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( Na Eun Lee ),( Hong Seon Son ),( Sung Hoon Choi ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir disoproxil fumarate (TDF) is considered as the preferred treatment option for chronic hepatitis B (CHB) patients with treatment failure or resistance to prior nucleos(t)ide analogues (NAs) treatment. We investigated the efficacy of long-term TDF-based therapy in CHB patients with previous NAs-experience. Methods: This study included total 251 patients who had previous history of NAs therapy and were treated with TDF mono (n=173) or TDF combined with other NA (n=78) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients was 49.3 years, median duration of TDF therapy was 27.2 months, 75.7% were HBeAg-positive, and median HBV DNA was 3.7 log10IU/mL. The cumulative rates of VR were 188/244 (77.0%), 180/211 (85.3%), and 146/161 (90.7%) at 12, 24, and 36 months, respectively. Multivariate analysis showed that body mass index (OR 0.77, 95% CI 0.61-0.95, p=0.0189) and duration of TDF therapy (OR 1.09, 95% CI 1.02-1.18, p=0.0221) was significantly associated with VR. TDF monotherapy, HBeAg-positivity, platelet count, serum albumin was associated with VR in the univariate analysis, but not significant in the multivariate analysis. In relation to renal safety, patients showed renal impairment (7, 3.0%), mild hypophosphatemia (15, 7.2%), severe hypophosphatemia (1, 0.4%). Conclusions: Long-term TDF-based therapy demonstrated highly effective in viral suppression and relatively favorable renal safety in CHB patients with previous NA-experience. The body mass index and duration of TDF therapy was independent factors associated with VR.
( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.
메트헤모글로빈혈증을 보인 indoxacarb 중독 1례
신재훈,이재광,박성수,나상준,박준석,Shin, Jae-Hoon,Lee, Jae-Kwang,Park, Seong-Soo,Na, Sang-Jun,Park, Joon-Seok 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.2
Acute methemoglobinemia is induced by various causes, especially ingestion of oxidizing agents such as phenazopyridine, dapsone, and nitrite. Indoxacarb is an oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. It is known to block voltage-gated Na+ channels in insects and mammals, but the mechanism is not yet well understood. We describe a case of a 41-year-old woman with methemoglobinemia that developed following Indoxacarb ingestion, which improved after intravenous injection of methylene blue. This is the first known such case. If signs and symptoms of methemoglobinemia occur after Indoxacarb ingestion, antidotal therapy with methylene blue should be considered as a necessary treatment.
Unilateral hypoglossal nerve palsy after mild COVID-19: a case report
Sang Jae Lee,Si Youn Song,Hyung Gyun Na,Chang Hoon Bae,Yong-Dae Kim,Yoon Seok Choi 제주대학교 의과학연구소 2023 The Journal of Medicine and Life Science Vol.20 No.2
Post-acute coronavirus disease (COVID-19) syndrome is defined as persistent symptoms or delayed complications after COVID-19. Several cases of cranial nerve invasion related to COVID-19 have been reported. However, to our knowledge, no cases of solitary unilateral hypoglossal nerve paralysis after mild COVID-19 without intubation have been reported to date. Herein, we report the case of a 64-year-old man with unilateral hypoglossal nerve palsy as a complication of COVID-19. He complained of dysarthria and tongue discomfort 2 weeks after COVID-19 onset. Brain and neck computed tomography, magnetic resonance imaging, ultrasonography, and blood tests ruled out other possible causes. The patient’s nerve palsy was rapidly diagnosed and improved with early rehabilitation. Understanding of the pathology of COVID-19 is still limited. Physicians should focus on patients’ symptoms and their relationship to COVID-19, and investigate complications immediately. This case highlights the importance of early detection and rehabilitation of post-acute COVID-19 syndrome.
