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- 저자 : Shikai Liu (검색결과 5 건)
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Qianli Liu,Kaikai Cao,Shikai Qi,You Yang,Shuheng Liang,Huihui Gao,Chen Yang,Dazhe Li,Mengjin Jiang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
The spinnability of semi-dilute poly(m-phenylene isophalamide) (PMIA) spinning dope was regulated by a smallamount of surfactants to make it suitable for dry-jet wet spinning. OP-10 shows the best effect of lowering the surface tensionof PMIA spinning dope among the selected surfactants. The effects of different amounts of OP-10 on surface tension andrheological behavior of PMIA spinning dope were investigated. Results show that when the content of OP-10 reaches0.5 wt.%, the surface tension of the PMIA dope reduces to a minimum. The apparent viscosity of the PMIA dope increaseswith the increment of OP-10 contents. The dynamic viscoelasticity study shows that OP-10 also enhances the elasticity of thePMIA spinning dope. The spinning dope with 0.5 wt.% OP-10 can be smoothly spun by dry-jet wet spinning, and theobtained PMIA filament shows excellent mechanical performance.
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Tong Ren,Jing Suo,Shikai Liu,Shu Wang,Shan Shu,Yang Xiang,Jing-He Lang 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.5
Objectives: We analyzed the chromosomal-arm-level copy number alterations (CNAs) in the cervical exfoliative cell and tissue samples by using the low-coverage whole genomic sequencing technique. Methods: In this study, we retrospectively collected 55 archived exfoliated cervical cell suspension samples and the corresponding formalin-fixed and paraffin-embedded tissue section samples including 27 invasive cervical cancer and 28 control cases. We also collected 19 samples of the cervical exfoliative cells randomly from women to verify the new algorithm model. We analyzed the CNAs in cervical exfoliated cell and tissue samples by using the low-coverage next generation of sequencing. Results: In the model-building study, multiple chromosomal-arm-level CNAs were detected in both cervical exfoliated cell and tissue samples of all cervical cancer cases. By analyzing the consistency of CNAs between exfoliated cells and cervical tissue samples, as well as the heterogeneity in individual patient, we also established a C-score algorithm model according to the chromosomal-arm-level changes of 1q, 2q, 3p, 7q. The C-score model was then validated by the pathological diagnosis of all 74 exfoliated cell samples (including 55 cases in model-building group and 19 cases in verification group). In our result, a cutoff value of C-score >6 showed 100% sensitivity and 100% specificity in the diagnosis of cervical cancer. Conclusion: In this study, we found that CNAs of cervical exfoliated cell samples could robustly distinguish invasive cervical cancer from cancer-free tissues. And we have also developed a C-score algorithm model to process the sequencing data in a more standardized and automated way.
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Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells
Xucai Zheng,Shengying Wang,Shikai Hong,Jianjun Liu,Chenghao Jiang 한국유전학회 2021 Genes & Genomics Vol.43 No.4
Background In ribosome establishment and the initiation of translation, eukaryotic translation initiation factor (eIF) 3a is a pivotal functional subunit of the eIF3 complex. In various cancer types, abnormal eIF3a expression plays an important role in tumorigenesis. Objective We aimed to explore the role of eIF3a in human thyroid cancer (TC). Material and methods The expression of eIF3a was determined in TC tissues by qRT-PCR and immunohistochemistry (IHC) assay, respectively. In addition, the expression of eIF3a in K1 and BCPAP cells were detected by qRT-PCR. Cell proliferation, cell cycle, and cell apoptosis were assessed after eIF3a knockdown in K1 in cell line. Results The expression of eIF3a mRNA was high in TC tissues and cancer cell lines. Moreover, eIF3a expression in TC tissues indicated that high eIF3a level was associated with tumor grade. In addition, eIF3a knockdown resulted in a signifcantly decrease in cell proliferation and increased the apoptosis of K1 cells. Cell cycle was arrested in both the S and G2/M phase. The levels of phosphorylated ERK1/2 and surviving were decreased after eIF3a knockdown. Conclusion Our study suggested that eIF3a contributed to TC cell proliferation. It may be a promising target for gene therapy in human thyroid cancer.
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Chaochen Ma,Jianbing Gao,Shikai Xing,Liwei Sun,Jiangquan Liu 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.12
Non-road diesel engines are important polycyclic aromatic hydrocarbon (PAH) sources in the environment due to their high emission concentration compared to on-road diesel engines. Particle- and gas-phase PAH concentrations of a non-road diesel engine were investigated. Non-thermal plasma (NTP) as an effective after-treatment technology was used to reduce PAH emissions. The results showed that particle-phase PAH concentrations were 329.7 μg/m3, 3,206.7 μg/m3, and 1,185.7 μg/m3 without the action of NTP at three different engine loads respectively. Relatively low concentrations were measured for gas-phase PAHs. Excellent linearity was shown for particle-phase with total PAH concentrations both with, and without, NTP. The gas-phase PAH concentrations linearly increased with engine load without NTP. The five most abundant compounds of PAHs were among low molecular weight (LMW) and medium molecular weight (MMW) compounds. Total PAH cleaning efficiency was beyond 50% when treated with NTP at the three different engine loads. We hypothesized that naphthalene (Nap) concentrations increased greatly at 60% and 80% engine loads because it was produced within the plasma zone by decomposition of high molecular weight (HMW) PAHs. The PAHs content of particulate matter (PM) aggregation at 60% load was approximately three times higher than at 40% and 80% loads. High correlation values were observed for MMW PAHs with total PAH concentrations. Correlations of PAH concentration reduction could be important to clarify the PAH reduction mechanism with NTP technology.
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Grid-Connected Dual Stator-Winding Induction Generator Wind Power System for Wide Wind Speed Ranges
Shi, Kai,Xu, Peifeng,Wan, Zengqiang,Bu, Feifei,Fang, Zhiming,Liu, Rongke,Zhao, Dean The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4
This paper presents a grid-connected dual stator-winding induction generator (DWIG) wind power system suitable for wide wind speed ranges. The parallel connection via a unidirectional diode between dc buses of both stator-winding sides is employed in this DWIG system, which can output a high dc voltage over wide wind speed ranges. Grid-connected inverters (GCIs) do not require booster converters; hence, the efficiency of wind energy utilization increases, and the hardware topology and control strategy of GCIs are simplified. In view of the particularities of the parallel topology and the adopted generator control strategy, we propose a novel excitation-capacitor optimization solution to reduce the volume and weight of the static excitation controller. When this excitation-capacitor optimization is carried out, the maximum power tracking problem is also considered. All the problems are resolved with the combined control of the DWIG and GCI. Experimental results on the platform of a 37 kW/600 V prototype show that the proposed DWIG wind power system can output a constant dc voltage over wide rotor speed ranges for grid-connected operations and that the proposed excitation optimization scheme is effective.
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