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Kwon, Yo Han,Woo, Sang‐,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang‐,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon‐,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.38
<P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>
Sang-Heon Cho,Jung-Hee Lee,Hyeong-Seok Lim,Kyoo-Hyung Lee,Dae-Young Kim,Sangmin Choe,Kyun-Seop Bae,Je-Hwan Lee 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT) participated in this prospective study. Patients were randomized to receive intravenous busulfan, either as the conventional dosage (3.2 mg/kg daily) or according to the new dosing scheme based on their actual body weight (ABW) (23×ABW<sup>0.5</sup> mg daily) targeting an area under the concentration-time curve (AUC) of 5924 μM∙min. Pharmacokinetic profiles were collected using a limited sampling strategy by randomly selecting 2 time points at 3.5, 5, 6, 7 or 22 hours after starting busulfan administration. Using an established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a <i>posteriori</i> Bayesian estimators were estimated to calculate the predicted AUC (AUC<sub>PRED</sub>). The accuracy and precision of the AUC<sub>PRED</sub> values were assessed by calculating the mean prediction error (MPE) and root mean squared prediction error (RMSE), and compared with the target AUC of 5924 μM∙min. VPC showed that most data fell within the 95% prediction interval. MPE and RMSE of AUC<sub>PRED</sub> were -5.8% and 20.6%, respectively, in the conventional dosing group and –2.1% and 14.0%, respectively, in the new dosing scheme group. These findings demonstrated the validity of a new dosing scheme for daily intravenous busulfan used as conditioning therapy for HCT.
Establishment of a Resource Population of SLA Haplotype-Defined Korean Native Pigs
Cho, Han-Ok,Ho, Chak-Sum,Lee, Yu-Joo,Cho, In-Cheol,Lee, Sung-Soo,Ko, Moon-Suck,Park, Chan-Kyu,Smith, Douglas M.,Jeon, Jin-Tae,Lee, Jun-Heon Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.5
The highly polymorphic porcine major histocompatibility complex (MHC), or the swine leukocyte antigens (SLA), has been repeatedly associated with variations in swine immune response to pathogens and vaccines as well as with production traits. The SLA antigens are also important targets for immunological recognition of foreign tissue grafts. We recently established a resource population of Korean native pigs as models for human transplantation and xenotransplantation research. In this study, 115 animals derived from three generations of the Korean native pigs were genotyped for three SLA class I (SLA-2, SLA-3 and SLA-1) and three SLA class II loci (DRB1, DQB1, DQA) using PCR with sequence-specific primers (PCR-SSP) at the allele group resolution. A total of seven SLA haplotypes (Lr-5.34, Lr-7.23, Lr-31.13, Lr-56.23, Lr-56.30, Lr-59.1, Lr-65.34), comprising six unique class I and five unique class II haplotypes, were characterized in the founding animals. Class I haplotype Lr-65.0 and class II haplotype Lr-0.34 were novel; and together with Lr-56.0 these haplotypes appeared to be breed-specific. In the progeny population, Lr-7.23 and Lr-56.30 appeared to be the most prevalent haplotypes with frequencies of 34.7% and 31.6%, respectively; the overall homozygosity was 27.4%. This resource population of SLA-defined Korean native pigs will be useful as large animal models for various transplantation and xenotransplantation experiments, as well as for dissecting the roles of SLA proteins in swine disease resistance and production traits.
Growth and Properties of Sb-doped ZnMgO Thin Films Deposited Using rf Magnetron Sputtering
Sung Mook Chung,Jae Heon Shin,Min Ki Ryu,Chi-Sun Hwang,Hye Yong Chu,Kyoung Ik Cho 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3
We report on the growth and the properties of Sb-doped ZnMgO thin films deposited using radiofrequency (rf) magnetron sputtering for applications as transparent thin film transistors (TFTs) with p-type channels. The target was prepared with high-purity MgO mixed with ZnO and Sb2O5 as doping agents. Thin films were heat-treated in vacuum, oxygen, and nitrogen atmospheres. The effects of the working gas (Ar/O2) ratios and the annealing conditions on the structural and the electrical properties were investigated. The atomic ratio of Zn/Mg in the films, and accordingly the films properties, depended on the post-annealing conditions and on the oxygen partial pressure in the working gas during sputtering. We report on the growth and the properties of Sb-doped ZnMgO thin films deposited using radiofrequency (rf) magnetron sputtering for applications as transparent thin film transistors (TFTs) with p-type channels. The target was prepared with high-purity MgO mixed with ZnO and Sb2O5 as doping agents. Thin films were heat-treated in vacuum, oxygen, and nitrogen atmospheres. The effects of the working gas (Ar/O2) ratios and the annealing conditions on the structural and the electrical properties were investigated. The atomic ratio of Zn/Mg in the films, and accordingly the films properties, depended on the post-annealing conditions and on the oxygen partial pressure in the working gas during sputtering.
