http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages
( Chung Won Lee ),( Sung Woon Chung ),( Mi Ju Bae ),( Seunghwan Song ),( Sang-pil Kim ),( Koanhoi Kim ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Peptidoglycan (PG), the gram positive bacterial pathogen-associated molecular patterns (PAMP), is detected in a high proportion in macrophage-rich atheromatous regions, and expression of chemokine CXCL8, which triggers monocyte arrest on early atherosclerotic endothelium, is elevated in monocytes/ macrophages in human atherosclerotic lesion. The aim of this study was to investigate whether PG induced CXCL8 expression in the cell type and to determine cellular signaling pathways involved in that process. Exposure of THP-1 cell, human monocyte/macrophage cell line, to PG not only enhanced CXCL8 release but also profoundly induced il8 gene transcription. PG-induced release of CXCL8 and induction of il8 gene transcription were blocked by OxPAPC, an inhibitor of TLR-2/4 and TLR4, but not by polymyxin B, an inhibitor of LPS. PG-mediated CXCL8 release was significantly attenuated by inhibitors of PI3K-Akt-mTOR pathways. PKC inhibitors, MAPK inhibitors, and ROS quenchers also significantly attenuated expression of CXCL8. The present study proposes that PG contributes to inflammatory reaction and progression of atherosclerosis by inducing CXCL8 expression in monocytes/macrophages, and that TLR-2, PI3K-Akt-mTOR, PKC, ROS, and MAPK are actively involved in the process.
Seunghwan Chung,Hyeongcheol Lee 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
The EPS (electric power steering) system has been used to replace the conventional HPS (hydraulic power steering) system in vehicles. This system assists the steering effort of the driver using an electric motor and a gear force reduction. In a previous study, an EPS control method was proposed that used the driver’s steering input torque and vehicle velocity. In addition, many papers have introduced estimation and control methods for the EPS motor’s angular velocity or angular torque to reduce the sense difference for the HPS. Therefore, this paper proposes an advanced control strategy for EPS that uses the lateral force of the front wheels. In addition, we experimented with this proposed control algorithm using a simulation and confirmed that it reduced the assist torque and saved motor power. Although it is difficult to obtain the lateral wheel force of the tires for the proposed method, it is able to reduce the torque ripple of the EPS actuator, as well as troublesome problems with steering wheel vibration. Moreover, this EPS control strategy can improve a vehicle’s dynamic stability.
Seunghwan Chung,Hyeongcheol Lee 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
The leading automotive manufacturers have attempted to apply active brake systems to passenger and commercial vehicles. The ESC (electronic stability control) system helps drivers to maintain directional stability and control over steering and under steering. Previous studies on passenger vehicle ESC systems have mainly dealt with the control algorithm and evaluation results. In addition, few papers have considered bus and commercial ESC systems. Therefore, this study proposed a method for estimating the desired yaw rate using the already developed ESC system. The desired yaw rate is estimated from the steering wheel angle, vehicle speed, and vehicle parameters. This paper presents the results of a sine with dwell evaluation analysis of a large bus equipped with an ESC system. Through this process, we are able to estimate the ESC control strategy of the leading producer of commercial buses based on an air brake system. The bus ESC evaluation results can be used as a reference for the development of the ESC control algorithm.
Effect of turning angle and path width of curved path on usability for wheelchair users
Chung Sik Kim,Heejin Kim,Hyunkyung Kim,Seunghwan Oh,Woojin Park,Min. K Chung 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
In this study, the experiment was conducted to investigate the effect of turning angle and width of path on usability for wheelchair users. A total of 12 subjects (6 males and 6 females) were participated in this experiment. We measured task completion time, the number of collision, and the number of correction as objective measures and perceived fatigue, the difficulty of performance, and overall satisfaction as subjective measures while changing turning angles (30º, 60º, 90º, 120º) and widths of path (90 cm, 100 cm, 110 cm). 30ºand 90cm showed the lowest usability on all of the measures. The angle and width were recommended above 90º and 100 cm in a curved path.
