한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

직장암에서 수술 전 방사선-화학요법 후 발생한 후기 합병증

이승현,이철민,안병권,백승언 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

OBJECTIVES: To compare the late complications after operations for rectal cancers with and without preoperative chemoradiation. METHODS: From January 2003 to December 2005, 55 patients underwent operation after preoperative chemoradiation for adenocarcinoma of the rectum. All of them received the full scheduled dose of radiation with concurrent chemotherapy. The interval between preoperative chemoradiation and surgery was 4-6 weeks. 47 patients who had tumors below 8 cm from the anal verge were enrolled into the study group (CRT group). During same period, we selected 153 patients who had adenocarcinoma of the rectum below 8cm from the anal verge, underwent surgery alone without postoperative radiotherapy non-CRT group). We compared the early and the late postoperative complications between the CRT group and the non-CRT group. RESULTS: Of the late complications, the incidence of anastomotic stricture was significantly higher in the CRT group (P = 0.018). The incidence of anal stricture was higher in the CRT group (P = 0.164). In the CRT group, 3 cases (17.6%) had failed to preserve the anal function due to moderate or severe anal stricture. Of the 3 cases, protective ileostomy was persistent in 2 cases, colostomy was performed in one case. Otherwise, the late complications of the CRT group were intestinal obstruction in 2 cases (4.3%), lymph edema in 2 cases (4.3%). CONCLUSION: In CRT group, failure of anal function preservation due to anastomotic stricture or anal stricture was more common and serious than non-CRT group. We emphasize the need for careful management for postoperative anal stricture after preoperative chemoradiation.

영양염류 제거를 위한 생물막 공정의 적용에 관한 연구

안승섭,박노삼,이수식,이관영,박상현 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

In this study, the removal possibility of nutrients of T-P, NH_3-N, NO_3-N, and T-N is examined through a positive experimental study using submerged biofilter of media packing channel method. From the analysis of nutrients removal efficiency for each run of the collected sample, following results are obtained. Firstly, the result of N/P surveying for inflow shows serious value that excess the limit value of 20 as the values are in the range of 12.0∼42.7 and the average is 25.73. Secondly, the highest concentration of the incoming NH_3-N reaches double of the standard since the concentrations of NH_3-N, and NO_3-N for inflow shows 0.06㎎/ℓ , and 2.5∼3.8㎎/ℓ respectively, and the average removal rate which passed the submerged biofilter adopted in this study is a satisfactory level. Next, the average removal rate of T-P of 51.5% shows the possibility of entrophication removal since the removal rate of T-P of 66.8∼68.8% in relative low temperature period of RUN 1∼2 appeared higher than in RUN 3∼6, and T-N shows relatively poor result with the average removal rate of 34.1%. And it is known that the bigger BOD/P and BOD/N are, the more removal rate increases from the examination result of the relation between BOD/P and BOD/N, and the treatment water T-P and T-N to decide the relation with the concentration of organic matters, and thought that the appropriate proportion is necessary for effective removal of nitrogen and phosphorus.

직장암 절제 수술 후에 발생하는 문합부 누출의 위험 인자

이승현,안병권,배승언 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: Anastomotic leakages are one of the most serious complications after rectal cancer resection. The aim of this study was to identify the relevant risk factors of anastomotic leakage after low anterior resection for rectal cancer. Methods: We reviewed retrospectively the medical records of 251 patients, who underwent low anterior resection for rectal cancers between January, 2001 and December, 2004. All patients underwent a tumor-specific mesorectal excision. We excluded the patients underwent emergent surgery, protective stoma formation and used pelvic drainage. Results: The mean distance of the tumor from the anal verge was 8.0 cm (3-16 cm). Lower anterior resection was performed in 214 patients and ultra-low anterior resection in 37 patients. Fifteen patients had preoperativechemoradiation for rectal cancer. The anastomotic leakage was identified in 10 patients (4.0%). Seven patients with anastomotic leakage underwent corrective surgery.Other postoperative complications included 5 rectovaginal fistula (2.0%) and 4 intra-abdominal abscess (1.6%). The incidences of anastomotic leakage were significantly different according to preoperative chemoradiation (13.3% vs. 3.4%, p=0.05) and rectal obstruction (33.3% vs. 3.3%, p=0.00). Conclusions: In patients with history of preoperative chemoradiation and rectal obstruction, the careful management for anastomotic leakage is necessary

소뇌출혈후 신경인성방광으로 배뇨장애를 주소로 한 환자 치험 1例

안정조,최영,조현경,임승민,김민상,오병렬,유병찬,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

In patients with Cerebral vascular accident, Voiding Dysfunction is very usual, but if with no improvement for a long time, it can cause many complexed-problems as urinarytract injury, infection or inflamation and patients suffering from pain, inconvenience and anxiety. In this case 58-year-old female with Voiding Dysfunction with Neurogenic Bladder after Cerebellum Hemorrhage, for 6 monts there was no interval change on symptom, We prescribed appropeiate herbal medication, and perform acupuncture and moxa. 5 days later after admission in Taejeon Oriental Hospital, The patien was able to have self-voiding and gradually improved. So we report it for the better treatment.

