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( Sejin Kim ),( Sejin Lee ),( Jee Yoon Park ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To evaluate the association between initial presentations and clinical outcomes of patients who were transferred for postpartum hemorrhage from local clinics to a tertiary center Methods: This is a retrospective cohort study from January 2009 to May 2018. The clinical data of patients who had been transferred for postpartum hemorrhage from various local obstetric clinics or secondary hospitals were analyzed. Results: A total of 550 patients were included. As a first line treatment, 32.9% (181/550) received pelvic artery embolization and 1.1% (6/550) underwent hysterectomy immediately after evaluation at emergency room. After exclusion of patients who had been transferred after 48 hours from delivery, 478 patients were remained and were divided into three groups according to the final management: group 1 treated with only conservative care (n=186), group 2 who received massive transfusion (10 units of Red blood cell (RBC)) and/or pelvic artery embolization (n=266), and group 3 who underwent hysterectomy (n=26). Initial systolic blood pressure (BP), diastolic BP, heart rate (HR), the values of hemoglobin, and platelet counts were significantly different among three groups. Among factors of vital signs, low systolic BP below 80 mmHg (Odds ratio 8.4, 95% confidence interval 3.2-22.1, p-value<0.001) and elevated HR over 100 /min (Odds ratio 3.0, 95% confidence interval 1.2-7.8, p-value=0.023) were associated with hysterectomy in multivariate logistic regression. Conclusion: Once transferring to a tertiary center has been decided for postpartum hemorrhage, the information on initial presentations including simple vital signs can help to predict the prognosis and to plan further management.
Comparison of the Right and Left Femur Bone Mineral Densities in Postmenopausal Women
Sejin Kim,Yoojin Na,Minji Ko,Jung Yoon Park,Hyonjee Yoon,Jae-Yen Song,Youn-Jee Chung,Inhye Shin,Chaewon Kim,Jung Hyun Park,Mee-Ran Kim 대한폐경학회 2023 대한폐경학회지 Vol.29 No.3
Objectives: Bone mineral density (BMD) is measured in the hip and posteroanterior spine; moreover, according to the 2019 International Society for Clinical Densitometry guidelines, unilateral hip can be used. This study aimed to determine whether there is a difference between the BMD of both the femurs in postmenopausal women.Methods: A total of 343 postmenopausal women were enrolled in this study from January 1, 2010, to December 31, 2019 at a single tertiary hospital. By using the Hologic® Horizon W DXA System, the femur and spine BMD was measured; BMD was recorded in g/cm2. Following regions were analyzed in both the femurs: the femur neck, the trochanter area, and total femur.Results: Mean age at imaging was 62 ± 9.7 years, and significant difference in the total BMD of both the femurs (P = 0.003) was observed. In secondary analysis, patients with osteoporosis showed significant contralateral BMD discrepancies in trochanter and total proximal femur BMD (P = 0.041 and P = 0.011, respectively). However, in women with normal BMD, no significant difference between the right and left femur BMD was observed. Furthermore, measurement of solely the unilateral hip can lead to a 16.9% of underdiagnosis in postmenopausal women.Conclusions: In conclusion, it is necessary to check BMD in both hips, particularly in patients suspected of osteoporosis.
