Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene

( Gang Bai ),( Yun Qiang Liu ),( Hao Zhang ),( Dan Su ),( Da Chang Tao ),( Yuan Yang ),( Yong Xin Ma ),( Si Zhong Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.6

Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression. Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5`-aza-2`-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645 is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region. [BMB reports 2010; 43(6): 400-406]

Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for Breast MRI Screening: a Meta-analysis

Yang, Xiao-Ping,Han, Yue-Dong,Ye, Jian-Jun,Chen, Gang,Luo, Ying,Ma, Hong-Xia,Yu, Xue-Wen,Niu, Juan-Qin,Ren, Fang-Yuan,Guo, You-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Background: As a common and essential contrast medium at present, gadobenate dimeglumine has shown better performance than some other agents when applied to Breast Magnetic Resonance Imaging Screening (Breast MRI Screening). Nevertheless, reports on the diagnostic performance of these two mediums (gadobenate dimeglumine and gadopentetate dimeglumine) are not completely consistent. Objective: To assess the diagnostic value of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening in patients suffering from breast cancer and to provide more convinced evidence to guide clinical practice in terms of appropriate contrast agents. Data Sources and Review Methods: Original articles in English and Chinese published before January 2013 were selected from available databases (The Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text). The criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis. Then, the area under curve (AUC) of SROC and the spearman rank correlation of sensitivity against (1-specificity) were calculated. Results: Total of 17 researches involving 1934 patients were included. The pooled sensitivity of gadobenate dimeglumine and gadopentetate dimeglumine were 0.99 (0.97, 1.00) and 0.93 (0.88, 1.00) respectively. The pooled specificity for these two contrast agents were 0.924 (0.902, 0.943) and 0.838 (0.817, 0.858) respectively, and the AUC of SROC curve were 0.9781 and 0.9215 respectively. Conclusions: Gadobenate dimeglumine can be regarded as a more effective and feasible contrast medium for Breast MRI Screening. At least 5% differences in diagnostic performance are usually considered as clinically relevant.

Deep electrical structure and dynamic mechanism of the Yinchuan Graben on the western margin of the Ordos Block

Gang Min,Bingxi Yin,Jinchao Chen,Yong Yang,Huiling Yuan,Yan Wang 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.1

The Yinchuan Graben (YG) is situated in the transitional area between the Tibetan Plateau, Ordos Block (OB) and Alxa Block (AB). The dynamic mechanism of the YG is controversial because of its unique tectonic environment. This study used a broadband magnetotelluric profile constrained by high-density point spacing to reliably obtain the deep electrical structure across the Helanshan Orogenic Belt and YG and to discuss the dynamic mechanism of the YG. The main research results are as follows. 1) Our profile and previous seismic profiles show a low-resistivity and low-velocity body in the deep YG, which extends upward and cuts through the bottom boundary of the upper crust, and all results indicate that this body may be the result of partial melting due to upwelling mantle material. 2) Our profile also shows a high-resistivity anomaly in the middle–lower crust of the Helanshan orogenic belt, which can be interpreted as intrusive rocks formed by the emplacement of partially melted materials. 3) The Helanshan east piedmont fault dips eastward and intersects with the Yellow River fault at the depth of 20 km, and the typical structure of the intersection may be the seismogenic structure of the Pingluo Ms8.0 earthquake. 4) The evolution of the YG may have been controlled by various dynamic mechanisms, and the initial formation of the YG may have resulted from the upwelling mantle material beneath the northern OB; the evolution of the YG since 10 Ma may also have been affected by lateral mantle flow from the Tibetan Plateau to the gap between the OB and AB.

Combinatorial Auction-Based Two-Stage Matching Mechanism for Mobile Data Offloading

( Gang Wang ),( Zhao Yang ),( Cangzhou Yuan ),( Peizhen Liu ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.6

In this paper, we study the problem of mobile data offloading for a network that contains multiple mobile network operators (MNOs), multiple WiFi or femtocell access points (APs) and multiple mobile users (MUs). MNOs offload their subscribed MUs` data traffic by leasing the unused Internet connection bandwidth of third party APs. We propose a combinatorial auction-based two-stage matching mechanism comprised of MU-AP matching and AP-MNO matching. The MU-AP matching is designed to match the MUs to APs in order to maximize the total offloading data traffic and achieve better MU satisfaction. Conversely, for AP-MNO matching, MNOs compete for APs` service using the Nash bargaining solution (NBS) and the Vickrey auction theories and, in turn, APs will receive monetary compensation. We demonstrated that the proposed mechanism converges to a distributed stable matching result. Numerical results demonstrate that the proposed algorithm well capture the tradeoff among the total data traffic, social welfare and the QoS of MUs compared to other schemes. Moreover, the proposed mechanism can considerably offload the total data traffic and improve the network social welfare with less computation complexity and communication overhead.

Extramedullary Plasmacytoma Involving the Bilateral Adrenal Glands on MR Imaging

Yuan Li,Ying-kun Guo,Zhi-gang Yang,En-sen Ma,Peng-qiu Min 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.3

We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands. Primary adrenal extramedullary plasmacytoma is extremely rare and only three cases of extramedullary plasmacytoma in the unilateral adrenal gland have currently been reported on. This case is of interest in that the bilateral adrenals were involved. In this article, we present the MRI findings and we briefly review the relevant literature.

