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A Survey of the Geographic Distribution of Ophiocordyceps sinensis
Yi Li,Xiao-Liang Wang,Lei Jiao,Yi Jiang,Hui Li,Si-Ping Jiang,Ngarong Lhosumtseiring,Shen-Zhan Fu,Cai-Hong Dong,Yu Zhan,Yi-Jian Yao 한국미생물학회 2011 The journal of microbiology Vol.49 No.6
Ophiocordyceps sinensis is one of the best known fungi in Traditional Chinese Medicine. Many efforts have been devoted to locating the production areas of this species resulting in various reports; however, its geographic distribution remains incompletely understood. Distribution of O. sinensis at the county level is clarified in this work based on both a literature search and fieldwork. More than 3600 publications related to O. sinensis were investigated, including scientific papers, books, and online information. Herbarium specimens of O. sinensis and field collections made by this research group during the years 2000-2010 were examined to verify the distribution sites. A total of 203 localities for O. sinensis have been found, of which 106 are considered as confirmed distribution sites, 65 as possible distribution sites, 29 as excluded distribution sites and three as suspicious distribution sites. The results show that O. sinensis is confined to the Tibetan Plateau and its surrounding regions, including Tibet, Gansu, Qinghai, Sichuan, and Yunnan provinces in China and in certain areas of the southern flank of the Himalayas, in the countries of Bhutan, India and Nepal, with 3,000 m as the lowest altitude for the distribution. The fungus is distributed from the southernmost site in Yulong Naxi Autonomous County in northwestern Yunnan Province to the northernmost site in the Qilian Mountains in Qilian County, Qinghai Province, and from the east edge of the Tibetan Plateau in Wudu County, Gansu Province to the westernmost site in Uttarakhand, India. The clarification of the geographic distribution of O. sinensis will lay the foundation for conservation and sustainable use of the species.
Yu, Yong-Jiang,Li, Yu-Min,Hou, Xu-Dong,Guo, Chao,Cao, Nong,Jiao, Zuo-Yi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Tissue factor (TF) is expressed abnormally in certain types of tumor cells, closely related to invasion and metastasis. The aim of this study was to construct a human gastric cancer cell line SGC7901 stably-transfected with human TF, and observe effects on oxaliplatin-dependent inhibition of invasion and the apoptosis induction. Methods: The target gene TF was obtained from human placenta by nested PCR and introduced into the human gastric cell line SGC7901 through transfection mediated by lipofectamine. Stably-transfected cells were screened using G418. Examples successfully transfected with TF-pcDNA3 recombinant (experimental group), and empty vector pcDNA3 (control group) were incubated with oxaliplatin. Transwell chambers were used to show change in invasive ability. Caspase-3 activity was detected using a colorimetric method and annexin-V/PI double-staining was applied to detect apoptosis. Results: We generated the human gastric cancer cell line SGC7901/TF successfully, expressing TF stably and efficiently. Compared with the control group, invasion increased, whereas caspase-3 activity and apoptosis rate were decreased in the experimental group. Conclusion: TF can enhance the invasive capacity of gastric cancer cells in vitro. Its increased expression may reduce invasion inhibition and apoptosis-inducing effects of oxaliplatin and therefore may warrant targeting for improved chemotherapy.
Yu, Changsong,Jia, Gang,Jiang, Yi,Deng, Qiuhong,Chen, Zhengli,Xu, Zhiwen,Chen, Xiaolin,Wang, Kangning Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.5
The glucagon-like peptide 2 (GLP-2) that is expressed in intestine epithelial cells of mammals, is important for intestinal barrier function and regulation of tight junction (TJ) proteins. However, there is little known about the intracellular mechanisms of GLP-2 in the regulation of TJ proteins in piglets' intestinal epithelial cells. The purpose of this study is to test the hypothesis that GLP-2 regulates the expressions of TJ proteins in the mitogen-activated protein kinase (MAPK) signaling pathway in piglets' intestinal epithelial cells. The jejunal tissues were cultured in a Dulbecco's modified Eagle's medium/high glucose medium containing supplemental 0 to 100 nmol/L GLP-2. At 72 h after the treatment with the appropriate concentrations of GLP-2, the mRNA and protein expressions of zonula occludens-1 (ZO-1), occludin and claudin-1 were increased (p<0.05). U0126, an MAPK kinase inhibitor, prevented the mRNA and protein expressions of ZO-1, occludin, claudin-1 increase induced by GLP-2 (p<0.05). In conclusion, these results indicated that GLP-2 could improve the expression of TJ proteins in weaned pigs' jejunal epithelium, and the underlying mechanism may due to the MAPK signaling pathway.
