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실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교
황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2
Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.
( Sang Bong Ahn ),( Jun Choi ),( Dae Won Jun ),( Hyunwoo Oh ),( Eileen L. Yoon ),( Hyoung Su Kim ),( Soung Won Jeong ),( Sung Eun Kim ),( Jae-jun Shim ),( Yong Kyun Cho ),( Hyo Young Lee ),( Sung Won 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: There are currently several prediction models for hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) receiving oral antiviral therapy. However, most models are based on pre-treatment clinical parameters. Therefore, using machine learning techniques and multicenter patient cohorts from Korea and the United States (US), the current study aimed to develop a novel and practical prediction model for HCC by using both pre- and post-treatment parameters in this population. Methods: We included two treatment-naïve CHB cohorts who were initiated on oral antiviral therapies: the derivation cohort (n=1,480, Korea prospective SAINT cohort comprising of 9 study centers) and the validation cohort (n=426, the US retrospective Stanford Bay cohort comprising of 4 centers). Included patients were followed for 3 years or until HCC, death or loss of follow-up whichever occurred first. We employed logistic regression, decision tree, lasso regression, support vector machine, and random forest algorithms to develop the HCC prediction model and selected the most optimal method. Results: We evaluated both pre-treatment and the 12-month clinical parameters on-treatment and found the 12-month on-treatment values to have superior HCC prediction performance. The lasso logistic regression algorithm using the presence of cirrhosis at baseline and alpha-fetoprotein and platelet at 12 months showed the best performance (AUROC=0.843 in the derivation cohort. The model performed well in the external validation cohort (AUROC=0.844) and better than other existing prediction models including the APA, PAGE-B, and GAG models (AUROC=0.769 to 0.818). Conclusions: We provided a simple-to-use HCC prediction model based on only two readily available and objective laboratory markers (AFP and platelets) measured 12 months after antiviral initiation. The model is highly accurate with excellent validation in an external cohort from a different country (AUROC 0.844).
Recurrent thrombosis after endovascular treatment for malignant superior vena cava syndrome
( Sang Ho Lee ),( Sun Young Kim ),( Heung Tae Kim ),( Chang Woo Shim ),( Ho Seok Chi ),( Hye In Lee ),( Do Il Choi ),( Hyun Bum Kim ),( In Jun Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Endovascular treatment (EVT) including angioplasty and stenting is an effective treatment for superior vena cava (SVC) syndrome. Recurrence of SVC syndrome is mainly caused by tumor progression and occurs in around 20% after EVT, but sometimes venous thrombosis within stent accounts for recurrence of SVC syndrome. Anticoagulation after EVT is still a controversial issue. In our case, a 73 year-old man with SVC syndrome caused by mediastinal lymph node metastasis from non-small cell lung cancer underwent EVT followed by anticoagulation with low molecular weight heparin (LMWH), but symptomatic progression due to in-stent thrombosis necessitated the second procedure after two weeks. A total of 4 sessions of EVT and anticoagulation with LMWH, warfarin and rivaroxaban did not induce durable resolution of in-stent thrombosis. The 4th EVT was done with stent -graft, but computed tomography after the last procedure revealed remained thrombus in SVC and newly developed pulmonary thromboembolism during warfarinization. Our case suggests refractory in-stent thrombosis could develop despite of anticoagulation after EVT for SVC syndrome.
( Sang Bong Ahn ),( Jae Yoon Jeong ),( Dae Won Jun ),( Eileen L. Yoon ),( Sung Eun Kim ),( Jae-jun Shim ),( Yong Kyun Cho ),( Soung Won Jeong ),( Hyoung Su Kim ),( Jun Choi ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: This study aimed to develop prediction model for the development of hepatocellular carcinoma (HCC) in treatment-naive patients receiving entecavir or tenofovir for chronic hepatitis B (CHB). Methods: We enrolled 3184 patients treated with chronic hepatitis B. We analyzed 1350 patients who were treated with entecavir or tenofovir as initial treatment, those with initial clinical records, and those without cancer within one year after treatment. HCC prediction decision tree was constructed through logistic regression using 90 variables including demographic, laboratory data, and cirrhosis. We also analysis with support vector machine (SVM) analysis and random forest analysis. Results: Eighty-four patients were diagnosed with hepatocellular carcinoma. Age (OR=12.3, P=0.001), family history of HBV (OR=7.2, P=0.006), cirrhosis (OR=35.1, P=0.001), diuretics use (OR=4.1, P=0.04), WBC count (OR=4.1, P=0.04), hemoglobin (OR=4.6, P=0.03), admission history (OR=6.2, P=0.01), and ascites (OR=10.7, P=0.001) were the significant predictors of hepatocellular carcinoma development. Cirrhosis, family history of HBV, serum albumin, serum alkaline phosphatase, smoking history, platelet count, and WBC count were selected to set up a decision tree as the prediction model. Decision tree algorithm showed high HCC prediction [96% (95% CI, 93.0-98.0)]. Decision tree algorithm show better area under the curve (AUC) than other analysis. Conclusions: Proposed decision tree algorithm produces high accuracy for prediction of hepatocellular carcinoma in chronic hepatitis B patients.
