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황남철,최문석,이준혁,고광철,백승운,유병철,이종철,이광웅,조재원,박철근 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2
목적: 간의 국소 결정성 과형성은 일반적으로 특별한 치료가 필요 없는 양성 종양이다. 그러나 드물지만 합병증이 발생한 경우와 진단이 불확실한 경우에는 수술을 시행하게 된다. 이에 저자들은 간절제술을 시행한 국소 결절성 과형성의 임상적, 영상학적 특징들을 알아보고자 하였다. 대상과 방법: 1995년부터 2003년까지 수술을 시행하여 조직을 확인한 국소 결절성 과형성 환자 10명을 대상으로 연령, 성별, 실험실 검사 및 영상 소견과 조직 소견을 분석하였다. 결과: 연령의 중앙값은 37.5세, 남녀 비는 1.5:1이었다. 5예에서는 간세포선종이나 간세포암종을 감별할 수 없어서 수술을 시행하였으며, 수술 후 우연히 진단된 예는 4예이었다. 간세포암종의 위험 인자를 가지고 있었던 예는 4예(B형 간염 바이러스 보유자 3예, 간경변 2예)이었다. CT검사가 시행되었던 6예 중 5예는 동맥기에서 조영 증강을 보였고 문맥기 및 지연기로 감에 따라 주변과 동일(4예)한 또는 감소(2예)되는 양상을 보여 간세포암종과의 감별이 어려웠다. 크기는 3.2±2.2㎝이었으며 위치는 간우엽의 후하구역(S6)에 가장 많았다(30.0%). 4예에서 수술 전 침생검을 시행하였으나 고분화 간세포암종이나 간세포선종과의 감별이 어려웠다. 결론: 임상상, 영상검사 및 간침생검으로도 간세포암종이나 간세포선종과의 감별이 어려운 경우 수술을 시행하였으며 수술 전에는 발견하지 못하였지만 다른 질환으로 인한 수술시 우연히 발견된 경우도 있어 국소 결절성 과형성의 수술 전 진단이 어려운 경우가 적지 않음을 알 수 있었다. Background/Aims: Focal nodular hyperplasia (FNH) is a benign hepatic tumor with few serious complications and no malignant transformation. However, differential diagnosis between FNH and other liver tumors, especially hepatocellular carcinoma, is often difficult. Methods: Clinical features of surgically resected FNH were reviewed. From January, 1995 to February, 2003, 10 patients with surgically resected FNH were enrolled. Their age, sex, results of laboratory examination, imaging studies and pathologic findings were evaluated. Results: Median age was 37.5 years and sex ratio (male:female) was 1.5:1. In 5 cases, resection to exclude hepatic adenoma or HCC was performed. Four cases were diagnosed incidentally after surgery. Four patients had risk factors for HCC, such as hepatitis B virus infection, liver cirrhosis or both. The size of FNH was 3.2 2.2 cm. The most common site of the tumor was segment 6 (30.0%). Differential diagnosis with HCC was difficult in 5 of six cases in whom CT was performed. Although needle biopsies were performed preoperatively in 4 cases, it was difficult to distinguish FNH from hepatic adenoma or HCC. Conclusions: FNH was resected due to uncertainty of diagnosis, or incidentally during hepatectomy in patients with other liver disease. In the former, differential diagnosis with hepatic adenoma or HCC was a major problem despite extensive work-up including dynamic CT or biopsy. (Korean J Hepatol 2004;10:135-141)
Rhee, Jae-Sung,Raisuddin, Sheikh,Hwang, Dae-Sik,Lee, Kyun-Woo,Kim, Il-Chan,Lee, Jae-Seong Elsevier 2009 Ecotoxicology and environmental safety Vol.72 No.1
<P><B>Abstract</B></P> <P>Metallothionein (<I>MT</I>) gene expression was studied in different tissues, development stages and gender types of the mangrove killifish (<I>Kryptolebias marmoratus</I>). <I>MT</I> expression was also studied in a time-series experiment after exposure to trace metals and endocrine-disrupting chemicals (EDCs). The brain showed the highest level of <I>MT</I> transcripts. Although all the development stage showed some level of <I>MT</I> expression, the adult hermaphrodites showed the highest expression which was significantly higher than the secondary males. In the trace metal-exposed fish, cadmium caused the strongest induction of <I>MT</I>. However, other trace metals such as copper and zinc also caused <I>MT</I> gene induction. All the EDCs suppressed the expression of <I>MT</I> gene, and the effect of EDCs were not gender-specific. <I>K. marmoratus</I> has previously shown its suitability as a model species for toxicity studies and cancer research. This study demonstrated utility of <I>MT</I> as biomarker in <I>K. marmoratus</I>. However, confounding factors such as age, gender, and tissue types appear to influence the <I>MT</I> expression. Response of trace and organic pollutants such as EDCs also varied greatly. These observations suggest that <I>MT</I> would be a specific biomarker of trace metal exposure in <I>K. marmoratus</I> and expression would be influenced by intrinsic factors.</P>
