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      • KCI등재

        A Case of Sudden Cardiac Death due to Pilsicainide-Induced Torsades de Pointes

        Shimpei Nakatani,Masayuki Taniike,Nobuhiko Makino, MD,Yasuyuki Egami,Ryu Shutta,Jun Tanouchi,Masami Nishino 대한심장학회 2014 Korean Circulation Journal Vol.44 No.2

        An 84-year-old male received oral pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert his paroxysmal atrialfibrillation to a sinus rhythm; the patient developed sudden cardiac death two days later. The Holter electrocardiogram, which was wornby chance, revealed torsade de pointes with gradually prolonged QT intervals. This drug is rapidly absorbed from the gastrointestinal tract,and most of it is excreted from the kidney. Although the patient’s renal function was not highly impaired and the dose of pilsicainide waslow, the plasma concentration of pilsicainide may have been high, which can produce torsades de pointes in the octogenarian. Althoughthe oral administration of class IC drugs, including pilsicainide, is effective to terminate atrial fibrillation, careful consideration must betaken before giving these drugs to octogenarians.

      • KCI등재

        Long-Distance Control of Nodulation:Molecules and Models

        Shimpei Magori,Masayoshi Kawaguchi 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.2

        Legume plants develop root nodules to recruit nitrogen-fixing bacteria called rhizobia. This symbiotic relationship allows the host plants to grow even under nitrogen limiting environment. Since nodule development is an energetically expensive process, the number of nodules should be tightly controlled by the host plants. For this purpose, legume plants utilize a long-distance signaling known as autoregulation of nodulation (AON). AON signaling in legumes has been extensively studied over decades but the underlying molecular mechanism had been largely unclear until recently. With the advent of the model legumes, L. japonicus and M. truncatula, we have been seeing a great progress including isolation of the AON-associated receptor kinase. Here, we summarize recent studies on AON and discuss an updated view of the long-distance control of nodulation.

      • Study on Visualization Method of Rice Yield and Quality Data

        ( Shimpei Saito ),( Hideo Hasegawa ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        One of the problems of Japanese agriculture has been decrease in the number of skilled farmers in order to retirement and aging in recent years. Therefore, it is serious problem to inherit farming techniques to the younger successors. The purpose of this study is to visualize growth situation by using UAV and GIS, and provide young farmers comprehensive data as a technical guidance. In this study, we visualized rice yield and quality of agricultural corporation from 2012 to 2017 in Central Part of Niigata Prefecture, Japan and clarified the growth situation of the paddy field at the young panicle formation stage. We extracted paddy fields to be improved from the stand point of cultivation skill based on data visualization. We overlaid field data on the aerial photograph of the corporation and extracted technological characteristics of rice paddy. In this research, we collected and visualized field information. By expressing the yield of the union fields with blue to red gradation, it was possible to intuitively confirm the state and progress of the fields. It was also easy to compare with adjacent fields, suggesting that not only information accumulation but also their work motivation was improved. The brown rice protein content was positively correlated with the yield, and it is thought that the rise in the protein content by the ground nitrogen influenced it. Sensing by UAV can visualize the variation of NDVI in the panicle formation stage, and the members can intuitively understand the variation in growth. By applying this knowledge to the fertilization work, it is thought that it will lead to added value by stabilizing the quality. In addition, we confirmed the decrease in growth due to field improvement, soil analysis and improvement in the field is required.

      • A Logistic Model Including Risk Factors for Lymph Node Metastasis Can Improve the Accuracy of Magnetic Resonance Imaging Diagnosis of Rectal Cancer

        Ogawa, Shimpei,Itabashi, Michio,Hirosawa, Tomoichiro,Hashimoto, Takuzo,Bamba, Yoshiko,Kameoka, Shingo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Background: To evaluate use of magnetic resonance imaging (MRI) and a logistic model including risk factors for lymph node metastasis for improved diagnosis. Materials and Methods: The subjects were 176 patients with rectal cancer who underwent preoperative MRI. The longest lymph node diameter was measured and a cut-off value for positive lymph node metastasis was established based on a receiver operating characteristic (ROC) curve. A logistic model was constructed based on MRI findings and risk factors for lymph node metastasis extracted from logistic-regression analysis. The diagnostic capabilities of MRI alone and those of the logistic model were compared using the area under the curve (AUC) of the ROC curve. Results: The cut-off value was a diameter of 5.47 mm. Diagnosis using MRI had an accuracy of 65.9%, sensitivity 73.5%, specificity 61.3%, positive predictive value (PPV) 62.9%, and negative predictive value (NPV) 72.2% [AUC: 0.6739 (95%CI: 0.6016-0.7388)]. Age (<59) (p=0.0163), pT (T3+T4) (p=0.0001), and BMI (<23.5) (p=0.0003) were extracted as independent risk factors for lymph node metastasis. Diagnosis using MRI with the logistic model had an accuracy of 75.0%, sensitivity 72.3%, specificity 77.4%, PPV 74.1%, and NPV 75.8% [AUC: 0.7853 (95%CI: 0.7098-0.8454)], showing a significantly improved diagnostic capacity using the logistic model (p=0.0002). Conclusions: A logistic model including risk factors for lymph node metastasis can improve the accuracy of MRI diagnosis of rectal cancer.