( Jun Sang Ahn ),( Jung Suh Shin ),( Min Ji Kim ),( Gi Hwal Son ),( Eung Gi Kwon ),( Jae Yoon Shim ),( Il Young Kim ),( Sung Myoun Cho ),( Sang Rae Cho ),( Byung Ki Park ) 한국축산학회(구 한국동물자원과학회) 2019 한국축산학회지 Vol.61 No.3
This study aimed to investigate the effects of temperature and retention time of the pressurized steam chamber on the ruminal fermentation characteristics and nutrient degradability of corn flakes in three Korean native Hanwoo cows and three Holstein cows implanted with a ruminal fistula. Corn kernels were categorized into 13 groups based on the chamber temperature (range, 100°C-116°C) and retention time (range, 700-950 s). The pH value was lowest in T1 regardless of breed. Propionate concentration was the highest in T2 (p < 0.05). Total-volatile fatty acid (VFA) concentration was slightly but not significantly greater in T2 than in other conditions. Dry matter (p < 0.05), starch, and crude protein (p < 0.05) degradability were the highest in T1. At different incubation times and with different breeds, dry matter, starch, and crude protein degradability of corn flakes were the highest in T1. Thus, the present results indicate that the optimal temperature and retention time of the pressurized steam chamber should be 100°C-105°C and 700-720 s.
Shim, Ji-Suk,Lee, Jeong-Yol,Choi, Yeon-Jo,Shin, Sang-Wan,Ryu, Jae-Jun The Korean Academy of Prosthodonitics 2015 The Journal of Advanced Prosthodontics Vol.7 No.1
PURPOSE. This study aimed to discover a way to increase the bond strength between bis-acryl resins, using a comparison of the shear bond strengths attained from bis-acryl resins treated with light curing, pressure, oxygen inhibition, and heat. MATERIALS AND METHODS. Self-cured bis-acryl resin was used as both a base material and as a repair material. Seventy specimens were distributed into seven groups according to treatment methods: pressure - stored in a pressure cooker at 0.2 Mpa; oxygen inhibition- applied an oxygen inhibitor around the repaired material,; heat treatment - performed heat treatment in a dry oven at $60^{\circ}C$, $100^{\circ}C$, or $140^{\circ}C$. The shear bond strength was measured with a universal testing machine, and the shear bond strength (MPa) was calculated from the peak load of failure. A comparison of the bond strength between the repaired specimens was conducted using one-way ANOVA and Tukey multiple comparison tests (${\alpha}$=.05). RESULTS. There were no statistically significant differences in the shear bond strength between the control group and the light curing, pressure, and oxygen inhibition groups. However, the heat treatment groups showed statistically higher bond strengths than the groups treated without heat, and the groups treated at a higher temperature resulted in higher bond strengths. Statistically significant differences were seen between groups after different degrees of heat treatment, except in groups heated at $100^{\circ}C$ and $140^{\circ}C$. CONCLUSION. Strong bonding can be achieved between a bis-acryl base and bis-acryl repair material after heat treatment.
( Sung Eun Kim ),( Jae Yoon Jeong ),( Dae Won Jun ),( Eileen L. Yoon ),( Jae-jun Shim ),( Sang Bong Ahn ),( Yong Kyun Cho ),( Soung Won Jeong ),( Hyoung Su Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: We investigate the efficacy and safety of entecavir (ETV) versus tenofovir (TDF) in treatment-naïve chronic hepatitis B (CHB) patients with chronic kidney disease (CKD) in real life setting. Methods: A total of 1,349 naïve CHB patients treated with ETV or TDF at least 1 year in 9 academic hospitals from Jan. 2012 to Dec. 2015 were enrolled. Among them, 44 patients had CKD at enrollment. CKD was defined as glomerular filtration rate <60ml/min/1.73m2. Renal functional decline was defined when serum creatinine level increased by more than 50% from baseline or over than 0.3 mg/dL at 1 year Results: A total of 44 patients (ETV=30 and TDF 14) were followed up for a median 28 months. There were no significant differences in cumulative biochemical response rate and culmulative HBeAg seroconversion rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment. However, there were significant differences in culmulative virologic response rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment (14%/31%/55% vs.14%/64%/86%, P =0.022). Renal functional decline occurred in 13 (29.5%) patients. Renal functional decline showed no significant difference between the ETV group and TDF group (33% vs. 21%, P=0.420). In multivariate analysis, serum albumin was an independent factor associated with renal functional decline (odd ratio, 0.28; confidence interval, 0.08- 0.95; P=0.041). However, age, sex, BMI, DM, hypertention, baseline HBV-DNA level, HBeAg positivity, cirrhosis, baseline renal function, bilirubin level, platelet count, hemoglobin level, ascites and treatment regimen were not associated with renal functional decline in CHB patient with CKD. Conclusions: TDF had better clinical efficacy than ETV in CHB patient with CKD. This study suggests that close monitoring of renal function are required for CHB patients with CKD and low albuminemia who are receiving antiviral agents.