( Rhee Jae Sung ),( Beom Soon Choi ),( Jeong Hoon Han ),( Soon Jin Hwang ),( Ik Young Choi ),( Jae Seong Lee ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.9
Microcystis aeruginosa is a cyanobacterium that can form harmful algal blooms (HABs) producing toxic secondary metabolites. We provide here draft genome information of four strains of this freshwater cyanobacterium that was obtained by the Next Generation Sequencing approach to provide a better understanding of molecular mechanisms at the physiological and ecological levels. After gene assembly, genes of each strain were identified and annotated, and a genome database and G-browser of M. aeruginosa were subsequently constructed. Such genome information resources will enable us to obtain useful information for molecular ecological studies with a better understanding of modulating mechanisms of environmental factors associated with blooming.
Rhee, Jae-Sung,Ki, Jang-Seu,Hwang, Dae-Sik,Park, Hyun,Ahn, In-Young,Lee, Jae-Seong Informa Healthcare 2012 Mitochondrial DNA Vol.23 No.5
<P>The complete mitochondrial genome was obtained from the assembled genome data sequenced by next-generation sequencing technology from the Arctic green sea urchin <I>Strongylocentrotus droebachiensis</I>. The mitochondrial genome sequence was 15,710 bp in size, and the gene order and contents were identical with previously reported sea urchin mitochondrial genomes. Of 13 protein-coding genes (PCGs), 1 gene (<I>Cytb</I>) had an incomplete stop codon. The base composition of the mitogenome of Arctic <I>S. droebachiensis</I> showed high A+T (58.36%) and anti-G bias (14.86%) on the third position of PCGs.</P>
HspA and HtpG Enhance Thermotolerance in the Cyanobacterium, Microcystis aeruginosa NIES-298
( Jae Sung Rhee ),( Jang Seu Ki ),( Bo Mi Kim ),( Soon Jin Hwang ),( Ik Young Choi ),( Jae Seong Lee ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.1
Heat shock proteins (Hsps) play a key role in the cellular defense response to diverse environmental stresses. Here, the role of Hsp genes in the acquisition of thermotolerance in the cyanobacterium Microcystis aeruginosa NIES-298 was investigated. Twelve Hsp-related genes were examined to observe their modulated expression patterns at different temperatures (10, 15, 25, and 35oC) over different exposure periods. HspA and HtpG transcripts showed an up-regulation of expression at low temperatures (10 and 15oC) and high temperature (35oC), compared with the control (25oC). To examine their effects upon thermotolerance, we purified recombinant HspA and HtpG proteins. During a thermotolerance study at 54oC, the HspA-transformed bacteria showed increased thermotolerance compared with the control. HtpG also played a role in the defense response to acute heat stress within 30 min. These findings provide a better understanding of cellular protection mechanisms against heat stress in cyanobacteria.
李淳宰,嚴玉今,黃春仙,李敬淑 효성여자대학교 새마을연구소 1985 새마을硏究論文集 Vol.5 No.-
In order to investigate the degree of changes in quality of fryingoils to be used at snack corners and street stalls in Taegu area,color density, acid value(AV), peroxide value(POV), carbonyl value(COV), and TBA Value were measured. 95 samples in summer and 91 samples in winter were collectedfrom oils fried for fish cake, hatdogs, chicken, vegetable and doug-hnuts. The mean value of color density, AV, POV and COV on thefrying oils collected In summer were higher than those in winter,while TBA value of oils in summer was similar to that in winter.According to the kinds of fried food, the degree of the change inquality of frying oil was high in order of fish cake, hotdog·, chicken,vegetable and doughnuts.