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오상민 ( Sang Min Oh ),박동욱 ( Dong Uk Park ),유성재 ( Seoung Jae Yu ),정진우 ( Jin Woo Jung ),임경택 ( Kyung Taek Lim ),이재환 ( Jae Hwan Lee ),하권철 ( Kwon Chul Ha ) 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.4
Objectives: Employee exposure record refers to a record containing information about environmental(workplace) monitoring or measuring of a toxic substance or harmful physical agent. The aims of this study were to examine problems related to exposure records and provide some amendments to the Korean Industrial Safety & Health Act for the effective management of chemical substances under the law. Methods: This study performed a literature search and review on legal provisions related to exposure records of a number of different countries, including Korea, the USA, Japan, EU, Germany, and the UK. They were compared and investigated and the amendment of articles was suggested. Results: The results of this study were provided as suggested amendments to the related act. There were a variety of ways of improvement, including a 30-year retention period and the introduction of new access methods, contents, transfer, and maintenance methods. All exposure data elements have to be standardized, including reference to a similar exposure group(SEG), sampling strategy, and circumstances of exposure(e.g., date, shift length, use of personal protective equipment, etc.). The SEGs are described by process, job, task, and environmental agent. Conclusions: This study is expected to provide for the amendment of the related act in order to ensure effective management of exposure records and is helpful for solving the cause and result of occupational disease by keeping exposure records according to the Industrial Safety & Health Act.
Sang-Yong Son,Nam-Joon Yi,Geun Hong,Hyeyoung Kim,Min Su Park,Young Rok Choi,Kyung-Suk Suh,Duck-Woo Kim,Seung-Yong Jeong,Kyu-Joo Park,Jae-Gahb Park,Kuhn-Uk Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4
Backgrounds/Aims: Hepatic resection has only guaranteed long-term survival in patients with colorectal liver metastasis (CRLM) even in the era of effective chemotherapy. The definite role of neoadjuvant chemotherapy (NCT) is to improve outcomes of unresectable CRLMs, but it its role has not been defined for initially resectable CRLMs (IR-CRLMs). Methods: We reviewed the medical records of 226 patients, who had been diagnosed and treated for IR-CRLM between 2003 and 2008; the patients had the following pathologies: 10% had more than 4 nodules, 11% had tumors larger than 5 cm, and 61% had synchronous CRMLs. Among these patients, 20 patients (Group Y) were treated with NCT, and 206 (Group N) did not receive NCT according to their physician’s preference. The median follow-up time was 34.1 months. Results: The initial surgical plans were changed after NCT to further resection in 20% and to limited resection in 10% of 20 patients. Complication rates of Groups Y (30%) were indifferent from Group N (23%) (p=0.233), but intraoperative transfusions were more frequent in Group N (15%) than in Group Y (5%) (p=0.006). There was one case of hospital mortality (0.44%). Disease-free survival rates in Groups Y and N were 23% and 39%, respectively, and patient survival rates were 42% and 66% (p>0.05). By multivariate analysis, old age (≥60 years), differentiation of primary tumor (poorly/mucinous), resection margin involvement, and no adjuvant chemotherapy were associated with poor patient survival; the number of CRLMs (≥4) was associated with poor disease-free survival. Conclusions: NCT had neither a positive impact nor a negative impact on survival, even with intraoperative transfusion, as observed on operative outcomes for patients with IR-CRLM. Further study is required to elucidate the role of NCT for treatment of patient with IR-CRLMs. (Korean J Hepatobiliary Pancreat Surg 2011;15:206-217)
( Sung Hoon Kim ),( Won Uk Koh ),( Jin Ho Rhim ),( Myong Hwan Karm ),( Hye Suk Yu ),( Bo Yoeng Lee ),( Jin Woo Shin ),( Jeong Gill Leem ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.4
Background: Elderly patients visiting pain clinic may be at greater risk of misunderstanding the explanation because of age-related cognitive decline. Video instruction may provide a consistent from of teaching in a visual and realistic manner. We evaluated the effect of educational video on the patient understanding and satisfaction in a group of geriatric patients visiting pain clinic. Methods: Ninety two patients aged more than 60 years old who were scheduled for transforaminal epidural block were recruited. After exposure to either video or paper instruction process, each patient was asked 5-item comprehension questions, overall satisfaction and preference question. During follow-up period, number of outpatient referral-line call for further explanation was counted. Results: We observed significantly better comprehension in the video education compared with paper instruction (P<0.001). Patient satisfaction was also higher in the video group (P = 0.015), and patients visiting pain clinic were more preferred video instruction (P<0.001). Proportion of referral-line call for further explanation were similar (P = 0.302). Conclusions: Video approach to instruction process before consent improves treatment comprehension in geriatric patient visiting pain clinic.
