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Structure and nuclear transport mechanism of HSP70 nuclear transporter, Hikeshi
Jinsue Song,Hyerim Hong,Jong Il Ko,Eun-Joo Park,Sang Mi Park,Se-Young Son,Soo Jae Lee 한국구조생물학회 2015 Biodesign Vol.3 No.3
Translocation of macromolecules across the nuclear membrane under the normal conditions has been well studied, but the mechanism of nuclear translocation under the heat-shock stress conditions remain elusive. Hikeshi is a nuclear transport receptor required for cell survival after heat-shock stress. It is in charge of heat shock-induced nuclear import of 70-kilodalton heat shock proteins (HSP70s) through interactions with FG repeats in nuclear pore complexes. Hikeshi forms an “asymmetric” homodimer that is a characteristic feature. Asymmetry of Hikeshi arises from the distinct conformation of the C-terminal domain and the flexibility of the linker regions which areas are essential for nuclear import of HSP70. A unique extended-loop (E-loop) in the N-terminal domain controls the interactions of Hikeshi with FG-Nups by opening or closing the F97 binding site. The recently reported X-ray structure of Hikeshi explains how Hikeshi participates in the nuclear import regulation through FG-Nups recognition, and which part of Hikeshi affects its binding to HSP70. In this review, we will discuss the structural insight on the highly unique import receptor Hikeshi in heat-shock stress condition.
Strategies for the Development of Watermelon Industry Using Unstructured Big Data Analysis
LEE, Seung-In,SON, Chansoo,SHIM, Joonyong,LEE, Hyerim,LEE, Hye-Jin,CHO, Yongbeen 한국유통과학회 2021 The Journal of Industrial Distribution & Business( Vol.12 No.1
Purpose: Our purpose in this study was to examine the strategies for the development of watermelon industry using unstructured big data analysis. That is, this study was to look the change of issues and consumer's perception about watermelon using big data and social network analysis and to investigate ways to strengthen the competitiveness of watermelon industry based on that. Methodology: For this purpose, the data was collected from Naver (blog, news) and Daum (blog, news) by TEXTOM 4.5 and the analysis period was set from 2015 to 2016 and from 2017-2018 and from 2019-2020 in order to understand change of issues and consumer's perception about watermelon or watermelon industry. For the data analysis, TEXTOM 4.5 was used to conduct key word frequency analysis, word cloud analysis and extraction of metrics data. UCINET 6.0 and NetDraw function of UCINET 6.0 were utilized to find the connection structure of words and to visualize the network relations, and to make a cluster of words. Results: The keywords related to the watermelon extracted such as 'the stalk end of a watermelon', 'E-mart', 'Haman', 'Gochang', and 'Lotte Mart' (news: 015-2016), 'apple watermelon', 'Haman', 'E-mart', 'Gochang', and' Mudeungsan watermelon' (news: 2017-2018), 'E-mart', 'apple watermelon', 'household', 'chobok', and 'donation' (news: 2019-2020), 'watermelon salad', 'taste', 'the heat', 'baby', and 'effect' (blog: 2015-2016), 'taste', 'watermelon juice', 'method', 'watermelon salad', and 'baby' (blog: 2017-2018), 'taste', 'effect', 'watermelon juice', 'method', and 'apple watermelon' (blog: 2019-2020) and the results from frequency and TF-IDF analysis presented. And in CONCOR analysis, appeared as four types, respectively. Conclusions: Based on the results, the authors discussed the strategies and policies for boosting the watermelon industry and limitations of this study and future research directions. The results of this study will help prioritize strategies and policies for boosting the consumption of the watermelon and contribute to improving the competitiveness of watermelon industry in Korea. Also, it is expected that this study will be used as a very important basis for agricultural big data studies to be conducted in the future and this study will offer watermelon producers and policy-makers practical points helpful in crafting tailor-made marketing strategies.
Seunghee KIM,Jeongho LEE,Hyerim SON,Ji Yeh HONG,Min Young JEONG,Su Jin CHOI,Kang Hyun LEE,Rusea GO,Sangho CHOI,Hah Young YOO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Since ancient times, some plants with antibacterial, anti-inflammatory and antioxidant properties have been used in traditional medicine. In this study, the tropical plants from Malaysia were obtained by the International Center for Biological Materials Research (IBMRC), and the antibacterial activity of 87 samples was investigated. The antibacterial activity was determined by the disc diffusion method using gram-positive and gram-negative bacteria. As a result, 6 extracts that significantly represented an inhibition zone against Gram-positive bacteria are as follows: Rhodamnia uniflora, Melastoma molle, Ochanostachys amentacea, Syzygium attenuatum, Melastoma muticu, Garcinia mangostana. In addition, extracts from G. mangostana and Leea indica showed antibacterial activity against Gram-negative bacteria. In conclusion, it was confirmed that extract from G. mangostana has high antibacterial activity and can be used as an antimicrobial substance with a wide range because it can be applied to both gram-positive and gram-negative.
Antioxidant Screening of Extracts from Mongolian Plants for Functional Cosmetic Applications
Jeongho LEE,Seunghee KIM,Hyerim SON,Minkyu SHIN,Hoin YU,Kang Hyun LEE,Badamtsetseg BAZARRAGCHAA,Sangho CHOI,Hah Young YOO 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Various Mongolian plant families including Rosaceae, Crassulaceae, Fabaceae are known as medicinal plants, which have bioactive properties such as antioxidant, antibacterial and anti-inflammatory. In this study, the antioxidant activity of extracts derived from Mongolian plants was investigated, and the 100 samples were provided by IBMRC (International Biological Material Research Center). Antioxidant activity was measured by ABTS and FRAP methods, and extracts of 6 samples (Saxifraga spinulosa, Salix kochiana, Orostachys fimbriata, Salix schwerinii, Chamaerhodos erecta and Potentilla bifurca) with relatively high activity were first selected. The extract from S. spinulosa showed the highest antioxidant activity, and the ABTS IC50 and FRAP value were found to be 0.1 ㎍/mL and 290.4 m㏖/L, respectively. Finally, the extract of S. spinulosa is expected to be beneficially utilized as functional cosmetic materials.