Myopericytoma Involving the Parotid Gland as Depicted on Multidetector CT

Zhi-Gang Chu,Jian-Qun Yu,Zhi-Gang Yang,Zhi-Yu Zhu,Hong-Mei Yuan 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.4

Myopericytoma is a newly proposed subgroup of perivascular tumors in the World Health Organization classification of soft tissue tumors. In this study, we report a case of a benign myopericytoma with detailed multidetector CT (MDCT) findings in the parotid gland, a location that has not been described for this type of tumor previously. The clinical presentation, imaging features, histopathological and immunohistochemical findings, and the differential diagnosis with other tumors in the parotid gland are described and reviewed.

Stereo-digital image correlation in the behavior investigation of CFRP-steel composite members

Xiao-Yuan He,Yun-Tong Dai,Hai-Tao Wang,Tian-Yuan Ge,Gang Wu,Jian-Xiao Wan,Shuang-Yin Cao,Fu-Jun Yang 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.6

The application of carbon fiber reinforced polymer (CFRP) in steel structures primarily includes two categories, i.e., the bond-critical application and the contact-critical application. Debonding failure and buckling failure are the main failure modes for these two applications. Conventional electrometric techniques may not provide precise results because of the limitations associated with single-point contact measurements. A nondestructive full-field measurement technique is a valuable alternative to conventional methods. In this study, the digital image correlation (DIC) technique was adopted to investigate the bond behavior and buckling behavior of CFRP-steel composite members. The CFRP-to-steel bonded joint and the CFRPstrengthened square hollow section (SHS) steel column were tested to verify the suitability of the DIC technique. The stereo- DIC technique was utilized to measure continuous deformation. The bond-slip relationship of the CFRP-to-steel interface was derived using the DIC data. Additionally, a multi-camera DIC system consisting of four stereo-DIC subsystems was proposed and applied to the compressive test of CFRP-strengthened SHS steel column. The precise buckling location and CFRP delamination of the CFRP-strengthened SHS steel column were identified. The experimental results confirm that the stereo-DIC technique can provide effective measurements for investigating the behaviors of CFRP-steel composite members.

Mathematical modeling of a six-axis force/moment sensor

Chao Yuan,Gang Xue,Mei-Zhi Yang,Lu-Ping Luo,Kyoo-Sik Shin,Xue-Wei Zhang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

In controlling the robot interacting with the external environment, an important role is played by the force/moment sensors. To design a good force sensor, we need to make a good model first. This paper presents a systematic modeling method of one type of force/moment sensor. A model of a previously designed sensor has been built on the basis of static and kinematic equations and a block form of the strain compliance matrix is obtained using the model.

Thermal phase transformation of In₂Se₃ nanowires studied by <i>in situ</i> synchrotron radiation X-ray diffraction

Li, Yang,Gao, Jing,Li, Qinliang,Peng, Mingfa,Sun, Xuhui,Li, Youyong,Yuan, Gang,Wen, Wen,Meyyappan, M. Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.19

<P>We report the preparation of α- and κ-phase In<SUB>2</SUB>Se<SUB>3</SUB> nanowires by thermal evaporation and investigation of their phase transformations <I>in situ</I> by synchrotron radiation X-ray diffraction (XRD) during a thermal annealing process. The κ-phase transformed into the α-phase at 500 °C and eventually transformed to high temperature α-phase with a layered structure of 5 atoms-5 atoms at 700 °C irreversibly. Different atomistic structures of In<SUB>2</SUB>Se<SUB>3</SUB> were modeled and optimized by DFT, which correlate well with the XRD results. The In<SUB>2</SUB>Se<SUB>3</SUB> nanowires also exhibit a large difference in resistivity before and after annealing.</P> <P>Graphic Abstract</P><P>In<SUB>2</SUB>Se<SUB>3</SUB> nanowires are synthesised by thermal evaporation and their phase transformations are investigated <I>in situ</I> by synchrotron radiation XRD. The nanowires also exhibit a large difference in resistivity before and after annealing. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm10419e'> </P>

Chromatographic Behavior of Proteins on Stationary Phase with Aminocarboxy Ligand

Li, Rong,Ju, Ming-Yang,Chen, Bin,Sun, Qing-Yuan,Chen, Guo-Liang,Shi, Mei,Wang, Xiao-Gang,Zheng, Jian-Bin Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.2

An aminocarboxy aspartic acid-bonded silica (Asp-Silica) stationary phase was synthesized using L-aspartic acid as ligand and silica gel as matrix. The standard protein mixtures were separated with prepared chromatographic column. The effects of solution pH, salt concentration and metal ion on the retention of proteins were examined, and also compared with traditional iminodiacetic acid-bonded silica (IDA-Silica) column. The results show that Asp-Silica column exhibited an excellent separation performance for proteins. The retention of proteins on Asp-Silica stationary phase was consistent with electrostatic characteristic of cation-exchange. The stationary phase displayed typical metal chelate property after fixing copper ion (II) on Asp-Silica. Under competitive eluting condition, protein mixtures were effectively isolated. Asp ligand showed better ion-exchange and metal chelating properties as compared with IDA ligand.