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Sang Hoon Ahn,Won Hyeok Choe,Yoon Jun Kim,Jeong Heo,Dorota Latarska-Smuga,Jiho Kang,Seung Woon Paik 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.3
Background/Aims: Chronic hepatitis C virus (HCV) infections put patients at risk of serious liver disease and adversely affects patient quality of life (QoL). MOSAIC (International Multicenter Prospective Observational Study to Evaluate the Epidemiology, Humanistic and Economic Outcomes of Treatment for Chronic Hepatitis C Virus) was a prospective, non-interventional, international, multicenter study that aimed to describe the epidemiology of the infection, the impact of the infection on health-related QoL (HRQoL) and daily activities, and healthcare resource use related to HCV and treatment. Here, we present the results on HRQoL and daily activity impairment in consecutively enrolled South Korean patients treated with interferon (IFN)-containing regimens prospectively followed for up to 48 weeks. Methods: General HRQoL, HCV-specific HRQoL, perceived health state, and work/general activity impairments were measured using the EuroQoL 5-dimension 5-level (EQ-5D-5L), HCV patient-reported outcomes (HCV-PRO), EQ-5D Visual Analog Scale, and Work Productivity and Activity Impairment questionnaires, respectively. Results: Thirty-three of the 100 enrolled patients initiated IFN-based treatment, with an intended duration of 24 weeks for 20 patients and 48 weeks for 12 patients; this information was missing for one patient. Fourteen patients (42.4%) prematurely withdrew. After treatment initiation, IFN-treated patients showed a trend towards deterioration of both general (baseline: 0.87±0.103, week 4: 0.77±0.153) and HCV-specific (baseline: 76.2±19.5, week 4: 68.2±22.3) HRQoL. The scores recovered somewhat towards the end of treatment (EOT) (0.84±0.146 for EQ-5D-5L and 70.8±21.9 for HCV-PRO). The perceived health state and work/general activity impairment displayed similar temporal patterns. Conclusions: Initiating IFN-based treatment prompted some deterioration in general and HCV-related HRQoL, accompanied by impaired daily activities and most work productivity measures; however, the HRQoL and productivity scores improved towards the EOT. HRQoL impairment upon treatment initiation likely contributed to treatment discontinuation.
Yoon, Byoung-Ha,Kim, Mirang,Kim, Min-Hyeok,Kim, Hee-Jin,Kim, Jeong-Hwan,Kim, Jong Hwan,Kim, Jina,Kim, Yong Sung,Lee, Daeyoup,Kang, Suk-Jo,Kim, Seon-Young Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.11
The stepwise development of T cells from a multipotent precursor is guided by diverse mechanisms, including interactions among lineage-specific transcription factors (TFs) and epigenetic changes, such as DNA methylation and hydroxymethylation, which play crucial roles in mammalian development and lineage commitment. To elucidate the transcriptional networks and epigenetic mechanisms underlying T-cell lineage commitment, we investigated genome-wide changes in gene expression, DNA methylation and hydroxymethylation among populations representing five successive stages of T-cell development (DN3, DN4, DP, $CD4^+$, and $CD8^+$) by performing RNA-seq, MBD-seq and hMeDIP-seq, respectively. The most significant changes in the transcriptomes and epigenomes occurred during the DN4 to DP transition. During the DP stage, many genes involved in chromatin modification were up-regulated and exhibited dramatic changes in DNA hydroxymethylation. We also observed 436 alternative splicing events, and approximately 57% (252) of these events occurred during the DP stage. Many stage-specific, differentially methylated regions were observed near the stage-specific, differentially expressed genes. The dynamic changes in DNA methylation and hydroxymethylation were associated with the recruitment of stage-specific TFs. We elucidated interactive networks comprising TFs, chromatin modifiers, and DNA methylation and hope that this study provides a framework for the understanding of the molecular networks underlying T-cell lineage commitment.
Sang-Hyeok Yoon,Tangnuer Sadike,Jin-Rui Ding,Kyo Seon Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.85 No.-
We demonstrate the cobalt phosphate (Co-Pi) modified 1-D WO3/BiVO4 nanowire heterojunctionphotoanode as oxygen evolution catalyst for photoelectrochemical (PEC) water splitting application. WO3 nanowires were prepared byflame vapor deposition (FVD) process and BiVO4 nanoparticles werespin-coated on top of WO3 nanowires. In order to improve oxygen evolution kinetics, WO3/BiVO4heterojunction photoanode was modified by photo-assisted electrodeposition of Co-Pi. Co-Pi improvethe PEC water oxidation efficiency of 1 D-WO3/BiVO4 by reducing the charge recombination, facilitatingthe hole transfer and reducing the overpotential of oxygen evolution reaction. The optimum amount ofCo-Pi for high photocurrent density was proposed. The loaded Co-Pi has enhanced the overall PECperformance showing largely shifted onset potential ( 450 mV) with significantly increased photocur-rent (2.7 times at 1.23 V vs. RHE). The prepared composite photoanode of 1-D WO3/BiVO4/Co-Pi showsthe higher incident photon to current efficiency and applied bias photon-to-current efficiency thanwithout Co-Pi loading. We obtain the highest level of PEC performance with WO3/BiVO4/Co-Piheterojunction composite photoanode which is based on 1-D framework of WO3 prepared by facile, rapidand economical FVD in this study.
