Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

옥수수 種實 形質의 遺傳分析

申昌浩,鄭丞根,車善佑 충북대학교 농업과학기술연구소 1990 農業科學硏究 Vol.8 No.1

Five inbreds and 20 F1s form a 5×5 diallel cross were used to obtain genetic informations on kernel characters in corn, which are necessary to improve seeds more adaptable to mechanical planter and to produce higher yielding hybrids with greater kernel dimension. Both general combining ability (GCA) and specific combining ability (SCA) were significant for kernel length (L), kernel width (W), kernel thickness (T), kernel weight, L/W, L/T and W/T. Greater GCA mean squares indicated additive effects were more important for W and L/W, while non-additive effects were more important for other characteristics. Significant reciprocal effects showed that female parents had greater effect on kernel dimension. Heterosis and heterobeltiosis were 14-43% and 8-31%, respectively, for all characteristics except T. GCA effects indicated that inbreds FR25 and KS42 increased L, KI16A increased W and WT, FR14A increased T, while FR2A decresed L, W, T, and WT. Genetic analysis also indicated the dominance and additive effect for W/T. No interactions between non-allelic genes and overdoinance were indicated for L, W and WT. Narrow sense heritability (0.29) indicated that selection for only W would be effective, although broad sense heritabilities for L, W and WT were 0.78-0.87

Hexamethonium, Guanethidine 及 Bretylium이 Angiotensin의 家兎血壓相乘效果에 미치는 影響

申丞浩 全南大醫大 1965 전남의대학술지 Vol.2 No.1

XML 문서의 효율적인 구조 검색을 위한 동적 색인 모델

신승호,손충범,유재수 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

XML문서는 정보 표현의 기본 단위인 엘리먼트로 구성되어져 있다. 이러한 정보 표현의 기본 단위인 엘리먼트가 XML문서 내에서 구조 변정 이 발생 할 경우 보다 빠른 검색을 위해 기존의 색인 구조 정보의 변경 없이 효율적으로 처리 되어져야 한다. 이를 위해 본 논문에서는 XML 문서의 구조 변정 시 기존의 색인 구조에 효을적으로 수용될 수 있는 동적 색인 모뗄을 제안한다. 본 논문에서 제안 하는 동적 색인 모뗄을 위한 구조정보는 기존의 EID(Element Id), ETID(Element TrPe Id), SORD(Sibling ORDer) SSORD(Same Sibling ORDer), Ccount 구조정보 추출 방법에 SSORD를 대신한 STSOL(Same TyPe Sibling ORDer List). Scount (STSOL내의 SORD 개수). 그리고 COL(Child ORDer List)을 추가함으로써 구성된다. 이러한 구조정보를 이용해 효율적인 검색을 지원하기 위한 동적 색인 구성 알고리즘을 기술하고 제한하는 색인 기법이 기존의 동적 색인을 지원하는 기법 보다 내용 색인, 구조 색인, 애트리뷰트 색인 측면에서 우수함을 성능 평가를 통해 보인다. XML documents consist of elements that are basic units of information. When the structure of XML documents is changed dynamically, we need to update structure information efficiently without changing the information of an index structure for fast retrieval In this Paper, we propose a dynamic index modelling scheme that update index struoture in real time as the structure of XML documents is changed by insertion and deletion of elements. In recent, for indexing XML documents. we have proposed a structural information representation method such as element ID(EID), element type ID(ETID), sibling order(SORD). same sibling order(SSORD) and child count(Ccount). Besides them, our proposed dynamic index modelling method in this paper extracts additional structural information, such as same type sibling order list(STSOL) that substitutes for SSORD. Scount that is the number of SORDS in STSOL. and child order Bist(COL). We design a dynamic indexing technique with our structural information. We show through various experiments that our method outperforms existing enes in processing various types of queries such as content based queries, structural queries and hybrid queries.

