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( Sang Haak Lee ),( Chin Kook Rhee ),( Kwangha Yoo ),( Jeong Woong Park ),( Suk Joong Yong ),( Jusang Kim ),( Taehoon Lee ),( Seong Yong Lim ),( Ji-hyun Lee ),( Hye Yun Park ),( Minyoung Moon ),( Ki-s 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.2
Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 μg to indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 μg once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV<sub>1</sub>) ≥50%, post-bronchodilator FEV<sub>1</sub>/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV1 at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV1 versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.
GO-12 : Primary squamous cell carcinoma of the endometrium; A case report
( Sang Gap Kim ),( Gun Sik Park ),( Byeung Jum Kim ),( Sang Kook Kim ),( Soo Jin Song ),( Sang Chill Kwon ),( Ja Seong Koo,),( Hyun Sik Youm ),( Hwal Woong Kim ),( Hwa Sook Moon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Primary squamous cell carcinoma of the endometrium is extremely rare and its pathogenesis is unclear. Exclusion of cervical squamous cell carcinoma, extended to endometrium and squamous differentiation of endometrioid carcinoma is necessary to make the diagnosis of primary squamous cell carcinoma of the endometrium. Case: A 51-year-old postmenopausal woman presented with heavy vaginal bleeding. The patient had normal Pap smear. Transvaginal ultrasonography revealed a 3.8 × 3.1 cm mass mimicking submucosal myoma in the uterine endometrial cavity. The frozen section of the mass obtained by hysteroscopy was reported as sarcoma. Subsequently, the patient underwent laparoscopic hysterectomy with BSO and bilateral pelvic lymph node dissection. There was no tumor involvement in dissected pelvic lymph nodes. Postoperative histology confirmed the presence of a poorly differentiated squamous cell carcinoma in the uterine body while the cervix was normal. The results of immunohistochemical stainings were diffusely positive for cytokeratin, and negative for vimentin. Based on the histomorphologic findings, the diagnosis was primary squamous cell carcinoma of the endometrium. The patient was treated with chemotherapy and is alive without recurrence and metastais 8 months after the operation. Conclusion: To make the diagnosis of primary squamous cell carcinoma excluding cervical squamous cell carcinoma, extended to endometrium and squamous differentiation of endometrioid carcinoma, it is important to carry out multiple sections, immunostainings, and mucin stainings.
Sung, Jung-Suk,Park, In-Kook The Korean Society for Integrative Biology 2005 Integrative biosciences Vol.9 No.2
Oxidized abasic residues arise as a major class of DNA damage by a variety of agents involving free radical attack and oxidation of deoxyribose sugar components. 2-deoxyribonolactone (dL) is a C1'-oxidized abasic lesion implicated in DNA strand scission, mutagenesis, and covalent DNA-protein cross-link (DPC). We show here that mammalian cell-free extract give rise to stable DPC formation that is specifically mediated by dL residue. When a duplex DNA containing dL at the site-specific position was incubated with cell-free extracts of Po ${\beta}-proficient$ and -deficient mouse embryonic fibroblast cells, the formation of major dL-mediated DPC was dependent on the presence of DNA polymerase (Pol) ${\beta}$. Formation of dL-specific DPC was also observed with histones and FEN1 nuclease, although the reactivity in forming dL-mediated DPC was significantly higher with Pol ${\beta}$ than with histones or FEN1. DNA repair assay with a defined DPC revealed that the dL lesion once cross-linked with Pol ${\beta}$ was resistant to nucleotide excision repair activity of cell-free extract. Analysis of nucleotide excision repair utilizing a model DNA substrate containing a (6-4) photoproduct suggested that excision process for DPC was inhibited because of DNA single-strand incision at 5' of the lesion. Consequently DPC mediated by dL lesion may not be readily repaired by DNA excision repair pathway but instead function as unusual DNA damage causing a prolonged DNA strand break and trapping of the major base excision repair enzyme.
