Glyceollins Inhibit Colon Cancer Cell Proliferation Promoted by an Inflammatory Cytokine

Hye Lin Seo,Jisun Oh,Ji YeonSeo,Su Jin Kang,Gwang Rae Jo,Sung Hee Ju,Ga In Jeong,Jong-Sang Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

산화 및 알칼리 후처리의 땅콩 껍질 바이오차를 이용한 철과 크롬 제거에 미치는 영향

서혜린(Hye-Lin Seo),인태연(Tae-Yeon Yin),권오인(Oh-In Kwon),전강민(Kangmin Chon) 대한환경공학회 2020 대한환경공학회지 Vol.42 No.2

목적 : 본 연구의 주요 목적은 단순 열분해를 통해 생산된 땅콩 껍질 바이오차(PB), KMnO₄ 후처리를 한 바이오차(PB-Ox), KMnO₄와 KOH 후처리를 한 바이오차(PB-Ox-A)에 의한 3가 철과 6가 크롬의 제거효율을 비교하는 것이다. 방법 : PB, PB-Ox, PB-Ox-A에 의한 3가 철과 6가 크롬의 제거기작을 알아보기 위하여 반응 동역학 모델과 흡착등온식 모델을 적용하였다. 또한, 다양한 변수들이 3가 철과 6가 크롬 흡착에 미치는 영향을 알아보기 위하여 투입량(0.8 - 2.4 g/L), 온도(15 - 35℃) 및 이온강도(0.05 - 0.2 M NaNO₃) 조건을 변화시키면서 흡착실험을 수행하였다. 결과 및 토의 : PB-Ox-A는 PB와 PB-Ox보다 중금속 흡착에 연관된 표면 작용기(O/C of PB = 0.064; O/C of PB-Ox= 0.058; O/C of PB-Ox-A = 0.188)가 잘 발달되었고, 더 넓은 표면적(PB = 351.5 m²/g; PB-Ox = 344.0 m²/g; PB-Ox-A = 2121.5 m²/g)과 공극(PB = 0.15 cm³/g; PB-Ox = 0.15 cm³/g; PB-Ox-A = 0.96 cm³/g)으로 인해 3가 철과 6가 크롬의 제거율이 높았다. PB, PB-Ox, PB-Ox-A의 투입량이 증가할수록 대상 중금속들에 대한 높은 제거율을 나타냈고, PB-Ox-A가 PB와 PB-Ox보다 높은 제거율을 나타내었다. PB, PB-Ox, PB-Ox-A에 의한 3가 철과 6가 크롬 제거는 유사 1차 속도모델보다 유사 2차 속도모델에 적합한 것으로 보아 화학적 흡착에 대한 특성을 따르는 것으로 나타났으며, PB, PB-Ox, PB-Ox-A를 이용한 3가 철과 6가 크롬의 제거는 모두 Freundlich 등온흡착모델에 적합한 것으로 보아 다층 흡착을 따르는 것으로 판단된다. 온도변화에 따른 PB, PB-Ox, PB-Ox-A에 의한 3가 철과 6가 크롬의 제거율의 변화는 크지 않는 것으로 나타났다. 바이오차에 의한 3가 철의 제거는 이온강도변화에 크게 영향을 받지 않았지만, 6가 크롬의 경우 이온강도가 증가할수록 제거율이 감소하였다. PB, PB-Ox, PB-Ox-A를 비교하였을 때 3과 철과 6가 크롬의 제거에 대해 PB-Ox-A가 가장 좋은 흡착제라는 것을 확인할 수 있었다. 결론 : 본 연구는 KMnO₄(산화)및 KOH(알칼리) 후처리가 표면특성 개선을 통하여 땅콩 껍질 바이오차의 중금속 흡착효율을 향상시킬 수 있다는 것을 입증하였다. 또한, 다양한 조건에서 PB, PB-Ox, PB-Ox-A에 의한 중금속 흡착 메커니즘을 조사한 결과 중금속의 물리화학적 특성과 흡착제의 표면 특징들이 PB, PB-Ox, PB-Ox-A의한 3가 철과 6가 크롬의 흡착에 중요한 역할을 하는 것으로 나타났다. Objectives : The main goal of this study was to compare the removal efficiency of trivalent iron and hexavalent chromium by peanut shell biochars (i.e., PB), post-treated peanut shell biochars using KMnO₄ (i.e., PB-Ox), and secondary post-treated peanut shell biochars using KOH (i.e., PB-Ox-A). Methods : The adsorption mechanisms of trivalent iron and hexavalent chromium by PB, PB-Ox, and PB-Ox-A were investigated using two types of adsorption kinetic and isotherm models. Furthermore, the adsorption experiments were performed under different adsorbent dosages (0.8 - 2.4 g/L), temperatures (15 - 35℃) and ion strengths (0.05 - 0.2 M NaNO₃) to identify their effects on the adsorption of trivalent iron and hexavalent chromium by PB, PB-Ox, and PB-Ox-A. Results and Discussion : Trivalent iron and hexavalent chromium could be more effectively removed by PB-Ox-A than PB and PB-Ox because of its higher contents of oxygen containing functional groups (O/C of PB = 0.064; O/C of PB-Ox = 0.058; O/C of PB-Ox-A = 0.188), higher surface area (PB = 351.5 m²/g; PB-Ox = 344.0 m²/g; PB-Ox-A = 2121.5 m²/g), and greater pore volume (PB = 0.15 cm³/g; PB-Ox = 0.15 cm³/g; PB-Ox-A = 0.96 cm³/g). The removal efficiencies of trivalent iron and hexavalent chromium by PB, PB-Ox and PB-Ox-A were increased with increasing the adsorbent dosages (PB-Ox-A > PB-Ox > PB). The adsorption kinetic experiments demonstrated that the pseudo second order rate model was suitable for the removal of trivalent iron and hexavalent chromium by PB (R² of Fe<SUP>3+</SUP> = 0.99; R² of Cr<SUP>6+</SUP> = 0.99), PB-Ox (R² of Fe<SUP>3+</SUP> = 0.98; R² of Cr<SUP>6+</SUP> = 0.98), PB-Ox-A (R² of Fe<SUP>3+</SUP> = 0.99; R² of Cr<SUP>6+</SUP> = 0.99). Furthermore, the removal of trivalent iron and hexavalent chromium using PB, PB-Ox and PB-Ox-A was well fitted to the Freundlich isotherm absorption model (R² of Fe<SUP>3+</SUP> = 0.997 - 0.999;R² of Cr<SUP>6+</SUP> = 0.995 - 0.998). The changes of temperature did not show significant effects on the removal of trivalent iron and hexavalent chromium by PB, PB-Ox, and PB-Ox-A. The removal efficiency of trivalent iron by PB, PB-Ox and PB-Ox-A was not influenced by the ionic strength whereas the removal efficiency of hexavalent chromium by PB, PB-Ox and PB-Ox-A was considerably decreased with increasing the ionic strength. These observations are evident that PB-Ox-A is the most effective adsorbent for the removal of trivalent iron and hexavalent chromium. Conclusions : The proposed post-treatment procedures might improve the surface properties of peanut shell biochars intimately associated with the removal of trivalent iron and hexavalent chromium. The physicochemical properties of the heavy metals and the biochars were found to be key factors governing the adsorption mechanisms of trivalent iron and hexavalent chromium by PB, PB-Ox and PB-Ox-A.

