Design of micro flexible wing mimicking insect flapping flight using fluid-structure interaction analysis

Daisuke Ishihara,Naoto Ohira,Masakatsu Takagi,Sunao Murakami,Tomoyoshi Horie 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.5

DEBRIS DISKS AND THE ZODIACAL LIGHT EXPLORED BY THE AKARI MID-INFRARED ALL-SKY SURVEY

DAISUKE ISHIHARA,NAMI TAKEUCHI,TORU KONDO,HIROSHI KOBAYASHI,HIDEHIRO KANEDA,SHU-ICHIRO INUTSUKA,SHINKI OYABU,TAKAHIRO NAGAYAMA,HIDEAKI FUJIWARA,TAKASHI ONAKA 한국천문학회 2017 天文學論叢 Vol.32 No.1

Debris disks are circumstellar dust disks around main-sequence stars. They are important observational clues to understanding the planetary system formation. The zodiacal light is the thermal emission from the dust disk in our Solar system. %For a comprehensive understanding of the nature andthe evolution of dust disks around main-sequence stars,we try a comparative study of debris disks and the zodiacal light. %We search for debris disks using the AKARI mid-infrared all-sky point source catalog. By applying accurate flux estimate of the photospheric emissionbased on the follow-up near-infrared observations with IRSF,we have improved the detection rate of debris disks. %For a detailed study of the structure and grain propertiesin the zodiacal dust cloud,as an example of dust disks around main-sequence stars,we analyze the AKARI mid-infrared all-sky diffuse maps. %As a result of the debris disks search,we found old ($>$1\,Gyr) debris disks which have large excess emissioncompared to their age, which cannot be explained simplyby the conventional steady-state evolution model. %From the zodiacal light analysis, we find the possibilitythat the dust grains trapped in the Earth's resonance orbitshave increased by a factor of $\sim$3 in the past $\sim$20 years. %Combining these results, we discuss the non-steady processes in debris disks and the zodiacal light.

Poster Session : PS 0339 ; Hematology : Study of Multiple Neoplasms Including Hematological Malignancies and Lung Cancer

( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ),( Kazuhiko Natori ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: It is a well-known fact that the prevalence of malignancy increases year by year. In addition, other malignancies may be found in the systemic screening before treatment or after several therapy during observation. Malignant lymphoma is often the most number of patients. We reviewed the complication with lung cancer that was a poor prognosis. We look for possibility of the prognosis improvement by determining a characteristic. Methods: In 290 cases multiple cancer including hematological malignancy in our department, we examined 20 cases that including lung cancer & malignant lymphoma. Reviewed the following is gender, age, outbreak style, strategy of therapy, clinical income, and overall survival. Diagnostic criteria of multiple cancer is according to Warren&Gates. It was distinguish synchronous and metachronous that synchronous double cancer diagnosed interval of 6 months. Results: The subjects were 20 patients, median age was 70 years. Synchronous cancer was found in 5 patients and metachronous in 15 patients. Malignant lymphoma was non-Hodgkin`s lymphoma in 11 patients, Hodgkin`s lymphomain 2 patients and lymphoma- stage mycosis fungoides in 1patient. Acute myelogeneous leukemia 3 cases, myelodysplastic syndrome 3 cases. All of the patients with ML underwent chemotherapy (CTx) and 8 and 4 of them achieved completeand partial remission, respectively, while 2cases had progressive disease. In 20 cases with LC, operation (Ope) alone was conducted in 6 cases, Ope+ adjuvant therapy in 3 cases, radiation therapy (RTx) in 1case, RTx + CTx in 1case, and CTx alone in 7 cases, non therapy 2 cases. The median survival was 11 months. Conclusions: For metachronous type, there is chance to fi nd second cancer, if they observed long time. I think that we must understand he has or will have another cancer. Prognosis improvement of the advanced lung cancer is expected.

Poster Session : PS 0331 ; Hematology : Experience of Chemotherapy of Malignant Lymphoma in More Than 90 Years

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Yukitoshi Toyoda ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Though oral infection represented by caries and periodontal disease is the infectious disease that is thought with life-style related diseases generally. Including hematological malignancy, the infectious disease research before taking anticancer drug treatment is important. A potential infectious disease may bring about a fatal infectious disease for bone marrow suppression period. We report it this time about an oral surgery area as a search before treatment of the malignant lymphoma. Methods: In eight years from 2003 to 2012, we intended for a case in newly diagosed malignant lymphoma in our hospital. We reviewed having consultation or not of the oral surgery, treatment contents, having exodontia or not. Results: Among 383 patients, the oral surgery consultation was 271 cases, male female ration was 150/121. T, and the age median was 67years. It was 154 cases that it was judged that treatment was necessary. The case performed exodontia was 53 cases. Among 53 patients, 33 cases were progression stages. Conclusions: With the onset of febril neutropenia, the infectious disease that is not seen occurs with the normal immune status. An oral cavity lesion is a neighborhood of the central nerve system and is in very danger. Fortunately, there was not the case of death for the infection of the oral cavity lesion. However, malignant neoplasms patients has much dentistry treatment, and the exodontia number accounts for the majority, too.

