SYNTHESIS OF TERCYCLOPENTADIENYL DIMETALLIC COMPOUNDS

Noh, Sang-Gyun,Koh, Seung-Tae,Han, Won-Hee 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

We synthesized tercyclopentadienyl dimetallic compounds which could be precursors of tercyclopentadienyl diheterotrimetallic complexes. The synthesis starts with taking dicyclopentadiene and sodium in ethylene glycol dimethyl ether(DME) to make cyclopentadienyl sodium-DME complex. Subsequent reaction of this complex with iodine and butyllithium furnished fulvalene dianion. The reaction of fulvalene(Fv) dianion and 3-chloro-2-cyclopentenone produces tercyclopentadienyl compounds. This mixture upon treatment with Ru3(CO)12 in DME gave tercyclopentadienyl dimetallic compounds.

SYNTHESIS OF TERCYCLOPENTADIENYL DIHETEROTRIMETALLIC COMPLEX

Noh,Sang-Gyun 東洋大學校 産業技術硏究所 1999 東洋大學校 産業技術硏究所 論文集 Vol.1 No.1

We synthesized Tercyclopentadienyl Diheterotrimetallic complex of which thermodynamic and kinetic stability would provide a good opportunity for studying metal-metal interactions. Compound 13 was added DIBAL-H in toluene to give 14. Compound 14 was transferred to a warned solution of p-TsOH·H₂O in benzene. The mixture was neutralized with aqueous NaHCO₃, dried over potassium carbonate and filtered through a plug of silica gel to produce 15. To the solution of 15 in THF maintained at 0℃ was added [(CH₃)₃Si]₂NaN and warmed up to room temperature. The solution was transferred into flask containing [????]? at -78℃ and the mixture was allowed to stir for 2hr at room temperature. Running column chromatography gave us compound 16 as yellow crystals.

Exploration of aging and cancer-dependent genes based on analysis of TCGA RNA-Seq dataset

( Sang Gyun Noh ),( Dae Hyun Kim ),( Hee Jin Jung ),( Su Gyeong Ha ),( Hae-young Chung ) 한국장기요양학회 2018 한국장기요양학회 추계학술대회자료집 Vol.2018 No.-

Aging is a biological phenomenon which is associated with promotion of cancer onset and progression. Therefore, we planned to search for molecular markers that could predict aging and cancer onset using The Cancer Genome Atlas (TCGA), biological database. The RNA-Seq data downloaded from TCGA were categorized according to the sample types, age, and stages of cancer. Differentially expressed genes (DEGs) among the categorized groups were calculated by EBSeq, a program for calculating DEGs. Moreover, calculated DEGs were divided into stages of cancer and were organized by Venn diagram. We obtained 22 genes from intersections between aging and cancer group of the Venn diagrams and their expression levels were confirmed by RT-qPCR. As a result, pro-inflammatory genes, CCL19, CXCL6 and IL36B, and metabolic genes, APOA2 and UGT2A1, were differentially expressed in the aged kidneys, which shows that they were involved in both aging and cancer. In conclusion, our study demonstrates that pro-inflammatory and metabolic genes could be candidate genes to predict aging and cancer in aged kidneys.

유류오염 토양 내 석유계 탄화수소 화합물의 분해에 대한 퇴비의 시용 효과

김성은 ( Sung Un Kim ),김용균 ( Yong Gyun Kim ),이상몽 ( Sang Mong Lee ),박현철 ( Hyean Cheal Park ),김근기 ( Keun Ki Kim ),손홍주 ( Hong Joo Son ),노용동 ( Yong Dong Noh ),홍창오 ( Chang Oh Hong ) 한국환경농학회 2015 한국환경농학회지 Vol.34 No.4