특수가공용 공작기계의 쇼트피닝기 모델설계에 관한 연구

신용승,이승호,서유원,정성교 서울産業大學校 1999 논문집 Vol.49 No.2

As developing the technology in industry, the materials with superior grade of stiffiness and lightness are required, and hence the higher fatigue strength characteristics are necessary. Thus, the non-traditional machining to increase fatigue strength is becoming influential as very important technology. Considering environmental problem, the shot peening process is selected as a good process to increase fatigue strength. But the data related to shot peening process are not enough in this country. Shot peening process is essential to ensure repeatability and uniformity on a part to part and lot to lot basis, while conforming to the applicable specifications. The shot material, size, shape and hardness as well as velocity and impact angle must be controlled to provide consistency in peening results. In order to effectively control the shot peening process, parameters must be addressed in the following order, such as media control, coverage control, intensity control, equipment control and so on.

날씨와 주가지수 수익률간의 상관관계 : 행태재무학적 접근 Behavioral Finance Approach

신진영,박승호 한국금융연구원 2003 금융연구 Vol.17 No.2

본 논문은 형태재무학적인 분석 방법을 통해 우리나라 주식시장에서 날씨가 주가에 영향을 미치는지를 검증한다. 전운량으로 측정된 날씨와 종합주가지수 일일 수익률간의 상관관계 분석을 통해, 외국인 거래가 확대되기 전인 IMF 금융위기 이전 기간은 날씨와 종합주가지수의 일일 수익률간에 통계적으로 유의한 관계가 존재하나 외국인 투자가 확대되고 투자한도제한이 철폐된 IMF 금융위기 이후기간에는 날씨와 주가의 유의적인 상관관계가 사라졌음을 확인할 수 있다. 이러한 결과는 Hirshleifer and Shumway(2003)의 연구 결과와 일치하는 것으로서, 1990년대 중반 이후 전세계적으로 진행된 자본시장의 세계화로 인해 주가에 대한 날씨효과가 사라지고 있다는 추론을 가능하게 한다. This paper seeks to determine if weather has affected stock returns in the Korean financial market. Analysis is conducted to find any statistically significant relationship between weather as measured by sky cover(SKC) and the daily stock index returns of the Korean Stock Exchange. In the years before foreign investors were allowed to trade on the Korean stock market, there had been a statistically significant relationship between weather and stock returns in that stocks tended to perform better on days when the sky was clearer. The weather effect on stock returns has since weakened and almost disappeared after the IMF crisis, when foreign investors started to establish a significant presence in the Korean financial market. These findings are consistent with those of Saunders(1993) and Hirshleifer and Shumway(2003). It can be inferred that globalization of the world financial markets since the mid 1990s has done much to remove the weather effect on stock returns.

