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RISS 인기검색어
- 검색키워드
- 저자 : Shi-Chao Teng (검색결과 3 건)
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Damage and stiffness research on steel shape steel fiber reinforced concrete composite beams
Chao Xu,Kai Wu,Ping zhou Cao,Shi qi Lin,Teng fei Xu 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.6
In this work, an experimental research has been performed on Steel Fiber-Steel Reinforced Concrete (SFSRC)specimens subjected to four-point bending tests to evaluate the feasibility of mutual replacement of steel fibers and conventional reinforcement through studying failure modes, load-deflection curves, stiffness of characteristic points, stiffness degradation curves and damage analysis. The variables considered in this experiment included steel fiber volume percentage with and without conventional reinforcements (stirrups or steel fibers) with shear span depth ratios of S/D=2.5 and 3.5. Experimental results revealed that increasing the volume percentage of steel fiber decreased the creation and propagation of shear and bond cracks, just like shortening the stirrups spacing. Higher crack resistance and suturing ability of steel fiber can improve the stability of its bearing capacity. Both steel fibers and stirrups improved the stiffness and damage resistance of specimens where stirrups played an essential role and therefore, the influence of steel fibers was greatly weakened. Increasing S/D ratio also weakened the effect of steel fibers. An equation was derived to calculate the bending stiffness of SFSRC specimens, which was used to determine mid span deflection; the accuracy of the proposed equation was proved by comparing predicted and experimental results.
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Phase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety
Zhichao Liao,Feng Li,Chao Zhang,Lei Zhu,Yehui Shi,Gang Zhao,Xu Bai,Shafat Hassan,Xinyue Liu,Ting Li,Peipei Xing,Jun Zhao,Jin Zhang,Ruwei Xing,Sheng Teng,Yun Yang,Kexin Chen,Jilong Yang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR- 2). We conducted a single-arm, nonrandomized phase II study (NCT03121846) to assess the efficacy and safety of apatinib in patients with stage IV sarcoma. We recruited 64 patients with stage IV sarcoma who had failed chemotherapy. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were progression-free survival rate (PFR), objective response rate (ORR), and disease control rate (DCR) at week 12. Treatment-related adverse effects (AEs) were evaluated. Fifty-nine patients were assessed for efficacy and 64 patients for AEs. The median PFS was 7.93 months. At 12 weeks, the PFR was 74%, the ORR was 16.95% (10/59), and the DCR was 86.44% (51/59). The final ORR was 15.25% (9/59) and the DCR was 57.63% (34/59). Notably, 22 patients (34.38%) who developed hypertension, hand-foot-skin reaction, or proteinuria had significantly longer OS than those without these AEs (18.20 vs. 10.73 months; P = 0.002). We conclude that apatinib is effective and well tolerated in patients with advanced sarcoma. The development of hypertension, hand-foot-skin reaction, or proteinuria may indicate a favorable prognosis, representing a novel finding in sarcoma patients.
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Lei Zhou,Xiao-Fei An,Shi-Chao Teng,Jing-Shun Liu,Wen-Bin Shang,Ai-Hua Zhang,Yang-Gang Yuan,Jiang-Yi Yu 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.5
Diabetic nephropathy (DN) is an important diabetic complication, and podocyte apoptosis plays a critical role in the development of DN. In the present study, we examined the preventive effect of the total flavone glycosides of Flos Abelmoschus manihot (TFA) on urinary microalbumin and glomerular podocyte apoptosis in experimental DN rats. The preliminary oral administration of TFA (200 mg/kg/day) for 24 weeks significantly decreased the urinary microalbumin to creatinine ratio and 24-h urinary total protein in streptozotocin-induced DN rats. Terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling assay indicated glomerular cell apoptosis in DN rats was significantly improved by pretreatment with TFA. Furthermore, fluorescence-activated cell sorting and Hoechst 33342 staining suggested preincubation with hyperoside (50 and 200 lg/mL), the major active constituent of TFA, could significantly mitigate cultured podocyte apoptosis induced by the advanced glycation end-products (AGEs). Western blot analysis showed that increased caspase-3 and caspase-8 expressions induced by AGEs were also inhibited by pretreatment with hyperoside at both doses. Our results demonstrate that TFA pretreatment can decrease urinary albumin excretion in early-stage DN, which might be accomplished by preventing renal damage and podocyte apoptosis.
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