A SOURCE EXTRACTION METHOD FOR THE AKARI MID-IR FAINT SOURCE CATALOGUE

KEICHIRO NAKAMICHI,DAISUKE ISHIHARA,HIDEHIRO KANEDA,SHINKI OYABU,TORU KONDO,TOMOYA AMATSUTSU,Hidetoshi Sano,TAKASHI ONAKA 한국천문학회 2017 天文學論叢 Vol.32 No.1

We plan to produce a faint source catalogue from the AKARI mid-infrared (IR) all-sky diffuse maps. In the publicly-available AKARI mid-IR point source catalogue (PSC), sources were extracted from single-scan images, and confirmed by using the other scan images. By stacking multiple scan images, we can detect fainter sources which are not listed in the PSC. We optimized the source extraction process using a $6^{\circ}\times6^{\circ}$ area around the star-forming region, Cepheus B. Then, we divided the all-sky data into three seasonal images, and checked the positions and the fluxes of the detected sources on the images. As a result, our new source extraction method works well; 90\% of the sources are also identified in the WISE catalogue. In this method, we obtain the detection limit twice deeper than that of the PSC. The number of sources increases by a factor of 2, as compared with the PSC.

Poster Session : PS 0333 ; Hematology : Multiple Neoplasms Including Malignant Lymphoma

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Yukitoshiq Toyoda ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The clinical outcome of the malignant lymphoma improved and longterm survivor increased. In addition, the improvement of the examination technology and available PET/CT, screening ability rose, multiple neoplasms increased drastically last decade. We reviewed multiple neoplasms including the ML which accounted for a major ratio in hematological malignancies. Methods: We were approved privacy policy by the Ethical Review Board. Between January 1988 and December 2013, we reviewed multiple neoplasms including hematological malignancies. The diagnosis of the multiple neoplasms depends on a criteria of Warren & Gates. The defi nition of metachronous type and synchronous type is 6 months interval. Results: During the studied period, 285 cases became the subject of the examination. The multiple neoplasms including the ML was 161 cases in that. Median age was 70 years, male/female ratio was 101/60, double neoplasms were 135 cases, triple neoplasms 24 cases, quadple neoplasms 2 cases. The type of multiple neoplasms, metachrounaous type, synchronous type, were 120 cases, 41 cases respectively. In metachronous double type, all cases were102, and median time of interval was 59 months. The Consist of malignant neoplasms, gastric cancer 39 cases, colon cancer 26 cases, lung cancer 24 cases, hepatocellular carcinoma 13 cases, breast cancer 13 cases, prostate carcinoma 10 cases, and 18 kind of diagnosis 64 cases. On the other hand, kind of malignant lymphoma, Hodgkin`s lymphoma 7 cases, non-Hodgkin`s lymphoma 153 cases, adult T cell lymphoma 1 case. Median overall survival time was 33 months. About double neoplasms, median overall survival time between metachronous and synchronous type, there is signifi cance difference. Conclusions: In metachronous double type, all cases were102, 41 cases out of 102 cases were diagnosed within 5 years. We can discover metachronous multiple neoplasms by serial observations of fi ve years from an initial diagnosis.

Poster Session : PS 0334 ; Hematology : Retrospective Study of the Follicular Lymphoma

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The malignant lymphoma is the ninth place cause of death in Japan. A ratio of non-Hodgkin`s lymphoma(NHL) is overwhelmingly big in malignant lymphoma in Japan. Follicular lymphoma was rather small ratio, not only Asian area but also European area. So we reviewed and report our experience of follicular lymphoma patients. Methods: In periods from 2003 to 2012, 446 patients whom malignant lymphoma was diagnosed in our hospital, we extracted follicular lymphoma. We reviewed gender, clinical stage, chemotherapy, clinical outcome, and prognosis. Results: During studied periods, eligible data for investigation was 58 cases, including female 36, male 22, median age was 62 years. About clinical stage, I 2 cases, II 8 cases, III 14 cases, IV 34 cases, advanced stage was dominant. In treatment strategy, aim to cure standard therapy that rituximab + CHOP or rituximab + CHOP like regimen performed 51 cases, RCHOP regimen 39 cases, RCHO regimen 9 cases, RCHOP like regimen 1case, RCVP regimen3 cases, radiation therapy alone 3 cases. About median survival time dose not reach, 5 years overall survival rate is 85. 8%. Compared between up to stageIII versus IV, each group dose not reach median survival time, and there is not signifi cant difference about survival. 5 years survival rate are 83. 2%, 88. 8% respectively. Cause of death, 7 cases were death, consist of cause of death, 5 cases were due to original disease, 1 case due to heart attack, 1 case due to gastric cancer. Conclusions: The clinical outcome of follicular lymphoma improved by rituximab. But some cases do not effect chemotherapy and not reach complete remission, especially in elderly, organs disfunction are trouble about anti-cancer agent dosage, so insuffi - cient therapy performed. We must manage such cases using new strategy.