BACKGROUND: Petroleum-contaminated soil from leaking above- and underground storage tanks and spillage during transport of petroleum products is widespread environmental problem in recent years. Application of compost may be the most promising, cost-effective, and eco-friendly technology for soil bioremediation because of its advantages over physical and chemical technology. The objective of this study was to evaluate effect of compost application on degradation of total petroleum hydrocarbon (TPH) in petroleum hydrocarbon-contaminated soil.METHOD AND RESULTS: An arable soil was artificially contaminated by diesel, and compost was applied at the different rate of 0, 10, 30, and 50 Mg/ha. Concentration of TPH in the soil decreased as application rate of compost increased. Degradation efficiency was highest at compost 30 Mg/ha; however, it slightly decreased with compost 50 Mg/ha. Kinetic modeling was performed to estimate the rates of chemical reaction. The correlation coefficient (R2) values for the linear plots using the second-order model were higher than those using the first-oder model. Compost 30 and 50 Mg/ha had the fastest TPH degradation rate in the second-order model. Change of microbial population in soil with compost application was similar to that of TPH.Microbial population in the soil increased as application rate of compost increased. Increasing microbial population in the contaminated soil corresponded to decreased in TPH concentration.CONCLUSION: Conclusively, compost application for soil bioremediation could be an effective response to petroleum hydrocarbon-contaminated soil. The increase in microbial population with compost suggested that compost application at an optimum rate might enhance degradation of TPH in soil.

에탄올-n-헵탄 공비 혼합물의 분리를 위한 압력변환 증류공정 연구

노상균(Sang Gyun Noh) 한국청정기술학회 2015 청정기술 Vol.21 No.4

본 연구에서는 에탄올-n-헵탄 이성분계 공비 혼합물의 분리를 위해 압력변환 증류공정(pressure-swing distillation, PSD)을 사용하여 전산모사 및 공정 최적화를 진행하였다. 저압-고압 컬럼 배열과 고압-저압 컬럼 배열을 통해 고순도 에탄올과 고순도 n-헵탄을 얻기 위한 압력변환 증류공정을 수행하였다. 전산모사 결과, 저압-고압 컬럼 배열 공정보다 고압-저압 컬럼 배열 공정을 사용할 경우 heat duty 값이 약 5.8% 정도 감소되어 에너지 소모량 면에서 더 경제적임을 확인할 수 있었다. In the present study, modelling and optimization of ethanol-n-heptane separation process were performed using pressure-swing distillation. The pressure-swing distillation process optimization was performed to obtain high purity ethanol and high purity n-heptane into a low-high pressure columns configuration and a high-low pressure columns configuration. The results of pressure-swing distillation process simulation and optimization using high-low pressure column configuration showed a reduced total reboiler heat duty at 5.8% which confirmed a more economical energy consumption.

Isolation of tyrosinase and melanogenesis inhibitory flavonoids from <i>Juniperus chinensis</i> fruits

Park, Sang-a,Jegal, Jonghwan,Chung, Ki Wung,Jung, Hee Jin,Noh, Sang Gyun,Chung, Hae Young,Ahn, Jongmin,Kim, Jinwoong,Yang, Min Hye Informa UK (TaylorFrancis) 2018 Bioscience, biotechnology, and biochemistry Vol.82 No.12

증기 재압축을 활용한 증발공정에서 스팀 절감에 대한 연구

노상균(Sang Gyun Noh) 한국청정기술학회 2016 청정기술 Vol.22 No.4

본 연구에서는 2중 효용 증발관을 이용하여 21.0 wt%의 NaCl 수용액에서 고형물의 NaCl을 1,524.58 kg h<SUP>-1</SUP>만큼 석출시키는 공정에 대해서 증기 재압축을 활용하여 스팀 소모량을 3,139 kg h-1에서 496 kg h<SUP>-1</SUP>로 줄이는 공정에 대한 전산모사 및 최적화작업을 수행하였다. 디에틸렌 글리콜(diethylene glycol)을 포함한 NaCl 수용액을 농축시키기 위한 증발농축 공정의 전산모사를 위해서는 AspenTech사의 Aspen Plus V8.8을 활용하였으며, 중간에 냉각기를 가지는 증기 재압축 공정의 전산모사를 위해서는 Schneider Electric사의 PRO/II with PROVISION V9.4를 이용하였다. 증기 재압축 공정에 대해서는 1기의 압축기를 사용한 공정과 중간에 냉각기를 가지는 2단 압축 공정을 상호 비교하였다. In this study, modeling and optimization study have been performed to obtain 1,524.58 kg h<SUP>-1</SUP> of a solidified NaCl by evaporating a 21.0 wt% of NaCl aqueous solution in order to reduce the steam consumption from 3,139 kg h<SUP>-1</SUP> to 496 kg h<SUP>-1</SUP> using a two-stage evaporation and a vapor recompression processes. Aspen Plus release 8.8 at AspenTech was utilized for the modeling of two stage evaporation process and PRO/II with PROVISION release 9.4 at Schneider Electric was also used for the simulation of two-stage vapor recompression process with an inter-cooler. For the simulation of the evaporation process containing NaCl aqueous solution, Aspen Plus release 8.8 at AspenTech Inc. was utilized and for the modeling of vapor recompression process PRO/II with PROVISION release at Schneider Electric Inc. For the vapor recompression process, single stage compression and two-stage compression system was compared.