어머니의 정서표현 수용태도와 정서 표현성이 유아의 정서조절전략에 미치는 영향

서혜린(Hye Lin Seo),이영(Young Lee) 한국아동학회 2008 아동학회지 Vol.29 No.2

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

Seo, Sang-Uk,Kwon, Hyung-Joon,Song, Joo-Hye,Byun, Young-Ho,Seong, Baik Lin,Kawai, Taro,Akira, Shizuo,Kweon, Mi-Na American Society for Microbiology 2010 Journal of virology Vol.84 No.24

<B>ABSTRACT</B><P>Recent studies have revealed that innate immunity is involved in the development of adaptive immune responses; however, its role in protection is not clear. In order to elucidate the exact role of Toll-like receptor (TLR) or RIG-I-like receptor (RLR) signaling on immunogenicity and protective efficacy against influenza A virus infection (A/PR/8/34 [PR8]; H1N1), we adapted several innate signal-deficient mice (e.g., TRIF<SUP>−/−</SUP>, MyD88<SUP>−/−</SUP>, MyD88<SUP>−/−</SUP> TRIF<SUP>−/−</SUP>, TLR3<SUP>−/−</SUP> TLR7<SUP>−/−</SUP>, and IPS-1<SUP>−/−</SUP>). In this study, we found that MyD88 signaling was required for recruitment of CD11b<SUP>+</SUP> granulocytes, production of early inflammatory cytokines, optimal proliferation of CD4 T cells, and production of Th1 cytokines by T cells. However, PR8 virus-specific IgG and IgA antibody levels in both systemic and mucosal compartments were normal in TLR- and RLR-deficient mice. To further assess the susceptibility of these mice to influenza virus infection, protective efficacy was determined after primary or secondary lethal challenge. We found that MyD88<SUP>−/−</SUP> and MyD88<SUP>−/−</SUP> TRIF<SUP>−/−</SUP> mice were more susceptible to primary influenza virus infection than the B6 mice but were fully protected against homologous (H1N1) and heterosubtypic (H5N2) secondary infection when primed with a nonlethal dose of PR8 virus. Taken together, these results show that MyD88 signaling plays an important role for resisting primary influenza virus infection but is dispensable for protection against a secondary lethal challenge.</P>

