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Okubo, H,Sasaki, S,Murakami, K,Kim, M K,Takahashi, Y,Hosoi, Y,Itabashi, M Nature Publishing Group 2008 International Journal of Obesity Vol.32 No.3
Objective:To examine associations between dietary patterns and obesity.Design:Cross-sectional study.Subjects:A total of 3760 Japanese female dietetic course students aged 18–20 years from 53 institutions in Japan.Measurements:Diet was assessed over a 1-month period with a validated self-administered diet history questionnaire with 148 food items, from which 30 food groups were created and entered into a factor analysis. Body mass index (BMI) was calculated from self-reported body height and weight.Results:Mean BMI (±s.d.) was 20.9±2.8 kg m<SUP>−2</SUP>. Four dietary patterns were identified. After adjustment for several confounding factors and total energy intake, the ‘Healthy’ pattern, characterized by high intakes of vegetables, mushrooms, seaweeds, potatoes, fish and shellfish, soy products, processed fish, fruit and salted vegetables, was significantly associated with a lower risk of BMI25 (odds ratio of the highest quintile vs lowest, 0.57; 95% confidence interval: 0.37–0.87; P for trend <0.05). In contrast, the ‘Japanese traditional’ pattern, characterized by high intakes of rice, miso soup and soy products, and the ‘Western’ pattern, characterized by high intakes of meats, fats and oils, seasonings, processed meats and eggs, were both significantly associated with an increased risk of BMI25 (OR: 1.77; 95% CI: 1.17–2.67; P for trend <0.01 and OR: 1.56; 95% CI: 1.01–2.40; P for trend=0.04, respectively).Conclusion:Three major dietary patterns, Healthy, Japanese traditional and Western, were all independently and significantly related to the risk of obesity even among a relatively lean young Japanese female population.International Journal of Obesity (2008) 32, 541–549; doi:10.1038/sj.ijo.0803737; published online 25 September 2007
Genome-wide association study of recalcitrant atopic dermatitis in Korean children
Kim, K.W.,Myers, R.A.,Lee, J.H.,Igartua, C.,Lee, K.E.,Kim, Y.H.,Kim, E.J.,Yoon, D.,Lee, J.S.,Hirota, T.,Tamari, M.,Takahashi, A.,Kubo, M.,Choi, J.M.,Kim, K.E.,Nicolae, D.L.,Ober, C.,Sohn, M.H. Mosby 2015 The Journal of allergy and clinical immunology Vol.136 No.3
Background: Atopic dermatitis (AD) is a heterogeneous chronic inflammatory skin disease. Most AD during infancy resolves during childhood, but moderate-to-severe AD with allergic sensitization is more likely to persist into adulthood and more often occurs with other allergic diseases. Objective: We sought to find susceptibility loci by performing the first genome-wide association study (GWAS) of AD in Korean children with recalcitrant AD, which was defined as moderate-to-severe AD with allergic sensitization. Methods: Our study included 246 children with recalcitrant AD and 551 adult control subjects with a negative history of both allergic disease and allergic sensitization. DNA from these subjects was genotyped; sets of common single nucleotide polymorphisms (SNPs) were imputed and used in the GWAS after quality control checks. Results: SNPs at a region on 13q21.31 were associated with recalcitrant AD at a genome-wide threshold of significance (P < 2.0 x 10<SUP>-8</SUP>). These associated SNPs are more than 1 Mb from the closest gene, protocadherin (PCDH)9. SNPs at 4 additional loci had P values of less than 1 x 10<SUP>-6</SUP>, including SNPs at or near the neuroblastoma amplified sequence (NBAS; 2p24.3), thymus-expressed molecule involved in selection (THEMIS; 6q22.33), GATA3 (10p14), and S-phase cyclin A-associated protein in the ER (SCAPER; 15q24.3) genes. Further analysis of total serum IgE levels suggested 13q21.31 might be primarily an IgE locus, and analyses of published data demonstrated that SNPs at the 15q24.3 region are expression quantitative trait loci for 2 nearby genes, ISL2 and proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), in immune cells. Conclusion: Our GWAS of recalcitrant AD identified new susceptibility regions containing genes involved in epithelial cell function and immune dysregulation, 2 key features of AD, and potentially extend our understanding of their role in pathogenesis.
