코넬노트 및 팀토의를 활용한 플립러닝 설계전략 방안 연구

송승아(Song, Seung-Ah) 한국경영교육학회 2020 경영교육연구 Vol.35 No.1

[연구목적] 빠르게 변화하는 경영환경에 능동적으로 대처하고 문제해결능력을 함양한 인재를 양성하는데 적합한 교수법인 플립러닝을 적용하여 강의를 개발하고 강의 운영전략을 새로이 수립하고 운영함에 있어서 팀 토론과 예습노트를 작성하는 것이 학습효과를 향상시킬 수 있는지에 대해 설문조사하였으며 실제 교과목 적용사례를 공유하고자 한다. [연구방법] 온라인 강의를 청취할 때 예습노트를 작성하고 준비된 코넬노트 양식의 예습노트를 가지고 오프라인 토론 시간에 참여함으로써 학습효과가 증가되었다고 인식하는지를 학기말에 설문하는 방식으로 연구를 진행하였으며, 수업 설계측면에서는 오프라인 수업 운영 방안에 대해 가이드라인을 제공한다. [연구결과] 설문결과 예습노트는 팀토의에 적극적으로 참여할 수 있도록 학생들을 준비시키는 보조 장치로 작용하였으며, 플립러닝 수업에 예습노트와 팀 토론양식을 적용한 것이 긍정적 학습효과를 가져왔다는 것을 확인할 수 있었다. [연구의 시사점] 예습노트와 팀 토론 양식을 동시에 플립러닝에 적용하고 그 학습효과에 대한 학생들의 인식을 조사함으로써 이론적, 실무적 시사점을 제공하였다. [Purpose] It takes time and effort for the instructor to change the teaching style, create new video lectures, and develop new teaching strategies. Even if you are ready, you may encounter many unexpected difficulties in the actual operation process, so this study aim to share a case study on a flip-learning application using cornell note and team discussion form that can help instructors who want to apply flip learning to business administration. [Methodology] At the end of the semester, the study was conducted by surveying whether the student perceived that the learning effect was increased by participating in the offline discussion with a cornell-note format based preliminary note prepared while listening to the online lecture and also in terms of class design, the study provides guidelines on how to operate offline classes. [Findings] This study found that preparation of preliminary note was used as an aid to prepare students to actively participate in the team discussion and applying the cornell notes and the team discussion form to the flip learning class showed a positive learning effect. [Implications] This study applies cornell notes and team discussion form to flip learning and students’ perceptions of the learning effects were examined to provide theoretical and practical implications.

Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

Kim, Se-Na,Ko, Song Ah,Park, Chun Gwon,Lee, Seung Ho,Huh, Beom Kang,Park, Yoh Han,Kim, Young Kook,Ha, Ahnul,Park, Ki Ho,Choy, Young Bin American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.8

<P>To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capacity of about 4.17%) to give the BMD-AMS, which could release the drug in a sustained manner over 8 h. BMD-AMS was also shown to be mucoadhesive due to the presence of both hydroxyl and amino groups in the surface, allowing for formation of hydrogen bonds and an ionic complex with the mucin, respectively. Therefore, when topically administered to rabbit eyes in vivo, BMD-AMS could reside in the preocular space for up to 12 h because of its adherence to the mucous layer. To assess in vivo efficacy, we examined the variance in intraocular pressure (IOP) and brimonidine concentration in the aqueous humor (AH) after applying BMD-AMS to the eye, which was compared with that induced by Alphagan P, the marketed brimonidine eye drops. For BMD-AMS, the duration in the decrease in IOP and the area under the drug concentration in the AH-time curve (AUC) were 12 h and 2.68 μg·h/mL, respectively, which were about twice as large as those obtained with Alphagan P; this finding indicated enhanced ocular bioavailability of brimonidine with BMD-AMS.</P> [FIG OMISSION]</BR>

