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Satoshi Hattori,Naomi Omi,Zhou Yang,Moeka Nakamura,Masahiro Ikemoto 한국운동영양학회 2021 Physical Activity and Nutrition (Phys Act Nutr) Vol.25 No.2
[Purpose] Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle glycogen by enhancing fat oxidation. Thus, we investigated the effect of GE ingestion on exercise capacity, skeletal muscle glycogen, and certain blood metabolites in exercised rats. [Methods] First, we evaluated the influence of GE ingestion on body weight and elevation of exercise performance in rats fed with different volumes of GE. Next, we measured the skeletal muscle glycogen content and free fatty acid (FFA) levels in GE-fed rats. Finally, we demonstrated that GE ingestion contributes to endurance capacity during intermittent exercise to exhaustion. [Results] We confirmed that GE ingestion increased exercise performance (p<0.05) and elevated the skeletal muscle glycogen content compared to the non- GE-fed (CE, control exercise) group before exercise (Soleus: p<0.01, Plantaris: p<0.01, Gastrocnemius: p<0.05). Blood FFA levels in the GE group were significantly higher than those in the CE group after exercise (p<0.05). Moreover, we demonstrated that exercise capacity was maintained in the CE group during intermittent exercise (p<0.05). [Conclusion] These findings indicate that GE ingestion increases skeletal muscle glycogen content and exercise performance through the upregulation of fat oxidation.
Satoshi Hattori,Naomi Omi 한국운동영양학회 2021 Physical Activity and Nutrition (Phys Act Nutr) Vol.25 No.2
[Purpose] Sex hormones deficiency leads to dramatically bone loss in particular postmenopausal women. Royal jelly has anti-osteoporosis effect due to maintain bone volume in that condition. We hypothesized that royal jelly protein (RJP, a latent residue after extracting royal jelly) also prevents bone deficient in ovariectomized (OVX) female rats, the animal model of postmenopausal women. [Methods] Female Sprague-Dawley rats (n = 30, 6 weeks age old) were sham operated (Sham; sham operated group, n = 7), OVX control group (OC, n = 7), OVX with low RJP intake group (ORL, n = 8), and OVX with high RJP intake group (ORH, n = 8) during 8 weeks experimental periods. In the end point of this experiment, the bone samples (lumbar spine, tibia, and femur) were surgically removed under anesthesia. These bone samples were evaluated bone mineral density (BMD) and bone strength. [Results] BMD of lumbar spine in RJP intake groups (ORL, ORH) were higher than that in OC group (p < 0.05 and p < 0.01) in RJP intake volume dependent manner. BMD of tibial proximal metaphysis and diaphysis in RJP intake groups were also higher than these in OC group (p < 0.01 and p < 0.01 / p < 0.05 and p < 0.001). In addition, breaking force of femur in RJP intake groups were significantly increase compared with that in OC group (p < 0.001 respectively). [Conclusion] These findings indicate that RJP contribute to prevent sex hormone related bone abnormality.
( Satoshi Hattori ),( Suhan Park ),( Jong-hoon Park ),( Naomi Omi ) 한국운동영양학회 2020 Physical Activity and Nutrition (Phys Act Nutr) Vol.24 No.4
[Purpose] Dehydroepiandrosterone (DHEA) administration reportedly recovers osteoporosis, a bone disorder associated with bone deficiency in postmenopausal women. However, the physiological mechanism of DHEA in osteoporosis remains elusive, especially in terms of intestinal calcium absorption. Therefore, we investigated the effect of DHEA administration on calcium absorption in ovariectomized (OVX) female rats using an estrogen receptor antagonist. [Methods] Female Sprague-Dawley rats (n=23, 6 weeks old) were randomized into three groups: OVX control group (OC, n=7), OVX with DHEA treatment group (OD, n=8), and OVX with DHEA inhibitor group (ODI, n=8) for 8 weeks. [Results] Intestinal calcium accumulation, as well as the rate of absorption, demonstrated no significant differences during the experimental period among investigated groups. The bone mineral density (BMD) of the tibia at the proximal metaphysis was higher in the OD group than that in the OC group (p<0.05); however, BMD of the ODI group showed no significant difference from investigated groups. Furthermore, the BMD of the tibia at the diaphysis did not significantly differ among these groups. [Conclusion] We revealed that DHEA administration does not involve intestinal Ca absorption, although this treatment improves BMD levels in OVX rats. These observations indicate that the effect of DHEA on the bone in postmenopausal women is solely due to its influence on bone metabolism and not intestinal calcium absorption.
Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone
Masashi Ohe,Satoshi Hashino,Atsuo Hattori 대한혈액학회 2012 Blood Research Vol.47 No.4
We report a case of diffuse large B-cell lymphoma (DLBCL) treated successfully with clarithromycin (CAM) and prednisolone (PSL). A 71-year-old woman presented with fever and cervical pain. DLBCL was diagnosed based on histological results from lymph node biopsy. Cervical pain was thought to be caused by the invasion of lymphoma cells into the cervical vertebrae. She initially received radiotherapy for the cervical lesion. She did not receive conventional chemotherapy because of the risk of recurrent non-tuberculous mycobacteria infection; therefore, she was treated with 20 mg/day PSL and 800 mg/day CAM to induce apoptosis in lymphoma cells. Complete remission was achieved after 6 months. The present findings suggest that CAM and PSL may be effective in some cases of DLBCL.