( Sung Hee Jung ),( Yun Jung Lee ),( Sung Hoon Lee ),( Hyang Le Lee ),( Hyeon Woong Yang ),( An Na Kim ),( Sang Woo Cha ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Alms: The frequency of intestinal involvement in Behcet`s disease is known to be 3~25% with geographic differences which is higher in East Asian patients including Koreans. We tried to find out the reliable gastrointestinal symptoms and laboratory data which can predict the verification of intestinal Behcet`s disease by colonoscopy. Methods: Between April 2004 and August 2007, 29 patients underwent colonoscopy among 186 patients who were diagnosed with complete or incomplete type Behcet`s disease at the department of rheumatology internal medicine, Eulji medical school hospital, Daejeon, Korea. We analyzed the relations among their symptoms, colonoscopic findings, and laboratory data, retrospectively using medical records. A p value of less than 0.05 was considered as statistically significant. Results: The mean age of the 29 patients was 43.3 years; most (23/29) of them were female. Twenty two (75.9%) patients complained of gastrointestinal symptoms, such as abdominal pain (41.1%), hematochezia, diarrhea, loose stool. On laboratory examination, mean Hb was 12.3 g/dL, ESR 31.8 mm/hr, and CRP 2.30 mg/dL. On colonoscopy, lesions were found in only 50% of the symptomatic patients. There was no significant relation with the presence of gastrointestinal symptoms and colonoscopic lesions (p>0.05). Hematochezia (p=0.004) and anemia (p=0.042) were strongly correlated to colonoscopic lesions unlike diarrhea, loose stool, abdominal pain, ESR, and CRP elevation Conclusions: We should consider the colonoscopic examination including terminal ileum to the Behcet`s disease patients who showed hematochezia and anemia for the early recognition of intestinal Behcet`s disease.
( Sang-hoon Kim ),( Hwa-sun Lee ),( Eui-ri Na ),( Jong-wook Moon ),( Young-joon Kim ) 조선대학교 구강생물학연구소 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.1
The noted anodic oxidation of titanium surfaces by the utilization of an electrochemical method is one of the procedures that can be used for the enhancement of osseointegration. This study evaluated the surface characteristics and the cell response of titanium samples that were modified by different treatment conditions. The samples were subsequently divided into 4 groups. In this study, Group I was noted as an anodized TiO<sub>2</sub> film using a constant voltage, 270 V for 30 sec. Further, Group II was noted as using an anodized TiO<sub>2</sub> film using a constant voltage, 270 V for 60 sec. Also, Group III was an anodized TiO<sub>2</sub> film using a constant voltage, 270 V for 90 sec. The control was a non-treated machined titanium surface. The results were as follows: the XRD analysis showed that the crystallinity of anodic oxide film was composed of anatase and rutile. The study continued with the procedure of increasing the time for anodization, whereby it was noted that the intensity of the TiO<sub>2</sub> peaks for anatase phase decreased, while the TiO<sub>2</sub> peak for the rutile phase was seen to have increased. In the MTT assay, it was noted that there was no significant difference in the response of fetal rat calvarial cells to the anodized titanium surfaces with the different treatment conditions. Similarly, the Group II and III showed higher ALP activity levels compared with the control and Group I (p<0.01). In the RT-PCR analysis, it is noted that the bone sialoprotein mRNA expression in Group II and III increased approximately 1.7-fold and 1.5-fold respectively, compared with the control, which was cp-Ti. The osteocalcin mRNA expression in Group II and III also increased approximately 1.6-fold and 1.7-fold respectively, compared with the control. Fundamentally, these results suggest that the anodized TiO<sub>2</sub> surfaces treated at 60 and 90 sec, should promote cellular activity of the noted and reviewed osteoblasts, as compared with the machined Ti surface.
