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김장길,석선호,Nathalie Rolland,Paul-Alain Rolland 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.
This paper describes polymer cap 0-level packaging of RF devices, which is based on successive wafer scale bonding and debonding techniques. Pre-fabricated benzocyclobutene (BCB) membranes on a carrier wafer were directly transferred onto a target substrate by wafer scale bonding process. Using an anti-adhesion layer of hydrophobic octadecyltrichlorosilane (OTS) self-assembled monolayer (SAM), the carrier wafer was mechanically detached from the membranes without any aggressive etching process. As a result, BCB packaging caps in various sizes have been successfully fabricated on a 3 inch Si substrate. BCB cap deformation by thermal residual stress was investigated using ANSYS simulation and the measured results were in good agreement with the simulated ones. Si3N4 film was deposited on the caps for hermetic sealing and the hermeticity was evaluated by N2 leak test. Finally, the suitability of BCB caps in RF applications was assessed by S-parameter measurement of gold coplanar waveguide (CPW) transmission lines. The insertion loss change by BCB packaging was negligible and the return loss was better than 20 dB from DC to 50 GHz.
Development of BCB Polymer Packaging for RF Applications
S. Seok,N. Rolland,P.-A. Rolland,Yeonsu Jang,Ill hwan Kim,Kukjin Chun 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
A whole Benzocyclobutene(BCB) membrane zero-level packaging using a wafer level bonding technique is presented. Wafer-scale membrane transfer technique using silicon carrier wafers was used to make BCB membrane caps placed above the device wafers. BCB multiple coating process using CYCLOTENE 4026-46 was developed for an encapsulation cap. The average height of the implemented BCB cap was approximately 40 ㎛ with a little curvature for the dimension of 2 ㎜ × 3 ㎜. Hermeticity of BCB was improved by depositing 0.5 ㎛-thick PECVD nitride on the membrane, which was verified by vacuum chamber test and the ANSYS model was developed to describe the BCB membrane movement depending on the vacuum level. Mechanical resonant frequency of the BCB membrane was also characterized 7.5 ㎑ with an optical measurement. In addition, RF characterization using coplanar waveguide (CPW) line and thin-film resonator were performed to estimate the effect of BCB film package from DC to 110 ㎓. The packaged thin-film resonator showed a frequency change of 100 ㎒ at 62.5 ㎓ resonance frequency and 200 ㎒ at 104 ㎓.
Thierry Paillard,Yves Rolland,Philipe de Souto Barreto 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.3
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders. Epidemiological data support an inverse relationship between the amount of physical activity (PA) undertaken and the risk of developing these two diseases. Beyond this preventive role, exercise may also slow down their progression. Several mechanisms have been suggested for explaining the benefts of PA in the prevention of AD. Aerobic physical exercise (PE) activates the release of neurotrophic factors and promotes angiogenesis, thereby facilitating neurogenesis and synaptogenesis, which in turn improve memory and cognitive functions. Research has shown that the neuroprotective mechanisms induced by PE are linked to an increased production of superoxide dismutase, endothelial nitric oxide synthase, brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factor, and vascular endothelial growth factor, and a reduction in the production of free radicals in brain areas such as the hippocampus, which is particularly involved in memory. Other mechanisms have also been reported in the prevention of PD. Exercise limits the alteration in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor commands and control by adaptive mechanisms involving dopamine and glutamate neurotransmission. AD and PD are expansive throughout our ageing society, and so even a small impact of nonpharmacological interventions, such as PA and exercise, may have a major impact on public health.