자기장 저속 냉동보관법을 이용한 쥐 치아 치주인대세포의 활성도 검사

안현정,김의성,김진,김덕원,김기열,이찬영,이승종 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.4

본 연구의 목적은 흰쥐 상악 대구치를 발거하여 자기장 저속 냉동보관법을 이용하여 냉동 시 치주인대세포의 활성도 및 세포 사멸도를 MTT검색법과 TUNEL검사를 이용하여 측정하고자 하였다. 4주령의 암컷 Sprague-Dawley계 된 쥐의 상악 좌우 제1,2대 구치를 발거하여 각군 당 12개의 쥐 치아를MTT검색에 이용하였고 6개의 치아를 TUNEL 검사에 이용하였다. 실험군은 5개군으로 대조군은 즉시 발치군이며 4℃냉장고에서 1주일간 보관한 냉장군, 발치 후 동해방지제 처리과정을 거쳐 -196℃의 액화질소에 넣어 급속 냉동한 액화질소군, 21.7 ㎃, 60 ㎐, 1 G의 자기장을 이용하여 -0.3℃/min 의 속도로 -20℃까지 냉동 후 -196℃로 급속 냉동한 자기장군, -0.3℃/min의 속도로 -20℃까지 냉동 후 -196℃에 급속 냉동한 저속 냉동군으로 나누었다. 보존액은 F medium을 사용했으며 동해방지제로 10% dimethyl sulfoxide (DMSO)를 사용하였다. 치근면을 단위면적으로 표준화하기 위해 MTT측정값을 Eosin 염색 후 530 ㎜에서 측정한 흡광도 값으로 나누었다. TUNEL 검사 시 각 조직슬라이드에서 400배 크기의 현미경 시야에서 임의로 세 부분을 지정하여 정상 세포수와 양성 세포수를 세어 그 비율을 계산하여 각 실험군 당 평균치를 구하였다. 통계 분석을 위해 one way ANOVA를 시행하였으며 사후검정으로 Scheffe와 Tukey HSD방법을 썼으며 결과는 다음과 같다. MTT검색에 의한 흡광도를 Eosin염색 후 측정한 흡광도로 나눈 값에서는 자기장군은 즉시 발치군보다 낮은 세포활성을 보였고 (p < 0.05) 액화질소군, 저속 냉동군과는 통계적으로 유의성 있는 차이를 보이지 않았다. 그러나 자기장군은 액화질소군, 저속 냉동군과 함께 냉장군보다는 높은 세포 활성도를 보였다 (p<0.05).TUNEL검사 결과도 자기장군은 즉시 발치군보다 치주인대의 세포사멸도가 높았으나 (p < 0.05) 저속 냉동군과 액화 질소군과는 통계적으로 유의한 차이를 보이지 않았다. 자기장군은 냉장군보다 세포사멸도가 낮았으며 냉장군은 모든 군 중에서 세포 사멸도가 가장 높았다 (p<0.05). The purpose of this study was to evaluate the viability of periodontal ligament cell in rat teeth using slow cryopreservation method with magnetic field through MTT assay and TUNEL test. For each group, 12 teeth of 4 weeks old white female Sprague-Dawley rat were used for MTT assay, and 6 teeth in TUNEL test. The Maxillary left and right, first and second molars were extracted as atraumatically as possible under tiletamine anesthesia. The experimental groups were groupl (immediately extraction), group 2 (cold preservation at 4℃ for 1 week), group 3 (rapid Cryopreservation in liquid nitrogen), group 4 (slow cryopreservation with magnetic field of 1 G), and group 5 (slow cryopreservation). F medium was used as preservation medium and 10% DMSO as cryoprotectant. After preservation and thawing, the MTT assay and TUNEL test were processed. One way ANOVA and Scheffe method were performed at the 95 % level of confidence. The value of optical density obtained after MTT analysis was divided by the value of eosin staining for tissue volume standardization. In both MTT assay and TUNEL test, it had showed no significant difference among group 3,4, and 5. And group 3 had showed higher viability of periodontal ligament cell than group 2. From this study, slow cryopreservation method with magnetic field can be used as one of cryopreservation methods.

효소를 이용한 Cyclic Meso-dicarboxylic acid anhydride의 고리열림 반응

안용현,이승준 단국대학교 1998 論文集 Vol.33 No.-

By using the enzyme, we have tried the ring opening of cyclic acid anhydride which is the intermediate in the synthesis of (+)­biotin. Lipase PS, lipase AK, lipase AY, porcine liver esterase, lipase AP­12, lipase M­10, prozyme 6 and lipase M were used as enzymes and methanol, n­propanol, n­octanol and (-)­menthol were applied as a nucleophile. In the absence of enzyme, reaction with n­butanol was proved to proceed less then 1%. The reaction progress was fast when the enzyme was used, but the optical purity of monoester was very poor. When the lipase AK and n­butanol were applied, the optical purity of monoester was 705%ee. However, (-)­menthol was used under the same condition, the optical rotation was opposite and optical purity was 11.2%ee.

