shinwon Hwang ),( Eun Jung Lee ),( Ji Young Kim ),( Min-young Park ),( Abdurrahman Almurayshid ),( Je-wook Yu ),( Sang Ho Oh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Emerging evidence demonstrates a critical role for inflammasome activation in vitiligo pathogenesis. Extracellular adenosine triphosphate (ATP) is a versatile mediator of inflammatory processes, which may be involved in vitiligo pathogenesis. Objectives: To investigate the role of ATP-P2X7 axis on pathogenesis of vitiligo Methods: Various experimental desing were used including mTT assay, confocal microscopy, western blotting, ELISA etc. Results: This study presents how extracellular ATP, released from keratinocytes by oxidative stress, affects melanocyte survival in vitiligo skins. H2O2-induced oxidative injury increased ATP release from keratinocytes and skin tissues. High concentration of extracellular ATP induced both ROS production and cell death in melanocytes. Treatment with ATP in melanocytes led to caspase-1 activation as well as production of active forms of IL-1β and IL-18 via P2X7 receptor (P2X7R). Lesional and perilesional skins of vitiligo showed higher levels of ATP as well as upregulation of active caspase-1 compared to non-lesional skins, suggesting its possible role in inflammasome activation in vitiligo. Moreover, the expression of CXCL9 in keratinocytes, mediated through ATP-P2X7R-dependent inflammasome activation, was responsible for CLA+ CD8+ T-cell chemotaxis into the skin. Conclusion: In conclusion, extracellular ATP as a danger signal not only activates inflammasome pathway as well as increases cutaneous chemotaxis of CD8+ T cells via CXCL9 in vitiligo.