Yoon, Hyun,Na, Seung Heon,Choi, Jae Young,Kim, Min Woo,Kim, Hayong,An, Hee Sang,Min, Byoung Koun,Ahn, SeJin,Yun, Jae Ho,Gwak, Jihye,Yoon, KyungHoon,Kolekar, Sanjay S.,van Hest, Maikel F. A. M.,Al-Deya American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.11
<P>We have demonstrated the first example of carbon- and oxygen-free Cu(In,Ga)(SSe)<SUB>2</SUB> (CIGSSe) absorber layers prepared by electrospraying a CuInGa (CIG) precursor followed by annealing, sulfurization, and selenization at elevated temperature. X-ray diffraction and scanning electron microscopy showed that the amorphous as-deposited (CIG) precursor film was converted into polycrystalline CIGSSe with a flat-grained morphology after post-treatment. The optimal post-treatment temperature was 300 °C for annealing and 500 °C for both sulfurization and selenization, with a ramp rate of 5 °C/min. The carbon impurities in the precursor film were removed by air annealing, and oxide that was formed during annealing was removed by sulfurization. The fabricated CIGSSe solar cell showed a conversion efficiency of 4.63% for a 0.44 cm<SUP>2</SUP> area, with <I>V</I><SUB>oc</SUB> = 0.4 V, <I>J</I><SUB>sc</SUB> = 21 mA/cm<SUP>2</SUP>, and FF = 0.53.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-11/am501286d/production/images/medium/am-2014-01286d_0016.gif'></P>
Kim, Min-woo,Yoon, Hyun,Ohm, Tae Yoon,Mali, Mukund G.,Choi, Sung Kyu,Park, Hyunwoong,Al-Deyab, Salem S.,Lim, Dong Chan,Ahn, SeJin,Yoon, Sam S. Elsevier 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.692 No.-
<P><B>Abstract</B></P> <P>Photoelectrochemical (PEC) water splitting was performed using co-evaporated Cu(In,Ga)Se<SUB>2</SUB> (CIGS, p-type) films as the photocathode. Pt was electrodeposited on CIGS and CIGS/CdS films. The effect of the electrodeposition time was investigated to determine the optimal deposition conditions. The CIGS film was covered with a 60-nm-thick CdS layer (n-type) using a chemical-bath deposition technique, which created a p-n junction. The effect of the Pt electroplating time was again investigated for the CIGS/CdS films; thus, the effect of CdS addition could be quantitatively investigated. The effect of the pH of 0.5 M Na<SUB>2</SUB>SO<SUB>4</SUB> electrolyte was also investigated. The optimal water-splitting performance occurred at −24.16 mA/cm<SUP>2</SUP> at −0.7 V vs. Ag/AgCl with a Pt electrodeposition time of 20 min and pH 9. The CIGS/CdS films were characterized by X-ray diffraction, scanning electron microscopy, and focused-ion beam transmission electron microscopy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The CIGS/CdS layers were electrodeposited with Pt using various deposition times. </LI> <LI> The Pt electrodeposition time of 20 min yielded −24.16 mA/cm<SUP>2</SUP> at optimum. </LI> <LI> The effect of the pH on the PEC performance was investigated. </LI> </UL> </P>
( Sejin Lee ),( Kyo Hoon Park ),( Yu Mi Kim ),( Namkyeong Kim ),( Jee Yoon Park ),( Joon-seokhong ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: To determine whether various immune-related proteins in cervicovaginal fluid (CVF), alone or in combination with clinical risk factors, can predict intra-amniotic infection and/or inflammation (IAI) in women with preterm premature rupture of membranes (PPROM) and to compare predictive ability of these biomarkers with that of amniotic fluid (AF) white blood cell (WBC) using invasive amniocentesis. Methods: This retrospective cohort study included 99 consecutive singleton pregnant women (23.0-33.6 gestational weeks) with PPROM who underwent amniocentesis. The amniotic fluid (AF) was cultured, and the white blood cell (WBC) count was determined. The stored CVF samples were assayed for complement C3a and C5a, TIMP-1, MMP-9, and M-CSF by using ELISA kits. Serum C-reactive protein (CRP) level was measured at the time of sampling. The primary outcome measures were IAI [defined as a positive AF culture and/or an elevated AF IL-6 level (2.6 ng/mL)]. Results: The overall prevalence of IAI was 50.5% (50/99). The CVF levels of C3a, C5a, TIMP-1, MMP-9, and M-CSF were significantly higher in women with IAI. The women with IAI had a significantly lower gestational age at sampling and a higher level of serum CRP. Using a stepwise regression analysis, a combined prediction model was developed, which included the CVF MMP-9 and serum CRP [area under the curve (AUC), 0.827]. The AUC for this model was significantly higher than either parameter retained in this model, but no differences were observed between the AUC of this model based on non-invasive variables, and AF WBC. Conclusion: This study suggests that TIMP-1, MMP-9, M-CSF, C3a and C5a in the CVF may be useful as new non-invasive predictors of IAI in women with PPROM and that the best predictive model, which combined these biomarkers with conventional clinical factors, can significantly improve the predictability for IAI.