What Is the Significance of a Large Number of Ruptured Aneurysms Smaller than 7 mm in Diameter?

Joo, Sang-Wook,Lee, Sun-Il,Noh, Seung-Jin,Jeong, Young-Gyun,Kim, Moo-Seong,Jeong, Yong-Tae The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.45 No.2

Objective : The International Study of Unruptured Intracranial Aneurysms (ISUIA) reported that the 5-year cumulative rupture rate of small unruptured aneurysms less than 7 mm in diameter is very low depending on the aneurysm's location. However, we have seen a large number of ruptured aneurysms less than 7 mm in clinical practice. The purpose of this study was to review our experience and to measure the size and location at which aneurysms ruptured in our patient population. Methods : We reviewed the characteristics of aneurysms, such as size and location, from the original angiograms of patients who were admitted to our hospital between January 2004 and December 2007. All aneurysms were treated surgically or through endovascular procedures. Results : Interventional or surgical treatment was given to a total of 889 patients, including 568 females and 321 males. At the time of our study, 627 cases were ruptured aneurysms and 262 cases were unruptured aneurysms. Of the ruptured cases, the mean diameter of the aneurysm was 6.28 mm. We found that 71.8% of ruptured aneurysms were smaller than 7 mm in diameter, and 87.9%, were smaller than 10 mm. Based on location, the data show that anterior communicating artery aneurysms most often presented with rupture sizes less than 7 mm (76.8%) and 10 mm (92.1%) in diameter. Most ruptured aneurysms were less than 7 mm in size, although recent studies have noted that small aneurysms are less likely to rupture. Conclusion : Although the natural history of unruptured intracranial aneurysms remains controversial, the aneurysm size and location play a signigicant role in determining the risk of rupture. Larger sample sizes and a long term study are needed to reveal the natural history and the rupture risk of unruptured intracranial aneurysms because the size of most ruptured aneurysms was less than 7 mm in diameter in our series.

한국인 신이식 환자에서 Interleukin-10과 Interferon-γ의 유전자 다형성이 이식신의 임상경과에 미치는 영향

박성훈 ( Sung Hoon Purk ),강기주 ( Ki Joo Kang ),송영림 ( Young Rim Song ),채동완 ( Dong Wan Chae ),오국환 ( Kook Hwan Oh ),김성균 ( Seong Gyun Kim ),노정우 ( Jung Woo Noh ),이영기 ( Young Ki Lee ),임춘수 ( Chun Su Lim ),김연수 ( 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.6

