Prediction Model for Screening Patients at Risk of Malnutrition after Gastric Cancer Surgery

Ji-Hyeon Park,Eunjung Kim,Eun-Mi Seol,Seong-Ho Kong,Do-Joong Park,Han-Kwang Yang,Jong-Ho Choi,Shin-Hoo Park,Hwi-Nyeong Choe,Meera Kweon,Jiwon Park,Yunhee Choi,Hyuk-Joon Lee 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11

Response to comment on “Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea”

Eunjung Park,Young Lee,Mihn-Sook Jue 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4

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Onboard Software Development and Performance Assessment of Enhanced Spaceborne GPS Receiver for Small Satellite System

Eunjung Choi,Jun Young Park,Hungu Lee,Sang Young Park,Kyu Hong Choi 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-

The spaceborne GPS receiver is one of the indispensable payloads for the high-resolution earth observation satellites. In this paper, the onboard software architecture, implementation and test results as well as the hardware system related to the on board software are described. The hardware design is mainly built with the 12 channel Ll C/A code baseband correlator and 32-bit floating-point DSP microprocessor. The onboard software architecture is designed using DSP/BIOS to support the real-time multitasking operating system. The on board software of the enhanced spaceborne GPS receiver contains the task scheduling, the algorithms of GPS signal baseband processing, satellite ephemeris calculations and real-time orbit determination. The performance test is based on hardware-in-the-loop simulations using GPS simulator. The experimental results show that implemented software gives the fast TTFF and stable tracking of GPS SV. In the event, the enhanced spaceborne GPS receiver is able to provide the position and velocity stably.

Cutaneous Pseudolymphoma caused by hair dye

( Eunjung Park ),( Taehan Koo ),( Mingyul Jo ),( Jisook Yoo ),( Mihn-sook Jue ),( Min-soo Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Cutaneous pseudolymphoma (CPL) refers to a group of benign T or/and B-cell lymphoproliferative processes of diverse causes that resemble cutaneous lymphomas. Lymphomatoid contact dermatitis (LCD) is a form of CPL that was first described in 1976 by Orbaneja. Since then, various antigens have been reported to cause this type of CPL. A 72-year-old male with presented with an 1-year history of a solitary erythematous crusted patch on right temple. He had a medical history of allergic contact dermatitis, seborrheic dermatitis and diabetes mellitus. He had been regularly coloring his hair for several years. Punch biopsy revealed a dense, nodular, dermal infiltrate of lymphocytes that formed lymphoid follicles surrounded by well-defined mantle zones with scattered tingible-body macrophages. Immunohistochemical staining revealed nodular aggregates of CD20+ lymphocytes, infiltrate of predominantly CD3, 4, 5, 8 + lymphocytes, and positive for the germinal center cell markers Bcl-6, CD10, Bcl-2, and Ki-67. Polyclonal immunoglobulin H gene rearrangement was detected. The diagnosis of CPL was finally made based on the clinical, histologic, and molecular findings. The patient was treated with intralesional injection of triamcinolone acetonide and the lesion was resolved. We herein report a rare case of CPL caused by hair dye. Clinicians should be aware of potential causative agent of hair dye for the development of CPL.

CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

Park, Jungmin,Ku, Minhee,Kim, Eunjung,Park, Yeonji,Hong, Yoochan,Haam, Seungjoo,Cheong, Jae-Ho,Park, Eun Sung,Suh, Jin-Suck,Huh, Yong-Min,Yang, Jaemoon Oxford University Press 2013 Integrative biology Vol.5 No.4

