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우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰
오영택,오현묵,김서우,김원용,손창규,조정효,Oh, Young-Taeck,Oh, Hyeon-Muk,Kim, Seo-Woo,Kim, Won-Yong,Son, Chang-Gue,Cho, Jung-Hyo 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1
Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.
Won Hyo Seo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Alcoholic liver disease is liver damage that results from alcohol misuse. Years of alcohol abuse induces simple steatosis and steatohepatitis as early types of liver diseases, however, continuous liver damage are able to induce liver fibrosis/cirrhosis, and hepatocellular carcinoma as known as late stage of liver disease. Albeit ALD is a major personal/public health problem, the pathogenesis of ALD has not been understood very well. About 8 to 10 percent of Americans drink heavily and, 10 to 15 percent will go on to develop ALD. ALD not only generates personal health issues, but also creates a lot of social problems such as drunken driving. The pathogenesis of ALD involves complex and unclear biological processes. Interestingly, alcohol consumption can profoundly disturb the normal functions of adipose tissue by inducing adipocyte death and altering secretion of adipokines, pro-inflammatory mediators and free fatty acids from adipose tissue, which have important direct and indirect effects on the pathogenesis of alcoholic liver disease. The association of the oxidative metabolites of ethanol (acetaldehyde and reactive oxygen species) have been well studied as crucial factors to understand clinical and pathological spectrum of ALD. Especially, acetaldehyde is known to be toxic to the liver and alters lipid homeostasis. Acetaldehyde generated from lipid peroxidation induce collagen synthesis by their ability to form protein adducts that further activate transforming-growth-factor-β-dependent and independent profibrogenic pathways in activated hepatic stellate cells (HSCs). Besides of oxidative alcohol metabolite, we have investigated that non-oxidative metabolites generated during alcohol metabolism act as factors promoting liver damage. Fatty acid ethyl esters (FAEEs), nonoxidative metabolites of ethanol, are detectable in the blood after ethanol ingestion, and on that basis have been proposed as markers of ethanol intake. The investigation of the association of oxidative alcohol metabolites and non-oxidative alcohol metabolites would provide very informative clues to understand more about the pathogenesis of alcohol-mediated liver injury.
A Numerical study for the efficacy of flow injection on the diminution of rudder cavitation
Seo, Dae-Won,Lee, Seung-Hee,Kim, Hyo-Chul,Oh, Jung-Keun The Society of Naval Architects of Korea 2010 International Journal of Naval Architecture and Oc Vol.2 No.2
The complete avoidance of cavitation, as a result of gap flow between the fixed and movable portion of a horn type rudder system, is difficult. To reduce gap flow, it is a common practice to attach a half round prismatic bar that protrudes beyond the concave surface of the horn facing the gap and laid along the centerplane of the rudder. However the employment of such a device does not always yield satisfactory results. Previously, the authors have shown that a pair of blocking bars, attached on the convex surface of the movable portion, better enhance the blocking ability of gap flow to that of a single centre bar installed on the concave surface. This also circumvents difficulties that might occur in practical applications. In the present study, a series of numerical computations show that flow injected into the gap of a rudder may also block the flow within, without employment of any physical devices, such as a half circular bar. This study also shows that the combination of flow injection and blocking bars may result in the synergic augmentation of blocking efficiency of gap flow, as demonstrated in computations for a three dimensional rudder system.
Wernicke’s Encephalopathy after Sleeve Gastrectomy for Morbid Obesity - A Case Report -
Hyo Jun Jeong,박지웅,김용진,Yang Gyun Lee,Yi Wook Jang,Jun Won Seo 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.4
Morbid obesity is a curable systemic disease that can cause several complications, including hypertension, diabetes mellitus, and osteoarthritis. However, it is not easy to control solely by conservative management. Bariatric surgeries, such as sleeve gastrectomy and gastric banding, are recently developed treatments that are applied to patients with morbid obesity in Korea. However, gastric surgery can cause surgical or metabolic complications, such as thiamine deficiency, which can lead to Wernicke’s encephalopathy. This metabolic complication presents with typical symptoms of confusion, ophthalmoplegia, nystagmus, and ataxia. In this case report, we present a case of Wernicke’s encephalopathy, which developed slowly following sleeve gastrectomy in a patient with morbid obesity.
Seo, Hyung-Ran,Jeong, Eun-Seon,Ahmed, Mohammad Shamsuddin,Lee, Hyo-Kyoung,Jeon, Seung-Won Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.6
The Schiff base N,N'-bis(pyridin-2-ylmethylene)benzene-1,2-diamine [BPBD] has been synthesized and explored as ionophore for preparing PVC-based membrane sensors selective to the silver ($Ag^+$) ion. Potentiometric investigations indicate high affinity of this receptor for silver ion. The best performance was shown by the membrane of composition (w/w) of ionophore: 1 mg, PVC: 33 mg, o-NPOE: 66 mg and additive were added 50 mol % relative to the ionophore in 1 mL THF. The sensor works well over a wide concentration range $1{\times}10^{-3}$ to $1.0{\times}10^{-7}$ M by pH 6 at room temperature (slope 58.6 mV/dec.) with a response time of 10 seconds and showed good selectivity to silver ion over a number of cations. It could be used successfully for the determination of silver ion content in environmental and waste water samples.
Seasonal Variations and Associated Factors of Gout Attacks: a Prospective Multicenter Study in Korea
Hyo Jin Choi,Ki Won Moon,Hyun-Ok Kim,Yeon-Ah Lee,Seung-Jae Hong,Ju-Yang Jung,Hyoun-Ah Kim,Chang Hee Suh,하유정,In Je Kim,Jisoo Lee,Eun-Kyoung Park,이승근,Mi Ryoung Seo,Han Joo Baek,최상태,송정수 대한의학회 2020 Journal of Korean medical science Vol.35 No.20
Background: We purposed to evaluate the seasonality and associated factors of the incidence of gout attacks in Korea. Methods: We prospectively enrolled patients with gout attacks who were treated at nine rheumatology clinics between January 2015 and July 2018 and followed them for 1-year. Demographic data, clinical and laboratory features, and meteorological data including seasonality were collected. Results: Two hundred-five patients (men, 94.1%) were enrolled. The proportion of patients with initial gout attacks was 46.8% (n = 96). The median age, body mass index, attack duration, and serum uric acid level at enrollment were 50.0 years, 25.4, 5.0 days, and 7.4 mg/ dL, respectively. Gout attacks were most common during spring (43.4%, P < 0.001) and in March (23.4%, P < 0.001). A similar pattern of seasonality was observed in the group with initial gout attacks. Alcohol was the most common provoking factor (39.0%), particularly during summer (50.0%). The median diurnal temperature change on the day of the attack was highest in the spring (9.8°C), followed by winter (9.3°C), fall (8.6°C), and summer (7.1°C) (P = 0.027). The median change in humidity between the 2 consecutive days (the day before and the day of the attack) was significantly different among the seasons (3.0%, spring; 0.3%, summer; −0.9%, fall; −1.2%, winter; P = 0.015). One hundred twenty-five (61%) patients completed 1-year follow-up (51% in the initial attack group). During the follow-up period, 64 gout flares developed (21 in the initial attack group). No significant seasonal variation in the follow-up flares was found. Conclusion: In this prospective study, the most common season and month of gout attacks in Korea are spring and March, respectively. Alcohol is the most common provoking factor, particularly during summer. Diurnal temperature changes on the day of the attack and humidity changes from the day before the attack to the day of the attack are associated with gout attack in our cohort.