Yoon Hee-Young,Lee Suk Hyun,Ha Sejin,Ryu Jin-Sook,Song Jin Woo 대한의학회 2021 Journal of Korean medical science Vol.36 No.41
Background: Several parameters are useful for assessing disease severity in idiopathic pulmonary fibrosis (IPF); however, the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is not well-defined. We aimed to evaluate the value of 18F-FDG PET/CT for assessing disease severity and prognosis in IPF patients. Methods: Clinical data of 89 IPF patients (mean age: 68.1 years, male: 94%) who underwent 18F-FDG PET/CT for evaluation of lung nodules or cancer staging were retrospectively reviewed. Mean and maximal standardized uptake values (SUVmean, SUVmax, respectively) were measured in the fibrotic area. Adjusted SUV, including SUV ratio (SUVR, defined as SUVmaxto-liver SUVmean ratio), tissue fraction-corrected SUVmean (SUVmeanTF), and SUVR (SUVRTF), and tissue-to-blood ratio (SUVmax/SUVmean venous; TBRblood) were obtained. Death was defined as the primary outcome, and associations between other clinical parameters (lung function, exercise capacity, C-reactive protein [CRP] level) were also investigated. Results: All SUV parameters were inversely correlated with the forced vital capacity, diffusing capacity for carbon monoxide, and positively correlated with CRP level and the gender-agephysiology index. The SUVmean, SUVmax, and SUVmeanTF were associated with changes in lung function at six months. The SUVR (hazard ratio [HR], 1.738; 95% confidence interval [CI], 1.011–2.991), SUVRTF (HR, 1.441; 95% CI, 1.000–2.098), and TBRblood (HR, 1.377; 95% CI, 1.038–1.827) were significant predictors for mortality in patients with IPF in the univariate analysis, but not in the multivariate analysis. Conclusion: 18F-FDG PET/CT may provide additional information on the disease severity and prognosis in IPF patients, and the SUVR may be superior to other SUV parameters.
Yoon Hyun Ju,Kim Gi-Cheon,Oh Sejin,Kim Hakhyun,Kim Yong Keon,Lee Yunji,Kim Min Seo,Kwon Gino,Ok Yeon-Su,권호근,김현석 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Immune checkpoint therapies, such as programmed cell death ligand 1 (PD-L1) blockade, have shown remarkable clinical benefit in many cancers by restoring the function of exhausted T cells. Hence, the identification of novel PD-L1 regulators and the development of their inhibition strategies have significant therapeutic advantages. Here, we conducted pooled shRNA screening to identify regulators of membrane PD-L1 levels in lung cancer cells targeting druggable genes and cancer drivers. We identified WNK lysine deficient protein kinase 3 (WNK3) as a novel positive regulator of PD-L1 expression. The kinase-dead WNK3 mutant failed to elevate PD-L1 levels, indicating the involvement of its kinase domain in this function. WNK3 perturbation increased cancer cell death in cancer cell–immune cell coculture conditions and boosted the secretion of cytokines and cytolytic enzymes, promoting antitumor activities in CD4+ and CD8+ T cells. WNK463, a pan-WNK inhibitor, enhanced CD8+ T-cell-mediated antitumor activity and suppressed tumor growth as a monotherapy as well as in combination with a low-dose anti-PD-1 antibody in the MC38 syngeneic mouse model. Furthermore, we demonstrated that the c-JUN N-terminal kinase (JNK)/c-JUN pathway underlies WNK3-mediated transcriptional regulation of PD-L1. Our findings highlight that WNK3 inhibition might serve as a potential therapeutic strategy for cancer immunotherapy through its concurrent impact on cancer cells and immune cells.