<P>We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.</P>

Angioimmunoblastic T-cell lymphoma initially diagnosed from skin lesions

( Eunjung Park ),( Taehan Koo ),( Mingyul Jo ),( Jisook Yoo ),( Min-soo Kim ),( Mihn-sook Jue ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral CD4+ T-cell lymphoma. Skin lesions have been reported to occur in 40-50% of AITL cases, but it is difficult to doubt AITL with only cutaneous lesions because of its various and nonspecific cutaneous findings. A 58-year-old male, who was admitted in hemato-oncology department for generalized edema since 3 weeks ago, was consulted to our department for dermatologic evaluation. Physical examination showed asymptomatic, generalized erythematous maculopatches on trunk and extremities. He had no subjective symptom. He had medical history of alcoholic liver cirrhosis and rectal cancer. Skin biopsies revealed perifollicular and periadnexal lymphocytic infiltration in dermis and immunohistochemical stains were positive for CD3, CD4, CD8, CD20, PD-1 and 20% of Ki-67, and negative for Epstein-Barr virus encoded small RNAs in situ hybridization. Systemic evaluations were performed for the suspicion of AITL. Abdominal and pelvic computed tomography showed signs of local lymphatic metastasis. Positron emission tomography showed multiple metastatic lymphadenopathies and metastasis to appendix and pancreas. Omental, mesentary lymph node biopsies were also done, which revealed AITL. The patient underwent chemotherapy regimen for CHOP. We herein report a case of AITL which was initially diagnosed from skin biopsy to emphasize the importance of clinical suspicion in diagnosing lymphomas.

[P097] Angioleiomyoma of the finger: an unusual presentation

( Eunjung Park ),( Mingyul Jo ),( Jisook Yoo ),( Mihn-sook Jue ),( Kwang-hyun Choi ),( Min-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Angioleiomyoma is a benign vascular neoplasm derived from the smooth muscle cells of arterial or venous walls. Angioleiomyoma occurs in the lower extremities most frequently, and less common on the trunk, head, and upper extremities. A 80-year-old female with medical history of diabetes mellitus, hypertension, depressive disorder came to our clinic complaining of about a solitary painful, slowly-growing subcutaneous nodule on the right 5th metacarpophalangeal (MCP) joint of finger from several months ago. Histopathological examination of the skin lesion showed diffuse vascularized subcutaneous nodules composed of well-differentiated smooth muscle fibers without cellular atypia. Immunohistochemical stain was positive for smooth-muscle actin (SMA), but negative for HMB-45, confirming the diagnosis of angioleiomyoma. The patient refused the complete excision of the tumor. Angioleiomyoma on the finger is uncommon, and to the best of our knowledge, there was no case of the angioleiomyoma on the finger in the dermatologic literature in Korea. We herein report a rare case of angioleiomyoma on the finger.

Cutaneous mucormycosis arising in an old patient with pityriasis lichenoides et varioliformis acuta (PLEVA)

( Eunjung Park ),( Taehan Koo ),( Mingyul Jo ),( Jisook Yoo ),( Min-soo Kim ),( Mihn-sook Jue ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Cutaneous mucormycosis (CM) is a rare opportunistic fungal infection caused by the order Mucorales, which associated with trauma, burns and surgical wounds. A 84-year-old male visited our clinic complaining of black necrotic ulcer with erythematous halo on right lateral shin since 2 weeks ago. The patient had medical history of hypertension and pityriasis lichenoides et varioliformis acuta (PLEVA) treated with 200mg/day of doxycycline. Physical examination revealed multiple, 1 to 3cm-sized, irregularly shaped ulcers with black eschar and peripheral erythematous halo simulating an ecthyma gangrenosum were on right shin, where the skin lesion of PLEVA was located. He denied any history of trauma on the lesion. He had no systemic symptoms. Skin biopsies were conducted from center and margin of the lesion, showed necrosis and inflammatory cell infiltration in the dermis to subcutaneous layer, and large, non-septate, right-angled branching hyphae with positive special staining for periodic acid-Schiff and Gomori methenamine silver. Rhizopus species was isolated from tissue culture, which was consistent with CM. The patient was successfully treated with a combination of surgical debridement and 20mg/day of amphotericin B intravenously, and the lesion was totally reepithelialized without any evidence of eschar. We herein report a interesting and educative case of CM arising in the site of PLEVA.