Evaluation of probiotic <i>Bacillus subtilis</i> P229 isolated from <i>cheonggukjang</i> and its application in soybean fermentation

Jeon, Hye-Lin,Yang, Seo-Jin,Son, Sung-Ho,Kim, Won-Suck,Lee, Na-Kyoung,Paik, Hyun-Dong Elsevier 2018 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.97 No.-

<P><B>Abstract</B></P> <P> <I>Bacillus subtilis</I> P229 was isolated from <I>cheonggukjang</I>, a Korean soybean fermented food, and its probiotic properties and utility in starter cultures for soybean fermentation were investigated. <I>B. subtilis</I> P229 spores were stable when exposed to simulated gastric and bile conditions. <I>B. subtilis</I> P229 vegetative cells did not produce β-glucuronidase, were sufficiently susceptible to antibiotics, and adhered strongly to human intestinal epithelial cells. Moreover, this strain did not induce hemolysis or carry enterotoxin genes. <I>B. subtilis</I> P229 showed high levels of autoaggregation, and its coaggregation with pathogens depended on the species involved. It did not produce hazardous biogenic amines from histidine and ornithine. <I>B. subtilis</I> P229-fermented soybean extracts were prepared using 70% ethanol. Fermented-soybean extracts demonstrated greater antioxidant effects and total phenolic content than unfermented soybean extracts. These results suggest that <I>B. subtilis</I> P229 isolated from <I>cheonggukjang</I> shows potential as a probiotic and as a component of starter cultures for fermented soybean foods.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Bacillus subtilis</I> P229 was isolated from <I>cheonggukjang.</I> </LI> <LI> <I>B. subtilis</I> P229 spores were stable in gastric conditions. </LI> <LI> <I>B. subtilis</I> P229 did not induce hemolysis or carry enterotoxin genes. </LI> <LI> Soybean extracts fermented by <I>B. subtilis</I> P229 showed antioxidant effects. </LI> <LI> <I>B. subtilis</I> P229 could be used as potential probiotics and starter culture. </LI> </UL> </P>

항균알지네이트 필름 제조를 위한 Zn 이온 농도의 영향

서혜진(Hye-Jin Seo),성효린(Hyo-Lin Seong),김지형(Ji-Hyeong Kim),손태원(Tae-Won Son) 한국고분자학회 2016 폴리머 Vol.40 No.5

7 wt% alginate를 용액상태로 제조한 후 필름 메이커를 이용하여 필름 형태로 만든 후 농도별 ZnSO₄, Al₂(SO₄)₃ 수용액에 필름을 고화시킨 후 수세하여 상온에서 건조시켜 안정화된 zinc aluminum alginate 필름을 제조하였다. 필름의 특성을 조사하기 위하여 수분용해도, 팽윤도, 항균성, FTIR, TGA, SEM, EDS 및 접촉각 분석 등을 측정하였다. ZnSO₄ 농도의 증가에 따라 수분용해도와 팽윤도는 점차 감소하였으며, Al₂(SO₄)₃의 처리를 하여 수분용해도가 더 감소함을 확인하였다. Zinc alginate 필름의 항균성은 포도상구균, 대장균에서 항균활성치가 4.5 이상이며 세균감소율 99.9%의 항균도를 확인하였으며, zinc alginate 필름의 항균활성치가 더 우수하였다. Antimicrobial zinc aluminum alginate was prepared by a film maker from a 7 weight% sodium alginate solution and solidified in a 0.5, 1.0, 1.5, and 2.0 weight% ZnSO₄ and Al₂(SO₄)₃ solution. The resulting film was washed and dried at room temperature. The characteristics were measured using several methods (water solubility, swelling degree, antimicrobial activity, FTIR, TGA, SEM, EDS, contact angle) and the film properties were investigated. The water solubility and swelling of the zinc alginate films decreased with increasing ZnSO₄ and Al₂(SO₄)₃ concentration. The antimicrobial test revealed that the zinc alginate films have excellent antimicrobial activity in the two strains (Staphylococcus, Escherichia coli).