Diffusion flame-derived fine particulate matters doped with iron caused genotoxicity in B6C3F1 mice
Park, Jin Hong,Han, Kyu Tae,Eu, Kook-Jong,Kim, Jun-Sung,Chung, Kyu Hyuk,Park, Bio,Yang, Go Su,Lee, Kee-Ho,Cho, Myung-Haing PRINCETON SCIENTIFIC PUBLISHING CO 2005 TOXICOLOGY AND INDUSTRIAL HEALTH Vol.21 No.3-4
<P>Potential genotoxic effects of diffusion flame-derived particulate matters (PMs), known to cause various adverse health problems, doped with iron, one of the representative heavy metals frequently found in the atmosphere, were examined. B6C3F1 mice were exposed to PMs [chamber 1 (low), 100; chamber 2 (middle), 200; and chamber 3 (high), 400 microg/m3] for 6 h/day, 5 days/week for one, two and four weeks in 1.5 m3 whole-body inhalation chambers. Our diffusion flame system produced 94.8 and 5.2% fine PM2.5 and PM10, respectively, with 89% of PM2.5 sized between 0.1 and 0.2 microm. Two cytogenetic endpoints were investigated through chromosomal aberration and supravital micronucleus (SMN) assays. Frequencies of cells with chromosome aberration (%) were observed in time- and concentration-dependent manners except in one-week exposure group, as also observed in SMN study. Generally, noniron flame induced less chromosome aberration than iron-doped flame, an indication that iron particles could potentiate urban PM toxicity. The above results indicate our diffusion flame system generated genotoxic fine PMs, whose effects were potentiated by organometallic particles such as iron. Our system can provide reliable PM models for studying the toxicity of urban fine PMs applicable for risk assessment.</P>
Sung-Ryoul Kim,Jae-Woo Kwak,Sung-Ka Lee,Seung-Gon Jung,Man-Seung Han,Bang-Sin Kim,Min-Suk Kook,Hee-Kyun Oh,Hong-Ju Park 대한구강악안면외과학회 2012 대한구강악안면외과학회지 Vol.38 No.1
Introduction: This study was conducted to evaluate ssrA expression resulting from adaptation of Escherichia coli (E. coli) to oral pathogens through signal exchange. Materials and Methods: Human cell lines Hep2 and HT29, wild-type E. coli (WT K-12), ssrA knock-out E. coli (Δ K-12), and Scleropages aureus (S. aureus) were used. A single culture consisting of Hep2, HT29, WT K-12, and Δ K-12, and mixed cultures consisting of Hep2 and WT K-12, Hep2 and Δ K-12, WT K-12 and S. aureus, Δ K-12 and S. aureus, and Hep2, WT K-12, and S. aureus were prepared. For HT29, a mixed culture was prepared with WT K-12 and with WT K-12 and S. aureus. Total RNA was extracted from each culture with the resulting expression of ssrA, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and p53 was evaluated by Reverse transcription polymerase chain reaction (RT-PCR). Results: The expression of ssrA in a single culture of WT K-12 was lower than that observed in the mixed culture of WT K-12 with S. aureus. Greater ssrA expression was observed in the mixed culture of WT K-12 with Hep2 than in the single culture of WT K-12. The expression of NF-κB was higher in the mixed culture of Hep2 with Δ K-12 than that in the mixed culture of Hep2 with WT K-12, and was lowest in the single culture of Hep2. The expression of ssrA was higher in the mixed culture of WT K-12 with Hep2 and S. aureus than in the mixed culture of WT K-12 with Hep2. Conclusion: These results suggest that ssrA plays an important role in the mechanism of E. coli adaptation to a new environment.
Sang Chul Shim,Young Gil Kwon,Chil Hoon Doh,Byung Won Woo,Jin Ook Baeg,Hong Seok Kim,Tae Jeong Kim,Dong Ho Lee,Young Woo Kwak,Jin Soon Cha,Hyung Soo Lee,Jae Kook Uhm,Young Bae Park Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.2
Ethanolic tetra carbonylhydridoferrate solution combined with dialdehyde (no of carbon; 4,5,6) is very efficient for the selective transformation of amino group into N-heterocyclic compound. However, a large variety of both aliphatic and aromatic amines react with the ferrate-pimelaldehyde at room temperature under an atmospheric pressure of carbon monoxide to give the corresponding N-(cyclohexylmethyl)-N-alkyiamine derivatives in moderate yields instead of the corresponding N-substituted perhydroazocine derivatives.