http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Rakesh Kumar Jha,Kanghae Kim,Mansik Jeon,JeeHyun Kim,Min Young Kang,Insook Han,Moonkyu Kim 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.5
Swept-source optical coherence tomography (SS-OCT), a bio-photonic imaging modality, was used to demonstrate an initial feasibility experiment for detecting morphological variations of invivo mouse hair follicles for the anagen and the telogen growth stages. Two C57BL/6 adult male mice, one undergoing the anagen stage and the other undergoing the telogen stage of the hair follicle growth cycle, were selected for the experiment. The OCT cross-sectional images of mice skin were acquired in-vivo within an interval of 15 days, and the observed morphological changes were analyzed. The micro-structural features of mice skin on the 15th experimental day were further compared with corresponding histological observations. The preliminary result of this study provides clear insights into the structural details of mouse skin, confirming the resemblance of the OCT images with the corresponding histological measurements, and ensures the suitability of SSOCT for non-invasive analysis of hair follicle conditions.
Rakesh Kumar Jha,Preety D Swami 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.10
Health monitoring of a rotating machine is mainly done by investigation of the vibration patterns generated by the machine. Leveraging the fact that faults occurring in different parts of a machine generate unique fault signatures, a fault diagnosis methodology is proposed that can identify nine different healthy and faulty categories under varying load and noisy conditions. Neural network is employed for classification of faults in various categories. The robustness of features such as semivariance, kurtosis and Shannon entropy make them strong candidates to train the artificial neural network. The matching of vibration textural patterns with wave atom basis functions ensures removal of noise. As a result, the enhanced features used to train the neural network have led to high accuracy in classification. The algorithm is tested at various load conditions for both bearing and gear fault experimental data sets acquired by machinery fault simulator in laboratory. Simulation results show high degree of accuracy for both bearing and gear fault diagnosis under no load to heavy load noisy conditions.
산화티타늄 나노 입자에 의한 실크 단백질 형광 증폭 연구
Rakesh Kumar Jha,김성환 한국광학회 2024 한국광학회지 Vol.35 No.1
We report a purely protein-based platform for green fluorescence by mixing silk protein with green fluorescence protein (GFP), and also report its enhancement by the incorporation of TiO 2 nanoparticles. The TiO 2 nanoparticles eployed have diameters of 100 and 300 nm, with a significant increase in fluorescence (by a factor of 7.5) observed when introducing 300-nm TiO 2 nanoparticles. Furthermore, an increase in particle distribution density is found to enhance fluorescence amplification. These research findings suggest that protein-based fluorescent films can be enhanced by the characteristics of nanoparticles, opening up new possibilities in the fields of optics and fluorescence applications.
Oxidative Stress and Antioxidants in Disease and Cancer: A Review
Gupta, Rakesh Kumar,Patel, Amit Kumar,Shah, Niranjan,Choudhary, Arun Kumar,Jha, Uday Kant,Yadav, Uday Chandra,Gupta, Pavan Kumar,Pakuwal, Uttam Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Reactive oxygen species (ROS), highly reactive molecules, are produced by living organisms as a result of normal cellular metabolism and environmental factors, and can damage nucleic acids and proteins, thereby altering their functions. The human body has several mechanisms to counteract oxidative stress by producing antioxidants. A shift in the balance between oxidants and antioxidants in favor of oxidants is termed as "oxidative stress". Paradoxically, there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is known about the initial and direct regulation of signaling molecules by ROS, or what we term the "oxidative interface." This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). This review also deals with classification as well as mechanisms of formation of free radicals, examining their beneficial and deleterious effects on cellular activities and focusing on the potential role of antioxidants in preventing and repairing damage caused by oxidative stress. A discussion of the role of phytochemical antioxidants in oxidative stress, disease and the epigenome is included.