In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

차아염소산나트륨을 이용한 데님의 탈색효과

홍승아,송화순 숙명여자대학교 건강·생활과학연구소 2006 生活科學硏究誌 Vol.- No.22

The denim fabric treated with washing agent has the natural color and smoothness as if it is worn for a long time. Also washing processing is treated to make denim fabric to improve the qualities and adjust the shrinking percentage. But on the other hand there could be such a quality deterioration as lowering of intensity. In this study we used the NaCIO as washing agent and find the proper condition to have the desired bleaching effect, while minimizing the damages of the fabric. When the concentration of NaCIO was 3%, weight loss and color difference were stable at 25℃ and 40℃. But, when the concentration of NaCIO was 6%, the denim fabric was stable under 40℃. The fiber structure of denim fabric was dispersed and fibrillation increased as the concentration and temperature became higher. The tensile strength and tearing strength of denim fabric dropped suddenly as the concentration and temperature became higher.

울산시 실직 여성가장의 현황

홍승아,이미영 울산과학대학 1999 연구논문집 Vol.26 No.1

이글은 여성의 실업문제에 주목하여, 특히 실직 여성가장에 대하여 살펴보고자 한다. 이를 위해 첫째, 여성실업의 문제를 바라보는 시각들을 정리해 보고, 둘째, 통계자료를 통하여 실업실태를 개관해 보고, 세째, 울산지역의 실직 여성가장의 현황에 대하여 살펴본 후에, 마지막으로 이를 토대로 실직 여성가장에 대한 제언을 제시해 보고자 한다. 실직 여성가장에 대한 실태조사는 설문조사 및 면접조사를 통하여 살펴보았으며 조사결과는 다음과 같다. 실직 여성가장은 최근 1년 이내에 실직을 경험한 경우가 53.9%로 나타났으며, 특히 이들이 가장 필요하다고 생각하는 것은 일자리와 생계대책으로(80.8%) 나타나, 당장의 생계와 재취업에의 열망이 가장 큰 것으로 조사되었다. 따라서 실직 여성가장에게 일자리를 창출할 수 있는 적극적인 여성정책이 요구된다. This paper empirically examines the status of the unemployed female- headed family in Ulsan area. This study uses data collected from usable 182 cases among 200 collected data who responded to the questionnaires. This study showed that the unemployed female-headed family are situated in the very vulnerable position. And the very things they really wanted are "job hunting" and the urgent subsistence maintenance. And they also wanted governmental financial assistance, social support system at a moderate level. Therefore they need a "positive and inclusive" women policy which can create job place for the them.

Autophagy 매개체인 LC3로 인한 Aβ 신경 독성의 증가

이승아;이현정;김도희;김옥현 박지애;김대진;정윤희;김경용;김성수;이원복 중앙대학교 의과대학 의과학연구소 2012 中央醫大誌 Vol.37 No.1/2

Autophagy is a highly regulated cellular mechanism that results in the bulk degradation process and which seems to be implicated in a variety of physiological and pathological conditions relevant to Alzheimer's disease (AD). Also, it has been suggested that the large part of autophagy is mediated by Light Chains 3 (LC3). Despite research suggesting an association between AD and autophagy, many issues remain to be addressed. To determine the relevance between autophagy and AD, we evaluated amyloid beta (Aβ) toxicity either in SH-SY5Y cells transfected with only EGFP or the cells exogeneously transfected with EGFP-LC3, mediating autophagy easily by overexpressed LC3. Without treatment of Aβ, the cell viabilities were quietly similar in both kinds of cells. The cell viability was decreased significantly in LC3 overexpressed cells. Consistently, more increased oxidative stress was detected in LC3 overexpressed cells. These results suggest that autophagy enhanced Aβ toxicity by way of increasing oxidative stress at least in part. This study will be of help to understand the role of autophagy in neurodegenerative diseases.