The Role of Age in Subclinical Atherosclerosis in Asian People Living with Human Immunodeficiency Virus

Park Sunghee,Park Se Yoon,Lee Eunjung,Kim Tae Hyong,Lee Eunyoung 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2

Background People living with human immunodeficiency virus (PLHIV) have an increased risk of atherosclerosis and cardiovascular disease, but specific guidance on when to suspect the onset of these diseases is limited. Materials and Methods We aimed to identify cardiovascular risk factors in PLHIV using carotid intima-media thickness (IMT) through a cross-sectional, retrospective cohort study that enrolled 217 PLHIV who underwent carotid IMT measurement at a teaching hospital in Korea. We compared clinical characteristics between PLHIV with subclinical atherosclerosis and PLHIV with IMT within the normal range, and used a receiver operating characteristic curve to determine the cut-off age for predicting subclinical atherosclerosis. Results Among the study population, 115 participants (53.0%) had subclinical atherosclerosis. In logistic regression, age and dyslipidemia were significantly associated with increased carotid IMT even after adjusting for other variables (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.06 - 1.15, P <0.001; OR: 3.92, 95% CI: 1.87 - 8.22, P <0.001, respectively). The cut-off age for predicting subclinical atherosclerosis was 39.5 years (area under the curve 0.78, 95% CI: 0.72 - 0.84, P <0.001). Conclusion Conventional risk factors including age and dyslipidemia were associated with subclinical atherosclerosis in Asian PLHIV. In particular, Asian PLHIV older than 40 years had an increased risk of subclinical atherosclerosis and may benefit from carotid IMT screening. Background People living with human immunodeficiency virus (PLHIV) have an increased risk of atherosclerosis and cardiovascular disease, but specific guidance on when to suspect the onset of these diseases is limited. Materials and Methods We aimed to identify cardiovascular risk factors in PLHIV using carotid intima-media thickness (IMT) through a cross-sectional, retrospective cohort study that enrolled 217 PLHIV who underwent carotid IMT measurement at a teaching hospital in Korea. We compared clinical characteristics between PLHIV with subclinical atherosclerosis and PLHIV with IMT within the normal range, and used a receiver operating characteristic curve to determine the cut-off age for predicting subclinical atherosclerosis. Results Among the study population, 115 participants (53.0%) had subclinical atherosclerosis. In logistic regression, age and dyslipidemia were significantly associated with increased carotid IMT even after adjusting for other variables (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.06 - 1.15, P <0.001; OR: 3.92, 95% CI: 1.87 - 8.22, P <0.001, respectively). The cut-off age for predicting subclinical atherosclerosis was 39.5 years (area under the curve 0.78, 95% CI: 0.72 - 0.84, P <0.001). Conclusion Conventional risk factors including age and dyslipidemia were associated with subclinical atherosclerosis in Asian PLHIV. In particular, Asian PLHIV older than 40 years had an increased risk of subclinical atherosclerosis and may benefit from carotid IMT screening.

A case of extruding pilomatricoma with perforating figure of the cheek

( Eunjung Park ),( Gayun Baek ),( Taehan Koo ),( Mingyul Jo ),( Jiho Park ),( Min-soo Kim ),( Mihn-sook Jue ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Pilomatricoma, also known as calcifying epithelioma of Malherbe, is a benign adnexal skin tumor arising from hair matrix cells. Clinically, pilomatricoma typically presents as a firm, bluish or red colored, deep-seated nodule with overlying normal skin. Several variants of pilomatricoma have been described including perforating, extruding, bullous, melanocytic, giant, keratoacanthoma-like, exophytic, lymphangiectatic, familial, anetodermic, and multiple, especially extruding variant have been very rarely reported. A 10-year-old girl presented with a 2-month history of a slow-growing, solitary, firm, skin-colored to pinkish, pedunculated papule with central crusted perforation on left cheek. She had medical history of spherocytosis and had a surgery of splenectomy, and no history of pain, trauma, infection, radiation or surgery at the lesion. A skin biopsy revealed a well circumscribed tumor located in superficial to mid dermis, composed of two cell types of basaloid cells and eosinophilic keratinized shadow cells. Superficial perforating and foreign body giant cell reactions were also seen. With the clinical and histological findings, we diagnosed of extruding pilomatricoma also has perforating figure. She had no signs of recurrence of the lesion for 8 months after punch removal. To our knowledge, this is the first report of extruding pilomatricoma with perforating figure.