( Sang Myung Woo ),( Sang Hyub Lee ),( Ji Won Yoo ),( Ki Young Yang ),( Jung Gyun Seo ),( Joo Kyung Park ),( Jin Hyeok Hwang ),( Woo Jin Lee ),( Ji Kon Ryu ),( Yong Tae Kim ),( Yong Bum Yoon ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: No standard chemotherapy has been established for advanced gallbladder cancer. The authors studied the activity and tolerability of a gemcitabine and ox-aliplatin (GEMOX) combination in unresectable gallbladder cancer (GBC). Methods: Adult patients with pathologically confirmed unresectable GBC were prospectively recruited at three centers. No patient had received prior chemotherapy or radiotherapy. Patients received cycles of gemcitabine at 1,000 mg/m2 on day 1, followed by oxaliplatin at 100 mg/m2 on day 2, every 2 weeks. The primary study endpoint was time to progression. Results: Forty patients with unresect-able GBC were enrolled. The median age was 60 years (range, 38 to 79 years). All patients showed good performance status. Of the 33 analyzable patients, 12 achieved partial re-sponse (36%), 17 stable disease (52%), and four progressive disease (12%). No patient achieved a complete response. The tumor control rate was 88%. At a median follow-up of 6.8 months, the median time to progression was 5.3 months (95% confidence interval [CI], 3.7 to 6.9), and median overall survival was 6.8 months (95% CI, 6.1 to 7.5). Nine of the 40 patients (23%) experienced at least a grade-3 adverse event, but no patient experienced a grade-4 adverse event. Conclu-sions: GEMOX combination therapy is a feasible option and is well tolerated in unresectable GBC. (Gut Liver 2013;7:594-598)
Case report : Immunoglobulin G4-Related Disease Mimicking Unresectable Gallbladder Cancer
( Yoon Suk Lee ),( Sang Hyub Lee ),( Min Geun Lee ),( Seung June Lee ),( Jin Hyeok Hwang ),( Eun Shin ),( Yoon Jin Lee ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Immunoglobulin G4 (IgG4)-related disease is a novel dis-ease entity that can involve diverse organs, causing specific diseases, including autoimmune pancreatitis, sclerosing cholangitis, cholecystitis, inflammatory aortic aneurysm, and inflammatory pseudotumor. IgG4-related disease is charac-terized by elevated serum IgG4 concentrations, abundant IgG4 lymphoplasmacytic infiltration, and dramatic steroid responses. It is clinically important to differentiate this rare disease from primary sclerosing cholangitis and cholangio-carcinoma, because the treatment and prognosis of these two diseases are completely different. However, the preoper-ative diagnosis is challenging, and the disease is frequently misdiagnosed. If the serum level of IgG4 is within the normal range, the diagnosis of IgG4-related disease is more difficult. This article reports on a 59-year-old man with IgG4-related disease mimicking unresectable gallbladder cancer with nor-mal serum IgG4 concentrations. (Gut Liver 2013;7:616-620)
Yoon, Sang-Hyeok,Park, Dong-Wha,Kim, Kyo-Seon Springer-Verlag 2017 Korean Journal of Chemical Engineering Vol.34 No.12
<P>Various thin films for photoelectrochemical (PEC) water splitting were prepared and their PEC performance was tested. The precursor solutions for WO3 and BiVO4 photocatalysts were synthesized by solution processes, and the graphene oxide (GO) was prepared by Tour's method and was calcined and converted to reduced graphene oxide (rGO). The composite photocatalyst thin films of WO3, BiVO4, WO3/BiVO4 and WO3/BiVO4-rGO were prepared on fluorine doped tin oxide glass by spin coating and calcination processes and the PEC performances were analyzed for those photocatalyst layers. The controlled WO3/BiVO4 heterojunction layer showed better PEC performance than the WO3 or BiVO4 single layer by the combined effects of photocatalysts. The WO3/BiVO4-rGO film with the optimum concentration of rGO showed a noticeable increase in photocurrent density because of the increased electrical conductivity by rGO and reduced recombination rate in BiVO4 layer.</P>
Yoon Gwang-Seok,Choi Seong Huan,Woo Seong-Ill,Baek Yong-Soo,Park Sang-Don,Shin Sung-Hee,Kim Dae-Hyeok,Kwan Jun,Lee Man-Jong,Kwon Sung Woo 대한의학회 2021 Journal of Korean medical science Vol.36 No.19
Background: The neutrophil-to-lymphocyte ratio (NLR) has been proven to be a reliable inflammatory marker. A recent study reported that elevated NLR is associated with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI). We investigated whether NLR at emergency room (ER) is associated with mechanical complications of STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 744 patients with STEMI who underwent successful primary PCI from 2009 to 2018 were enrolled in this study. Total and differential leukocyte counts were measured at ER. The NLR was calculated as the ratio of neutrophil count to lymphocyte count. Patients were divided into tertiles according to NLR. Mechanical complications of STEMI were defined by STEMI combined with sudden cardiac arrest, stent thrombosis, pericardial effusion, post myocardial infarction (MI) pericarditis, and post MI ventricular septal rupture, free-wall rupture, left ventricular thrombus, and acute mitral regurgitation during hospitalization. Results: Patients in the high NLR group (> 4.90) had higher risk of mechanical complications of STEMI (P = 0.001) compared with those in the low and intermediate groups (13% vs. 13% vs. 23%). On multivariable analysis, NLR remained an independent predictor for mechanical complications of STEMI (RR = 1.947, 95% CI = 1.136–3.339, P = 0.015) along with symptom-to balloon time (P = 0.002) and left ventricular dysfunction (P < 0.001). Conclusion: NLR at ER is an independent predictor of mechanical complications of STEMI undergoing primary PCI. STEMI patients with high NLR are at increased risk for complications during hospitalization, therefore, needs more intensive treatment after PCI.