정형외과 영역에서 Sulperazon(Sulbactam/cefoperzon)의 Non-Comparative study

신현대,임상덕,안상로,이준규,이광진,윤승호 최신의학사 1989 最新醫學 Vol.32 No.2

복강경 대장절제술의 초기 경험

이승현,안병권,백승언 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Background : Laparoscopic colon resection has many benefits, such as decreased incidence of pulmonary complication, faster return of the bowel function, decreased narcotic requirements, shorter hospital stay, and faster recovery time. However it has long learning curve because of complex mesenteric blood supply, multiple quadrant location and bowel anastomosis. The aim of this study was to identify the clinical outcome for laparoscopic colorectal surgery as initial experience. Methods : From Jan. 2002 to Dec. 2006, we reviewed 16 patients who had underwent laparoscopic colon resection at Kosin University Gospel Hospital. We studied the clinical outcome, such as operative time, passage of flatus, retrieved lymph node, complications, hospital stay. Results : Of the 16 patients, 6 cases were male, 10 cases were female. The median age was 50.1 years(26-69). The primary diseases were cancer in 15 cases (93.7%), and benign in 1 case. The operative procedure were right hemicolectomy in 3 cases (18.8%), left hemicolectmy in 1 cases (6.3%), anterior resection in 6 cases (37.5%), low anterior resection in 4 cases (25.0%) and total colectomy in 1 case (6.3%). The mean operative time was 227.8 minutes (150-370). The flatus passage was 2.6 days (1-6). The mean number of retrieved lymph node was 12.2 (3-27). The postoperative complication was wound infection in 2 cases. The mean hospital stay was 11.1 days. Conclusions : The laparoscopic colorectal surgery seems to be safe. To evaluate the benefit compare to open colorectal surgery, we need further study.

韓醫學的 診斷類型에 따른 韓藥方劑의 抗癌 및 免疫調節作用에 미치는 影響

朴鐘鉉,金楨氾,崔昇勳,安圭錫 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1

연구배경 : 암은 사망의 주요한 원인이 되는 질환으로서, 우리나라에 있어서도 급격히 증가하는 추세이다. 한의학에서는 암의 유형을 크게 간울기체형, 기체혈어형, 비허습담형, 음허내열형 등으로 분류하고 있는데, 각 유형에 응용할 수 있는 소요산, 소복축어탕, 사군자탕, 육미지황탕의 항암효능을 비교 연구함으로써, 암치료에 대한 한약재의 임상활용도를 높이고자 함. 방법 : Mouse에 Sarcoma-180으로 복강암을 유발한 후, 약제를 21일 간 투여하고 생존율, T cell, B cell, 혈청항체가, IL-2 생산능, NK cell의 세포살상능을 측정하였다. 결과 : 생존기간의 연장효과는 모든군에서 증가하는 경향이 있었으나 유의성이 없었고, T cell 및 B cell은 모든군에서 증가하였으며, 임파구 증식반응 및 IL-2 생산능은 사군자탕과 육미지황탕에서, NK cell 활성도는 소복축어탕 엑기스 투여군에서 유의성이 있었다. 결론 : 이상으로 보아 이들 처방은 면역조절작용을 통한 항암효과가 있을 것으로 볼 수 있으며, 변증분형에 따라 처방을 달리해야 함을 알 수 있다. In order to investigate the effects of Formules according to Pattern Identification on anti-tumor and immunodulatory reaction to the ICR and C57BL/6 mice which have abdominal tumor after Sarcoma-180 cells were transplanted, the extracts of herbal medicines above mentioned were orally administered to the mice for 21 days to observe the extention of survial duration of the mice, quantitation of T cells and B cells, productivity of interleukin-2, lymphocytes transformation, hemagglutinin titer and hemolysin titer and activity of splenic natural killer cells. The results are summarized as follows ; 1. In the effect of life extention, all groups appeared to survive longer than the Control group, which are not meaningful. 2. Considering T cell and B cell content, all groups had a meaningful increase in both T cell and B cell (P<0.01). 3. Considering serum antibody titer was no significant difference between all groups. 4. In lymphocyte transformation marked a significant increase the sijunzitang-medicated mice group, marked a significant (P<0.01), and showed a significant increase the mice group medicated with Liuweidihuangtang (P<0.05). 5. As for the productivity of interleukin-2, showed a significant increase the mice group medicated with Sijunzitang ans Liuweidihuangtang (P<0.05). 6. In the effect of activity of NK cells, Shaofuzhuyutang-medicated mice group had a meaningful increase (P<0.05).