Characterization and cis/trans isomerase activity of Bombyx mori Cyclophilin A
Sung Wan Kim,Eun Young Yun,Kwang Ho Choi,Min Uk Kang,Seok Woo Kang,O-Yu Kwon,Tae Won Goo 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Peptidyl prolyl cis/trans isomerases (PPIases) catalyze the slow cis/trans isomeraization of proline peptide (Xaa-Pro) bonds in oligopeptides and accelerates slow, rate-limiting steps in the folding of several proteins. We studied the characterization of Cyclophilin A (bCyp A) isolated from Bombyx mori . The cDNA of bCyp A is 947 bp. There is a 5´-untranslated region of 91 nucleotides followed by an initiating ATG codon. The TAA termination codon occurs at nucleotide 588. Thus translation of the sequence from nucleotides 91 to 588 would produce a protein of 166 amino acids with a calculated molecular mass of 18.2kDa. The 'AATAAA' consensus polyadenylation signal and poly A tail are present in the 3´-untranslated region. To analysis of PPIase activity, we expressed the bCyp A protein in Sf9 cell by using baculovirus expression vector system (BEVS). SDS-PAGE and Western blot analysis showed that the molecular weights of intracelluar expressed protein was approximately 28.2 kDa. The PPIase activity assay was monitored by proteolytic cleavage of the chromophore p-nitroanilide byα-chymotrypsin. As substrate the synthetic tetrapeptide succinyl-Ala-Ala- Pro-Phe-p-nitroanilide was used.
Rare Cerebral Infarction in Patient with Type B Aortic Dissection
Sung Jin Park,In Uk Song,Sung Woo Chung 대한임상노인의학회 2017 대한임상노인의학회지 Vol.18 No.2
A 65 years old woman was admitted with sudden visual disturbance. She had a history of cerebral infarction which led to the diagnosis of type B aortic dissection. Transthoracic echocardiography revealed mobile echogenic mass in the false lumen of dissection. Thoracic aorta computed tomography angiography showed partial thrombosis with mild aneurysmal change of the false lumen at the proximal descending aorta. The patient was transferred to the department of thoracic surgery for surgical treatment of aortic dissection. The presented case is notable for rare atypical presentation of cerebral infarction resulting from type B aortic dissection.
Sang Uk Choi,Kyoung Woo Kim,Jeong Kyu Lee 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.2
Purpose: To evaluate the clinical outcomes of balanced deep lateral and medial orbital wall decompression and to estimate surgical effects using computed tomography (CT) images in Korean patients with thyroid-associated ophthalmopathy (TAO). Methods: Retrospective chart review was conducted in TAO patients with exophthalmos who underwent balanced deep lateral and medial orbital wall decompression. Exophthalmos was measured preoperatively and mpostoperatively at 1 and 3 months. Postoperative complications were evaluated in all study periods. In addition, decompressed bone volume was estimated using CT images. Thereafter, decompression volume in each decompressed orbital wall was analyzed to evaluate the surgical effect and predictability. Results: Twenty-four patients (48 orbits) with an average age of 34.08 ± 7.03 years were evaluated. The mean preoperative and postoperative exophthalmos at 1 and 3 months was 18.91 ± 1.43, 15.10 ± 1.53, and 14.91 ± 1.49 mm, respectively. Bony decompression volume was 0.80 ± 0.29 cm3 at the medial wall and 0.68 ± 0.23 cm3 at the deep lateral wall. Postoperative complications included strabismus (one patient, 2.08%), upper eyelid fold change (four patients, 8.33%), and dysesthesia (four patients, 8.33%). Postsurgical exophthalmos reduction was more highly correlated with the deep lateral wall than the medial wall. Conclusions: In TAO patients with exophthalmos, balanced deep lateral and medial orbital wall decompression is a good surgical method with a low-risk of complications. In addition, deep lateral wall decompression has higher surgical predictability than medial wall decompression, as seen with CT analysis.
Syringoma localized to the umbilicus
( Sang-woo Park ),( Sang-kyung Lee ),( Eui-sung Jung ),( Hyun-bin Kwak ),( Su-kyung Park ),( Jin Park ),( Han-uk Kim ),( Seok-kweon Yun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Syringomas are relatively common and benign appendageal tumors derived from the intraepidermal ducts of eccrine glands. They occur predominantly in women, presenting at puberty or later in life. Syringomas typically appear as soft, skin-colored to yellow-brown papules on the eyelid, but rarely can arise on the skin in other areas such as scalp, forehead, cheeks, trunk, extremities, genitalia, and buttocks. Although eruptive syringomas may also involve the umbilicus, it is very rare for the lesions to be only limited to this region. Herein, we report a rare and interesting case of a patient with umbilical syringomas. A 25-year-old man presented with numerous quiescent, localized papules on his umbilicus, with a history of onset four years ago. The patient was otherwise asymptomatic and healthy. There was no family history of similar skin lesions. On physical examination, we observed multiple 1-2 mm sized, firm, light-brown colored papules on the umbilicu. The histopathological examination of the biopsy sample revealed multiple ductal and small cystic structures, dispersed within a fibrous connective tissue stroma in the upper dermis. The ductal and cystic spaces were lined by 1 to 2 rows of flattened epithelial cells. Some of the cysts with their small comma-like tails, resembled tadpoles. The patient was diagnosed with localized umbilical syringomas, however he refused further management.