Poster Session : PS 0336 ; Hematology : Hodgkin`s Lymphoma in Our Hospital

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: In Japan, ML is hematological malignancies with much number of cases. non-Hodgkin`s lymphoma(NHL) is more than 90%. There is extremely little number of patients Hodgkin`s lymphoma(HL). In Europe, the rarion between NHL and HL, is almost half and half. So we paid attention to HL and examined. Methods: We intended for patient which ML was diagnosed in our hospital from January 2003 to December, 2012. We studied and reported 38 cases about age, gender, pathological fi ndings, therapy, median survival time, 5 years survival rate. Survival was measured from the diagnosis of multiple cancer to time of death or last contact. Results: All cases were 38 cases, gender ration was male 23 cases, female 16 cases. Median age was 45 years, pathological fi ndings, L-D 1 case, L-P 1 case, L-R 6 cases, MC 15 cases, PHL 1 case, NS 14 cases. About clinical stage, I was 5 cases, II was 15 cases, III was 10 cases, IV was 7 cases. Adult patients were 25 cases, elderly patients were 13 cases. About therapy, more than 65 years old that assumed Bleomycine skipped. ABVD therapy performed 26 cases, ABVD therapy + RTx 1 case, AVD therapy 8 cases, C-MOPP therapy 3 cases. Median survival time was 84 months, and 5 years survival rate was 79. 6%. About age, less than 60 years group did not reach median survival time, median survival time of more than 60 years group was 76 months. There is no signifi cant difference between 2 group. 29 cases were survivor and death cases were 9 cases. Cause of death, 8 cases due to original disease, 1 case another reason( because of lung cancer). Conclusions: HL is good prognosis disease in hematological malignancies, but in more than 60 years patients, there is many problem.

THE CURRENT STATUS OF THE AKARI MID-INFRARED ALL-SKY DIFFUSE MAPS

TOMOYA AMATSUTSU,DAISUKE ISHIHARA,TORU KONDO,HIDEHIRO KANEDA,SHINKI OYABU,MITSUYOSHI YAMAGISHI,KEICHIRO NAKAMICHI,Hidetoshi Sano,TAKASHI ONAKA 한국천문학회 2017 天文學論叢 Vol.32 No.1

We are creating all-sky diffuse maps from the AKARI mid-infrared survey datawith the two photometric bands centered at wavelengths of 9 and 18~$\micron$. The AKARI mid-infrared diffuse maps achieve higher spatial resolution and higher sensitivitythan the IRAS maps. In particular, the 9~$\micron$ data are unique resources as anall-sky tracer of the emission of polycyclic aromatic hydrocarbons (PAHs). However, the original data suffer many artifacts. Thus, we have been developing correction methods. Among them, we have recently improvedcorrection methods for the non-linearity and the reset anomaly of the detector response. These corrections successfully reduce the artifact level down to 0.1\,MJy sr$^{-1}$ on average,% reduce the intensity error from a $\sim 0.2 \ \mjysr$ level down to $\sim 0.1 \ \mjysr$,which is essential for discussion onfaint extended emission (e.g., the Galactic PAH emission). We have also made progress in the subtraction of the scattered lightcaused in the camera optics. We plan to release the improved diffuse maps to the public within a year.

Poster Session : PS 0328 ; Hematology : Metachronous Double Cancer Included B-Cell Chronic Lymphocytic Leukemia and Pancreatic Cancer That Diagnosed After Progression of Diabetes

( Kazuhiko Natori ),( Daisuke Nagase ),( Susumu Ishihara ),( Akiko Sakai ),( Motohiro Kato ),( Yasunobu Kuraishi ),( Kazuho Arai ),( Haruka Izumi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Among the gastrointestinal cancers, pancreatic cancer has the poorest prognosis. It is important to diagnose patients when the pancreatic cancer is still operable, which remains the only effective procedure. The initial manifestations of pancreatic cancer include abnormal glucose tolerance and onset of diabetes. Methods: We experienced a patient with B-cell chronic lymphocytic leukemia (B-CLL) who was diagnosed with pancreatic cancer after progression of diabetes. Results: A 74-year-old man was diagnosed with B-cell chronic lymphocytic leukemia and was followed up at our outpatient department. In March 2011, he suffered from deterioration of diabetes (HgbA1c: 7. 6%) and underwent detailed examination. After examination, patient was diagnosed with Stage IV pancreatic cancer and is treated with gemcitabine monotherapy. Conclusions: The incidence of diabetes and abnormal glucose tolerance complicated with pancreatic cancer is relatively high. It has been shown that diabetes correlates positively with the risk of onset of pancreatic cancer. However, it has also been demonstrated that diabetes is the result rather than the risk factor of pancreatic cancer onset. Although abnormal glucose tolerance and diabetes onset are important as the initial manifestations of pancreatic cancer. It is necessary to diagnose patients in the early stage of pancreatic cancer, when it is still operable. In comparison with the conventional risk factors of smoking and diabetes, a family history of pancreatic cancer and various hereditary syndromes are much superior risk factors. Patients with pancreatic cancer who have at least 2 fi rst-degree relatives are considered to have familial pancreatic cancer.