Yi Jiang,Linglei Kong,Jianfeng Yu,Chunjian Hua,Wansheng Zhao 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.12
The present describes a porous electrode for electrical discharge machining (EDM) that can decrease the concentration of corrosion products in the discharge gap. The electrode is prepared by high-temperature sintering of copper particles. A large number of red copper particles become connected together through sintering necks to form a structure with a large number of pores that act as flushing channels. By exploring the preparation method, material, sintering temperature, and holding time, a porous electrode is prepared such that copper particles do not fall off during the discharge process. The flow of the flushing medium is simulated in the porous electrode, and the action of the flushing flow field in the discharge gap on erosion products is identified. In agreement with the simulation results, experimental results for the EDM of the titanium alloy Ti6Al4V show that the material removal rate with a porous electrode is 3 times higher than that for traditional EDM with a solid electrode. Moreover, the electrode wear is lower due to the effective discharge of the corrosion products by the flushing liquid. Experimental results when rough machining a complex semi-closed cavity show that the porous electrode can greatly shorten the machining time by 47 %, which demonstrates that a porous electrode improves the machining of a complex cavity in a titanium alloy.
Jiang, Wei,Huang, Yong,Wang, Jing-Peng,Yu, Xiao-Yun,Zhang, Lin-Yi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Background: Artesunate, extracted from Artemisia annua, has been proven to have anti-cancer potential. Allicin, diallyl thiosulfinate, the main biologically active compound derived from garlic, is also of interest in cancer treatment research. This object of this report was to document synergistic effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo. Methods: After treatment with artesunate and allicin at various concentrations, the viability of osteosarcoma cells was analyzed by MTT method, with assessment of invasion and motility, colony formation and apoptosis. Western Blotting was performed to determine the expression of caspase-3/9, and activity was also detected after drug treatment. Moreover, in a nude mouse model established with orthotopic xenograft tumors, tumor weight and volume were monitored after drug administration via the intraperitoneal (i.p.) route. Results: The viability of osteosarcoma cells in the combination group was significantly decreased in a concentration and time dependent manner; moreover, invasion, motility and colony formation ability were significantly suppressed and the apoptotic rate was significantly increased through caspase-3/9 expression and activity enhancement in the combination group. Furthermore, suppression of tumor growth was evident in vivo. Conclusion: Our results indicated that artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis.
Yi Lingzhi,Jiang Ganlin,Zhang Guoyong,Yu Wenxin,Guo You,Sun Tao 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4
In order to improve the accuracy and reliability of fault diagnosis for oil-immersed transformers, a fault diagnosis method for oil-immersed transformers based on improved Harris Hawks optimized random forest is proposed in this paper. First, logistic chaotic mapping is used to adjust the key parameters of the algorithm; then a nonlinear energy factor adjustment strategy is used to control the algorithm to transition from global search to local search; fi nally, the method of Gaussian mutation is introduced to strengthen the local search ability, and when the algorithm is stagnant, fi refl y perturbation is performed on the optimal solution to make the algorithm jump out of local optimum. The number of n_trees and n_layers of the random forest are jointly optimized by the improved Harris Hawks optimization algorithm, and the fault diagnosis model of oil-immersed transformer is established. The noncoded ratios of dissolved characteristic gases in oil are used as the characteristic input of the diagnosis model to obtain the fi nal diagnosis results. Compared with other models and verifi ed by examples, the results show that the proposed method has the advantage of high diagnostic accuracy and has certain practical engineering application value.
Yu Jiang Hua,Qi Tao Yi,Young Chul Kim 대한환경공학회 2009 Environmental Engineering Research Vol.14 No.4
This study examined the separation characteristics of particles in the rainfall runoff from paved roads using a φ7.5 cm hydrocyclone. The volume fraction and total suspended solids concentrations in the overflow and underflow from the hydrocyclone, as well as the separation efficiency were determined. The results indicated that the overflow volume increased with increasing operational pressure, but decreased with decreasing ratio of underflow outlet to inlet sizes (Du/Di), while the underflow to overflow volumes showed contrary behavior. The total suspended solid (TSS) concentration ratio between the overflow and inflow (TSSover/in) decreased as a function of the operational pressure, while the corresponding ratio of underflow to inflow (TSSunder/in) increased. There was no visible difference in the TSSover/in with increasing Du/Di ratio, but the TSSunder/in decreased sharply. The particle removal efficiency was mainly affected by the particle size.