Cho, Sung Chun,Rhim, Ji Heon,Son, Young Hoon,Lee, Suk Jin,Park, Sang Chul Informa UK Ltd. 2010 Free radical research Vol.44 No.8
<P>The antibiotic drug 4,4′-diaminodiphenylsulphone (DDS) is used to treat several dermatologic diseases, including Hansen's disease. This study confirmed the antioxidant nature of DDS in hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>)-induced oxidative stress and assessed its role in other apoptotic stresses in human diploid fibroblasts (HDFs). Oxidative stress was effectively reduced by DDS in a dose-dependent manner. Moreover, the oxidative stress-induced increases in the levels of the p53 and p21 proteins were inhibited by pre-treatment with DDS. In addition, H<SUB>2</SUB>O<SUB>2</SUB> and DDS increased the level of cytochrome P450 (CYP450) IIE1 in HDFs, implicating a role for DDS in H<SUB>2</SUB>O<SUB>2</SUB> scavenging via the activation of CYP450. DDS treatment increased the activity of catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the GSH/GSSG ratio, indicating activation of the glutathione system against oxidative stress. However, DDS showed no protective effects on HDFs against other apoptotic stimuli, such as thapsigargin and staurosporine, suggesting that DDS would act only against oxidative stress. Therefore, in addition to its antibiotic function, DDS is a potent antioxidant against H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidative stress in HDFs.</P>
BiP Internal Ribosomal Entry Site Activity Is Controlled by Heat-Induced Interaction of NSAP1
Cho, Sungchan,Park, Sung Mi,Kim, Tae Don,Kim, Jong Heon,Kim, Kyong-Tai,Jang, Sung Key American Society for Microbiology 2007 Molecular and cellular biology Vol.27 No.1
<B>ABSTRACT</B><P>TheBiP protein, a stress response protein, plays an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5′ nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. Here we report that NSAP1 specifically enhances the IRES activity of BiP mRNA by interacting with the IRES element. Overexpression of NSAP1 in 293T cells increased the IRES activity of BiP mRNA, whereas knockdown of NSAP1 by small interfering RNA (siRNA) reduced the IRES activity of BiP mRNA. The amount of NSAP1 bound to the BiP IRES increased under heat stress conditions, and the IRES activity of BiP mRNA was increased. Moreover, the increase in BiP IRES activity with heat treatment was not observed in cells lacking NSAP1 after siRNA treatment. BiP mRNAs were redistributed from the heavy polysome to the light polysome in NSAP1 knockdown cells. Together, these data indicate that NSAP1 modulates IRES-dependent translation of BiP mRNA through an RNA-protein interaction under heat stress conditions.</P>
Protective effect of 4,4'-diaminodiphenylsulfone against paraquat-induced mouse lung injury
Cho, Sung-Chun,Rhim, Ji-Heon,Choi, Hae-Ri,Son, Young-Hoon,Lee, Seok-Jin,Song, Kye-Yong,Park, Sang Chul Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.9
Although 4,4'-diaminodiphenylsulfone (DDS, dapsone) has been used to treat several dermatologic conditions, including Hansen disease, for the past several decades, its mode of action has remained a topic of debate. We recently reported that DDS treatment significantly extends the lifespan of the nematode $C.$ $elegans$ by decreasing the generation of reactive oxygen species. Additionally, in $in$ $vitro$ experiments using non-phagocytic human fibroblasts, we found that DDS effectively counteracted the toxicity of paraquat (PQ). In the present study, we extended our work to test the protective effect of DDS against PQ $in$ $vivo$ using a mouse lung injury model. Oral administration of DDS to mice significantly attenuated the lung tissue damage caused by subsequent administration of PQ. Moreover, DDS reduced the local expression of mRNA transcripts encoding inflammation-related molecules, including endothelin-1 (ET-1), macrophage inflammatory protein-$1{\alpha}$ (MIP-$1{\alpha}$), and transforming growth factor-${\beta}$ (TGF-${\beta}$). In addition, DDS decreased the PQ-induced expression of NADPH oxidase mRNA and activation of protein kinase $C{\mu}$ ($PKC{\mu}$). DDS treatment also decreased the PQ-induced generation of superoxide anions in mouse lung fibroblasts. Taken together, these data suggest the novel efficacy of DDS as an effective protective agent against oxidative stress-induced tissue damages.