Son, S.,Ko, S.K.,Kim, J.W.,Lee, J.K.,Jang, M.,Ryoo, I.J.,Hwang, G.J.,Kwon, M.C.,Shin, K.S.,Futamura, Y.,Hong, Y.S.,Oh, H.,Kim, B.Y.,Ueki, M.,Takahashi, S.,Osada, H.,Jang, J.H.,Ahn, J.S. Pergamon Press 2016 Phytochemistry Vol.122 No.-
Twelve metabolites, including five highly oxygenated azaphilones, geumsanols A-E, along with seven known analogues were isolated from Penicillium sp. KCB11A109, a fungus derived from a ginseng field. Their structures were assigned by spectroscopic means (NMR and MS), and stereochemistries were determined by extensive spectroscopic analyses (<SUP>1</SUP>H-<SUP>1</SUP>H coupling constants, NOESY, and HETLOC) and chemical derivatizations (modified Mosher's method and acetonide formation). The isolates were evaluated for their anticancer, antimicrobial, antimalarial activities, and phenotypic effects in zebrafish development. Of these compounds possessing no pyranoquinone core, only geumsanol E exhibited cytotoxic activities and toxic effects on zebrafish embryos, suggesting that a double bond at C-11 and C-12 is important for biological activity.
Measurement of High Energy Neutron Induced Cross Sections for Chromium
S. Sekimoto,T. Utsunomiya,H. Yashima,H. Joto,S. Shibata,K. Ninomiya,D. Satoh,Y. Iwamoto,T. Omoto,R. Nakagaki,N. Takahashi,A. Shinohara,T. Shima,M. Hagiwara,H. Matsumura,K. Nishiizumi,Y. Matsushi,H. Ma 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Reaction cross sections for Cr induced by neutrons at 287 MeV were measured by using ^7Li(p,n) reaction at N0 beam line in the Research Center for Nuclear Physics (RCNP), Osaka University. To estimate quasi-monoenergetic neutron-induced cross sections, the Cr sample was irradiated on the two angles of 0° and 30° for the axis of the primary proton beam. Proton-induced reaction cross sections for Cr at 300 MeV were also measured. The measured cross section data in the ^(nat)Cr(n,x) and ^(nat)Cr(p,x) reactions are compared with the literature values and the JENDL high-energy file. Furthermore, those in the ^(nat)Cr(n,x) reactions are also compared with those in the ^(nat)Cr(p,x) reaction.
Carbon nanotube active-matrix backplanes for conformal electronics and sensors.
Takahashi, Toshitake,Takei, Kuniharu,Gillies, Andrew G,Fearing, Ronald S,Javey, Ali American Chemical Society 2011 Nano letters Vol.11 No.12
<P>In this paper, we report a promising approach for fabricating large-scale flexible and stretchable electronics using a semiconductor-enriched carbon nanotube solution. Uniform semiconducting nanotube networks with superb electrical properties (mobility of 20 cm2 V(-1) s(-1) and ION/IOFF of 10(4)) are obtained on polyimide substrates. The substrate is made stretchable by laser cutting a honeycomb mesh structure, which combined with nanotube-network transistors enables highly robust conformal electronic devices with minimal device-to-device stochastic variations. The utility of this device concept is demonstrated by fabricating an active-matrix backplane (128 pixels, physical size of 64 cm2) for pressure mapping using a pressure sensitive rubber as the sensor element.</P>
POSTWEANING GROWTH OF BRAHMAN AND SANTA GERTRUDIS STEERS UNDER FEEDLOTS IN THE SUBTROPICS
Takahashi, J.,Rojas, S.S.,Castellani, P.G.,Denis, F.C. Asian Australasian Association of Animal Productio 1988 Animal Bioscience Vol.1 No.3
Postweaning performances of steer from 11 to 18 months of age under intensive feedlot condition were examined in Brahman and Santa Gertudis cattle breeds which have been established in Paraguay. Fitting of growth data in each breed to an empirical growth model with non-linear least square analysis resulted in the following age(t; months) - weight(w; kg) function made out each breed: w=638.26($1-2.341e^{-0.010965t}$) for Brahman and w=716.38($1-2.365e^{-0.10741t}$) for Santa Gertrudis. The estimated mature size of Brahman steers(638 kg) was 11% lower than that of Santa Gertrudis steers(716 kg). However, slightly larger k value (rate of maturing) of Brahman steer in the mechanistic model suggested relatively earlier maturing tendency in the breed. No significant differences in dressing percentage (Brahman, 59.3%; Santa Gertrudis, 58.8%) of chilled carcass weight to live-weight were observed between breed.