Adil Asghar,Rakesh Kumar Jha,Apurba Patra,Binita Chaudhary,Brijendra Singh 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.1
The Gantzer’s muscle is often present in the flexor compartment of the forearm. It lies underneath flexor digitorum superficialis and compresses the anterior interosseous nerve. Furthermore, this muscle frequently bestows an accessory muscle of flexor pollicis longus or flexor digitorum profundus, or sometimes together. The current meta-analysis aims to compute the prevalence of subtypes of Gantzer’s muscle. Major electronic databases (PubMed, Scopus, Google Scholar, etc.) were searched for title and abstract. After removing the duplicate citations, the titles/abstracts were shortlisted with the help of inclusion and exclusion criteria. The shortlisted titles/abstracts were downloaded or collected from the library. The data of all subtypes of Gantzer’s muscle were pooled from shortlisted published manuscripts for meta-analysis. The pooled estimate of other anatomical characteristics was also observed. A total of 59 cadaveric studies of sample size 5,903 were evaluated for pooled prevalence of flexor pollicis longus (accessory head). Similarly, the authors evaluated 14 studies of 1,627 upper limbs for flexor digitorum profundus (accessory head). The unit of analysis was per 100 upper limbs. The Pooled prevalence of accessory muscle of flexor pollicis longus and flexor digitorum profundus were 48% (95% CI, 44%-52%) and 17% (95% CI, 13%-21%), respectively. The Gantzer’s muscle is present in 2/3rd of the upper limbs. Accessory head of flexor pollicis longus is almost three times more common than the accessory head of flexor digitorum profundus. A classification of Gantzer’s muscle is needed to reduce the ignorance of these variants.
Park, Yoonho,Jha, Rakesh Kumar,Park, Chulwon,Rhee, Sang-Bong,Lee, Jae-Hyun,Park, Chang-Gi,Lee, Se-Hee Institute of Electrical and Electronics Engineers 2018 IEEE transactions on power delivery Vol.33 No.6
<P>A fully coupled finite element analysis (FEA) technique was proposed for solving the ion-flow field due to corona discharge under a high-voltage direct-current (HVDC) bipolar transmission line employing a field enhancement factor. To cover the shape and roughness effects for the stranded wire conductor, the field enhancement factor was introduced in the charge generation mechanism. The employed fully coupled FEA can solve the corona electric field with space charge propagation without the Deutsch assumption and is stable and fully convergent regardless of the possible higher values of wind speed. First, we simulated a dc ±500 kV transmission line tower consisting of six subconductor bundles in a bipolar configuration. Furthermore, the accuracy and the reliability of the simulated results were validated using the experimental results from the literature for a dc ±800 kV one-bipolar transmission line with six subconductor bundles. Moreover, the electric fields were assessed with and without consideration of the space charge, including the wind effect. Overall, the simulated results agree with the experimental results from the literature.</P>
Bhamore, Jigna R.,Jha, Sanjay,Singhal, Rakesh Kumar,Park, Tae Jung,Kailasa, Suresh Kumar Elsevier 2018 Journal of molecular liquids Vol.264 No.-
<P><B>Abstract</B></P> <P>In this work, we synthesized fluorescent carbon dots (CDs) using <I>Pyrus pyrifolia</I> (pear) fruit <I>via</I> hydrothermal method at 180 °C for 6 h without using any further treatment or surface passivating agents. The synthesized CDs possess intense blue fluorescence under UV lamp at 365 nm and exhibit emission peak at 471 nm when excited at 390 nm. Because of specific surface functional groups, the synthesized CDs showed high selectivity to detect Al<SUP>3+</SUP> ion through chelation enhanced fluorescence (CHEF) mechanism. The emission peak intensity of CDs at 471 nm was gradually enhanced with increasing concentration of Al<SUP>3+</SUP> ion, thereby Al<SUP>3+</SUP> ion was quantified by plotting calibration curve over the range of 0.005–50 μM with a detection limit of 0.0025 μM (2.5 nM). The nanoprobe was subsequently evaluated by assaying Al<SUP>3+</SUP> ion from spiked water samples, signifying the utility of nanoprobe for assaying of Al<SUP>3+</SUP> ion real samples. Furthermore, we also demonstrate that the bioimaging ability of CDs for imaging of <I>Bacillus subtilis</I> bacterial cell, suggesting that the nanoprobe can be used for cell imaging applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fluorescent carbon dots are derived from <I>Pyrus pyrifolia</I> (pear) fruit. </LI> <LI> Al<SUP>3+</SUP> ion was detected <I>via</I> chelation enhanced fluorescence mechanism. </LI> <LI> Al<SUP>3+</SUP> ion detection limit is 0.0025 μM (2.5 nM). </LI> <LI> The CDs acted as probes for imaging of <I>Bacillus subtilis</I> bacterial cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic representation for fabrication of CDs using pear fruit and sensing of Al<SUP>3+</SUP> ion <I>via</I> chelation enhanced fluorescence mechanism.</P> <P>[DISPLAY OMISSION]</P>