ADVANTAGES OF THE AKARI FIR ALL-SKY MAPS
YASUO DOI,SATOSHI TAKITA,TAKAFUMI OOTSUBO,KO ARIMATSU,MASAHIRO TANAKA,TAKAHIRO MORISHIMA,MITSUNOBU KAWADA,SHUJI MATSUURA,YOSHIMI KITAMURA,MAKOTO HATTORI,TAKAO NAKAGAWA,GLENN WHITE,NORIO IKEDA 한국천문학회 2017 天文學論叢 Vol.32 No.1
We present the {\it AKARI} far-infrared (FIR) all-sky maps and describe its characteristics, calibration accuracy and scientific capabilities. The {\it AKARI} FIR survey has covered 97\% of the whole sky in four photometric bands, which cover continuously 50--180 micron with band central wavelengths of 65, 90, 140, and 160 microns. The data have been publicly released in 2014 \citep{2015PASJ...67...50D} with improved data quality that have been achieved since the last internal data release \citep{2012PKAS...27..111D}. The accuracy of the absolute intensity is $\leq10$\% for the brighter regions. Quantitative analysis of the relative intensity accuracy and its dependence upon spatial scan numbers has been carried out. The data for the first time reveal the whole sky distribution ofinterstellar matter with arcminute-scale spatial resolutions at the peakof dust continuum emission, enabling us to investigate large-scaledistribution of interstellar medium in great detail. The filamentarystructure covering the whole sky is well traced by the all-sky maps. We describe advantages of the AKARI FIR all-sky maps for the study of interstellar matter comparing to other observational data.
SMALL-SCALE STRUCTURE OF THE ZODIACAL DUST CLOUD OBSERVED IN FAR-INFRARED WITH AKARI
TAKAFUMI OOTSUBO,YASUO DOI,SATOSHI TAKITA,SHUJI MATSUURA,MITSUNOBU KAWADA,TAKAO NAKAGAWA,KO AROMATSU,MASAHIRO TANAKA,TORU KONDO,DAISUKE ISHIHARA,Fumihiko Usui,MAKOTO HATTORI 한국천문학회 2017 天文學論叢 Vol.32 No.1
The zodiacal light emission is the thermal emission from the interplanetary dust and the dominant diffuse radiation in the mid- to far-infrared wavelength region. Even in the far-infrared, the contribution of the zodiacal emission is not negligible at the region near the ecliptic plane. The AKARI far-infrared all-sky survey covered 97\% of the whole sky in four photometric bands with band central wavelengths of 65, 90, 140, and 160~$\mu$m. AKARI detected the small-scale structure of the zodiacal dust cloud, such as the asteroidal dust bands and the circumsolar ring, in far-infrared wavelength region. Although the most part of the zodiacal light structure in the AKARI far-infrared all-sky image can be well reproduced with the DIRBE zodiacal light model, there are discrepancies in the small-scale structures. In particular, the intensity and the ecliptic latitude of the peak position of the asteroidal dust bands cannot be reproduced precisely with the DIRBE models. The AKARI observational data during more than one year has advantages over the 10-month DIRBE data in modeling the full-sky zodiacal dust cloud. The resulting small-scale zodiacal light structure template has been used to subtract the zodiacal light from the AKARI all-sky maps.
AKARI FAR-INFRARED ALL-SKY SURVEY MAPS
Doi, Yasuo,Komugi, Shinya,Kawada, Mitsunobu,Takita, Satoshi,Arimatsu, Ko,Ikeda, Norio,Kato, Daisuke,Kitamura, Yoshimi,Nakagawa, Takao,Ootsubo, Takafumi,Morishima, Takahiro,Hattori, Makoto,Tanaka, Masa The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
Far-infrared observations provide crucial data for the investigation and characterisation of the properties of dusty material in the Interstellar Medium (ISM), since most of its energy is emitted between ~ 100 and $200{\mu}m$. We present the first all-sky image from a sensitive all-sky survey using the Japanese AKARI satellite, in the wavelength range $50-180{\mu}m$. Covering > 99% of the sky in four photometric bands with four filters centred at $65{\mu}m$, $90{\mu}m$, $140{\mu}m$, and $160{\mu}m$ wavelengths, this achieved spatial resolutions from 1 to 2 arcmin and a detection limit of < 10 MJy $sr^{-1}$, with absolute and relative photometric accuracies of < 20%. All-sky images of the Galactic dust continuum emission enable astronomers to map the large-scale distribution of the diffuse ISM cirrus, to study its thermal dust temperature, emissivity and column density, and to measure the interaction of the Galactic radiation field and embedded objects with the surrounding ISM. In addition to the point source population of stars, protostars, star-forming regions, and galaxies, the high Galactic latitude sky is shown to be covered with a diffuse filamentary-web of dusty emission that traces the potential sites of high latitude star formation. We show that the temperature of dust particles in thermal equilibrium with the ambient interstellar radiation field can be estimated by using $90{\mu}m$, $140{\mu}m$, and $160{\mu}m$ data. The FIR AKARI full-sky maps provide a rich new data set within which astronomers can investigate the distribution of interstellar matter throughout our Galaxy, and beyond.