목 적 : Interleukin-10 (IL-10) 유전자 프로모터 (promoter)에 존재하는 3가지 단일 염기 다형성 (aingle nucleotide polymorphism : SNP)과 Interferon-γ (INF-γ) 유전자 첫 번째 인트론의 allele*C와 *A의 병렬적 반복횟수의 다형성 (variable numbers of tandem repeat : VNTR)은 각각 mitogen 자극에 의한 IL-10과 IFN-γ의 생성량에 영향을 주는 것으로 보고되고 있다. INF-γ와 IL-10은 각각 주된 Th1과 Th2 사이토카인으로 이식항원에 대한 개체의 면역반응에 중요한 역할을 한다. 따라서 이식 환자의 유전적 다형성에 따른 이식항원에 대한 IFN-γ와 IL-10의 생성양의 차이는 이식신에 대한 면역반응의 차이를 유발하고 궁극적으로 이식신의 임상경과에 영향을 미치리라 판단된다. 이에 연구자들은 신이식 수술을 받은 한국인 환자에서 IFN-γ와 IL-10의 유전자 다형성을 조사하고, 이들 사이토카인의 유전적 다형성이 이식신의 임상적 경과에 미치는 영향을 파악하고자 본 연구를 시행하였다. 방 법 : 1991년부터 2000년까지 강동성심병원에서 신이식 수술을 받고 5개월 이상 추적 관찰된 185명의 환자와 혈압이 정상이고 병력 및 검사소견에서 신질환의 증거가 없는 98명의 대조군을 대상으로 하였다. PCR과 특정 제한효소를 이용한 PCR -RFLP의 방법으로 IL-10 promoter의 세 가지의 SNP를 조사하였고, IFN-γ 유전자 첫 번째 인트론에 존재하는 CA 염기의 VNTR은 PCR 생성물의 크기에 따라 측정하였다. 유전적 다형성과 이식 환자의 임상적 경과의 관련성은 Chi-square test와 fisher`s Exact test 및 student t-test를 이용하여 평가하였다. 결 과 : IFN-γ에서는 신이식 환자와 대조군간의 allele*2와 allele*3의 분포의 차이는 없었다. 모든 연구 대상에서 IL-10 promoter의 전사시작부위에서 -592 위치의 allele*A와 *C은 각각 -819 위치의 allele*T와 *C과 연관 (ilnkeage)되었다. -1,082 위치의 *C/*A genotype은 신이식 환자에서 7.0%로 대조군의 17.3%에 비하여 낮았다(p=0.02). *C/*G genotype은 모든 대상 환자에서 관찰되지 않았다. IL-10와 IFN-γ의 유전적 다형성은 급성거부반응의 빈도나 중증조와는 관련이 없었고, 추적 관찰기간 중 혈청 크레아티닌 농도의 증가에도 영향을 주지 않았다. 결 론 : 한국인의 IFN-γ첫 번째 intron의 VNTR 다형성의 분포는 서양인에서의 보고와 유사하였으나 IL-10 promotor SNP 다형성은 서양인과 대단히 상이한 분포가 관찰되었고 -1,082 *G/*A genotype의 빈도가 신이식 환자에서 대조군에 비하여 낮았다. 한국인에서의 IL-10와 IFN-γ의 유전적 다형성은 이식신의 임상적 경과에 의미있는 영향을 주지 못하였다. Background : The single nucleotide polymorphism (SNP) of interleukin-10 and the variable number of tandem repeat (VNTR) of CA dinucleotide of Interferon-γ are reported to have an influence on the production of IL-10 and IFN-γ respectively. The aims of this study are to investigate the gene polymorphisms of IL-10 and IFN-γ in Korean renal transplant patients and to assess their impacts on the clinical courses of renal allografts. Methods : The one hundred eighty-five patients who received renal allografts and were followed for more than 5 months from 1991 to May 2000 in Kangdong Sacred Heart Hospital, and ninety-eight normal healty controls were investigated, Three SNPs in promoter region of IL-10 gene were assayed by PCR-RFLP. The (CA) dinucleotide repeat polymorphism of IFN-γwere assessed by evaluation of size of PCR products. Results : Allele*2 and allele*3 were major alleles of IFN-γ in our study and there was no significant difference of alleleic and genotypic distribution between recipient and control group. The -592*A and -592*C in the IL-10 promotor region were tightly linded to -819*T and -819*C, respectively. The frequency of -1082*G/*A genotype of recipent group was 7.0% and smaller than that of control group (17.3%, p=0.02). The *G/*G genotype (IL-10 high producer) was absent in all our study subjects, which was quite different from Western studies. IFN-7 and IL-10 gene polymorphisms had no impact on the incidence and severity of acute rejection, and long term graft fucntion after transplantation. Conclusion. Unlike IFN-γ the SNPs of IL-10 promoter were qua different from those in Western patients. The frequency of -1,082*G/*A genotype of IL-10 was smaller in recipient group. In conclusion, the polymorphisms of IL-10 and IFN-γ had no impact on the clinical courses of renal allografts under the current therapeutic strategies.

GPS센서와 MCL알고리즘을 이용한 실외환경에서의 이동로봇 위치 추정

노성우(Sung-Woo Noh),김태균(Tae-Gyun Kim),고낙용(Nak-Yong Ko) 한국지능시스템학회 2011 한국지능시스템학회 학술발표 논문집 Vol.21 No.2