Plant Cell and Signaling Symposium : Plant sugar sensing and signaling networks
( Jen Sheen ),( Filip Rolland ),( Wan Hsing Cheng ),( Shuichi Yanagisawa ),( Qi Hall ),( Elena Baena Gonzalez ),( Young Hee Cho ),( Sang Dong Yoo ),( Patricia Leon ),( Brandon Moore ),( Li Zhou ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-
( Afifa Ait-belgnaoui ),( Isabelle Payard ),( Claire Rolland ),( Cherryl Harkat ),( Viorica Braniste ),( Vassillia Theodorou ),( Thomas A Tompkins ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.1
Background/Aims Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) prevents chronic stress-mediated brain function abnormalities by attenuating the HPA axis response. Here, we compared the effect between different probiotic treatments on the perception of visceral pain during colorectal distension (CRD) following a chronic stress and the consequences to the activity of the HPA axis. Methods After a 2-week treatment with a combined probiotic formulation, or L. helveticus or B. longum alone in stressed mice, the visceral pain in response to CRD was recorded. The expression of glucocorticoid receptors was determined in the different brain areas involved in the stress response (hypothalamus, hippocampus, and prefrontal cortex). The plasma levels of stress hormones were also measured. Results A pretreatment using the combination of probiotic formulation significantly reduces the chronic stress-induced visceral hypersensitivity respectively at 0.06, 0.08, and 0.10 mL CRD volume. However, a single probiotic (B. longum or L. helveticus) administration is less effective in reducing visceral pain in stressed mice. Moreover, the expression of the glucocorticoid receptor mRNA was consistently up-regulated in several brain areas after pretreatment with a combined probiotic, which correlated with the normalization of stress response compared to the inconsistent effects of a single probiotic. Conclusion The combination of L. helveticus and B. longum is more effective in regulating glucocorticoid negative feedback on the HPA axis than probiotic alone and subsequently in treating stress-induced visceral pain. (J Neurogastroenterol Motil 2018;24:138-146)
Tong, Ming-Sze,Sauleau, Ronan,Rolland, Anthony,Chang, Tae-Gyu Wiley Subscription Services, Inc., A Wiley Company 2007 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.49 No.9
<P>Study of electromagnetic band-gap (EBG) structures has become a hot topic in computational electromagnetics. In this article, some EBG structures integrated inside a circular waveguide are studied. They are formed by a series of air-gaps within a circular dielectric-filled waveguide. A body-of-revolution finite-difference time-domain (BOR-FDTD) method is adopted for analysis of such waveguide structures, due to their axial symmetric properties. The opening ends of the waveguide are treated as a matched load using an unsplit perfectly matched layer technique. Excitations on a waveguide in BOR-FDTD are demonstrated. Numerical results of various air-gap lengths with respect to the period of separation are given, showing an interesting tendency of EBG behavior. A chirping-and-tapering technique is applied on the EBG pattern to improve the overall performance. The proposed EBG structures may be applied into antenna structures or other system for unwanted signal suppression. Results show that the BOR-FDTD offers a good alternative in analyzing axial symmetric configurations, as it offers enormous savings in computational time and memory comparing with a general 3D-FDTD algorithm. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2201–2206, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22668</P>
Zheng, Wei,McLerran, Dale F.,Rolland, Betsy A.,Fu, Zhenming,Boffetta, Paolo,He, Jiang,Gupta, Prakash Chandra,Ramadas, Kunnambath,Tsugane, Shoichiro,Irie, Fujiko,Tamakoshi, Akiko,Gao, Yu-Tang,Koh, Woon Public Library of Science 2014 PLoS medicine Vol.11 No.4
<▼1><P>Wei Zheng and colleagues quantify the burden of tobacco-smoking-related deaths for adults in Asia.</P><P><I>Please see later in the article for the Editors' Summary</I></P></▼1><▼2><P><B>Background</B></P><P>Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest.</P><P><B>Methods and Findings</B></P><P>We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ≥45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan—accounting for ∼71% of Asia's total population. An approximately 1.44-fold (95% CI = 1.37–1.51) and 1.48-fold (1.38–1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI = 14.3%–17.2%) and 3.3% (2.6%–4.0%) of deaths, respectively, in men and women aged ≥45 y in the seven countries/regions combined, with a total number of estimated deaths of ∼1,575,500 (95% CI = 1,398,000–1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ≥45 y.</P><P><B>Conclusions</B></P><P>Tobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ≥45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented.</P><P><I>Please see later in the article for the Editors' Summary</I></P></▼2><▼3><P><B>Editors' Summary</B></P><P><B>Background</B></P><P>Every year, more than 5 million smokers die from tobacco-related diseases. Tobacco smoking is a major risk factor for cardiovascular disease (conditions that affect the heart and the circulation), respiratory disease (conditions that affect breathing), lung cancer, and several other types of cancer. All told, tobacco smoking kills up to half its users. The ongoing global “epidemic” of tobacco smoking and tobacco-related diseases initially affected people living in the US and other Western countries, where the prevalence of smoking (the proportion of the population that smokes) in men began to rise in the early 1900s, peaking in the 1960s. A similar epidemic occurred in women about 40 years later. Smoking-related deaths began to increase in the second half of the 20th century, and by the 1990s, tobacco smoking accounted for a third of all deaths and about half of cancer deaths among men in the US and other Western countries. More recently, increased awareness of the risks of smoking and the introduction of various tobacco control measures has led to a steady decline in tobacco use and in smoking-related diseases in many developed countries.</P><P><B>Why Was This Study Done?</B></P><P>Unfortunately, less well-developed tobacco control programs, inadequate public awareness of smoking risks, and tobacco company marketing have recently led to sharp increases in the prevalence of smoking in many low- and middle-income countries, particularly in Asia. More than 50% of men in many Asian countries are now smokers, about tw