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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Kim, Jae-Hun,Ha, Tae Lin,Im, Geun Ho,Yang, Jehoon,Seo, Sang Won,Chung, Julius Juhyun,Chae, Sun Young,Lee, In Su,Lee, Jung Hee Lippincott WilliamsWilkins 2014 NEUROREPORT - Vol.25 No.4
<P>In this study, we have shown the potential of a voxel-based analysis for imaging amyloid plaques and its utility in monitoring therapeutic response in Alzheimer’s disease (AD) mice using manganese oxide nanoparticles conjugated with an antibody of Aβ1-40 peptide (HMON-abAβ40). T1-weighted MR brain images of a drug-treated AD group (<I>n</I>=7), a nontreated AD group (<I>n</I>=7), and a wild-type group (<I>n</I>=7) were acquired using a 7.0 T MRI system before (D−1), 24-h (D+1) after, and 72-h (D+3) after injection with an HMON-abAβ40 contrast agent. For the treatment of AD mice, DAPT was injected intramuscularly into AD transgenic mice (50 mg/kg of body weight). For voxel-based analysis, the skull-stripped mouse brain images were spatially normalized, and these voxels’ intensities were corrected to reduce voxel intensity differences across scans in different mice. Statistical analysis showed higher normalized MR signal intensity in the frontal cortex and hippocampus of AD mice over wild-type mice on D+1 and D+3 (<I>P</I><0.01, uncorrected for multiple comparisons). After the treatment of AD mice, the normalized MR signal intensity in the frontal cortex and hippocampus decreased significantly in comparison with nontreated AD mice on D+1 and D+3 (<I>P</I><0.01, uncorrected for multiple comparisons). These results were confirmed by histological analysis using a thioflavin staining. This unique strategy allows us to detect brain regions that are subjected to amyloid plaque deposition and has the potential for human applications in monitoring therapeutic response for drug development in AD.</P>
Lin-Hu Quan,Jin-Ying Piao,Jin-Woo Min,Ho-Bin Kim,Sang-Rae Kim,Dong-Uk Yang,Deok Chun Yang 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.3
Ginsenoside Rb<sub>1</sub>is the main component in ginsenosides. It is a protopanaxadiol-type ginsenoside that has a dammarane-type triterpenoid as an aglycone. In this study, ginsenoside Rb<sub>1</sub> was transformed into gypenoside XVII, ginsenoside Rd, ginsenoside F<sub>2</sub> and compound K by glycosidase from Leuconostoc mesenteroides DC102. The optimum time for the conversion was about 72 h at a constant pH of 6.0 to 8.0 and the optimum temperature was about 30℃. Under optimal conditions, ginsenoside Rb<sub>1</sub> was decomposed and converted into compound K by 72 h post-reaction (99%). The enzymatic reaction was analyzed by high-performance liquid chromatography, suggesting the transformation pathway: ginsenoside Rb<sub>1</sub>→gypenoside XVII and ginsenoside Rd→ginsenoside F<sub>2</sub>→compound K.
Kim, Yoonkyung,Jung, Hye‐,youn,Choe, Yun Hui,Lee, Chaewoon,Ko, Sung‐,Kyun,Koun, Soonil,Choi, Yohan,Chung, Bong Hyun,Park, Byoung Chul,Huh, Tae‐,Lin,Shin, Injae,Kim, Eunkyoung WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.12
<P><B>Mit photochromem Diarylethen vernetzte Dendrimere</B> (blau im Bild) wurden mit dem Fluoreszenzfarbstoff Cy3 (rot) zur reversiblen Fluoreszenzphotoschaltung markiert. Bestrahlt man die erhaltenen Nanocluster mit UV‐Licht, wird die Cy3‐Fluoreszenz durch das Diarylethen in seiner ring‐geschlossenen Form gelöscht, während Bestrahlung mit sichtbarem Licht die Nanocluster fluoreszieren lässt. In lebenden Zebrafischen konnten hochkontrastige Fluoreszenzbilder aufgenommen werden.</P>
Kim, Do Hwan,Shin, Hyeon-Jin,Lee, Hyo Sug,Lee, Jiyoul,Lee, Bang-Lin,Lee, Wi Hyoung,Lee, Jong-Hwa,Cho, Kilwon,Kim, Woo-Jae,Lee, Sang Yoon,Choi, Jae-Young,Kim, Jong Min American Chemical Society 2012 ACS NANO Vol.6 No.1
<P>Molecularly hybridized materials composed of polymer semiconductors (PSCs) and single-walled carbon nanotubes (SWNTs) may provide a new way to exploit an advantageous combination of semiconductors, which yields electrical properties that are not available in a single-component system. We demonstrate for the first time high-performance inkjet-printed hybrid thin film transistors with an electrically engineered heterostructure by using specially designed PSCs and semiconducting SWNTs (sc-SWNTs) whose system achieved a high mobility of 0.23 cm<SUP>2</SUP> V<SUP>–1</SUP> s<SUP>–1</SUP>, no <I>V</I><SUB>on</SUB> shift, and a low off-current. PSCs were designed by calculation of the density of states of the backbone structure, which was related to charge transfer. The sc-SWNTs were prepared by a single cascade of the density-induced separation method. We also revealed that the binding energy between PSCs and sc-SWNTs was strongly affected by the side-chain length of PSCs, leading to the formation of a homogeneous nanohybrid film. The understanding of electrostatic interactions in the heterostructure and experimental results suggests criteria for the design of nanohybrid heterostructures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-1/nn2041472/production/images/medium/nn-2011-041472_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn2041472'>ACS Electronic Supporting Info</A></P>
An Efficient Data Transfer Control Algorithm of Environment Sensor on Zigbee
Sung-Il Hong,Su-Yeon Song,Young Sook Kim,Chi-Ho Lin 한국정보통신학회 2014 2016 INTERNATIONAL CONFERENCE Vol.6 No.1
In this paper, we proposes an efficient data transfer control algorithm of environment sensor on zigbee. The proposed data transfer control algorithm was an efficient algorithm that simultaneously enables the transfer control of data by comparing the tolerance range of the sensing data on multiple sensor nodes, as the data processing method for the transfer control of sensor data. In this paper, the proposed an efficient multi sensor data transfer control algorithm could alleviate the bottleneck that is concentrated on the sink node by apply the gateway based WLAN, and it could reduce the power consumption of the terminal node. In addition, it provides improved system performance due to the use of an efficient multi sensor data transfer control algorithm that ensures independence by delegation to each task module.
Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy.
Kim, Hyun-Chul,Kim, Eunjoo,Jeong, Sang Won,Ha, Tae-Lin,Park, Sang-Im,Lee, Se Guen,Lee, Sung Jun,Lee, Seung Woo RSC Pub 2015 Nanoscale Vol.7 No.39
<P>Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.</P>