Na, Youngjun,Li, Dong Hua,Choi, Yongjun,Kim, Kyoung Hoon,Lee, Sang Rak Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8
Objective: Two experiments were conducted to determine the effects of feeding level on nutrient digestibility and enteric methane ($CH_4$) emissions in growing goats and Sika deer. Methods: Three growing male goats (initial body weight [BW] of $22.4{\pm}0.9kg$) and three growing male deer (initial BW of $20.2{\pm}4.8kg$) were each allotted to a respiration-metabolism chamber for an adaptation period of 7 d and a data collection period of 3 d. An experimental diet was offered to each animal at one of three feeding levels (1.5%, 2.0%, and 2.5% of BW) in a $3{\times}3$ Latin square design. The chambers were used for measuring enteric $CH_4$ emission. Results: Nutrient digestibility decreased linearly in goats as feeding level increased, whereas Sika deer digestibility was not affected by feeding level. The enteric production of $CH_4$ expressed as g/kg dry matter intake (DMI), g/kg organic matter intake, and % of gross energy intake decreased linearly with increased feeding level in goats; however, that of Sika deer was not affected by feeding level. Six equations were estimated for predicting the enteric $CH_4$ emission from goats and Sika deer. For goat, equation 1 was found to be of the highest accuracy: $CH_4(g/d)=6.2({\pm}14.1)+10.2({\pm}7.01){\times}DMI(kg/d)+0.0048({\pm}0.0275){\times}dry$ matter digestibility (DMD, g/kg)-0.0070 (${\pm}0.0187$)${\times}$neutral detergent fiber digestibility (NDFD; g/kg). For Sika deer, equation 4 was found to be of the highest accuracy: $CH_4(g/d)=-13.0({\pm}30.8)+29.4({\pm}3.93){\times}DMI(kg/d)+0.046(0.094){\times}DMD(g/kg)-0.0363({\pm}0.0636){\times}NDFD(g/kg)$. Conclusion: Increasing the feeding level increased $CH_4$ production in both goats and Sika deer, and predictive models of enteric $CH_4$ production by goats and Sika deer were estimated.
( Na Young Kim ),( Dong Ho Lee ),( Joo Sung Kim ),( Hyun Chae Jung ),( In Sung Song ),( Kyung Phil Kang ),( Jung Hoon Lee ),( Jae Il Chung ),( Hyun Cheul Choi ),( Taek Man Nam ),( Sang Hyup Lee ),( Yo 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: The prevalence of gastric cancer and Helicobacter pylori (Hp) infection is high in Korea. This study was performed to evaluate the prevalence rate of atrophic gastritis (AG) and intestinal metaplasia (IM) and their risk factors in the aspect of Hp virulence factors, environmental and host factors in normal population. Methods: The subjects consisted of 389, 135 H. pylori-negative and 254 H. pylori-positive. AG and IM were scored histologically by the Sydney classification in the antrum and body, respectively. Prevalence rate and bacterial factors such as cagA, vacA m1, m2, and oipA; environmental factors such as smoking, alcohol drinking; host factors such as genetic polymorphisms for IL-IB-511, IL-IRN, TNF-A, IL-10-592, IL-10-819, IL-10-1082, IL-8-251, IL-6-572, GSTP1, and p53 codon 72 were evaluated. Risk factors were calculated by multiple logistic regression analysis. Results: The prevalence rate of AG increased from 25%, 0% in the age of 20s, 45% and 22% in the 40s and 50% and 35% in the over 70s in the antrum and body, respectively (p<0.001). In case of IM it increased from 11.1% and 6.4% in the 30s up to 43% and 43% in over 70s in the antrum and body, respectively, (p<0.001). The positive rates of AG and IM were significantly higher in the Hp-positive than in the Hp-negative subjects. Multivariate analysis showed that the risk factors for AG were Hp infection, age ≥60, cagA and vacA m1 positive. In case of IM the risk factors were Hp infection, age ≥60, smoking, spicy food, occupation (unemployed or non professional vs. professional), IL6-572 G carrier over C/C and IL10-592 C/A vs. A/A. Conclusions: The prevalence rate of AG and IM increased proportional to age. The most risk factor for AG and IM was Hp infection. Bacterial factors were important for AG but environmental and host factors were rather important in case of IM.