완속여과 시스템에서 입자 제거와 손실수두(headloss)의 관계

신승식,홍진아,전항배 충북대학교 건설기술연구소 2003 建設技術論文集 Vol.22 No.1

The operational performance of slow sand filters can be considerably improved by the application of a layer of non-woven synthetic fabric to the top surface of the sand media. This improvement is manifested in terms of an increased filter run time and the avoidance of headloss development within the sand media. The relationship between particulate removal and headloss development were investigated with two pilot-scale slow sand filters(filter A and filter B(ACF)) of which diameter was 140 mm and packed with sand in the depth of 850 ㎜. One of the filters was amended by covering the surface of slow sand filters with a ACF(activated carbon fiber) of which specific surface area was more than 1000 ㎡/g and thickness was 3 ㎜. Effective size and uniform coefficient of the sand medium was 0.31 ㎜ and 2.0 respectively. Initial filtration rate was 0.167 m/hr and the raw water turbidity and pH were in the range of 1.5-2.0 NTU, and 7.0-7.7, respectively. The particle removal efficiency of small than 2 ㎛ showed 86, 78% and greater than 3 ㎛ showed 96, 95% in the slow sand filter A and B(ACF), respectively. NPOC removed within upper 50 ㎜ depth and Schmutzdecke in slow sand filter B(ACF). Therefore, amended slow sand filter with non-woven fabric could reduce filter ripening time.

장애인직업재활상담 서비스 전달체계 연구

김승아 한국장애인고용촉진공단 고용개발원 1992 조사연구 Vol.- No.2

"Disabled persons" means an individual whose prospects of securing and retaining suitable employment are substantially reduced as a result of physical or mental impairment. Terefore, "vocational rehabilitation" means that part of the continuous and coordinated process of rehabilitation which involves the provision of those vocational services, e, g, vocational training, and selective placement, designed to enabled a disabled person to secure and retain suitable employment . Also, effective service delivery system included that entry functions, accountability functions, provision of services, planning and control functions. The purpose of service delivery system of vocational rehabilitation counselling as key to enable a disabled person to secure, retain and advance in suitable employment and thereby to further such person's intergration or reintergration into society. We have to examine the over all service delivery system of vocational rehabilitation counselling for the purpose of searching the effective and workable plans. The research methods for the study were as follows : ① Establishment of theoretical bases of service delivery system of vocational rehabilitation counselling for the disabled through reference study. service dilivery system included that various functions and principles. Vocational rehabilitation included that intake, evaluation, counselling, training, placement, and follow-up. ② Visit and survey to in Seoul, Kyeong-Gi' s, policy office, medical office, vocational rehabilitation centrers, training ceters, special school's, special classrooms, and other welfare facilities in order to grasp the conditions of the institutes, vocational rehabilitation process, and its officer opinion for effective service delivery system of vocational rehabilitation. As a result of these methods, it was concluded that without improvement such as fellows below, the disabled persons in institute wouldn't be able to free themselves from unemployment when they want to job. First, administrative and financial support system need to be established, speecial school are under the control of Ministry of Education, vocational training are under the control of Ministry of Labor, and vocational rehabilitation centers and welfare facilities are under the control of the Ministry of Health and Social Wealfare. Therefore, a highter organizational system is necessary in order to bind the agencies together facilitation cooperation. Second, service delivery system need to be established. Each institutes never cooperates and helps each in order to serve better to disabled, - included that intake, evaluation, counselling, training, placement, and follow-up. Above all are interconnected. All institutes and other social association, and advocates need to share information and cooperate for the best service to each disabled. Third, for the purpose of effective service delivery system of vocational rehabilitation, we plan need to be developed for study, e, g, professional person and materials for vocational rehabilitation. Fourth, the vocational rehabilitation should be continuous. We need to be specialized the service, and facilitated the referral with institutes. Fifth, It the korea employment promotion agency for the dis abled that specially roles to execute a plan for the disabled. We need to view differently toward the plans for special stage. At last, policy shall aim at ensuring that appropriate vocational rehabilitation me asures are made available to all categories of disabled persons, and at promoting employment opportunities for disabled persons in the open market.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용

김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.