스키소비자 인구통계학적 특성에 따른 스키리조트 선택속성과 구매형태

신승호,이종호 한국스포츠산업경영학회 2001 한국스포츠산업경영학회지 Vol.6 No.2

본 연구는 스키리조트 소비자 인구통계학적 특성에 따른 스키리조트 선택속성과 구매형태에 대하여 알아보기 위하여 유층적집락무선표집법을 이용하여 3개 스키리조트를 선정하여 스키관광객514명을 대상으로 설문을 실시하였다. 스키리조트 선택속성에 관한 설문지는 McCarty의 분류인 product, place, price, promotion의 마케팅 믹스를 기준으로 신우성(2000) 등 선행연구 논문을 참고하여 본 연구의 목적에 적합하도록 설문지 초안이 작성되었으며, 작성된 설문지 초안은 전문가의 자문과 예비검사를 통하여 설문내용의 신뢰도를 검증한 후 본 연구의 설문지로 사용하였다. 본 설문지의 신뢰도계수가 α= .612∼.862 사이에 위치함으로써 조사도구의 신뢰도가 비교적 양호한 것으로 나타났다. 자료분석을 위하여 본 연구에서 사용한 통계기법은 빈도분석, 요인분석, 교차분석, 일원변량분석(scheffe' 사후검증) 등이다. 이와 같은 연구방법 및 절차를 통하여 다음과 같은 결론을 얻었다. 첫째, 스키리조트의 주고객은 대학생 위주의 20-30세대인 것으로 나타났다. 둘째, 스키리조트 선택속성에 대하여 요인분석을 실시한 결과 프로모션, 장소(접근의 용이성), 가격, 시설요인 등 4개 하위요인이 도출되었다. 셋째, 스키리조트 소비자 구매형태는 다량구매, 중간구매, 그리고 소량구매형태 순으로 나타나고 있으며, 구매형태와 성별, 수입별, 직업별, 그리고 연령별간에는 통계적으로 유의한 차이를 보이고 있다. 넷째, 스키리조트 소비자 인구통계학적 특성에 따른 주어진 스키리조트 선택속성(프로모션, 장소, 가격, 시설요인)에 대한 인식정도에 있어서 성별, 연령별, 직업별, 그리고 수입별간에 통계적으로 유의한 차이를 보이고 있다. 이상을 종합해보면 전체적으로 스키리조트 소비자 인구통계학적 특성에 따른 주어진 선택속성 요인과 구매형태간에는 유의한 차이가 나타났으며, 구매형태는 다량 및 중간구매형태를 보이고 있다. 따라서 스키시장의 저변확대를 통한 스키시장의 발전을 꾀하기 위해서는 스키리조트 소비자 인구통계학적 특성에 따른 다양한 프로그램 및 서비스 품질의 개발, 적절한 요금체계, 최적의 시설유지 및 보완 등이 경영자 중심이 아닌 소비자중심의 차원에서 이루어질 수 있도록 새로운 마케팅 전략이 강구되어야 할 것으로 보여진다. The purpose of this study was to examine the selection attributes of the ski resort and purchase types according to different consumers' demographic characteristics. To accom plish The purpose of this study, 514 visitors from three randomly selected ski resorts were surveyed by means of the revised questionnaires. The content validity and reliability of the questionnaires was determined by conducting a pilot study. The reliability coefficients for the questionnaire were found to be α=.612∼.862. The questionnaire utilized a five-point Likert-type scale was employed. The statistical methods for the data analysis were frequency analysis, factor analysis. Chi-Square, t-test, and one-way ANOVA. All tests of significance were set at an alpha level of .05. The main results of this study were as follows: First, as a result of factors analysis on the selection attributes of ski resorts, four factors of promotion. place(easy access). price and facilities were derived. Second, the purchase types of ski resort consumers were shown as heavy users, medium users. and light users by order, and the correlations among sex, family income, job, and age were statistically significant. Fourth, for the recognition degree on the given selection attributes(promotion. place, price and facility) of ski resorts according to the different demographic characteristics of ski resort consumers, the correlations among sex, family income, job, and age were statistically significant.

제7차 고등학교 체육과교육과정에 대한 인식

신승호,한상준 江原大學校附設體育科學硏究所 2003 江原大學校附設體育科學硏究所論文集 Vol.- No.26

The purpose of this study was to examine how much the high school students understand the 7th physical education curriculum, to find out the better teaching method for physical training class and to give basic data needed for using selection focused curriculum. To attain this purpose, this paper dealt with the survey with the 1st-2nd grade students, 1173 students who live in cities and counties whose population is more than 200,000 and less than 100,000. The results are as follows. Most students felt positive about the structures and class aims of the 7th curriculum in high school physical education. boy students and high graded group had relatively higher regards and participation of the 7th physical education curriculum. They also had positive regards about the present physical training evaluation. In other words, boy students, high graded group and county's group had more positive thought about the evaluation process and results of the physical training class than girl students, low graded group and city's group.

강재 슬릿형 댐퍼를 부착한 철근콘크리트조 골조의 거동

신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.