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Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.
( Seunghee Lee ),( Hong-sun Song ),( Saejong Park ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1
Purpose: Cardiorespiratory fitness in youth is related to positive health outcoms in the current and/or in the future. The purpose of this study was to develop criterion-referenced cardiorespiratory fitness cut-off values using the receiver operating characteristic (ROC) curves for Korean adolescents. Method: The participants (n = 1,968, girl 48%) were middle and high school students, aged 13 to 17 years in 2013. The cardiorespiratory fitness (VO2max) was estimated from a 20m progressive aerobic cardiovascular endurance run (PACER) test. The metabolic syndrome was classified using established standards based on the National Cholesterol Education Program (Adult Treatment Panel III) definition modified for age (modified NCEP). ROC curve analysis was used to identify the cardiorespiratory fitness thresholds using VO2max z-scores as the test and metabolic syndrome as the criterion. Result: Based on the modified NCEP criteria for metabolic syndrome, the area under the curves (AUC) for VO2max was 0.876 and 0.835 for boys and girls, respectively. Converting VO2max thresholds were estimated from the resulting z-scores and published LMS (L=skewness, M=median curve and S=coefficient of variation) curves. The ROC analysis based on the modified NCEP criteria indicated that the VO2max cut-off values were 43.9 ml·kg-1·min-¹ to 47 ml·kg-¹·min-¹ for boys and 37.6 ml·kg-¹·min-¹ to 39 ml·kg-¹·min-¹ for girls. Conclusion: Age- and sex-specific VO₂max cut-off values were identified in relation to meta-bolic syndrome status in Korean adolescents.
Lee Kyung Eun,Mun Seyoung,Kim Song-mi,Shin Wonseok,Jung Won,Paek Joon,Lee Jungnam,Hudson Erin,Reeves Wesley H.,Han Kyudong,Cha Seunghee 한국유전학회 2022 Genes & Genomics Vol.44 No.10
Background: The innate immune regulation, especially by the type I IFN signature in the CD14+ monocytes, is known to be critical in the pathogenesis of autoimmune Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE). Objective: Since patients with one condition can be overlapped with another, this study is to identify shared differentially expressed genes (DEGs) in SjS and SLE compared to healthy controls (HCs) and refine transcriptomic profiles with the integrated Reactome and gene-drug network analysis for an anti-inflammation therapy. Methods: CD14+ monocytes were purified from whole blood of SjS and SLE patients (females, ages from 32 to 62) and subject to bulk RNA-sequencing, followed by data analyses for comparison with HC monocytes (females, ages 30 and 33). Functional categorizations, using Gene Ontology (GO) and the Reactome pathway analysis, were performed and DEGs associated with therapeutic drugs were identified from the Drug Repurposing Hub (DHUB) database. Results: The GO analysis revealed that DEGs in the inflammatory response and the cellular response to cytokine were highly enriched in both conditions. A propensity toward M1 macrophage differentiation appears to be prominent in SjS while the Response to Virus was significant in SLE monocytes. Through the Reactome pathway analysis, DEGs in the IFN signaling and the cytokine signaling in immune system were most significantly enriched in both. Upregulation of NGF-induced transcription activity in SjS and the complement cascade activity in SLE were also noted. Multiple anti-inflammatory drugs, such as prostaglandin-endoperoxide synthase and angiotensin-I-converting- enzyme were associated with the DEGs in these conditions. Conclusions: Taken together, our analysis indicates distinct inflammatory transcriptomic profiles shared in SjS and SLE monocytes. Comprehensive characterizations of the data from these conditions will ultimately allow differential diagnosis of each condition and identification of therapeutic targets.
Lee, Bora,Lee, Seunghee,Agulnick, Alan D.,Lee, Jae W.,Lee, Soo-Kyung The Company of Biologists Limited 2016 Development (Cambridge) Vol.143 No.10
<P>LIM homeodomain factors regulate the development of many cell types. However, transcriptional coactivators that mediate their developmental function remain poorly defined. To address these, we examined how two related NLI-dependent LIM complexes, which govern the development of spinal motor neurons and V2a interneurons, activate the transcription in the embryonic spinal cord. We found that single-stranded DNA-binding proteins are recruited to these LIM complexes via NLI, and enhance their transcriptional activation potential. Ssdp1 and Ssdp2 (Ssdp1/2) are highly expressed in the neural tube and promote motor neuron differentiation in the embryonic spinal cord and P19 stem cells. Inhibition of Ssdp1/2 activity in mouse and chick embryos suppresses the generation of motor neurons and V2a interneurons. Furthermore, Ssdp1/2 recruit histone-modifying enzymes to the motor neuron-specifying LIM complex and trigger acetylation and lysine 4 trimethylation of histone H3, which are well-established chromatin marks for active transcription. Our results suggest that Ssdp1/2 function as crucial transcriptional coactivators for LIM complexes to specify spinal neuronal identities during development.</P>
The Effect of Folding Wing on Aerodynamics and Power Consumption of a Flapping Wing
Lee, Seunghee,Han, Cheolheui The Society for Aerospace System Engineering 2016 International Journal of Aerospace System Engineer Vol.3 No.2
Experimental study on the unsteady aerodynamics analysis and power consumption of a folding wing is accomplished using a wind tunnel testing. A folding wing model is fabricated and actuated using servo motors. The flapping wing consists of an inboard main wing and an outboard folding wing. The aerodynamic forces and consumed powers of the flapping wing are measured by changing the flapping and folding wings inside a low-speed wind tunnel. In order to calculate the aerodynamic forces, the measured forces are modified using static test data. It was found that the effect of the folding wing on the flapping wing's total lift is small but the effect of the folding wing on the total thrust is larger than the main wing. The folding motion requires the extra use of the servo motor. Thus, the amount of the energy consumption increases when both the wings are actuated together. As the flight speed increases, the power consumption of the folding wing decreases which results in energy saving.