디자이너 메가요트의 공간디자인 사례 연구

손서연(Son, Seo-Yeon),오혜린(Oh, Hye-Lin),이솔지(Lee, sol-ji),안성모(Ahn, Seong-Mo),김개천(Kim, Kai-Chun) 한국실내디자인학회 2017 한국실내디자인학회 학술대회논문집 Vol.2017 No.10

Recently, the world"s maritime leisure industry has become increasingly concerned, with increasing interest in luxury goods. Our country has a natural environment surrounded by the sea and has the experience and know-how of the Shipbuilding industry, so the marine leisure industry has enough potential to develop the marine leisure industry. Nowadays Korean government takes interest in megayacht, one of marine leisure industry, therefore highly supporting it. Also, high improvement on mega-yacht industry is expected by increased interest on mega-yacht due to the increase of income. The development and value of these marine leisure industries can be an opportunity for designers to expand the scope of design. Mega-yachts are high-end vessels that require comfortable indoor spaces for leisure and relaxation. Therefore, design of exterior and interior space is essential for design of mega-yacht, and mega-yacht interior space design can be stretched and developed to high value-added space design of luxurious interior. Therefore in this study, we investigate space organization of designer megayacht made by internationally well-known designer, and by analyzing distinguishing features of such megayacht, we can develop megayatch industry into highly competitive marine leisure industry which accommodates Korean marine environment.

제5차 대한간학회 춘계학술대회 초록집 : 포스터 토의 순서 ; 위암의 간전이에서의 간절제술

노혜린 ( No Hye Lin ),고영택 ( Go Yeong Taeg ),서경석 ( Seo Gyeong Seog ),이건욱 ( Lee Geon Ug ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)

메가요트 실내 공간의 배치유형 및 동선체계 분석 연구

오혜린(Oh, Hye-Lin),손서연(Son, Seo-Yeon),박정남(Park, Jung-Nam),안성모(Ahn, Seong-Mo),김개천(Kim, Kai-Chun) 한국실내디자인학회 2017 한국실내디자인학회 학술대회논문집 Vol.2017 No.5

Along with the enhanced interest on the convergence of shipping and IT technology, recuperation and leisure due to the 4th Industrial Revolution, high added-value maritime leisure industry has a considerable growth potential. Accordingly, this research analyzed the space formation factors, placing type, interior space division and traffic line of 3DECK, the most representative mega yacht. The summarized results are as follows. First, mega yachts with the whole length shorter than 36.5m are consisted of 3 decks (sun deck, main deck and low deck) and their space formation is categorized into A~E types according to placing. Secondly, characteristics of A~E types showcased fly bridge for sun deck, stern deck, salon, dining room, wheel house, bow deck for main deck, master room, guest room, VIP room, staff room, tender boat and engine room for low deck for A, C types. For B, D, E types, staff room was mainly located in the bow area and the wheel house in the sun deck. Thirdly, they are flat-divided into the staff area and passenger & ship owner area with a partition wall and elevation-divided by a deck. Typically, main traffic line of passengers and ship owners are shown on the starboard and the traffic line of the staff on the portside.

증례(症例) : 급성기 병변을 보인 지연성 저산소성 뇌병증

임미혜 ( Mi Hye Lin ),정석영 ( Seok Young Jeong ),오선영 ( Sun Young Oh ),정슬기 ( Seul Ki Jung ),서만욱 ( Man Wook Seo ),김영현 ( Young Hyun Kim ),신병수 ( Byoung Soo Shin ) 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.1

Delayed postanoxic encephalopathy is a rare complication of hypoxic events. The underlying pathological lesion is thought to be progressive diffuse demyelination in the cerebral white matter. It is difficult to predict and diagnosis such sequelae early. We presents a 76-year-old woman who showed abnormal behavior and memory impairment due to delayed hypoxic demyelination with a serially performed diffusion weighted MRI imaging (DWIs) and 1H-MRS at initial insult of CO poisoning and after the appearance of delayed sequelae. We proposed that the DWIs of acute stage of insult can be considered as predictor for delayed postanoxic demyelination.