      • KCI등재후보

        「シネマ57」がアマチュアに求めた映畵表現 ―映畵制作者の存在を觀客に開示する技法と「主體」―

        大谷晋平 ( Otani Shimpei ) 동서대학교 일본연구센터 2018 次世代 人文社會硏究 Vol.14 No.-

        本論は、1950年代末に活動した實驗的映畵の硏究·制作グル一プである「シネマ57」が當時のアマチュア映畵から、映畵においてその制作者の存在を開示する表現技法探求の面においていかなる影響を受けているかを明らかにしている。 第二次世界大戰終戰後、徐?に戰前の活況を取り?しつつあったアマチュア映畵界では、羽仁進や勅使河原宏ら、當時の若手映畵監督からも注目されるような高い質の映畵を作る者もいた。羽仁らが所屬した「シネマ57」はそのような映畵を取りあげて批評し、アマチュアが制作時に資金面や行動範圍において大きな制約を受けている特徵を擧げ、だからこそ身近な素材や出來事を掘り下げていくような映畵が多作されることを指摘した。例えば「シネマ57」は家族のイヴェントを題材とするような映畵では、撮影者と被寫體の關係を表現するような撮り方がなされていることに着目し、それは「シネマ57」が求めた「作家の眼」の表現にも應用される表現であった。さらに、上記のような、映畵制作者の存在を觀客に開示する映畵表現の探求は、映畵監督の「主體」をいかに表現すべきかということを巡って展開される日本の新しい波ヌ一ヴェルヴァ一グの活動の端緖として理解される。 This paper clarifies that, “Cinema 57”, a research and production group of experimental movies that was active in the late 1950s, was influenced in any way from the amateur movie of the time in terms of the expression technique exploration that discloses the creator’s existence in the movie. In the amateur movie circle, which gradually recovered the boom before, those who made high quality movies that attracted attention from young film director at that time, such as Hani Susumu and Teshigahara Hiroshi. “Cinema 57” belonging to Hani and Teshigahara, criticized such a movie and pointed out that amateurs are subject to great restrictions in terms of finance and action at the time of production compared to professional, and that’s why the familiar materials and events, so they also pointed out that movies that will delve the fmiliar ivents will be prolific. “Cinema 57” focuses on the fact that the way of making a movie like expressing the relationship between the camera and the subject, especially with families and friends events, and that “Cinema 57” sought for the expression of “the eye of the author”. The search for movie expressions that disclose the existence of filmmakers to audiences as the beginning of the activity of the new wave of Japan (Nouvelle Vague) developed around how to express the “subject” of the film director.

      • KCI등재후보

        戦中ㆍ戦後日本映画における連続性批判の考察 ―日本の「新しい波」による批評を切り口に―

        大谷晋平 ( Otani Shimpei ) 동서대학교 일본연구센터 2020 次世代 人文社會硏究 Vol.16 No.-

        本論は映画監督の大島渚と松本俊夫による日本映画における戦爭ㆍ戦後責任の指摘を切り口にして、戦中の戦爭プロパガンダ映画と戦後の平和主義的映画の連続性について考察し、その上で大島の『飼育』を取り上げて彼がいかに戦爭ㆍ戦後責任の問題に取り組んだのかを明らかにするものである。 本論では特に大島らによる批判の対象となった木下惠介の『二十四の瞳』を例に挙げる。そして同作が平和主義的なテ一マでありながら、軍国主義的な表象がなされていることを、彼の戦爭プロパガンダ映画との共通点を見出しながら指摘する。 その上で大島渚の『飼育』を分析し、一般人が加害者としての一面を持っていた点を映画で表されていることを指摘し、戦爭ㆍ戦後責任の表象について考察する。 This paper considers the continuity of war propaganda films and post-war pacifist films, based on the criticism of war responsibility and post-war responsibility in Japanese films by film directors Oshima Nagisa and Matsumoto Toshio. On that basis, Oshima's “The Catch(Shiiku)” is taken up to clarify how he tackled the issue of war responsibility and post-war responsibility. In this paper, I will cite “Twenty-four Eyes” by Kinoshita Keisuke, who was especially criticized by Oshima. And this paper points out that the work is a pacifistic theme, but that it has a militaristic representation, while finding similarities with his war propaganda film. On that basis, I will analyze Oshima Kaoru's “breeding”, point out that the citizens have represented one aspect of the perpetrators in movies, and consider the representation of war responsibility and post-war responsibility.

      • KCI등재

        Usefulness of Endoscopic Transpapillary Tissue Sampling for Malignant Biliary Strictures and Predictive Factors of Diagnostic Accuracy

        Hiroki Tanaka,Shimpei Matsusaki,Youichirou Baba,Yoshiaki Isono,Tomohiro Sase,Hiroshi Okano,Tomonori Saito,Katsumi Mukai,Tetsuya Murata,Hiroki Taoka 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.2

        Background/Aims: It is sometimes difficult to distinguish between malignant and benign biliary strictures using imaging studiesalone, and pathological diagnosis is necessary. The aim of this study was to determine the usefulness of endoscopic transpapillary tissuesampling and factors predictive of diagnostic accuracy. Methods: From April 2008 to December 2014, 136 patients underwent endoscopic transpapillary tissue sampling for malignantbiliary strictures. The cytological and histological findings were reported as negative, suspicious, or positive. Suspicious and positivefindings were defined as pathologically positive. Results: The sensitivity was 65.0% for forceps biopsy, 49.5% for brush cytology, 46.2% for bile aspiration cytology, and 21.9% forendoscopic nasobiliary drainage cytology. The combination of these procedures improved the sensitivity (72.8%). Endoscopictranspapillary tissue sampling was more sensitive for lesions of biliary origin (91.4%) than for extrabiliary lesions (66.3%). In surgicalcases, the sensitivity for tumors with an infiltrative growth pattern (53.3%) was significantly lower than for a tumor with an expandingor intermediate growth pattern (87.5%). Conclusions: Combining procedures can improve diagnostic accuracy. It may be possible to predict the sensitivity of endoscopictranspapillary tissue sampling by evaluating the etiology and tumor growth pattern using preoperative imaging studies.

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