Inbum Chung,Jaeseong Oh,SeungHwan Lee,In-Jin Jang,Youngjo Lee,Jae-Yong Chung 대한임상약리학회 2018 Translational and Clinical Pharmacology Vol.26 No.1
Because bioequivalence studies are performed using a crossover design, information on the intrasubjectcoefficient of variation (intra-CV) for pharmacokinetic measures is needed when determiningthe sample size. However, calculated intra-CVs based on bioequivalence results of identicalgeneric drugs produce different estimates. In this study, we collected bioequivalence results usingpublic resources from the Ministry of Food and Drug Safety (MFDS) and calculated the intra-CVs of various generics. For the generics with multiple bioequivalence results, pooled intra-CVswere calculated. The estimated intra-CVs of 142 bioequivalence studies were 14.7±8.2% for AUCand 21.7±8.8% for Cmax. Intra-CVs of Cmax were larger than those of area under the concentrationtimecurve (AUC) in 129 studies (90.8%). For the 26 generics with multiple bioequivalence results,the coefficients of variation of intra-CVs between identical generics (mean±sd (min ~ max)) were38.0±24.4% (1.9 ~ 105.3%) for AUC and 27.9±18.2% (4.0 ~ 70.1%) for Cmax. These results suggestthat substantial variation exists among the bioequivalence results of identical generics. In this study,we presented the intra-CVs of various generics with their pooled intra-CVs. The estimated intra-CVs calculated in this study will provide useful information for planning future bioequivalencestudies. (This is republication of the article 'Transl Clin Pharmacol 2017;25:179-182' retracted fromcritical typographic errors. See the 'Retraction and Republication section of this issue for furtherinformation)
Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages
Lee, Chung Won,Chung, Sung Woon,Bae, Mi Ju,Song, Seunghwan,Kim, Sang-pil,Kim, Koanhoi The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Peptidoglycan (PG), the gram positive bacterial pathogen-associated molecular patterns (PAMP), is detected in a high proportion in macrophage-rich atheromatous regions, and expression of chemokine CXCL8, which triggers monocyte arrest on early atherosclerotic endothelium, is elevated in monocytes/ macrophages in human atherosclerotic lesion. The aim of this study was to investigate whether PG induced CXCL8 expression in the cell type and to determine cellular signaling pathways involved in that process. Exposure of THP-1 cell, human monocyte/macrophage cell line, to PG not only enhanced CXCL8 release but also profoundly induced il8 gene transcription. PG-induced release of CXCL8 and induction of il8 gene transcription were blocked by OxPAPC, an inhibitor of TLR-2/4 and TLR4, but not by polymyxin B, an inhibitor of LPS. PG-mediated CXCL8 release was significantly attenuated by inhibitors of PI3K-Akt-mTOR pathways. PKC inhibitors, MAPK inhibitors, and ROS quenchers also significantly attenuated expression of CXCL8. The present study proposes that PG contributes to inflammatory reaction and progression of atherosclerosis by inducing CXCL8 expression in monocytes/macrophages, and that TLR-2, PI3K-Akt-mTOR, PKC, ROS, and MAPK are actively involved in the process.
Simulink와 Rapid Control Prototyping 장비를 이용한 Brushless DC 모터 제어
정승환(Seunghwan Chung),정완교(Wankyo Jung),이형철(Hyeongcheol Lee) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
This paper presents the control system design procedure of the Brushless DC (BLDC) motor by using Simulink and the Rapid Control Prototyping (RCP) devices. Modeling of a BLDC motor and control algorithm design are carried out using Simulink to simulate the velocity control of the BLDC motor. The test bench is designed and built by designing the BLDC motor and the inverter and by using the dSPACE MicroAutoBox as the main controller. The control algorithm programmed by Simulink is applied to the test bench to verify the overall control system.